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■ Abbreviation / Long Form : ATF4 / activating transcription factor 4

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Total Number of Papers: 817
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Abbreviation:   ATF4  (>> Co-occurring Abbreviation)
Long Form:   activating transcription factor 4
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No. Year Title Co-occurring Abbreviation
2022 4-PBA Treatment Improves Bone Phenotypes in the Aga2 Mouse Model of Osteogenesis Imperfecta. 4-PBA, ASBMR, BiP, CHOP, ER, OI, PERK
2022 Abnormally decreased renal Klotho is linked to endoplasmic reticulum-associated degradation in mice. EerI, ERAD, GRP78, PDI, RIF, TGF, UPR, UUO
2022 ATF4-mediated microRNA-145/HDAC4/p53 axis affects resistance of colorectal cancer cells to 5-fluorouracil by regulating autophagy. 5-FU, CRC, HDAC4, miR-145
2022 ATF4/CEMIP/PKCα promotes anoikis resistance by enhancing protective autophagy in prostate cancer cells. Bcl-2, CEMIP, ECM, PCa, PKCalpha
2022 Curcumin Attenuates the PERK-eIF2α Signaling to Relieve Acrylamide-Induced Neurotoxicity in SH‑SY5Y Neuroblastoma Cells. ACR, CHOP, CREB, GSK-3beta, MDA, PERK, ROS
2022 Endoplasmic reticulum stress downregulates PGC-1α in skeletal muscle through ATF4 and an mTOR-mediated reduction of CRTC2. CREB, CRTC2, ER, mTOR, PPARgamma
2022 Endoplasmic reticulum stress-dependent activation of TRB3-FoxO1 signaling pathway exacerbates hyperglycemic nephrotoxicity: Protection accorded by Naringenin. CHOP, ER, p-eIF2alpha, p-PERK, TRB3, XBP-1s
2022 Etiopathophysiological role of the renin-angiotensin-aldosterone system in age-related muscular weakening: RAAS-independent beneficial role of ACE2 in muscle weakness. ACE2, eIF2alpha, ER
2022 Folate ameliorates homocysteine-induced osteoblast dysfunction by reducing endoplasmic reticulum stress-activated PERK/ATF-4/CHOP pathway in MC3T3-E1 cells. ALP, Bax, Bcl-2, FA, GRP-78, Hcy
10  2022 High ATF4 Expression Is Associated With Poor Prognosis, Amino Acid Metabolism, and Autophagy in Gastric Cancer. Asn, AUC, GC, GSEA, KEGG, OS, PI, qPCR, ROC
11  2022 Intricate coupling between the transactivation and basic-leucine zipper domains governs phosphorylation of transcription factor ATF4 by casein kinase 2. ---
12  2022 Local anesthetics elicit immune-dependent anticancer effects. ATF6, CALR, ER, HMGB1
13  2022 Mechanism of Endoplasmic Reticulum Stress Pathway in the Osteogenic Phenotypic Transformation of Aortic Valve Interstitial Cells. CAVD, VICs
14  2022 Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients. COVID-19, ER, SARS-CoV-2
15  2022 MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling. GCN1, MIRO2
16  2022 Montelukast ameliorated pemetrexed-induced cytotoxicity in hepatocytes by mitigating endoplasmic reticulum (ER) stress and nucleotide oligomerization domain-like receptor protein 3 (NLRP3) activation. CHOP, ER, GADD34, LDH, NF-kappaB, NLRP3, NOX4, NSCLC, PEM, ROS
17  2022 Neonatal Hyperoxia Activates Activating Transcription Factor 4 to Stimulate Folate Metabolism and Alveolar Epithelial Type 2 Cell Proliferation. AT2, PNDs
18  2022 Nicotinamide mononucleotide alleviates heat stress-induced oxidative stress and apoptosis in BMECs through reducing mitochondrial damage and endoplasmic reticulum stress. BMECs, CHOP, Drp1, Fis1, GRP78, Mfn1, 2, NMN, ROS
19  2022 PRMT5 regulates ATF4 transcript splicing and oxidative stress response. AML, PRMT5
20  2022 Protective Effects of Taraxasterol against Deoxynivalenol-Induced Damage to Bovine Mammary Epithelial Cells. ATF6, BAX, Bcl-2, CHOP, DON, ER, GRP78, LDH, MAC-T, MDA, ROS, T-AOC, T-SOD
21  2022 Protocatechuic acid protects hepatocytes against hydrogen peroxide-induced oxidative stress. ER, IRE1alpha, MAPK, PARP, PCA, ROS
22  2022 Saxagliptin enhances osteogenic differentiation in MC3T3-E1 cells, dependent on the activation of AMP-activated protein kinase α (AMPKα)/runt-related transcription factor-2 (Runx-2). ALP, AMPK, AMPKalpha, DPP-4, ODIM, OPN
23  2022 Sestrin2 protects against cholestatic liver injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis. AMPK, BDL, ER, mTOR
24  2022 Sevoflurane Induces Ferroptosis of Glioma Cells Through Activating the ATF4-CHAC1 Pathway. Chac1, ROS, SEV
25  2022 Silencing ATF4 inhibits JMJD3-dependent JUNB/ETS1 axis and mitigates cerebral ischemic injury. MCAO
26  2022 Subchronic Acrylamide Exposure Activates PERK-eIF2α Signaling Pathway and Induces Synaptic Impairment in Rat Hippocampus. ACR, BDNF, CHOP, pCREB, PERK
27  2022 The PERK/ATF4/CHOP signaling branch of the unfolded protein response mediates cisplatin-induced ototoxicity in hair cells. CHOP, PERK, UPR
28  2022 The Possible Protective Effect of Boric Acid in an Alkaline-Induced Corneal Neovascularization Rat Model. BA, CNV, Nrf2
29  2022 The Role of Sirtuin 1 in Palmitic Acid-Induced Endoplasmic Reticulum Stress in Cardiac Myoblasts. CHOP, ER, PA, SIRT1
30  2022 Translational control by heme-regulated elF2α kinase during erythropoiesis. mTORC1
31  2022 [Effect of moxibustion at "oppositely-located points" on neurogenic bladder after spinal cord injury and endoplasmic reticulum stress pathway in rats]. BBB, caspase-12, GRP78, SCI
32  2021 3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice. KMO
33  2021 A (dis)integrated stress response: Genetic diseases of eIF2alpha regulators. ISR, mRNAs
34  2021 A comparative study of toxicity of graphdiyne and graphene oxide to human umbilical vein endothelial cells. ER, GDY, GO, GSDMD, HUVECs, NLRP3, NMs, sICAM-1, XBP-1s
35  2021 A maternal low-protein diet during gestation induces hepatic autophagy-related gene expression in a sex-specific manner in Sprague-Dawley rats. ChIP, CHOP
36  2021 A novel endoplasmic stress mediator, Kelch domain containing 7B (KLHDC7B), increased Harakiri (HRK) in the SubAB-induced apoptosis signaling pathway. CEBPB, CHOP, ER, HRK, KLHDC7B, LEE, PARP, PERK, STEC
37  2021 Acriflavine, a Potent Inhibitor of HIF-1alpha, Disturbs Glucose Metabolism and Suppresses ATF4-Protective Pathways in Melanoma under Non-Hypoxic Conditions. HIF, MITF, PDK1, VEGF
38  2021 Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide. GB, ISR
39  2021 Activating transcription factor 4 regulates angiogenesis under lipid overload via methionine adenosyltransferase 2A-mediated endothelial epigenetic alteration. HFD, MAT2A, NCD, PA
40  2021 Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine. NAC
41  2021 Activation of the EGFR-PI3K-CaM pathway by PRL-1-overexpressing placenta-derived mesenchymal stem cells ameliorates liver cirrhosis via ER stress-dependent calcium. BDL, CaM, CHOP, EGFR, eIF2alpha, ER, MCU, PI3K, PRL-1, SD, SERCA2b, TG, VDAC1
42  2021 Adipose-derived stem cells (ADSCs) inhibit the expression of anti-apoptosis proteins through up-regulation of ATF4 on breast cancer cells. ADSCs, AFG, RT-qPCR, UMSCs
43  2021 Andrographolide Induces Noxa-Dependent Apoptosis by Transactivating ATF4 in Human Lung Adenocarcinoma Cells. AD, siRNA, TCM
44  2021 Antioxidative effects of polypyrimidine tract-binding protein-associated splicing factor against pathological retinal angiogenesis through promotion of mitochondrial function. 4-HNE, CHOP, eIF2alpha, ER, ERK, HO-1, HRMECs, IRNV, PDI, PKR, PSF, ROS
45  2021 ATF4 loss of heterozygosity is associated with poor overall survival in medullary thyroid carcinoma. MTC
46  2021 ATF4 promotes lung cancer cell proliferation and invasion partially through regulating Wnt/beta-catenin signaling. CBP, CREB
47  2021 ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking. DRG, TRPM3
48  2021 ATF4-dependent heme-oxygenase-1 attenuates diabetic nephropathy by inducing autophagy and inhibiting apoptosis in podocyte. DN, WB
49  2021 ATF4-mediated histone deacetylase HDAC1 promotes the progression of acute pancreatitis. AP, HDACs, KLF4, NEP
50  2021 ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model. ATOH8, betaAtf4-KO, ER, ISR
51  2021 Betulinic acid attenuates T-2 toxin-induced cytotoxicity in porcine kidney cells by blocking oxidative stress and endoplasmic reticulum stress. BA, CAT, CHOP, eIF2alpha, GSH-Px, LDH, MDA, PERK, ROS, SOD
52  2021 Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy. ---
53  2021 Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism. BAs
54  2021 Calcium mitigates fluoride-induced kallikrein 4 inhibition via PERK/eIF2alpha/ATF4/CHOP endoplasmic reticulum stress pathway in ameloblast-lineage cells. ALCs, CHOP, GRP78, KLK4, PERK
55  2021 Canagliflozin Improves Liver Function in Rats by Upregulating Asparagine Synthetase. AMPK, ASNS, CANA, Nrf2
56  2021 Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-beta1/SMAD2/3 pathway and ABCC1 transactivation. CAFs, PDAC
57  2021 CK1δ stimulates ubiquitination-dependent proteasomal degradation of ATF4 to promote chemoresistance in gastric Cancer. BTZ, CK1delta
58  2021 Colloidal Particles in Tuna Head Soup: Chemical Localization, Structural Change, and Antioxidant Property. CHOP, TCPs
59  2021 Cooperation of ATF4 and CTCF promotes adipogenesis through transcriptional regulation. ---
60  2021 Coordinated signaling of activating transcription factor 6α and inositol-requiring enzyme 1α regulates hepatic stellate cell-mediated fibrogenesis in mice. ATF6alpha, BDL, hHSCs, HSC, IRE1alpha, mHSCs, PERK, TGF-beta, UPR
61  2021 CPEB1 enhances erastin-induced ferroptosis in gastric cancer cells by suppressing twist1 expression. Chac1, CPEB1, GC, GPX4, MDA, ROS
62  2021 CRABP2 involvement in a mechanism of Golgi stress and tumor dry matter in non-small cell lung cancer cells via ER dependent Hippo pathway. CHOP, CRABP2, EMT, ER, NSCLC, p-eIF2alpha, PERK
63  2021 Crosstalk between Endoplasmic Reticulum Stress and Oxidative Stress in Heat Exposure-Induced Apoptosis Is Dependent on the ATF4-CHOP-CHAC1 Signal Pathway in IPEC-J2 Cells. CHOP, cyt c, ERS, HS, ROS, SOD2, UPR
64  2021 Cystine and Methionine Deficiency Promotes Ferroptosis by Inducing B-Cell Translocation Gene 1. BTG1
65  2021 Dapagliflozin attenuates pressure overload-induced myocardial remodeling in mice via activating SIRT1 and inhibiting endoplasmic reticulum stress. Ang II, CHOP, DAPA, GRP78, SGLT2, SIRT1
66  2021 Dexmedetomidine Preconditioning Reduces Myocardial Ischemia-Reperfusion Injury in Rats by Inhibiting the PERK Pathway. CHOP, DEX, eIF2alpha, GRP78, I/R, KH, PERK, YOH
67  2021 Downregulation of activating transcription factor 4 attenuates lysophosphatidycholine-induced inflammation via the NF-κB pathway. 4-PBA, HUVECs, IL, LPC, ox-LDL, UPR
68  2021 Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress. eIF3, mRNAs, O-GlcNAc, uORFs
69  2021 Effect of pulsatile stretch on unfolded protein response in a new model of the pulmonary hypertensive vascular wall. ER, IRE1alpha, PPHN, UPR
70  2021 Endoplasmic reticulum stress increases LECT2 expression via ATF4. ER, LECT2, NAFLD, UPR
71  2021 Endoplasmic reticulum stress response mediated by the PERK-eIF2α-ATF4 pathway is involved in odontoblastic differentiation of human dental pulp cells. ALP, BSP, DPCs, DSPP, ER, GRP78, OCN, PERK, PERK, RT-PCR, sXBP1
72  2021 ER stress and its PERK branch enhance TCR-induced activation in regulatory T cells. ER, GRP78, IL-10, PKR, TCR, TG, TGF-beta, UPR
73  2021 Free Deoxycholic Acid Exacerbates Vascular Calcification in CKD through ER Stress-Mediated ATF4 Activation. BAs, DCA, ER, FXR
74  2021 Glucose deprivation-induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity. Bax, CHOP, DR5, ER, TRAIL
75  2021 Head and Neck Cancer Cell Death due to Mitochondrial Damage Induced by Reactive Oxygen Species from Nonthermal Plasma-Activated Media: Based on Transcriptomic Analysis. CHOP, HNC, mtROS, NTPAM, ROS
76  2021 Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery. AQ, ER, HIF-1alpha, ICH, OL, PHD, SCI
77  2021 Identification of amino acid response element of SLC38A9 as an ATF4-binding site in porcine skeletal muscle cells. AARE, mTORC1
78  2021 Inhibition of AKT Enhances the Sensitivity of NSCLC Cells to Metformin. AKT
79  2021 Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis. 25-HC, INSIGs
80  2021 Involvement of endoplasmic reticulum stress-activated PERK-eIF2α-ATF4 signaling pathway in T-2 toxin-induced apoptosis of porcine renal epithelial cells. 4-PBA, CHOP, ER, GRP78, PERK
81  2021 LSD1-directed therapy affects glioblastoma tumorigenicity by deregulating the protective ATF4-dependent integrated stress response. GBM, ISR, LSD1i, TICs
82  2021 Lutein activates downstream signaling pathways of unfolded protein response in hyperglycemic ARPE-19 cells. ATF6, ER, IRE1, UPR, XBP1
83  2021 Melatonin Inhibits Glucose-Induced Apoptosis in Osteoblastic Cell Line Through PERK-eIF2alpha-ATF4 Pathway. BiP, CHOP, eIF2alpha, ER, PERK
84  2021 Mid-pregnancy maternal immune activation increases Pax6-positive and Tbr2-positive neural progenitor cells and causes integrated stress response in the fetal brain in a mouse model of maternal viral infection. MIA
85  2021 miR-1283 Contributes to Endoplasmic Reticulum Stress in the Development of Hypertension Through the Activating Transcription Factor-4 (ATF4)/C/EBP-Homologous Protein (CHOP) Signaling Pathway. Bid, CHOP, EPCR, ET-1, HAECs, miR, NO, TM, vWF
86  2021 NEFA Promotes Autophagosome Formation through Modulating PERK Signaling Pathway in Bovine Hepatocytes. ATG7, BECN1, CHOP, eIF2alpha, ER, GRP78, LC3, NEB, NEFA, PERK
87  2021 Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes. ER, mTORC1, NNMT, PKA, UPR
88  2021 NLRP1 Functions Downstream of the MAPK/ERK Signaling via ATF4 and Contributes to Acquired Targeted Therapy Resistance in Human Metastatic Melanoma. ERK, MAPK, NLRP1, PKA, RSK2, TRA, VEM
89  2021 OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21. BAT, FGF21, OPA1
90  2021 PERK mediates oxidative stress and adipogenesis in Graves' orbitopathy pathogenesis. C/EBP, CSE, ER, GO, PERK, PPARgamma, ROS, siRNA
91  2021 PERK/ATF4-Dependent ZFAS1 Upregulation Is Associated with Sorafenib Resistance in Hepatocellular Carcinoma Cells. ER, HCC, lncRNAs, PERK, UPR, ZFAS1
92  2021 Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2alpha/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells. CPE, eIF2alpha, IDD, Ihh, NP, p-eIF2alpha, ROS, TNF
93  2021 Physiologic Responses to Dietary Sulfur Amino Acid Restriction in Mice Are Influenced by Atf4 Status and Biological Sex. ISR, SAAR
94  2021 PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway. alpha-Syn, alphaSynPFF, DAergic, ERS, mitoROS, MMCs, NLRP3, p-IRE1alpha, PD, PKCdelta, SAL, Trx, TXNIP
95  2021 Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs. Bax, Bcl-2, Caspase-3, CHOP, CVD, DFPP, eIF2alpha, ER, FCM, GRP78, IL, LDL, PBMCs, PCSK9, ROS, sdLDL, TNF-alpha
96  2021 Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients. AML, GDTLs, MAPK
97  2021 Protease Inhibitor Anti-HIV, Lopinavir, Impairs Placental Endocrine Function. ATF6, GRP78, hCG, HSD3B1, LPV, MLN64, OPA1, RTV, ST, sXBP1, UPR, VCT
98  2021 Protective Effects of Astilbin Against Cadmium-Induced Apoptosis in Chicken Kidneys via Endoplasmic Reticulum Stress Signaling Pathway. ASB, Bcl-2, C/EBP, Cd, ERS, iNOS, NO, Perk
99  2021 Puerarin Inhibits the PERK-eIF2[Formula: see text]-ATF4-CHOP Pathway through Inactivating JAK2/STAT3 Signal in Pancreatic beta-Cells. CCK-8, CHOP, ER, JAK2, PERK, STAT3, T1D
100  2021 Recombinant human growth hormone improves the immune status of rats with septic encephalopathy: The role of VEGFR2 in the prevalence of endoplasmic reticulum stress repair module. BBB, CHOP, eIF2alpha, ERS, GADD153, GH, IRE1alpha, JNK, mTOR, PERK, rhGH, VEGFR2