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■ Abbreviation / Long Form : AA / Asiatic acid

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Total Number of Papers: 135
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Abbreviation:   AA  (>> Co-occurring Abbreviation)
Long Form:   Asiatic acid
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No. Year Title Co-occurring Abbreviation
2020 Anti-Cancer Effects of Asiatic Acid, a Triterpene from Centilla asiatica L: A Review. ---
2020 Asiatic acid ameliorates obesity-related osteoarthritis by inhibiting myeloid differentiation protein-2. ECM, ELISA, HFD, OA, PA
2020 Asiatic acid attenuates hypertrophic and fibrotic differentiation of articular chondrocytes via AMPK/PI3K/AKT signaling pathway. ACAN, ACLT, ALP, alpha-SMA, AMPK, MMP-13, OA, SOX9
2020 Asiatic Acid Glucosamine Salt Alleviates Ultraviolet B-induced Photoaging of Human Dermal Fibroblasts and Nude Mouse Skin. ---
2020 Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-gamma. CKD, nSREBP-1, UUO
2020 Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice. Akt, DOX, ROS
2020 Asiatic Acid, Extracted from Centella asiatica and Induces Apoptosis Pathway through the Phosphorylation p38 Mitogen-Activated Protein Kinase in Cisplatin-Resistant Nasopharyngeal Carcinoma Cells. NPC
2020 Effect and mechanism of asiatic acid on autophagy in myocardial ischemia-reperfusion injury in vivo and in vitro. MIRI, OGD, ROS
2020 Mitigating Perspectives of Asiatic Acid in the Renal Derangements of Streptozotocin-Nicotinamide Induced Diabetic Rats. Hb, NAD, STZ
10  2020 Pentacyclic triterpenoid-rich fraction of the Hardy kiwi (Actinidia arguta) improves brain dysfunction in high fat diet-induced obese mice. CFAA, HFD, MA
11  2020 Preparation and evaluation of PEGylated asiatic acid nanostructured lipid carriers on anti-fibrosis effects. ALB, ALT, AST, DSC, P-AA-NLCs, TEM, XRD
12  2020 RGD-decorated solid lipid nanoparticles enhance tumor targeting, penetration and anticancer effect of asiatic acid. RGD-SLNs
13  2020 Synthesis and Cytotoxic Activity of Novel C-23-Modified Asiatic Acid Derivatives. SAR
14  2019 An aligned porous electrospun fibrous scaffold with embedded asiatic acid for accelerating diabetic wound healing. PLLA
15  2019 Antiobesity efficacy of asiatic acid: down-regulation of adipogenic and inflammatory processes in high fat diet induced obese rats. aP2, FAS, IR, PPARgamma, TNF, UCP2
16  2019 Asiatic Acid Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress and Apoptosis Via AKT/GSK-3beta Signaling Pathway in Wistar Rats. AChE, AD
17  2019 Asiatic Acid Attenuates Bone Loss by Regulating Osteoclastic Differentiation. NF-kappaB, TGF-beta
18  2019 Asiatic acid enhances intratumor delivery and the antitumor effect of pegylated liposomal doxorubicin by reducing tumor-stroma collagen. IHC, PLD, Tt-DDSs
19  2019 Asiatic acid inhibits cardiac fibrosis throughNrf2/HO-1 and TGF-beta1/Smads signaling pathways in spontaneous hypertension rats. CFs, MDA, Nrf2, ROS, SHRs, SOD
20  2019 Asiaticoside but not its aglycone exhibits neuritogenicity through TrkA receptor signaling: a bridge between ERK1/2-CREB and Akt-GSK3beta/RhoA. AS, GSK3beta, RhoA, TrkA
21  2019 Combination of carnosine and asiatic acid provided greater anti-inflammatory protection for HUVE cells and diabetic mice than individual treatments of carnosine or asiatic acid alone. ROS, TNF
22  2019 Effect of asiatic acid on epithelial-mesenchymal transition of human alveolar epithelium A549 cells induced by TGF-beta1. EMT, TGF-beta1
23  2019 Protective effects of Asiatic acid against pelvic inflammatory disease in rats. MPO, NF-kappaB, NLRP3, PID
24  2019 Strategies for Improving Healing of the Gastric Epithelium Using Oral Solid Dispersions Loaded with Pentacyclic Triterpene-Rich Centella Extract. AS, MA, MS, PRE, PRE-ESD
25  2019 Synthesis and discovery of asiatic acid based 1,2,3-triazole derivatives as antitumor agents blocking NF-kappaB activation and cell migration. ---
26  2018 Antiangiogenic effects of AA-PMe on HUVECs in vitro and zebrafish in vivo. AA-PMe, HUVECs, VEGF, VEGFR2
27  2018 Asiatic Acid (AA) Sensitizes Multidrug-Resistant Human Lung Adenocarcinoma A549/DDP Cells to Cisplatin (DDP) via Downregulation of P-Glycoprotein (MDR1) and Its Targets. DDP, MDR, NF, RT-PCR, YB1
28  2018 Asiatic acid ameliorates CCl4-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-kappaB/IkappaBalpha, and JAK1/STAT3 signaling pathways. NF-kappaB, STAT3
29  2018 Asiatic Acid Ameliorates Doxorubicin-Induced Cardiac and Hepato-Renal Toxicities with Nrf2 Transcriptional Factor Activation in Rats. DXR
30  2018 Asiatic acid ameliorates hepatic ischemia/reperfusion injury in rats via mitochondria-targeted protective mechanism. A/R, AST, I/R, MMP
31  2018 Asiatic acid and maslinic acid attenuated kainic acid-induced seizure through decreasing hippocampal inflammatory and oxidative stress. IL, KA, MA, NGF
32  2018 Asiatic acid attenuates CCl4-induced liver fibrosis in rats by regulating the PI3K/AKT/mTOR and Bcl-2/Bax signaling pathways. ECM
33  2018 Asiatic acid attenuates high-fat diet-induced impaired spermatogenesis. HFD
34  2018 Asiatic acid attenuates lipopolysaccharide-induced injury by suppressing activation of the Notch signaling pathway. IL-1beta
35  2018 Asiatic acid inhibits proliferation, migration and induces apoptosis by regulating Pdcd4 via the PI3K/Akt/mTOR/p70S6K signaling pathway in human colon carcinoma cells. EMT, mTOR, PI3K
36  2018 Asiatic acid nullified aluminium toxicity in in vitro model of Alzheimer's disease. AD, Al, ROS
37  2018 Asiatic Acid Prevents Oxidative Stress and Apoptosis by Inhibiting the Translocation of alpha-Synuclein Into Mitochondria. PD
38  2018 Asiatic Acid Prevents Retinal Ganglion Cell Apoptosis in a Rat Model of Glaucoma. IOP, PhNR, RGCs
39  2018 Asiatic acid prevents the development of interstitial lung disease in a hypochlorous acid-induced mouse model of scleroderma. HOCl, PF, SSc, TGF-beta1
40  2018 Asiatic acid protects against cisplatin-induced acute kidney injury via anti-apoptosis and anti-inflammation. CIS, CON, KIM-1
41  2018 Asiatic acid protects differentiated PC12 cells from Abeta25-35-induced apoptosis and tau hyperphosphorylation via regulating PI3K/Akt/GSK-3beta signaling. AD, MMP
42  2018 Assessment of Toxicity and Absorption of the Novel AA Derivative AA-Pme in SGC7901 Cancer Cells In Vitro and in Zebrafish In Vivo. AA-PMe
43  2018 Differences in Neuritogenic Activity and Signaling Activation of Madecassoside, Asiaticoside, and Their Aglycones in Neuro-2a cells. AS, CREB, MA, MS
44  2018 Fabrication of peptide-linked albumin nanoconstructs for receptor-mediated delivery of asiatic acid to the brain as a preventive measure in cognitive impairment: optimization, in-vitro and in-vivo evaluation. DTE, EE, GU, QbD
45  2018 Neuroprotective Properties of Asiatic Acid against 5-Fluorouracil Chemotherapy in the Hippocampus in an Adult Rat Model. MDA, Nrf2, SGZ, SOX2
46  2018 Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer's disease. AD
47  2018 Obesity-alleviating potential of asiatic acid and its effects on ACC1, UCP2, and CPT1 mRNA expression in high fat diet-induced obese Sprague-Dawley rats. ACC, BW, CPT1, HFD, UCP2
48  2018 Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise. ---
49  2018 Pharmacological Review on Asiatic Acid and Its Derivatives: A Potential Compound. ---
50  2018 The protective effect of asiatic acid on podocytes in the kidney of diabetic rats. ---
51  2017 A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling pathway. AA-PMe, MMP, STAT3
52  2017 Antifibrotic effect of Centella asiatica Linn and asiatic acid on arecoline-induced fibrosis in human buccal fibroblasts. CA, HBF, HPTLC
53  2017 Asiatic acid abridges pre-neoplastic lesions, inflammation, cell proliferation and induces apoptosis in a rat model of colon carcinogenesis. ACF, AgNORs, DMH, PCNA
54  2017 Asiatic acid ameliorates pulmonary fibrosis induced by bleomycin (BLM) via suppressing pro-fibrotic and inflammatory signaling pathways. BALF, BLM, NLRP3, TGF-beta1
55  2017 Asiatic acid attenuates methamphetamine-induced neuroinflammation and neurotoxicity through blocking of NF-kB/STAT3/ERK and mitochondria-mediated apoptosis pathway. ERK, METH, NF-kappaB, STAT, TNFR
56  2017 Asiatic acid attenuates pre-neoplastic lesions, oxidative stress, biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis. ACF, DMH, LPO
57  2017 Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation. ARE, GCLC, HO-1, Nrf2, ROS, TBHP
58  2017 Asiatic acid enhances survival of human AC16 cardiomyocytes under hypoxia by upregulating miR-1290. ---
59  2017 Asiatic Acid Exhibits Anti-inflammatory and Antioxidant Activities against Lipopolysaccharide and d-Galactosamine-Induced Fulminant Hepatic Failure. AMPK, FHF, GalN, GSK3beta, IL, LPS, MAPK, NF-kappaB, NQO1, Nrf2, PDCD4
60  2017 Asiatic acid inhibits lung cancer cell growth in vitro and in vivo by destroying mitochondria. LC3, PCNA, ROS
61  2017 Asiatic acid protects against cognitive deficits and reductions in cell proliferation and survival in the rat hippocampus caused by 5-fluorouracil chemotherapy. 5-FU, NOL, SGZ, VPA
62  2017 Asiatic acid protects against hepatic ischemia/reperfusion injury by inactivation of Kupffer cells via PPARgamma/NLRP3 inflammasome signaling pathway. I/R, KCs, LPS, NLR, NPCs, PPARgamma
63  2017 Effect of Asiatic Acid on the Treatment of Spinal Cord Injury: An Experimental Study in Rats. SCI
64  2017 Neuroprotective effect of asiatic acid on rotenone-induced mitochondrial dysfunction and oxidative stress-mediated apoptosis in differentiated SH-SYS5Y cells. PD
65  2017 Neurotrophic Effect of Asiatic acid, a Triterpene of Centella asiatica Against Chronic 1-Methyl 4-Phenyl 1, 2, 3, 6-Tetrahydropyridine Hydrochloride/Probenecid Mouse Model of Parkinson's disease: The Role of MAPK, PI3K-Akt-GSK3beta and mTOR Signalling Pathways. NTFs, PD
66  2017 Pharmacological effects of asiatic acid in glioblastoma cells under hypoxia. ---
67  2017 Protective effect of asiatic acid in an experimental cerulein-induced model of acute pancreatitis in mice. AP, CCK, IL, NF, TNF
68  2017 Protective effects of asiatic acid in a spontaneous type2 diabetic mouse model. PH, PI3K
69  2017 The anti-inflammatory effects of asiatic acid in lipopolysaccharide-stimulated human corneal epithelial cells. CCK-8, HCECs, IL-1beta, IL-6, IL-8, LPS, qRT-PCR, ROS, TGF-beta, TNF-alpha
70  2017 [Oral absorption of asiatic acid nanoparticles modified with PEG]. ---
71  2016 AA-PMe, a novel asiatic acid derivative, induces apoptosis and suppresses proliferation, migration, and invasion of gastric cancer cells. AA-PMe
72  2016 Anti-glioma activity and the mechanism of cellular uptake of asiatic acid-loaded solid lipid nanoparticles. AA-MS-SLNs, BBB, DS, MS, SLNs, TS
73  2016 Asiatic acid attenuated apoptotic and inflammatory stress in the striatum of MPTP-treated mice. IL, MPTP, TLR
74  2016 Asiatic acid inhibits lactate-induced cardiomyocyte apoptosis through the regulation of the lactate signaling cascade. CCK-8, MCT1, ROS
75  2016 Asiatic acid inhibits left ventricular remodeling and improves cardiac function in a rat model of myocardial infarction. MI
76  2016 Asiatic Acid Inhibits Lipopolysaccharide-Induced Acute Lung Injury in Mice. ALI, BALF, LPS, MPO
77  2016 Asiatic acid inhibits pulmonary inflammation induced by cigarette smoke. BALF, COPD, CS, TECA
78  2016 Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKalpha Signalling Pathway. AMPKalpha, ERK, mTOR
79  2016 Asiatic acid-pectin hydrogel matrix patch transdermal delivery system influences parasitaemia suppression and inflammation reduction in P.berghei murine malaria infected Sprague-Dawley rats. CHQ
80  2016 Neuroprotective effect of asiatic acid against spinal cord injury in rats. HO, NLRP, Nrf, ROS, SCI
81  2016 Protective Effects of Asiatic Acid Against Spinal Cord Injury-Induced Acute Lung Injury in Rats. ALI, CAT, MDA, MPO, PPI, ROS, SCI, SOD
82  2016 Synthesis and anticancer activity of novel fluorinated asiatic acid derivatives. ---
83  2016 [Response surface method for optimization of asiatic acid nanoparticles modified with PEG and its enhancing effects on intestinal absorption]. AA-NLC, Peff
84  2015 Anti-apoptotic and anti-glycative effects of asiatic acid in the brain of D-galactose treated mice. AGE, BDNF, DG, GFAP, IL, RAGE, TNF
85  2015 Antioxidative and antiinflammatory activities of asiatic acid, glycyrrhizic acid, and oleanolic acid in human bronchial epithelial cells. COX-2, GA, NF-kappaB, OA
86  2015 Apoptosis of HL-60 human leukemia cells induced by Asiatic acid through modulation of B-cell lymphoma 2 family proteins and the mitogen-activated protein kinase signaling pathway. Bcl-2, ERK, JNK, Mcl-1
87  2015 Asiatic acid and maslinic acid protected heart via anti-glycative and anti-coagulatory activities in diabetic mice. MA, NF-kappaB
88  2015 Asiatic Acid Attenuates the Progression of Left Ventricular Hypertrophy and Heart Failure Induced by Pressure Overload by Inhibiting Myocardial Remodeling in Mice. TAC
89  2015 Asiatic acid inhibits cardiac hypertrophy by blocking interleukin-1beta-activated nuclear factor-kappaB signaling in vitro and in vivo. ANP, EMSA, IL, NF, qPCR, TAC
90  2015 Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in Goto-Kakizaki rat, a spontaneous type 2 diabetic animal model. GK
91  2015 Evaluation of the anxiolytic and antidepressant effects of asiatic acid, a compound from Gotu kola or Centella asiatica, in the male Sprague Dawley rat. EPM, FST, GABAA, MANOVA
92  2015 Glucose uptake through translocation and activation of GLUT4 in PI3K/Akt signaling pathway by asiatic acid in diabetic rats. GLUT4, IR, IRS, PI3K
93  2015 Pentacyclic triterpenes combined with ciprofloxacin help to eradicate the biofilm formed in vitro by Escherichia coli. UA
94  2015 Pentacyclic Triterpenoids Inhibit IKKbeta Mediated Activation of NF-kappaB Pathway: In Silico and In Vitro Evidences. CA, IFN-gamma, IKKbeta, NF-kappaB, PTs, UA
95  2015 Structural analysis of metabolites of asiatic acid and its analogue madecassic acid in zebrafish using LC/IT-MSn. MA
96  2015 Synthesis, anti-tumor and anti-angiogenic activity evaluations of asiatic Acid amino Acid derivatives. ---
97  2015 Treatment of renal fibrosis by rebalancing TGF-beta/Smad signaling with the combination of asiatic acid and naringenin. NG
98  2015 [Protective effect of asiatic acid from Potentilla chinensis on alcohol hepatic injury in rats]. ---
99  2014 Anti-glycative effects of asiatic acid in human keratinocyte cells. AGE, BSA, HaCaT, IL, MMP, RAGE
100  2014 Antidiabetic and antihyperlipidemic activity of asiatic acid in diabetic rats, role of HMG CoA: in vivo and in silico approaches. HMG-CoA, STZ