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■ Abbreviation / Long Form : CMZ / chlormethiazole

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Total Number of Papers: 40
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Abbreviation:   CMZ  (>> Co-occurring Abbreviation)
Long Form:   chlormethiazole
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No. Year Title Co-occurring Abbreviation
2020 CYP2E1 and miRNA-378a-3p contribute to acetaminophen- or tripterygium glycosides-induced hepatotoxicity. DILI, TG
2018 2-(4-methyl-thiazol-5-yl) ethyl nitrate maleate-potentiated GABAA receptor response in hippocampal neurons. AD, LTP
2018 Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver. 4-HNE, AFL, CYP2E1, CYP2E1-HepG2, IGF-1, MDA, NAC, NAFLD, NC-HepG2, PI3K, PTEN
2018 Inhibitory effect of chlormethiazole on the toxicokinetics of diethylnitrosamine in normal and hepatofibrotic rats. CL, DEN, HPLC, i.p
2016 Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole. HLMs
2014 CMZ reversed chronic ethanol-induced disturbance of PPAR-alpha possibly by suppressing oxidative stress and PGC-1alpha acetylation, and activating the MAPK and GSK3beta pathway. ACC, AFL, AMPK, CYP2E1, FAS, MAPK, PPAR-alpha
2014 Effect of Alcohol Administration on Mg2+ Homeostasis in H9C2 Cells. DTT, NAC
2014 Inhibition of cytochrome P4502E1 by chlormethiazole attenuated acute ethanol-induced fatty liver. 4-HNE, CYP2E1, DGAT2, MDA, PPAR-alpha, SREBP-1, TNF-alpha
2014 Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation. MZ
10  2013 Acute effect of ethanol on hepatic reticular G6Pase and Ca2+ pool. DTT, EtOH, G6P, G6Pase, Pi
11  2013 Cytochrome P4502E1 inhibitor, chlormethiazole, decreases lipopolysaccharide-induced inflammation in rat Kupffer cells with ethanol treatment. LPS, NF-kappaB, ROS, TNF
12  2013 Estrogen-related receptor gamma controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol. CYP2E1, ERRgamma, ROS
13  2012 Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats. 8-OHdG, CYP2E1
14  2009 Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease. 4-HNE, ALD, CYP2E1, HCC
15  2007 Angiogenesis as a predictive marker of neurological outcome following hypoxia-ischemia. HI, NOS
16  2007 Docosahexaenoic acid induces apoptosis in CYP2E1-containing HepG2 cells by activating the c-Jun N-terminal protein kinase related mitochondrial damage. DHA, JNK, LPOs
17  2007 Mitochondrial involvement in transhemispheric diaschisis following hypoxia-ischemia: Clomethiazole-mediated amelioration. GM-CSF, HI, IL, TNF
18  2006 Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5. ---
19  2006 Modeling drug- and system-related changes in body temperature: application to clomethiazole-induced hypothermia, long-lasting tolerance development, and circadian rhythm in rats. ---
20  2005 Clomethiazole: mechanisms underlying lasting neuroprotection following hypoxia-ischemia. HI, NOS
21  2005 Differential neuroprotective effects for three GABA-potentiating compounds in a model of hypoxia-ischemia. HI
22  2005 Neuro-overprotection? A functional evaluation of clomethiazole-induced neuroprotection following hypoxic-ischemic injury. AD, HI, VIH
23  2004 Treatment of alcohol withdrawal: chlormethiazole vs. carbamazepine and the effect on memory performance--a pilot study. CBZ
24  2003 Symptom-triggered versus standard chlormethiazole treatment of inpatient alcohol withdrawal: clinical implications from a chart analysis. ---
25  2003 The effect of clomethiazole on plasma concentrations of interleukin-6, -8, -1beta, tumor necrosis factor-alpha, and neutrophil adhesion molecule expression during experimental extracorporeal circulation. IL
26  2001 Physicochemical characterisation of a drug-containing phospholipid-stabilised o/w emulsion for intravenous administration. DSC, NMR, PCS
27  1999 Clomethiazole (ZENDRA, CMZ) improves hind limb motor function and reduces neuronal damage after severe spinal cord injury in rat. MAP2, SCI
28  1999 Cubic phases for studies of drug partition into lipid bilayers. 4-PBA, HTS
29  1999 Functional benefit from clomethiazole treatment after focal cerebral ischemia in a nonhuman primate species. pMCAO
30  1999 Post-translational inhibition of cytochrome P-450 2E1 expression by chlomethiazole in Fao hepatoma cells. CYP2E1, hnRNA
31  1998 Clomethiazole (Zendra) in acute ischemic stroke: basic pharmacology and biochemistry and clinical efficacy. ---
32  1998 Discriminative stimulus functions of CNS sedative drugs assessed by drug versus drug discrimination procedures in gerbils. CDP, EtOH, P-barb
33  1998 The discriminative stimulus effects of clomethiazole in the rat. GABAA, NMDA
34  1998 Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole. ALD, CYP2E1, IL, PCR, TGF-beta1, TNF-alpha
35  1997 Effects of clomethiazole on radial-arm maze performance following global forebrain ischemia in gerbils. ---
36  1995 Inhibition of CYP2E1 activity does not abolish pulsatile urine alcohol concentrations during chronic alcohol infusions. BECs, CYP2E1, DAS, DHC, PET, UECs
37  1994 Chlormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver. ---
38  1987 Chlormethiazole acts on chloride channels in cultured spinal cord neurons. ---
39  1983 The effects of chlormethiazole on single unit activity in rat brain; interactions with inhibitory and excitatory neurotransmitters. GABA
40  1982 Ethanol as a discriminative stimulus: effects of cyanamide, acetaldehyde and chlormethiazole. EtOH, OF