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■ Abbreviation / Long Form : A2AR / A2A receptor

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Total Number of Papers: 247
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Abbreviation:   A2AR  (>> Co-occurring Abbreviation)
Long Form:   A2A receptor
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2019 Adenosine A2A receptor (A2AR) activation triggers Akt signaling and enhances nuclear localization of beta-catenin in osteoblasts. A2AKO, A2ARs
2019 Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells. N1ICD, TCR
2019 Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Hippocampus: Cannabidiol Blunts Delta9-Tetrahydrocannabinol-Induced Cognitive Impairment. CB1R, CBD, Delta9-THC
2019 Adenosine from a biologic source regulates neutrophil extracellular traps (NETs). ADO, HNE, MSCs, NETs
2019 Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons. D1R, D2R, MSNs, PKA
2019 Blockade of microglial adenosine A2A receptor suppresses elevated pressure-induced inflammation, oxidative stress, and cell death in retinal cells. ---
2019 Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats. cAMP, GD, PCE, PKA, PW, TCH
2019 CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling. MPTP
2019 Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice. ---
10  2019 Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function. PAM, SWS
11  2019 Extracellular adenosine and slow-wave sleep are increased after ablation of nucleus accumbens core astrocytes and neurons in mice. DT, GFAP, NAc, SWS
12  2019 Membrane cholesterol depletion reduces downstream signaling activity of the adenosine A2A receptor. beta2AR, CCM, GPCRs, MbetaCD
13  2019 Pharmacological profile of adenosine A2A receptors in patients with lower extremity peripheral artery disease and associated coronary artery disease: A pilot study. CAD, LE-PAD, PBMCs
14  2019 Reduction in Blood Glutamate Levels Combined With the Genetic Inactivation of A2AR Significantly Alleviate Traumatic Brain Injury-Induced Acute Lung Injury. TBI, TBI-ALI
15  2019 Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats. mPFC
16  2019 Regulation of human brown adipose tissue by adenosine and A2A receptors - studies with [15O]H2O and [11C]TMSX PET/CT. BAT, WAT
17  2019 Spironolactone inhibits endothelial-mesenchymal transition via the adenosine A2A receptor to reduce cardiorenal fibrosis in rats. EndMT, HUVECs, ISO
18  2019 The role of microRNA-16 in the pathogenesis of autoimmune diseases: A comprehensive review. ACVR, GDF5, miRNAs
19  2018 A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment. HD, HNSCC
20  2018 A2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21. BAT, FGF21, IBAT, WT
21  2018 A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti-PD-(L)1 and Anti-CTLA-4 in Preclinical Models. ---
22  2018 Adenosine A2A receptor (A2AR) stimulation modulates expression of semaphorins 4D and 3A, regulators of bone homeostasis. RANKL/OPG, Sema
23  2018 Adenosine A2A receptor antagonists act at the hyperoxic phase to confer protection against retinopathy. OIR, ROP
24  2018 Adenosine A2A receptor inhibition restores the normal transport of endothelial glutamate transporters in the brain. EAATs, NKAs, OGD, TBI
25  2018 Adenosine A2A receptors are required for glutamate mGluR5- and dopamine D1 receptor-evoked ERK1/2 phosphorylation in rat hippocampus: involvement of NMDA receptor. NMDAR, TBS
26  2018 Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex. FS, LTP, mPFC, PFC
27  2018 Adenosine A2A receptors modulate the dopamine D2 receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex. PFC
28  2018 Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors. AD
29  2018 Amyotrophic Lateral Sclerosis (ALS) and Adenosine Receptors. ALS
30  2018 Antipsychotic-Like Efficacy of Dopamine D2 Receptor-Biased Ligands is Dependent on Adenosine A2A Receptor Expression. AMPH, BiLC, BRET, D2R
31  2018 Behavioral control by striatal adenosine A2A -dopamine D2 receptor heteromers. GPCR, PPI
32  2018 Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease. AD
33  2018 Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease. AD
34  2018 Blockade of microglial adenosine A2A receptor impacts inflammatory mechanisms, reduces ARPE-19 cell dysfunction and prevents photoreceptor loss in vitro. AMD, RPE
35  2018 Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy. AMPK, NHEKs, RNAi, ROS, SIRT3, UV
36  2018 Critical roles of adenosine A2A receptor in regulating the balance of Treg/Th17 cells in allergic asthma. ELISA, OVA, PBMCs, qPCR
37  2018 Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein. GPCR
38  2018 Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go. 5-HT1BR, beta2-AR, GPCRs
39  2018 Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats. AUD, D2R, NAc, sigma1R
40  2018 Enhancement of inosine-mediated A2AR signaling through positive allosteric modulation. PAM
41  2018 Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase. AC5, D2R
42  2018 Gastrodia elata alleviates mutant huntingtin aggregation through mitochondrial function and biogenesis mediation. CREB, GE, HD, mHtt, PGC-1alpha
43  2018 Hypoxia-induced miR-214 expression promotes tumour cell proliferation and migration by enhancing the Warburg effect in gastric carcinoma cells. Prdm16
44  2018 Impaired autophagic flux is associated with the severity of trauma and the role of A2AR in brain cells after traumatic brain injury. AAV, ATG12, ATG5, CQ, KO, SQSTM1, TBI
45  2018 Induction of antiinflammatory purinergic signaling in activated human iNKT cells. iNKT, SCD
46  2018 Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions. LTP
47  2018 Occupancy of adenosine A2A receptors by istradefylline in patients with Parkinson's disease using 11C-preladenant PET. BPND, PD
48  2018 PBF509, an Adenosine A2A Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders. L-DOPA, LID, PD
49  2018 Pediatric tolerogenic DCs expressing CD4 and immunoglobulin-like transcript receptor (ILT)-4 secrete IL-10 in response to Fc and adenosine. IL, ILT, NECA, tmDCs
50  2018 PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling. beta1AR, GPCRs
51  2018 Remote control of movement disorders using a photoactive adenosine A2A receptor antagonist. l-DOPA, PD
52  2018 Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum. CB1R
53  2018 Specific Pharmacological Profile of A2A Adenosine Receptor Predicts Reduced Fractional Flow Reserve in Patients With Suspected Coronary Artery Disease. CAD, cAMP, FFR, group 1, PBMC
54  2018 Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A2A receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats. MCT, PAs, PDE5i, PH, RV
55  2018 Targeting adenosine A2A receptor antagonism for treatment of cancer. ---
56  2018 The adenosine A2A receptor agonist T1-11 ameliorates neurovisceral symptoms and extends the lifespan of a mouse model of Niemann-Pick type C disease. NOR
57  2018 The Corticostriatal Adenosine A2A Receptor Controls Maintenance and Retrieval of SpatialWorking Memory. DNMTP, WM
58  2018 The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease. HD
59  2017 A2AR Binding Kinetics in the Ligand Depletion Regime. ---
60  2017 Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces. GPCRs, muOR
61  2017 Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration. A1R
62  2017 Adenosine A2A receptor and ERK-driven impulsivity potentiates hippocampal neuroblast proliferation. 5-CSRTT, dHip, DRL
63  2017 Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice. KO, PGD2, WT
64  2017 Adenosine A2A Receptor Gene Knockout Prevents l-3,4-Dihydroxyphenylalanine-Induced Dyskinesia by Downregulation of Striatal GAD67 in 6-OHDA-Lesioned Parkinson's Mice. AIMs, GAD, KO, l-DOPA, LID, PD
65  2017 Adenosine A2A receptor mediates hypnotic effects of ethanol in mice. NREM
66  2017 Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4+ T cells from a BTBR T+ Itpr3tf/J mouse model of autism. GATA3, T-bet
67  2017 Adenosine A2A receptors are up-regulated and control the activation of human alveolar macrophages. ---
68  2017 Adenosine A2A receptors in the olfactory bulb suppress rapid eye movement sleep in rodents. OB, REM
69  2017 Adenosine A2A Receptors Modulate alpha-Synuclein Aggregation and Toxicity. A2AR KO, aSyn, PD
70  2017 Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A2A receptor. WT
71  2017 Angiotensin II type 1/adenosine A 2A receptor oligomers: a novel target for tardive dyskinesia. AT1R, D2Rs, TD, VCM
72  2017 Baicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2A receptor-induced SDF-1/CXCR4/PI3K/AKT signaling. CXCR4, HPH, mCAP, PAH, PI3K, PKB, RVSP, SDF-1, WT
73  2017 Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma. HNSCC
74  2017 Caffeine preferentially protects against oxygen-induced retinopathy. OIR, ROP
75  2017 Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses. ---
76  2017 Calcium modulates calmodulin/alpha-actinin 1 interaction with and agonist-dependent internalization of the adenosine A2A receptor. ---
77  2017 Chronic oral administration of MPEP, an antagonist of mGlu5 receptor, during gestation and lactation alters mGlu5 and A2A receptors in maternal and neonatal brain. mGlu receptors, mGlu5, MPEP, PLC
78  2017 Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket. BRIL, Cmpd-1, ICL3, LCP, NR2B
79  2017 Dopamine-Induced Changes in Galphaolf Protein Levels in Striatonigral and Striatopallidal Medium Spiny Neurons Underlie the Genesis of l-DOPA-Induced Dyskinesia in Parkinsonian Mice. IHC, l-DOPA, LID, MSNs, PD, PLA
80  2017 Expression and Purification of Mini G Proteins from Escherichia coli. GPCRs
81  2017 Expression, Purification and Crystallisation of the Adenosine A2A Receptor Bound to an Engineered Mini G Protein. GPCRs
82  2017 Expressions of adenosine A2A receptors in coronary arteries and peripheral blood mononuclear cells are correlated in coronary artery disease patients. CAD, PBMC
83  2017 Human Adenosine A2A Receptor: Molecular Mechanism of Ligand Binding and Activation. ARs, GPCRs
84  2017 In Situ Reconstitution of the Adenosine A2A Receptor in Spontaneously Formed Synthetic Liposomes. ---
85  2017 Membrane cholesterol access into a G-protein-coupled receptor. GPCRs
86  2017 Perivascular AQP4 dysregulation in the hippocampal CA1 area after traumatic brain injury is alleviated by adenosine A2A receptor inactivation. p-tau, TBI
87  2017 Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease. iNKT, SCD, VO
88  2017 Strategy for the Thermostabilization of an Agonist-Bound GPCR Coupled to a G Protein. GPCRs
89  2017 Striatal Galphaolf/cAMP Signal-Dependent Mechanism to Generate Levodopa-Induced Dyskinesia in Parkinson's Disease. cAMP, DA, LID, MSNs, PD
90  2017 Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid. DHA, PD
91  2017 Synthesis and Evaluation of Phenylxanthine Derivatives as Potential Dual A2AR Antagonists/MAO-B Inhibitors for Parkinson's Disease. PX
92  2017 The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo. GPR37, PD
93  2017 Toll-like receptors, NF-kappaB, and IL-27 mediate adenosine A2A receptor signaling in BTBR T+ Itpr3tf/J mice. TLRs
94  2017 Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage. IR
95  2017 [Minocycline Prevent Microglial Activation via Suppression of Adenosine A 2A Receptor in a Rat Stroke Ischemia/Reperfusion Model]. I/R
96  2016 A critical role of striatal A2A R-mGlu5 R interactions in modulating the psychomotor and drug-seeking effects of methamphetamine. KO
97  2016 A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. AD
98  2016 Aberrant adenosine A2A receptor signaling contributes to neurodegeneration and cognitive impairments in a mouse model of synucleinopathy. alpha-Syn
99  2016 Activation of the A2A adenosine G-protein-coupled receptor by conformational selection. ---
100  2016 Activation of the adenosine A2A receptor attenuates experimental autoimmune encephalomyelitis and is associated with increased intracellular calcium levels. EAE, MS