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■ Abbreviation / Long Form : CDK4 / cyclin-dependent kinase 4

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Total Number of Papers: 628
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Abbreviation:   CDK4  (>> Co-occurring Abbreviation)
Long Form:   cyclin-dependent kinase 4
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No. Year Title Co-occurring Abbreviation
2020 All-trans-retinoid acid induces the differentiation of P19 cells into neurons involved in the PI3K/Akt/GSK3beta signaling pathway. DEMs, GSK3beta, mRNAs, NEFM, RA
2020 CDK4/RB/E2Fs axis as potential therapeutic target of endometrial cancer. EC, mRNA
2020 Circular RNA circ_001621 promotes osteosarcoma cells proliferation and migration by sponging miR-578 and regulating VEGF expression. circRNAs, miRNA, MMP9, VEGF
2020 Heterogeneous EGFR, CDK4, MDM4, and PDGFRA Gene Expression Profiles in Primary GBM: No Association with Patient Survival. EGFR, GBM, iFISH, MDM4, PDGFRA
2020 LINC00511 influences cellular proliferation through cyclin-dependent kinases in papillary thyroid carcinoma. CDK2, EZH2, LINC00511, lncRNAs, PTC, qRT-PCR
2020 Promising Anticancer Effect of Aurisin A Against the Human Lung Cancer A549 Cell Line. Bcl-2, EGFR, p-p38, SRB
2020 SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1. CDK6, PCa, PD, PI, siSOX7, SOX7
2020 Triptolide inhibits PDGF-induced proliferation of ASMCs through G0/G1 cell cycle arrest and suppression of the AKT/NF-kappaB/cyclinD1 signaling pathway. ASMCs, CCK-8, NF-kappaB, PCNA, PDGF, PDTC, PI3K
2019 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes injury-induced vascular neointima formation in mice. AhR, TCDD, VSMCs
10  2019 A clinical comparison between dedifferentiated low-grade osteosarcoma and conventional osteosarcoma. COS, DLOS, IQR, MDM2, OAS, PFS
11  2019 Ara-c induces cell cycle G1/S arrest by inducing upregulation of the INK4 family gene or directly inhibiting the formation of the cell cycle-dependent complex CDK4/cyclin D1. CCND1, INK4
12  2019 Bear Bile Powder Inhibits Growth of Hepatocellular Carcinoma via Suppressing STAT3 Signaling Pathway in Mice. BBP, CD31, HCC, IHC, PCNA, RT-PCR, STAT3, VEGF-A
13  2019 beta-Thujaplicin inhibits basal-like mammary tumor growth by regulating glycogen synthase kinase-3beta/beta-catenin signaling. AKT, ER
14  2019 Bisphenol S promotes the cell cycle progression and cell proliferation through ERalpha-cyclin D-CDK4/6-pRb pathway in MCF-7 breast cancer cells. BPS, pRb
15  2019 Carvacrol Induced Program Cell Death and Cell Cycle Arrest in Androgen-Independent Human Prostate Cancer Cells via Inhibition of Notch Signaling. ROS
16  2019 CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival. FLCN
17  2019 Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1. ---
18  2019 Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy. ---
19  2019 Cross-disease analysis identified novel common genes for both lung adenocarcinoma and lung squamous cell carcinoma. EPAS1, LA, LSCC, MLR, SLC2A1
20  2019 Curcumin Promoted miR-34a Expression and Suppressed Proliferation of Gastric Cancer Cells. Bcl-2, mRNA
21  2019 Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB. Rb
22  2019 Differential Apoptotic and Mitogenic Effects of Lectins in Zebrafish. Akt, Bad, Bcl-2, G6PD, GLUD, PNA, Rb, SBA, TOR
23  2019 Exportin-T promotes tumor proliferation and invasion in hepatocellular carcinoma. ANLT, CCK-8, CCNA1, CCNB1, CCNB2, CCNE2, CDK1, CDK2, GSEA, HCC, si
24  2019 Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion. MDM2, NF
25  2019 Extended proliferation of chicken- and Okinawa rail-derived fibroblasts by expression of cell cycle regulators. HPV, SV40T
26  2019 High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone. Bax, ERK, HBlEpCs, p38 MAPK
27  2019 Huganpian, a traditional chinese medicine, inhibits liver cancer growth in vitro and in vivo by inducing autophagy and cell cycle arrest. CDK2, HGP
28  2019 Human-Derived Corneal Epithelial Cells Expressing Cell Cycle Regulators as a New Resource for in vitro Ocular Toxicity Testing. TERT
29  2019 Ifenprodil and Flavopiridol Identified by Genomewide RNA Interference Screening as Effective Drugs To Ameliorate Murine Acute Lung Injury after Influenza A H5N1 Virus Infection. ALI, NMDA, RNAi
30  2019 In vitro study to assess the efficacy of CDK4/6 inhibitor Palbociclib (PD-0332991) for treating canine mammary tumours. CMTs, pRb
31  2019 Interferon-gamma regulates cell malignant growth via the c-Abl/HDAC2 signaling pathway in mammary epithelial cells. BMECs, c-Abl, HDAC2, IFN-gamma, VPA
32  2019 Interleukin-6 and tumour necrosis factor-alpha cooperatively promote cell cycle regulators and proliferate rheumatoid arthritis fibroblast-like synovial cells. IL-6, phospho-pRB, pRb, RA-FLSs, sIL-6R, TNF-alpha
33  2019 LncRNA KB-1471A8.2 Overexpression Suppresses Cell Proliferation and Migration and Antagonizes the Paclitaxel Resistance of Ovarian Cancer Cells. ---
34  2019 MicroRNA-338-3p inhibits tumor growth and metastasis in osteosarcoma cells by targeting RUNX2/CDK4 and inhibition of MAPK pathway. MAPK, miRNAs, MTT, OS
35  2019 miR-216a-5p promotes mesangial cell proliferation by targeting FoxO1 in diabetic nephropathy. CCK-8, DN, FOXO1, HMC, miRNAs, PI, qRT-PCR, WB
36  2019 MiR-34b-3p represses cell proliferation, cell cycle progression and cell apoptosis in non-small-cell lung cancer (NSCLC) by targeting CDK4. 3'-UTR, miRNAs, NSCLC
37  2019 Mucin O-glycosylating enzyme GALNT2 facilitates the malignant character of glioma by activating the EGFR/PI3K/Akt/mTOR axis. EGFR, IHC, MMP2, MMP9, qRT-PCR
38  2019 Overexpression of CMTM7 inhibits cell growth and migration in liver cancer. CKLF, CMTM7, CMTMs, MARVEL
39  2019 Regulation of p53 in the red-eared slider (Trachemys scripta elegans) in response to salinity stress. CDK6
40  2019 Repressing of NHERF1 inhibits liver cancer progression by promoting the production of ROS. HCC, JNK, PTEN, ROS
41  2019 Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex. SARD
42  2019 Schizandrin A inhibits proliferation, migration and invasion of thyroid cancer cell line TPC-1 by down regulation of microRNA-429. ERK, MEK, MMP, NC, Sch A, TC
43  2019 Short-chain fatty acids inhibit bovine rumen epithelial cells proliferation via upregulation of cyclin-dependent kinase inhibitors 1A, but not mediated by G protein-coupled receptor 41. BRECs, CDKN1A, GPR41, GPR41KD, SCFAs
44  2019 Stephanthraniline A suppresses proliferation of HCT116 human colon cancer cells through induction of caspase-dependent apoptosis, dysregulation of mitochondrial function, cell cycle arrest and regulation of Akt/p38 signaling pathways. STA
45  2019 SWOG S1400C (NCT02154490)-A Phase II Study of Palbociclib for Previously Treated Cell Cycle Gene Alteration-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Substudy). CCND1, CCND2, CCND3, CI
46  2019 Tanshinone I inhibits vascular smooth muscle cell proliferation by targeting insulin-like growth factor-1 receptor/phosphatidylinositol-3-kinase signaling pathway. EdU, GSK3beta, IGF-1, IRS, mTOR, MTS, PI3K, rpS6, VSMC
47  2019 Tetrandrine inhibits colon carcinoma HT-29 cells growth via the Bcl-2/Caspase 3/PARP pathway and G1/S phase. CCND1, pRb, Tet
48  2019 The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1. ss
49  2019 The functions of microRNA-124 on bladder cancer. BC, qPCR, VEGF
50  2019 The role of cyclin-dependent kinases in oral potentially malignant disorders and oral squamous cell carcinoma. OPMDs, OSCC
51  2019 Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells. CDK2, GLTP, GSL, pMLKL, RIPK-3
52  2019 WD repeat and SOCS box containing protein 2 in the proliferation, cycle progression, and migration of melanoma cells. EdU, pRb, WSB
53  2019 Wound Healing Potential of Spirulina Protein on CCD-986sk Cells. BrdU, CDK2, CDK6, PI3K, SPCP
54  2019 Yes-associated protein regulates podocyte cell cycle re-entry and dedifferentiation in adriamycin-induced nephropathy. PCNA, TEAD, WT1, YAP
55  2019 [A Case of Dedifferentiated Liposarcoma of the Spermatic Cord]. MDM2
56  2019 [Construction of miR-331-3p overexpression vector and its effect on cell proliferation]. CDK2, CDK3, CDKN1A, miR-331-3p NC, PI
57  2019 [Role of p53/p21 signal transduction pathway in the malignant transformation of human embryonic lung fibroblasts induced by quartz]. PFT-alpha, T-HELF
58  2018 A case report of primary cardiac sarcoma: a diagnostic and therapeutic challenge. ---
59  2018 A combination of the PI3K pathway inhibitor plus cell cycle pathway inhibitor to combat endocrine resistance in hormone receptor-positive breast cancer: a genomic algorithm-based treatment approach. Rb
60  2018 A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway. MAPK, ROS
61  2018 An Intrinsic Mitochondrial Pathway Is Required for Phytic Acid-Chitosan-Iron Oxide Nanocomposite (Phy-CS-MNP) to Induce G₀/G₁ Cell Cycle Arrest and Apoptosis in the Human Colorectal Cancer (HT-29) Cell Line. iNOS, JNK1, MMP9, NF-kappaB, PCR, Phy-CS-MNP, VEGF-A
62  2018 Berberine inhibits experimental varicocele-induced cell cycle arrest via regulating cyclin D1, cdk4 and p21 proteins expression in rat testicles. BBR, H and E, IHC, VCL
63  2018 Bioactive fraction of Rhodiola algida against chronic hypoxia-induced pulmonary arterial hypertension and its anti-proliferation mechanism in rats. Hct, HPAH, PCNA
64  2018 Cdc37 facilitates cell survival of colorectal carcinoma via activating the CDK4 signaling pathway. Cdc37, CRC, Hsp90, RB1
65  2018 CDK4 expression in chordoma: A potential therapeutic target. ---
66  2018 CDK4, a new metabolic sensor that antagonizes AMPK. AMPK
67  2018 Correction of GSK3beta at young age prevents muscle pathology in mice with myotonic dystrophy type 1. GSK3beta, HSALR
68  2018 Cyclin-dependent kinase 4 is a preclinical target for diet-induced obesity. FDA-approved
69  2018 EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis. AURKA, circMMP9, circRNAs, eIF4A3, GBM
70  2018 Expression and therapeutic implications of cyclin-dependent kinase 4 (CDK4) in osteosarcoma. siRNA, TMA
71  2018 Expression of human mutant cyclin dependent kinase 4, Cyclin D and telomerase extends the life span but does not immortalize fibroblasts derived from loggerhead sea turtle (Caretta caretta). ---
72  2018 EZH2-mediated suppression of lncRNA-LET promotes cell apoptosis and inhibits the proliferation of post-burn skin fibroblasts. EZH2, HDF, lncRNA
73  2018 FGF9/FGFR2 increase cell proliferation by activating ERK1/2, Rb/E2F1, and cell cycle pathways in mouse Leydig tumor cells. FGF9, FGFR2, Rb
74  2018 Gomisin A Suppresses Colorectal Lung Metastasis by Inducing AMPK/p38-Mediated Apoptosis and Decreasing Metastatic Abilities of Colorectal Cancer Cells. Bcl-2, CRC, GA, MMP
75  2018 Guanidinoacetic Acid Regulates Myogenic Differentiation and Muscle Growth Through miR-133a-3p and miR-1a-3p Co-mediated Akt/mTOR/S6K Signaling Pathway. CCND1, GAA, miRNA, MyHC, MYOG
76  2018 Hedyotisdiffusa Willd inhibits proliferation and induces apoptosis of 5‑FU resistant colorectal cancer cells by regulating the PI3K/AKT signaling pathway. CRC, EEHDW, HDW, PI3K, PTEN
77  2018 HPV acting on E-cadherin, p53 and p16: literature review. EMT, HPV, IHC, LC, OC, OSCC
78  2018 Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer. CHIP, MAPK3, OUT, PRMT1, Ub
79  2018 Inhibition of CREPT restrains gastric cancer growth by regulation of cycle arrest, migration and apoptosis via ROS-regulated p53 pathway. DCF, KD, MMP-1, NAC, ROS
80  2018 LFM-A13, a potent inhibitor of polo-like kinase, inhibits breast carcinogenesis by suppressing proliferation activity and inducing apoptosis in breast tumors of mice. DMBA, PLK
81  2018 LncRNA NEAT1 regulates cervical carcinoma proliferation and invasion by targeting AKT/PI3K. lncRNAs, MMP2, MTT, NEAT1, p-Akt, p-PI3K, siRNA
82  2018 Long noncoding RNA gastric cancer-related lncRNA1 mediates gastric malignancy through miRNA-885-3p and cyclin-dependent kinase 4. GC, GCRL1, lncRNAs, miR-885-3p
83  2018 MFAP5 suppression inhibits migration/invasion, regulates cell cycle and induces apoptosis via promoting ROS production in cervical cancer. ECM, EMT, JNK, MFAP5, ROS
84  2018 MicroRNA-338-3p Inhibits Proliferation and Promotes Apoptosis of Multiple Myeloma Cells Through Targeting Cyclin-Dependent Kinase 4. miR-338-3p, MM
85  2018 MicroRNA-506-3p inhibits osteosarcoma cell proliferation and metastasis by suppressing RAB3D expression. MMP9
86  2018 Modulation of Rb phosphorylation and antiproliferative response to palbociclib: the preoperative-palbociclib (POP) randomized clinical trial. GE, HR, POP
87  2018 Omega 3 polyunsaturated fatty acids inhibit cell proliferation by regulating cell cycle in fad3b transgenic mouse embryonic stem cells. ESC, PCR, PUFAs
88  2018 Oncogene RPA1 promotes proliferation of hepatocellular carcinoma via CDK4/Cyclin-D pathway. HCC, RPA, shRNA
89  2018 Palbociclib for treatment of metastatic melanoma with copy number variations of CDK4 pathway: case report. CNVs
90  2018 PAQR4 has a tumorigenic effect in human breast cancers in association with reduced CDK4 degradation. PAQR4
91  2018 Physical exercise promotes proliferation and differentiation of endogenous neural stem cells via ERK in rats with cerebral infarction. ERK, NSCs
92  2018 Piperlongumine decreases cell proliferation and the expression of cell cycle-associated proteins by inhibiting Akt pathway in human lung cancer cells. NF-kappaB, PL, Rb
93  2018 Primary endobronchial liposarcoma successfully resected via bronchoscopy: A rare case report with genetic analysis. ALT-WDLS, CD34, CT, MDM2
94  2018 Proteins of the retinoblastoma pathway, FEN1 and MGMT are novel potential prognostic biomarkers in pancreatic adenocarcinoma. DFS, FEN1, PDAC, RFS
95  2018 Resveratrol attenuates hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats: Role of ROS and ROS-mediated cell signaling. pRb, SHR, VSMC, WKY
96  2018 Resveratrol inhibits angiotensin II‑induced proliferation of A7r5 cells and decreases neointimal hyperplasia by inhibiting the CaMKII‑HDAC4 signaling pathway. Ang II, CaMKII, HDAC4, PCNA
97  2018 Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development. BA, fl, FXR, HCC, mRNAs, MYC, TCA, TMCA, WT
98  2018 Transcriptional alterations in hereditary and sporadic nonfunctioning pancreatic neuroendocrine tumors according to genotype. Lef1, MEN1, mRNA, NFPanNETs, NIC, PDGFRB, VHL
99  2018 Triggering of cancer cell cycle arrest by a novel scorpion venom-derived peptide-Gonearrestide. ---
100  2018 Tsantan Sumtang Alleviates Chronic Hypoxia-Induced Pulmonary Hypertension by Inhibiting Proliferation of Pulmonary Vascular Cells. alpha-SMA, HPH, mPAP, NE, PCNA, RVHI