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â–  Abbreviation / Long Form : BSEP / bile salt export pump

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Total Number of Papers: 403
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Abbreviation:   BSEP  (>> Co-occurring Abbreviation)
Long Form:   bile salt export pump
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2020 ABCB11 deficiency presenting as transient neonatal cholestasis: Correlation with genotypes and BSEP expression. BRIC, PFIC, PPV, TNC
2020 Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice. BAs, FXR, MCD, WT
2020 Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies. ADRs, DILI, LTKB, RM
2020 Genotype correlates with the natural history of severe bile salt export pump deficiency. SBD
2020 Heterozygous knockout of Bile salt export pump ameliorates liver steatosis in mice fed a high-fat diet. FXR, HFD, NASH, WT
2020 Hypoglycemic and hypolipidemic activities of Grifola frondosa polysaccharides and their relationships with the modulation of intestinal microflora in diabetic mice induced by high-fat diet and streptozotocin. BAs, CYP7A1, FBG, FFA, HFD, LDL-C, OGT, STZ, TG
2020 Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression. HPH
2020 MicroRNA-210 Promotes Bile Acid-Induced Cholestatic Liver Injury by Targeting Mixed-Lineage Leukemia-4 Methyltransferase in Mice. BAs, FXR, KLF4, miR-210, MLL4, PBC, SHP
2020 Moving beyond Binary Predictions of Human Drug-Induced Liver Injury (DILI) toward Contrasting Relative Risk Potential. DILI, HRM
10  2020 Pharmacological premature termination codon readthrough of ABCB11 in bile salt export pump deficiency: an in vitro study. PFIC2
11  2020 Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway. AMPK, ANIT, NTCP, PIC, UGT1A1
12  2020 Picroside II protects against cholestatic liver injury possibly through activation of farnesoid X receptor. AhR, ANIT, CYP7A1, FXR, PPARalpha, PXR, Sult2a1, Ugt1a1
13  2020 Proposal of a liver histology-based scoring system for bile salt export pump deficiency. ---
14  2020 Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats. PDTC, RIF, TNF
15  2020 Protective effects of n-Butanol extract and iridoid glycosides of Veronica ciliata Fisch. Against ANIT-induced cholestatic liver injury in mice. ALP, AST, BE, CAT, DBIL, GGT, i.g, IG, IL-6, MDA, MRP2, NF-kappaB, Ntcp, SOD, TBA, TBIL, TNF-alpha, UCDA
16  2020 Spironolactone ameliorates lipopolysaccharide-induced cholestasis in rats by improving Mrp2 function: Role of transcriptional and post-transcriptional mechanisms. BSIBF, LPS, MRP2, SL
17  2020 Successful Treatment with Rituximab and Immunoadsorption for an Auto-Antibody Induced Bile Salt Export Pump Deficiency in a Liver Transplanted Patient. GGT, LT
18  2020 The protective mechanism of Lactobacillus plantarum FZU3013 against non-alcoholic fatty liver associated with hyperlipidemia in mice fed a high-fat diet. CYP7A1, NAFL, TC, TG
19  2020 [Lipid-lowering effect and mechanism of Danhong Injection on hyperlipidemia rats based on lipid metabolism disorder]. ACOX1, AI, AMP, CAT, CETP, HDL-C, LCAT, LDL-C, PPARgamma, SOD, TC, TG
20  2019 A Change in Bile Flow: Looking Beyond Transporter Inhibition in the Development of Drug-induced Cholestasis. DIC, DILI
21  2019 Alloimmunity and Cholestasis After Liver Transplantation in Children With Progressive Familial Intrahepatic Cholestasis. AIBD, LT
22  2019 Association between bile salt export pump polymorphisms and intrahepatic cholestasis of pregnancy susceptibility: a meta-analysis of case-control studies. CI, ICP, OR
23  2019 Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver. ALP, DILI, TCA
24  2019 Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis. ATP, BA, BKO, CAR, DKO, FXR, PFIC5, SHP, TKO
25  2019 Development of an in vitro cholestatic drug-induced liver injury evaluation system using HepG2-hNTCP-C4 cells in sandwich configuration. BA, DILI, SCHepG2-hNTCP-C4
26  2019 Development of Bifunctional Three-Dimensional Cysts from Chemically Induced Liver Progenitors. CLiPs, Mdr1
27  2019 Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications. DILI, GCA, TCA
28  2019 Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile. HE, IHC, siRNA
29  2019 Functional analysis of the correlation between ABCB11 gene mutation and primary intrahepatic stone. ABCB, MDCK, PIS
30  2019 Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats. BA, CYP7A1, HFD
31  2019 Heme oxygenase-1 induction by hemin prevents oxidative stress-induced acute cholestasis in the rat. BR, CAT, HO-1, MRP2, OS, SOD, t-BuOOH
32  2019 Hydrophilic bile acids prevent liver damage caused by lack of biliary phospholipid in Mdr2-/- mice. DKO, HCC, MDR3, PFIC2, THBAs
33  2019 Invitro bile acid-dependent hepatocyte toxicity assay system using human induced pluripotent stem cell-derived hepatocytes: Current status and disadvantages to overcome. BA, DILI, iPS cell, SCH
34  2019 n-3 Fatty Acids Abrogate Dyslipidemia-Induced Changes in Bile Acid Uptake, Synthesis, and Transport in Young and Aged Dyslipidemic Rats. ALA, ASBT, BA, BAT, CYP7A1, DHA, EPA, FA, FXR, HF, HMG-CoA, HNF4A, LRH-1, mRNA, Ntcp, SHP
35  2019 Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization. DILI, MRP2, P-gp, ZO-2
36  2019 Paradoxical Effects of Emodin on ANIT-Induced Intrahepatic Cholestasis and Herb-Induced Hepatotoxicity in Mice. AMPK, ANIT, BAs, FXR, PM, SC
37  2019 Phytochemicals protect L02 cells against hepatotoxicity induced by emodin via the Nrf2 signaling pathway. DMY, Nrf2
38  2019 Pioglitazone prevents cholesterol gallstone formation through the regulation of cholesterol homeostasis in guinea pigs with a lithogenic diet. ABC, CGD, EZE, HMGCR, LD, NPC1L1, PIO, SREBP2
39  2019 Probiotic Lactobacillus rhamnosus GG prevents progesterone metabolite epiallaopregnanolone sulfate-induced hepatic bile acid accumulation and liver injury. CA, FXR, ICP, LGG
40  2019 Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity. QST
41  2019 Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury. ETC, PBPK, QST, T2D
42  2019 Severe Hepatotoxicity of Mithramycin Therapy Caused by Altered Expression of Hepatocellular Bile Transporters. FXR
43  2019 The Role of the Sodium-taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) in Related Liver Disease. ---
44  2019 Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity. KD
45  2019 Vesicle- and Hepatocyte-Based Assays for Identification of Drug Candidates Inhibiting BSEP Function. ---
46  2018 A Drug Regimen for Progressive Familial Cholestasis Type 2. ---
47  2018 Allogeneic haematopoietic stem cell transplantation eliminates alloreactive inhibitory antibodies after liver transplantation for bile salt export pump deficiency. ---
48  2018 Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective. DILI
49  2018 Clinical phenotype and molecular analysis of a homozygous ABCB11 mutation responsible for progressive infantile cholestasis. PFIC2
50  2018 De Novo Endotoxin-Induced Production of Antibodies against the Bile Salt Export Pump Associated with Bacterial Infection following Major Hepatectomy. LPS
51  2018 Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk? iDILI
52  2018 Drug-induced Cholestasis: Mechanisms, Models, and Markers. BAs, DILI
53  2018 Dysregulation of BSEP and MRP2 May Play an Important Role in Isoniazid-Induced Liver Injury via the SIRT1/FXR Pathway in Rats and HepG2 Cells. DBIL, FXR, MRP2, SIRT1, TBA, TBIL
54  2018 Effect of YHHJ on the expression of the hepatocellular bile acid transporters multidrug resistance-associated protein 2 and bile salt export pump in ethinylestradiol-induced cholestasis. EE, ICP, MRP2, TBA, TBIL
55  2018 Effects of Red Ginseng Extract on the Pharmacokinetics and Elimination of Methotrexate via Mrp2 Regulation. MRP2, P-gp, RGE
56  2018 Glycyrrhizin has a high likelihood to be a victim of drug-drug interactions mediated by hepatic organic anion-transporting polypeptide 1B1/1B3. MRP, OATP, PBPK
57  2018 Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition. DILI, LC/MS
58  2018 Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition. ---
59  2018 Long-term outcomes after cholecystocolostomy for progressive familial intrahepatic cholestasis. FIC1, GGT, OLT, PFIC
60  2018 Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI. BDDCS, DILI
61  2018 Pinelliae Rhizoma Praeparatum Involved in the Regulation of Bile Acids Metabolism in Hepatic Injury. MRP2, Nrf2, PRP
62  2018 Transcriptomic, Proteomic, and Functional Long-Term Characterization of Multicellular Three-Dimensional Human Liver Microtissues. ATP, hLiMTs, MRP2, NPCs, PHH
63  2018 Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency. ABCB11
64  2017 A preliminary investigation on single nucleotide polymorphism rs2287622 of bile salt export pump gene in patients with chronic hepatitis C virus infection in Hunan, China. CHB, CHC, HCV, ORs, SNP
65  2017 ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population. ABC
66  2017 Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. ALGS, ChiLDReN, FIC1, GBC, IEs, PEBDs
67  2017 Antibiotic-Induced Elevations of Plasma Bile Acids in Rats Independent of Bsep Inhibition. DILI, TCA
68  2017 Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations. DIC, ECM
69  2017 Assessment of Bile Salt Export Pump (BSEP) Inhibition in Membrane Vesicles Using Radioactive and LC/MS-Based Detection Methods. DILI, LC/MS
70  2017 Assessment of the Drug Interaction Potential of Unconjugated and GalNAc3-Conjugated 2'-MOE-ASOs. 2'-MOE-ASOs, BCRP, DDI, OAT1, OATP1B1, OCT1, P-gp
71  2017 Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone. BCRP, KO, MRP2, TGZ, TS, WT
72  2017 Cholestasis After Pediatric Liver Transplantation-Recurrence of a Progressive Familial Intrahepatic Cholestasis Phenotype as a Rare Differential Diagnosis: A Case Report. AIBD, GGT, PFIC2, YFP
73  2017 Cholestyramine alters bile acid amounts and the expression of cholesterol-related genes in rabbit intestinal and hepatic tissues. CHO, CYP7A1, IBABP, LDLR, SHP
74  2017 Defects in myosin VB are associated with a spectrum of previously undiagnosed low gamma-glutamyltransferase cholestasis. GGT, MVID
75  2017 Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. ALP, AST, FG, FXR, gamma-GT, SHP, T-alpha-MCA, TBAs, TCA, TCBAs, TCDCA
76  2017 Editor's Highlight: Clofibrate Decreases Bile Acids in Livers of Male Mice by Increasing Biliary Bile Acid Excretion in a PPARalpha-Dependent Manner. BA, CLOF, FXR, Ntcp, OATP, PPARalpha, WT
77  2017 Effects of High-cholesterol Diet on Pravastatin Disposition in the Perfused Rat Liver. HC, MRP, OATP, PCR
78  2017 Evaluation of Farnesoid X Receptor Target Gene Induction in Human Hepatocytes: Amino Acid Conjugation. BACS, BAT, FXR, MDR3, MRP2, SHP
79  2017 Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells. 4-PBA, BD-HLCs, BD-iPSC, HLCs, PFIC2
80  2017 Genetic and Proteomic characterization of Bile Salt Export Pump (BSEP) in Snake Liver. ATP
81  2017 Glutamine attenuates obstructive cholestasis in rats via farnesoid X receptor-mediated regulation of Bsep and Mrp2. BDL, CYP7A1, FXR, Gln, MRP2, Ntcp, SHP
82  2017 How Reactive Metabolites Induce an Immune Response That Sometimes Leads to an Idiosyncratic Drug Reaction. IDRs
83  2017 Identification of Bile Acids Responsible for Inhibiting the Bile Salt Export Pump, Leading to Bile Acid Accumulation and Cell Toxicity in Rat Hepatocytes. BA, CDCA, CsA, DCA, GDCA, SCH
84  2017 Identification of urine tauro-beta-muricholic acid as a promising biomarker in Polygoni Multiflori Radix-induced hepatotoxicity by targeted metabolomics of bile acids. BAs, HDCA, PMR, TbetaMCA
85  2017 In Vitro Drug-Induced Liver Injury Prediction: Criteria Optimization of Efflux Transporter IC50 and Physicochemical Properties. DILI, MRP
86  2017 Paeoniflorin ameliorates cholestasis via regulating hepatic transporters and suppressing inflammation in ANIT-fed rats. ALP, ANIT, AST, CYP7A1, DBIL, gamma-GT, IL-1beta, MRP2, NF-kappaB, Ntcp, TBA, TBIL
87  2017 Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation. BS, HEK, PEBD, PFIC2, TC, TCDC
88  2017 Pectin penta-oligogalacturonide reduces cholesterol accumulation by promoting bile acid biosynthesis and excretion in high-cholesterol-fed mice. ABCA1, ABCG1, apoA-I, BA, CYP7A1, FXR, HCD, HDL-C, RCT, SR-BI
89  2017 PPARalpha activation protects against cholestatic liver injury. ANIT, PPARalpha
90  2017 Preserved Gut Microbial Diversity Accompanies Upregulation of TGR5 and Hepatobiliary Transporters in Bile Acid-Treated Animals Receiving Parenteral Nutrition. BAs, EN, OA, PN
91  2017 Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and enhancing the Nrf2-mediated adaptive response. AKP, AST, ATF4, ATP, CHOP, DBIL, DILI, gamma-GT, GRP78, IBIL, LDH, MDR1, MRP2, Nrf2, NTCP, Oatp2, OSTbeta, PERK, RFP, TBA, TBIL, TUDCA
92  2017 Structure based classification for bile salt export pump (BSEP) inhibitors using comparative structural modeling of human BSEP. ---
93  2017 Troglitazone Inhibits Bile Acid Amidation: A Possible Risk Factor for Liver Injury. BA, CDCA, DCA
94  2016 Antitubercular Agent Delamanid and Metabolites as Substrates and Inhibitors of ABC and Solute Carrier Transporters. ABC, SLC
95  2016 Bile salt export pump deficiency disease: two novel, late onset, ABCB11 mutations identified by next generation sequencing. BRIC, NGS, PFIC
96  2016 Bile salt export pump deficiency disease: two novel, late onset, ABCB11 mutations identified by next generation sequencing. BRIC, NGS, PFIC
97  2016 Bile salt export pump-reactive antibodies form a polyclonal, multi-inhibitory response in antibody-induced bile salt export pump deficiency. AIBD, Ig, OLT, PFIC2
98  2016 Biliary excretion of pravastatin and taurocholate in rats with bile salt export pump (Bsep) impairment. KO, WT
99  2016 Bipolar and Related Disorders Induced by Sodium 4-Phenylbutyrate in a Male Adolescent with Bile Salt Export Pump Deficiency Disease. 4-PB, PFIC2
100  2016 BSEP and MDR3: Useful Immunohistochemical Markers to Discriminate Hepatocellular Carcinomas From Intrahepatic Cholangiocarcinomas and Hepatoid Carcinomas. Arg1, HepPar-1, MDR3