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■ Abbreviation / Long Form : 3alpha-HSD / 3alpha-hydroxysteroid dehydrogenase

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Abbreviation:   3alpha-HSD  (>> Co-occurring Abbreviation)
Long Form:   3alpha-hydroxysteroid dehydrogenase
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No. Year Title Co-occurring Abbreviation
1  2022 Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone. iPR, mPR, Sig-1R
2  2021 Combined MD and QM/MM Investigations of Hydride Reduction of 5alpha-Dihydrotestosterone Catalyzed by Human 3alpha-Hydroxysteroid Dehydrogenase Type 3: Importance of Noncovalent Interactions. 5 alpha-DHT, MD, NADPH, NCI, QM/MM
3  2020 Epigenetic regulation of steroidogenic enzymes expressed in peripheral blood mononuclear cells from healthy individuals and from patients with chronic lymphocytic leukemia. 17beta-HSD, 3beta-HSD, 5alpha-R, CLL, P450scc, PBMCs
4  2019 Developing an Enzyme-Assisted Derivatization Method for Analysis of C27 Bile Alcohols and Acids by Electrospray Ionization-Mass Spectrometry. EADSA
5  2018 A novel electrochemical biosensor for ultrasensitive detection of serum total bile acids based on enzymatic reaction combined with the double oxidation circular amplification strategy. POCT, SPCE, TBA
6  2018 PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma. CSF, EFP, MLP, PTSD
7  2018 Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD. CSF, DHEA, GABA, GC-MS, NMDA, PTSD
8  2017 Effects of Fungicides on Rat's Neurosteroid Synthetic Enzymes. RDH2
9  2017 Effects of Refined Xiaoyaosan on Depressive-Like Behaviors in Rats with Chronic Unpredictable Mild Stress through Neurosteroids, Their Synthesis and Metabolic Enzymes. 3beta-HSD, 5AR, ALLO, CUMS, PREG, PROG, XYS
10  2016 Indirect electrochemical detection for total bile acids in human serum. IED, SPCE, TBA
11  2016 Progesterone treatment modulates mRNA OF neurosteroidogenic enzymes in a murine model of multiple sclerosis. 3beta-HSD, EAE, StAR, TSPO, VDAC
12  2015 Environmental enrichment attenuates the age-related decline in the mRNA expression of steroidogenic enzymes and reduces the methylation state of the steroid 5alpha-reductase type 1 gene in the rat hippocampus. ---
13  2015 Expression, purification and functional characterization of a novel 3alpha-hydroxysteroid dehydrogenase from Pseudomonas aeruginosa. ORF, SBAs
14  2015 One step affinity recovery of 3alpha-hydroxysteroid dehydrogenase from cloned Escherichia coli. hsdA
15  2014 5alpha-reductase type I expression is downregulated in the prefrontal cortex/Brodmann's area 9 (BA9) of depressed patients. 5alpha-RI, ALLO, BA9, CSF, mRNA, NPS, NSE, PTSD, SBSSs
16  2014 Enabling multi-enzyme biocatalysis using coaxial-electrospun hollow nanofibers: redesign of artificial cells. DP
17  2014 Expression levels of mRNA for neurosteroidogenic enzymes 17beta-HSD, 5alpha-reductase, 3alpha-HSD and cytochrome P450 aromatase in the fetal wild type and SF-1 knockout mouse brain. 17beta-HSD, SF-1
18  2014 Fluoxetine elevates allopregnanolone in female rat brain but inhibits a steroid microsomal dehydrogenase rather than activating an aldo-keto reductase. AKR
19  2014 Selective inhibition of steroidogenic enzymes by ketoconazole in rat ovary cells. 20alpha-HSD, KCZ, TLC
20  2014 Ultrasensitive enzyme-linked immunosorbent assay (ELISA) of proteins by combination with the thio-NAD cycling method. ELISA, thio-NAD
21  2014 Understanding androgen action in adipose tissue. 17beta-HSD, AR, DHT, s.c
22  2013 A highly sensitive electrically driven electrochemiluminescent assay for quantification of bile acids in human serum. ECL
23  2012 Enzyme biosensor for androsterone based on 3alpha-hydroxysteroid dehydrogenase immobilized onto a carbon nanotubes/ionic liquid/NAD+ composite electrode. MWCNTs
24  2011 Variation in genes encoding the neuroactive steroid synthetic enzymes 5alpha-reductase type 1 and 3alpha-reductase type 2 is associated with alcohol dependence. 5alpha-R, AD
25  2010 Non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors. 5alpha,3alpha-THSs
26  2010 [Measurement of the transport activities of bile salt export pump using chemiluminescence detection method]. hBSEP, PFIC2, RI, TCA
27  2009 Determination of total bile acid levels using a thick-film screen-printed Ir/C sensor for the detection of liver disease. ---
28  2008 3alpha-Hydroxysteroid dehydrogenase type III deficiency: a novel mechanism for hirsutism. 3alpha-diol, DHT
29  2008 Androgen biosynthetic pathways in the human prostate. 3alpha-diol, DHEA, DHEAS, DHT
30  2008 Evaluation of a fluorometric-enzymatic method based on 3alpha-hydroxysteroid dehydrogenase for the mycotoxin zearalenone determination in corn. ZEN
31  2008 Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice. 5alpha-RI, AAS, SBSS
32  2007 Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice. 5alpha-RI, ALLO, SI
33  2007 Effects of swim stress on mRNA and protein levels of steroid 5alpha-reductase isozymes in prefrontal cortex of adult male rats. 5alpha-R, LIF-CE
34  2007 Electronic effects of para-substitution on acetophenones in the reaction of rat liver 3alpha-hydroxysteroid dehydrogenase. ---
35  2007 Steroid metabolism and profile of steroidogenic gene expression in Episkin: high similarity with human epidermis. 17beta-HSD, 20alpha-HSD, ADT, DHEAS, DHT
36  2006 Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. 5alpha-R, ALLO, THDOC
37  2006 Chiral inversion of RS-8359: a selective and reversible MAO-A inhibitor via oxido-reduction of keto-alcohol. ---
38  2006 Crystallization and preliminary X-ray analysis of the complex of NADH and 3alpha-hydroxysteroid dehydrogenase from Pseudomonas sp. B-0831. ---
39  2006 Discrete analysis of bile acid in serum and bile with 3 alpha-hydroxysteroid dehydrogenase and diaphorase immobilized onto alkylamine glass beads. CV, NBT
40  2006 Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma. 3alpha-diol, AKR, PG
41  2006 Leydig cell function in mice lacking connexin43. 17beta-HSD, 5alpha-R, Cx43
42  2005 Arginine 276 controls the directional preference of AKR1C9 (rat liver 3alpha-hydroxysteroid dehydrogenase) in human embryonic kidney 293 cells. ---
43  2005 Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3alpha-hydroxysteroid dehydrogenase activity. SSRIs
44  2005 Inhibition of 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) activity of human lung microsomes by genistein, daidzein, coumestrol and C(18)-, C(19)- and C(21)-hydroxysteroids and ketosteroids. 17beta-HSD
45  2005 [Isolation and identification of Comamonas testosteroni: cloning and overexpression of 3alpha-hydroxysteroid dehydrogenase in E.coli]. IPTG
46  2004 5alpha-reduced androgens may have actions in the hippocampus to enhance cognitive performance of male rats. 3alpha-diol, DHT
47  2004 Kinetic study of the enzymatic cycling reaction conducted with 3alpha-hydroxysteroid dehydrogenase in the presence of excessive thio-NAD(+) and NADH. ---
48  2004 New tools for molecular imaging of redox metabolism: development of a fluorogenic probe for 3 alpha-hydroxysteroid dehydrogenases. ---
49  2004 Testosterone's metabolism in the hippocampus may mediate its anti-anxiety effects in male rats. 3alpha-diol, DHT
50  2004 Transient-phase kinetic studies on the nucleotide binding to 3alpha-hydroxysteroid dehydrogenase from Pseudomonas sp. B-0831 using fluorescence stopped-flow procedures. AKR, cat, SDR
51  2004 [Expression analysis of mouse homologous proteins with human aldose reductase like-1]. ARL-1, CHO-Red, LeAR, MVDP, RaK-c, rARLP
52  2003 Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes. ---
53  2003 Characterization and modulation of sex steroid metabolizing activity in normal human keratinocytes in primary culture and HaCaT cells. 17beta-HSD, 3beta-HSD, DEX, DHT, IL-4
54  2003 Differential recognition of the free versus bound retinol by human microsomal retinol/sterol dehydrogenases: characterization of the holo-CRBP dehydrogenase activity of RoDH-4. SDR
55  2003 Proposed mechanism for sperm chromatin condensation/decondensation in the male rat. 3alpha-diol, 5 alpha-DHT, ABP
56  2003 Role of human type 3 3alpha-hydroxysteroid dehydrogenase (AKR1C2) in androgen metabolism of prostate cancer cells. 3alpha-diol, 5 alpha-DHT, AKRs
57  2003 The 3alpha-hydroxy-steroid-dehydrogenase-mRNA and -protein are more prevalent in pericentral than in periportal hepatocytes. ---
58  2002 Pathogenesis of diabetic neuropathy--do hyperglycemia and aldose reductase inhibitors affect neuroactive steroid formation in the rat sciatic nerves? AR, DHP, THP
59  2002 Purification, crystallization and preliminary X-ray diffraction results of human 17beta-hydroxysteroid dehydrogenase type 5. 17beta-HSDs
60  2001 3alpha-Hydroxysteroid dehydrogenase in animal and human tissues. ---
61  2001 3alpha-hydroxysteroid dehydrogenase messenger RNA transcription in the immature rat ovary in response to an ovulatory dose of gonadotropin. PCR
62  2001 Characterization of the 5alpha-reductase-3alpha-hydroxysteroid dehydrogenase complex in the human brain. CX, SC
63  2001 Cloning of the human RoDH-related short chain dehydrogenase gene and analysis of its structure. ---
64  2001 Modulation of the androgenic response by recombinant human 11-cis retinol dehydrogenase. 11-cis-RoDH, 3alpha-diol, DHT, HEK293, pCMV-11-cisRoDH, PSA
65  2001 Proteome analysis of rat hepatomas: carcinogen-dependent tumor-associated protein variants. Rak-c, rARLP-1
66  2001 Steroid 5alpha-reductases and 3alpha-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism. 5 alpha-DHT, 5alpha-R
67  2000 Feigrisolides A, B, C and D, new lactones with antibacterial activities from Streptomyces griseus. ---
68  2000 Functional expression, purification, and characterization of 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. ---
69  2000 Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. 3alpha-androstanediol, AKR, cat
70  2000 Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase. 3alpha-diol, DHT
71  2000 Interactions between type 1 astrocytes and LHRH-secreting neurons (GT1-1 cells): modification of steroid metabolism and possible role of TGFbeta1. 5alpha-R, DHP, DHT, TGF-beta1, THP
72  2000 Mutation of nicotinamide pocket residues in rat liver 3 alpha-hydroxysteroid dehydrogenase reveals different modes of cofactor binding. ---
73  2000 New 1-O-acyl alpha-L-rhamnopyranosides and rhamnosylated lactones from Streptomyces sp., inhibitors of 3 alpha-hydroxysteroid-dehydrogenase (3alpha-HSD). ---
74  1999 Characterization of homogeneous recombinant rat ovarian 20alpha-hydroxysteroid dehydrogenase: fluorescent properties and inhibition profile. 20alpha-HSD, AKR
75  1999 Metabolism of dihydrotestosterone in human liver: importance of 3alpha- and 3beta-hydroxysteroid dehydrogenase. 3alpha-diol, 3beta-HSD, DHT
76  1999 Opposing changes in 3alpha-hydroxysteroid dehydrogenase oxidative and reductive activities in rat leydig cells during pubertal development. 3alpha-diol, DHT
77  1999 Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. SSRIs
78  1998 Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution. 5 alpha-DHT, AR, HSD
79  1998 Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat Leydig cells. 17beta-HSD, 3alpha-diol, 5alpha-R, AO, mRNA
80  1997 Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate. 17beta-HSD, 3alpha-adiol, RoDH1
81  1996 Characterization of the substrate binding site in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein fluorescence. ---
82  1994 Progesterone 5-alpha-reduction in neuronal and in different types of glial cell cultures: type 1 and 2 astrocytes and oligodendrocytes. ---
83  1978 Electrophoretic and histochemical studies on hepatic 3 alpha-hydroxysteroid dehydrogenase in the rat. ---
84  1975 Effects of testosterone mediated or modulated by pituitary factors. TP