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■ Abbreviation / Long Form : AR / amphiregulin

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Total Number of Papers: 219
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Abbreviation:   AR  (>> Co-occurring Abbreviation)
Long Form:   amphiregulin
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No. Year Title Co-occurring Abbreviation
2019 Amphiregulin Promotes Vascular Endothelial Growth Factor-C Expression and Lymphangiogenesis through STAT3 Activation in Human Chondrosarcoma Cells. LECs, VEGF-C
2019 Valproic acid-induced amphiregulin secretion confers resistance to temozolomide treatment in human glioma cells. GBM, TMZ, VPA
2018 Amphiregulin enhances cardiac fibrosis and aggravates cardiac dysfunction in mice with experimental myocardial infarction partly through activating EGFR-dependent pathway. CF, EGFR, HF, MI
2018 Amphiregulin enhances cell migration and resistance to doxorubicin in chondrosarcoma cells through the MAPK pathway. DOX, r-AR
2018 Cold atmospheric plasma (CAP) activates angiogenesis-related molecules in skin keratinocytes, fibroblasts and endothelial cells and improves wound angiogenesis in an autocrine and paracrine mode. Ang, Ang-2, CAP, ET-1, FGF-2
2018 Development of a three-plex single molecule immunoassay enabling measurement of the EGFR ligands amphiregulin, betacellulin and transforming growth factor alpha simultaneously in human serum samples. BTC, TGF-alpha
2017 Amphiregulin enhances VEGF-A production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR-206 via FAK/c-Src/PKCdelta pathway. VEGF-A
2017 Positive feedback of the amphiregulin-EGFR-ERK pathway mediates PM2.5 from wood smoke-induced MUC5AC expression in epithelial cells. EGFR, PM
2017 Prognostic value of rare and complex mutations in EGFR and serum levels of soluble EGFR and its ligands in non-small cell lung carcinoma patients. EGFR, NSCLC
10  2016 Epidermal growth factor is a potential biomarker for poor cetuximab response in tongue cancer cells. EGF, EGFR, EPR, rh
11  2015 Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis. HCC, HSC, NAFLD, NASH, TACE
12  2015 Amphiregulin activates regulatory T lymphocytes and suppresses CD8+ T cell-mediated anti-tumor response in hepatocellular carcinoma cells. HCC
13  2015 Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway. ---
14  2014 Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles. DEP, EGFR, HB, MAPK, PBEC, TGF alpha
15  2014 EGFR ligands as pharmacodynamic biomarkers in metastatic colorectal cancer patients treated with cetuximab and irinotecan. EGF, EGFR, mCRC
16  2014 Expression of the epidermal growth factor system in human middle ear cholesteatoma. EGF, EPI, HB-EGF, TGF
17  2014 The human Cathelicidin LL-37 induces MUC5AC mucin production by airway epithelial cells via TACE-TGF-alpha-EGFR pathway. FRET, HB-EGF, sLL-37, TACE, TGF-alpha
18  2013 A disintegrin and metalloproteinase 17 regulates TNF and TNFR1 levels in inflammation and liver regeneration in mice. ADAM17, ADAM17 m-KO, KO, LPS, PH, TNF
19  2013 A novel predictive strategy by immunohistochemical analysis of four EGFR ligands in metastatic colorectal cancer treated with anti-EGFR antibodies. EREG, HB-EGF, mCRC, TGF-alpha
20  2013 Intermittent hypoxia induces the proliferation of rat vascular smooth muscle cell with the increases in epidermal growth factor family and erbB2 receptor. EGF, ER, IH, NRG1, RASMC, SH, VSMCs
21  2012 Amphiregulin stimulates liver regeneration after small-for-size mouse liver transplantation. BrdU, EGFR, PCNA
22  2012 Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-beta-induced pulmonary fibrosis. ---
23  2012 Clinical significance of amphiregulin and epidermal growth factor in colostrum. EGF, TGF-alpha
24  2012 Comparison of follicular fluid amphiregulin and EGF concentrations in patients undergoing IVF with different stimulation protocols. COS, EGF, FF, GnRH-a, IVF-ET, LH
25  2012 EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling. EGF, EGFR, TGF alpha
26  2012 Epidermal growth factor receptor signaling in hepatocellular carcinoma: inflammatory activation and a new intracellular regulatory mechanism. EGFR, HCC, TNF
27  2012 Evolution of the predictive markers amphiregulin and epiregulin mRNAs during long-term cetuximab treatment of KRAS wild-type tumor cells. CTX, EPI, LPT, Tzb, WT
28  2012 Nuclear translocation of pro-amphiregulin induces chemoresistance in gastric cancer. EGFR
29  2012 Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling: implications in ADPKD cell proliferation. ADPKD, AP-1
30  2012 Regulation of amphiregulin gene expression by beta-catenin signaling in human hepatocellular carcinoma cells: a novel crosstalk between FGF19 and the EGFR system. EGFR, FGF19, HCC
31  2011 Clinical impact of amphiregulin expression in patients with epidermal growth factor receptor (EGFR) wild-type nonsmall cell lung cancer treated with EGFR-tyrosine kinase inhibitors. EGFR, NSCLC, TKIs, WT
32  2011 Effect of heparin-binding EGF-like growth factor and amphiregulin on the MAP kinase-induced production of vascular endothelial growth factor by human granulosa cells. HB-EGF, VEGF
33  2011 Levels of the epidermal growth factor-like peptide amphiregulin in follicular fluid reflect the mode of triggering ovulation: a comparison between gonadotrophin-releasing hormone agonist and urinary human chorionic gonadotrophin. FF
34  2011 Role of size and composition of traffic and agricultural aerosols in the molecular responses triggered in airway epithelial cells. PAH, PM, Rur S, UF, Urb S
35  2010 A novel signaling pathway of tissue kallikrein in promoting keratinocyte migration: activation of proteinase-activated receptor 1 and epidermal growth factor receptor. EGFR, ERK, HB-EGF, PKC
36  2010 Amphiregulin is not essential for induction of contact hypersensitivity. CHS, DC, DNFB, EPO, FITC, Ig, MPO
37  2010 Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice. BAL, OVA
38  2010 Antisense inhibition of amphiregulin expression reduces EGFR phosphorylation in transformed human breast epithelial cells. EGFR
39  2010 The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia. AOM, DSS, PGE 2, TLR4
40  2010 Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury. DSS, EGFR, EPI, IEC, LPS, siRNA, TLR4
41  2010 [Novel role of growth factors in ovary function]. ADAMs, EGF, Ep
42  2009 Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop. EGFR
43  2009 Amphiregulin induces the alternative splicing of p73 into its oncogenic isoform DeltaEx2p73 in human hepatocellular tumors. EGFR, HCC, pre-mRNA
44  2009 Amphiregulin is much more abundantly expressed than transforming growth factor-alpha and epidermal growth factor in human follicular fluid obtained from patients undergoing in vitro fertilization-embryo transfer. EGF, TGF alpha
45  2009 Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. IM
46  2009 Critical role of ESCRT machinery in EGFR recycling. ESCRTs, siRNA
47  2009 Differential regulation of betacellulin and heparin-binding EGF-like growth factor in cultured zebrafish ovarian follicle cells by EGF family ligands. BTC, EGF, HB-EGF, TGF alpha
48  2009 EGF-like growth factors as LH mediators in the human corpus luteum. Ep
49  2009 Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor. EGF, EGFR, siRNA, TGF-alpha
50  2009 Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB-EGF and TGF-alpha. AP, BTC, EGFR, EPR, HB-EGF, TGF
51  2009 Mitochondrial dysfunction-induced amphiregulin upregulation mediates chemo-resistance and cell migration in HepG2 cells. mtDNA, ROS
52  2009 Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer. COX-2, CRC, PGE2
53  2009 The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression. APP, APR, EGFR, HCC, IL-6, OSM
54  2008 3',5'-cyclic adenosine monophosphate response element binding protein up-regulated cytochrome P450 lanosterol 14alpha-demethylase expression involved in follicle-stimulating hormone-induced mouse oocyte maturation. COCs, CREB, EGF, PKA
55  2008 AMP-activated protein kinase is involved in hormone-induced mouse oocyte meiotic maturation in vitro. ACC, AICAR, AMPK, ara-A, CEO, FSH, GV
56  2008 Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer. HER2
57  2008 EGF-like peptides mediate FSH-induced maturation of cumulus cell-enclosed mouse oocytes. BIM I, CEO, DO, EGF, EGFR, GVB
58  2008 Epidermal growth factor receptor activation by protein kinase C is necessary for FSH-induced meiotic resumption in porcine cumulus-oocyte complexes. EGF, EGFR, PKC
59  2008 Plasma-membrane-anchored growth factor pro-amphiregulin binds A-type lamin and regulates global transcription. ---
60  2008 The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis. EGFR
61  2008 The kinetics of the hydrogen/deuterium exchange of epidermal growth factor receptor ligands. ER, HB-EGF, TGF-alpha
62  2007 A hypothetical mechanism of intraepidermal neurite formation in NC/Nga mice with atopic dermatitis. AD, CONV, Dsg3, SPF, ZO-1
63  2007 Alteration of the serum levels of the epidermal growth factor receptor and its ligands in patients with non-small cell lung cancer and head and neck carcinoma. EGF, HNC, NSCLC, sEGFR, TGF-alpha
64  2007 Amphiregulin: a new growth factor in hepatocarcinogenesis. EGFR
65  2007 Effects of PM2.5 components in the release of amphiregulin by human airway epithelial cells. EGFR, NHNE, PM
66  2007 Human corneal epithelial cell proliferation by epiregulin and its cross-induction by other EGF family members. EGF, EGFRs, HB-EGF, HCECs, TGF-alpha
67  2007 Insulin induces a transcriptional activation of epiregulin, HB-EGF and amphiregulin, by a PI3K-dependent mechanism: identification of a specific insulin-responsive promoter element. EPI, HB-EGF
68  2007 Intraepidermal nerve fibers increase in dry skin of acetone-treated mice. NGF, SC, TEWL
69  2007 Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice. EGFR, SPEM
70  2007 Regulation of amphiregulin, EGFR-like factor expression by hCG in cultured human granulosa cells. EGF, LHR
71  2006 Amphiregulin as a tumor promoter for oral squamous cell carcinoma: involvement of cyclooxygenase 2. COX-2, EGF, EGFR-1, SCC
72  2006 Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells. EGFR
73  2006 Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells. EGF, EGFR
74  2006 Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth. ChIP, EGFR, ERalpha, MAPK, Tam-R, WT-MCF-7
75  2006 Concomitant cell growth and differentiation are dependent on erbB1 and integrin activation in an autonomously surviving colon adenocarcinoma: involvement of autocrine amphiregulin secretion. ---
76  2006 Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. EGF
77  2006 Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-alpha-induced IL-8 secretion in the human airway epithelial cell line NCI-H292. EGF, EGFR, IL-8, TACE, TNF-alpha
78  2006 Novel function of ovarian growth factors: combined studies by DNA microarray, biochemical and physiological approaches. ADAMs, EGF, Ep
79  2006 PGE2 up-regulates EGF-like growth factor biosynthesis in human granulosa cells: new insights into the coordination between PGE2 and LH in ovulation. COX-2, Ep, MAPK, PKA
80  2006 Protection by GDNF and other trophic factors against the dopamine-depleting effects of neurotoxic doses of methamphetamine. DA, GDNF, HPLC, HRG-beta1, METH, TGF-alpha
81  2006 Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. HB, tRA
82  2006 Roles of myofibroblasts in prostaglandin E2-stimulated intestinal epithelial proliferation and angiogenesis. COX, HGF, PG, VEGF-A
83  2005 Amphiregulin causes functional downregulation of adherens junctions in psoriasis. ---
84  2005 Amphiregulin is a novel growth factor involved in normal bone development and in the cellular response to parathyroid hormone stimulation. EGF, PTH
85  2005 Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. IGF1, NSCLC
86  2005 Epidermal growth factor family members: endogenous mediators of the ovulatory response. BTC, EGF, ER
87  2005 Expression of the epidermal growth factor system in human endometrium during the menstrual cycle. BCL, EGF, Ep, HB, HER1, TGF alpha
88  2005 Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells. ERK, HAT, PAR-2 AP, PAR2, TACE
89  2005 Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. CA, CRC, DCA, EGFR, PGs
90  2005 Stimulation of amphiregulin expression in osteoblastic cells by parathyroid hormone requires the protein kinase A and cAMP response element-binding protein signaling pathway. CRE, PGE2, PKA, PTH
91  2005 Tobacco smoke stimulates the transcription of amphiregulin in human oral epithelial cells: evidence of a cyclic AMP-responsive element binding protein-dependent mechanism. AhR, cAMP, EGFR
92  2005 Transforming growth factor alpha (TGF-alpha) and other targets of tumor necrosis factor-alpha converting enzyme (TACE) in murine polycystic kidney disease. ARPKD, BUN, BW, EGF, HB-EGF, KW, TACE, TGF-alpha
93  2005 [Amphiregulin antisense RNA expression inhibits angiogenesis of human breast cancer in nude mice]. HMEC
94  2004 Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK. EGF, ERK, GF, NHKs
95  2004 Clinical relevance of amphiregulin and VEGF in primary breast cancers. IDC, PgR
96  2004 Fine particulate matter induces amphiregulin secretion by bronchial epithelial cells. EGFR, ERK, GM-CSF, MAP, PM, PM2.5
97  2004 Growth, differentiation and senescence of normal human urothelium in an organ-like culture. CK, HB-EGF, TGF alpha, UP
98  2004 Prostaglandin E2 synergistically enhances receptor tyrosine kinase-dependent signaling system in colon cancer cells. COX, EGFR
99  2004 Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency. BTC, EGF, HB, TGF-alpha
100  2004 Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis. INV-AR, K14-ARGE