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■ Abbreviation / Long Form : 12-HETE / 12-hydroxyeicosatetraenoic acid

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Abbreviation:   12-HETE  (>> Co-occurring Abbreviation)
Long Form:   12-hydroxyeicosatetraenoic acid
 Abbreviation Variation
 Long Form Variation
 Pair(Abbreviation/Long Form) Variation
No. Year Title Co-occurring Abbreviation
2020 12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages. 12-LO, COX, MT, NF, p38 MAPK, PG, PKC, sPLA2
2020 Activation of metabolite receptor GPR91 promotes platelet aggregation and transcellular biosynthesis of leukotriene C4. 12-HHT, cES, cPLA2, LC-MS, LTC4, PMN, TX
2019 Changes in platelet function with inflammation in patients undergoing vascular surgery. AA, COX, TXB2
2018 12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-kappaB pathway in ovarian cancer. 12-LOX, ILK, LDH, NF-kappaB
2018 A new copper ionophore DPMQ protects cells against ultraviolet B irradiation by inhibiting the TRPV1 channel. ROS, UVB
2018 Aberrant fatty acid metabolism in skeletal muscle contributes to insulin resistance in zinc transporter 7 (znt7)-knockout mice. FABP3, KO, znt7
2018 Arachidonic acid metabonomics study for understanding therapeutic mechanism of Huo Luo Xiao Ling Dan on rat model of rheumatoid arthritis. AA, COX, HLXLD, LOX, LTB4, PGE2, RA, TCM, TXB2
2018 Female mice carrying a defective Alox15 gene are protected from experimental colitis via sustained maintenance of the intestinal epithelial barrier function. DSS, ZO-1
2018 Omega-6-derived oxylipin changes in serum of patients with hepatitis B virus-related liver diseases. 13-HODE, 14,15-DiHETrE, AFP, CYP450, HBV, HCC, TXB2
10  2018 Profile of Arachidonic Acid-Derived Inflammatory Markers and Its Modulation by Nitro-Oleic Acid in an Inherited Model of Amyotrophic Lateral Sclerosis. 15-HETE, AA, ALS, HO-1, LOX, NFA
11  2017 A serum metabolomics-driven approach predicts orange juice consumption and its impact on oxidative stress and inflammation in subjects from the BIONAOS study. HPJ, NPJ, OJ
12  2017 Elevated 12-hydroxyeicosatetraenoic acid (12-HETE) levels in serum of individuals with newly diagnosed Type 1 diabetes. ---
13  2016 A lipidomic analysis approach in patients undergoing lipoprotein apheresis. 14-HDHA, AA, DHA, EPA, GC, LDL
14  2016 Pharmacological inhibition of eicosanoids and platelet-activating factor signaling impairs zymosan-induced release of IL-23 by dendritic cells. DC, LT, TNF-a
15  2015 Activation of PPARgamma by 12/15-lipoxygenase during cerebral ischemia-reperfusion injury. I/R, OGD, PPARgamma, SD
16  2015 Changes in PTGS1 and ALOX12 Gene Expression in Peripheral Blood Mononuclear Cells Are Associated with Changes in Arachidonic Acid, Oxylipins, and Oxylipin/Fatty Acid Ratios in Response to Omega-3 Fatty Acid Supplementation. ALOX12, ARA, DHA, EPA, FA, IL-8, PBMCs, PE, PGE2, PTGS1, PTGS2, qPCR
17  2015 In vivo solid-phase microextraction liquid chromatography-tandem mass spectrometry for monitoring blood eicosanoids time profile after lipopolysaccharide-induced inflammation in Sprague-Dawley rats. AA, PP, PPB, SPME
18  2015 Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain. OA, TRPV1
19  2015 Metabolic signatures of bacterial vaginosis. BV
20  2014 12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition. COX-1, LOX, NSAIDs, TXA2
21  2014 Analysis, physiological and clinical significance of 12-HETE: a neglected platelet-derived 12-lipoxygenase product. 12-LOX, COX, ELISA, HPLC, RIA
22  2014 Integrated metabolomic profiling of hepatocellular carcinoma in hepatitis C cirrhosis through GC/MS and UPLC/MS-MS. GC/MS, HCC
23  2013 Eicosanoids and docosanoids in plasma and aorta of healthy and atherosclerotic rabbits. PUFAs
24  2013 Endothelial 12(S)-HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse mesenteric arteries. AA
25  2013 Individual variation in lipidomic profiles of healthy subjects in response to omega-3 Fatty acids. 12-HEPE, DHA, EPA, PGE2, TXB2
26  2013 Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease. 15-HETE, 17,18-diHETE, 17,18-EpETE, 19,20-diHDoPE, 19,20-EpDPE, AD, APP, ChE, PGD2, SMs
27  2013 Oral green tea catechin metabolites are incorporated into human skin and protect against UV radiation-induced cutaneous inflammation in association with reduced production of pro-inflammatory eicosanoid 12-hydroxyeicosatetraenoic acid. GTC, UVR
28  2013 Transient heparin-induced platelet activation linked to generation of platelet 12-lipoxygenase. Findings from a randomised controlled trial. 12-LOX, AA, ADP, CEA, COX-1, LMWH
29  2012 12-hydroxy-eicosatetraenoic acid (12-HETE): a biomarker of Churg-Strauss syndrome. BALF, CSS, EBC, HC, HES
30  2012 Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. Abcc, LPC, MCD, NASH, SLC10A1, Slco
31  2012 Effect of cyclooxygenase genotype and dietary fish oil on colonic eicosanoids in mice. COXs
32  2012 Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury. ALI, LPS, WT
33  2012 Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction. 12-LO, NOX-1, ROS
34  2011 12-lipoxygenase: a potential target for novel anti-platelet therapeutics. ---
35  2011 Analysis of omega-3 and omega-6 fatty acid-derived lipid metabolite formation in human and mouse blood samples. 12-HEPE, 12-LOX, 14-HDHA, DHA, EPA
36  2011 Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization. 12-LOX, NV, OIR, PDR, PEDF, VEGF
37  2011 Inhibition of renin release by arachidonic acid metabolites, 12(s)-HPETE and 12-HETE: role of TRPV1 channels. Ang I, ARNA, LS, RD, TRPV1
38  2011 Mass spectrometry-based quantitative analysis and biomarker discovery. CysLT, TDM, TX
39  2011 Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2alpha differently for cyclooxygenase-1 and 12-lipoxygenase catalysis. COX-1, PAR
40  2010 Endogenous Levels of Five Fatty Acid Metabolites in Exhaled Breath Condensate to Monitor Asthma by High-Performance Liquid Chromatography: Electrospray Tandem Mass Spectrometry. EBC, LOQ
41  2009 Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. 12-hLO, AA, KIE, LA, SIE
42  2009 Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease. PEs
43  2008 Effect of the interaction between lipoxygenase pathway and progesterone on the regulation of hydroxysteroid 11-Beta dehydrogenase 2 in cultured human term placental trophoblasts. hsd11b2, LOX, NDGA
44  2008 Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation. 12-HPETE, 13-HODE, 13-HPODE, AA, LA
45  2007 12(S)-hydroperoxyeicosatetraenoic acid (12-HETE) increases mitochondrial nitric oxide by increasing intramitochondrial calcium. NO
46  2007 Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism. 2-AG, AA, L-12LO, LOs, p12-LO
47  2007 Dual inhibition of cyclooxygenase and lipoxygenase enzymes by human cerebrospinal fluid. AA, COX, CSF, TXA2
48  2007 Physiologic and pathophysiologic roles of lipid mediators in the kidney. COX, EETs, LO
49  2006 Disparate effects of 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid in vascular endothelial and smooth muscle cells and in cardiomyocytes. 12-LO
50  2006 Monitoring eicosanoid biosynthesis via lipoxygenase and cyclooxygenase pathways in human whole blood by single HPLC run. 12-HHT, 15-HETE, 5-HETE, LTB4
51  2006 Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase. 12-LOX, HUVECs, MAPKs, PPARalpha
52  2005 12/15-lipoxygenase inhibitors in diabetic nephropathy in the rat. BHPP, CDC, Cr, DM, DN
53  2005 Arachidonic acid induces neuronal death through lipoxygenase and cytochrome P450 rather than cyclooxygenase. AA, COX, CYP450, LOX
54  2005 Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited. 20-HETE, AA, COX, EETs, LOX
55  2005 Delayed autoregulation of glucose transport in vascular endothelial cells. 12-LO
56  2005 Impaired arachidonic acid-mediated dilation of small mesenteric arteries in Zucker diabetic fatty rats. AA, CDC, ZDF
57  2005 In vivo antioxidant activity of methanol extract from quinoa fermented with Rhizopus oligosporus. GSH-Px, SOD, TBARS
58  2005 Lipoxygenase pathway of arachidonic acid metabolism in growth control of tumor cells of different type. AA, LOX
59  2005 The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin. alpha-SMA, COX, PG, RMC, TX
60  2004 Incorporation of arachidonic and linoleic acid hydroperoxides into cultured human umbilical vein endothelial cells. 12-HPETE, 13-HODE, 13-HPODE, AA, HUVEC, LA
61  2004 [Lipoxygenase inhibition and protection of cardiovascular system]. LO
62  2003 Determination of urinary 12(S)-hydroxyeicosatetraenoic acid by liquid chromatography-tandem mass spectrometry with column-switching technique: sex difference in healthy volunteers and patients with diabetes mellitus. DM
63  2003 Overexpression of 12-lipoxygenase and cardiac fibroblast hypertrophy. 12-LO, Ang II, CHO
64  2002 12-hydroxyeicosatetrenoate (12-HETE) attenuates AMPA receptor-mediated neurotoxicity: evidence for a G-protein-coupled HETE receptor. AMPAR
65  2002 A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid. LO
66  2002 Bacterial challenge stimulates formation of arachidonic acid metabolites by human keratinocytes and neutrophils in vitro. ---
67  2002 Hepoxilin B3 and its enzymatically formed derivative trioxilin B3 are incorporated into phospholipids in psoriatic lesions. 12-oxoETE, HxB3, TrXB3
68  2002 Key role of P38 mitogen-activated protein kinase and the lipoxygenase pathway in angiotensin II actions in H295R adrenocortical cells. 12-LO, Ang II, MAPKs
69  2002 Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model. 12-LO, HLHG, HLNG, LO, NLHG, NLNG
70  2002 [Leukotrienes and 12-HETE: key mediators of angiotensin II-mediated vascular effects.Rol in hypertension]. ---
71  2001 Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism. 12-HPETE, PHGPx
72  2001 Monohydroxylated fatty acid content in peripheral blood mononuclear cells and immune status of people at long times after the Chernobyl accident. ---
73  2001 Role of 'platelet-type' 12-lipoxygenase in skin carcinogenesis. ---
74  2000 Assessment of toxic potential of industrial chemicals using a cultured human bioartificial skin model: production of interleukin 1alpha and hydroxyeicosatetraenoic acids. IL-1alpha, SLS
75  2000 Augmented insulinotropic action of arachidonic acid through the lipoxygenase pathway in the obese Zucker rat. AA
76  2000 Effects of arachidonic acid metabolites in a murine model of squamous cell carcinoma. AA, COX, LOX, LTB4, PGE2
77  2000 Evidence that 12-lipoxygenase product 12-hydroxyeicosatetraenoic acid activates p21-activated kinase. ERK, PAK1, PI3K
78  2000 Inhibition of 12(S)-hydroxyeicosatetraenoic acid (12-HETE) production suppressed the intimal hyperplasia caused by poor-runoff conditions in the rabbit autologous vein grafts. BrdU, HL group, PR group
79  2000 Positional- and stereo-selectivity of fatty acid oxygenation catalysed by mouse (12S)-lipoxygenase isoenzymes. 13- and 9-HODE
80  2000 Promutagenic etheno-DNA adducts in multistage mouse skin carcinogenesis: correlation with lipoxygenase-catalyzed arachidonic acid metabolism. 8-HETE, DMBA, TPA
81  1999 Antiangiogenicity of docosahexaenoic acid and its role in the suppression of breast cancer cell growth in nude mice. DHA, VEGF
82  1999 Incorporation and effect of arachidonic acid on the growth of the human K562 cell line. AA
83  1999 Melatonin: an endogenous negative modulator of 12-lipoxygenation in the rat pineal gland. LOX
84  1999 Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice. 12-LO, 12-LOKO
85  1999 Trout thrombocytes contain 12- but not 5-lipoxygenase activity. 12-HEPE, LO, LT, LX, MACS
86  1998 12-hydroxyeicosatetraenoic acid is a long-lived substance in the rabbit circulation. ---
87  1998 12-Hydroxyeicosatetraenoic acid upregulates P-selectin-induced tissue factor activity on monocytes. ---
88  1998 Endothelium is required for 12-hydroperoxyeicosatetraenoic acid-induced vasoconstriction. 12-HPETE
89  1998 Two distinct effects of 12S-hydroxyeicosatetraenoic acid on platelet aggregation by zooxanthellatoxin-A and ionomycin. TXA2, TXB2, ZT-A
90  1997 Antioxidative mechanism and apoptosis induction by 3-hydroxyanthranilic acid, an antioxidant in Indonesian food Tempeh, in the human hepatoma-derived cell line, HuH-7. HAA
91  1997 Effect of nicotine on arachidonic acid metabolites and epithelial parameters in rat oral mucosa. LTB4, TXB2
92  1997 Effects of high glucose on vascular endothelial growth factor expression in vascular smooth muscle cells. 12-LO, Ang II, PSMC, VEGF, VSMC
93  1997 Effects of reactive oxygen species on the biosynthesis of 12 (S)-hydroxyeicosatetraenoic acid in mouse epidermal homogenate. ROS
94  1997 Elevated 12-lipoxygenase activity in the spontaneously hypertensive rat. Ang II, LO, VSMC, WKY
95  1997 Fatty acid composition, eicosanoid production and permeability in skin tissues of rainbow trout (Oncorhynchus mykiss) fed a control or an essential fatty acid deficient diet. 12-HEPE, 14-HDHE, AA, DHA, EFA, EPA, LTC4, LTC5, OM, PC, PE, PGF2 alpha, PGF3alpha, PI, PL, PS, PUFA
96  1997 Role of arachidonic acid metabolites in tumor growth inhibition by nonsteroidal antiinflammatory drugs. AA, ELISA, LTB4, PGE2, RIA, SCC
97  1997 Role of the lipoxygenase pathway in angiotensin II-induced vasoconstriction in the human placenta. Ang II, LO
98  1997 Role of the lipoxygenase pathway in phenylephrine-induced vascular smooth muscle cell proliferation and migration. ---
99  1996 A 12-lipoxygenase product, 12-hydroxyeicosatetraenoic acid, is increased in diabetics with incipient and early renal disease. HH, NIDDM
100  1996 Albumin prevents metabolism of 12-hydroxyeicosatetraenoic acid by leukocytes in vitro. ---