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■ Abbreviation / Long Form : CO / cyclooxygenase

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Total Number of Papers: 128
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Abbreviation:   CO  (>> Co-occurring Abbreviation)
Long Form:   cyclooxygenase
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No. Year Title Co-occurring Abbreviation
2015 Biological and pharmacological activities of 1,3,4-thiadiazole based compounds. APN, CA, MMPs, NEP, PDEs
2011 Eicosanoid-induced store-operated calcium entry in dendritic cells. 5-LO, APC, DC, GM-CSF, IL-4, SOCE, STIM1, TRPC
2011 [Prophylaxis and treatment of NSAID-related peptic ulceration: present status and prospects]. GI, NSAIDs
2010 [Role of proton pump inhibitor in the management of low dose aspirin related ulcerations]. GI, PPI
2005 Avena Rhealba inhibits A23187-stimulated arachidonic acid mobilization, eicosanoid release, and cPLA2 expression in human keratinocytes: potential in cutaneous inflammatory disorders. AA, AR, LO
2003 [Synthesis of eicosanoids in the colonic mucosa in patients with ulcerative colitis]. CM, HETEA, LO, LTB4, PG, TB2, UC
2001 Inhibitors of arachidonic acid metabolism have variable effects on calcium signaling pathways. 7-ER, AA, Ang II, CAF, ETI, IBU, LO, Ry, TG, VSMC
1998 Antiinflammatory effect of tepoxalin: blood and synovial tissue studied in patients with knee arthrosis. 5-LO, PGE2, RIA, TXB2
1998 Role of free oxygen radicals and prostanoids in the pathogenesis of Henoch-Schonlein Purpura. HSP, MDA, PGE, Vit E
10  1997 Cyclooxygenase and lipoxygenase metabolite generation in nasal polyps. AA, ASA, LO, LTs, PGs
11  1997 Cytotoxic action of alpha-linolenic and eicosapentaenoic acids on myeloma cells in vitro. AA, ALA, CPZ, DGLA, DHA, EPA, GLA, IM, LA, LO, LTs, NDGA, OA, PGs, SOD, TFP
12  1997 Effects of tepoxalin, a dual inhibitor of cyclooxygenase/5-lipoxygenase, on events associated with NSAID-induced gastrointestinal inflammation. 5-LO, NSAIDs
13  1997 Ozone inactivates cyclooxygenase in human tracheal epithelial cells without altering PGHS-2 mRNA or protein. PG, PGHS-2, ROS, TE
14  1996 Biochemical activity, pharmacokinetics and tolerability of tepoxalin, a cyclooxygenase/5-lipoxygenase inhibitor, in man. 5-LO
15  1996 Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity. 5-LO
16  1996 Investigation into the role of cyclooxygenase products in the bradykinin response on isolated human myometrium and umbilical artery. BK
17  1996 Pharmacological targeting of signaling pathways in protein kinase C-stimulated superoxide generation in neutrophil-like HL-60 cells: effect of phorbol ester, arachidonic acid and inhibitors of kinase(s), phosphatase(s) and phospholipase A2. HL-60, MAPK, MEK, PKC, PSP, PTK, PTP
18  1995 Effect of intravitreal administration of indomethacin on experimental subretinal neovascularization in the subhuman primate. SRN
19  1995 Hydroxylamine analogs of 2,6-di-t-butylphenols: dual inhibitors of cyclooxygenase and 5-lipoxygenase or selective 5-lipoxygenase inhibitors. 5-LO, DTBP
20  1995 Modulation of superoxide generation in in vivo lipopolysaccharide-primed rat alveolar macrophages by arachidonic acid and inhibitors of protein kinase C, phospholipase A2, protein serine-threonine phosphatase(s), protein tyrosine kinase(s) and phosphatase(s). 5-LO, AA, LPS, PKC, PLA2, PMA, PSP, PTK, PTP, SAL
21  1995 Ozone exposure of human tracheal epithelial cells inactivates cyclooxygenase and increases 15-HETE production. 15-HETE, AA, PGE2, TE, TLC
22  1995 Suppression of NF kappa B activation and NF kappa B-dependent gene expression by tepoxalin, a dual inhibitor of cyclooxygenase and 5-lipoxygenase. 5-LO, NF-kappaB
23  1995 Tepoxalin, a novel dual inhibitor of the prostaglandin-H synthase cyclooxygenase and peroxidase activities. NSAIDs, PO
24  1995 The pruritogenic and inflammatory effects of prostanoids in the conjunctiva. ---
25  1994 A useful method for differential evaluation of anti-inflammatory effects due to cyclooxygenase and 5-lipoxygenase inhibitions in mice. 5-LO
26  1994 Analytical and pharmacological studies on Mahonia aquifolium. 5-LO
27  1994 Anti-inflammatory active polyacetylenes from Bidens campylotheca. 5-LO
28  1994 Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis. Evaluation and synthesis of 4,5-bis(4-methoxyphenyl)-2-substituted-thiazoles. ---
29  1994 Arachidonic acid metabolism in benign and malignant prostatic tissue in vitro: effects of fatty acids and cyclooxygenase inhibitors. DAG, ETYA, FA, KPN, LO, LTs, PGs, PL
30  1994 Cytokine suppressive anti-inflammatory compounds inhibit bone resorption in vitro. FRLB, LO, PTH
31  1994 Effects of tebufelone (NE-11740), a new anti-inflammatory drug, on arachidonic acid metabolism. 5-LO, AA, DTBP, NSAID
32  1994 Endothelium-dependent relaxation to arachidonic acid in porcine coronary artery: is there a fourth pathway? AA, BK, CP450, INDO, L-NAME, LO, NO, PCA, PLA
33  1994 Evidence that secretory phospholipase A2 plays a role in arachidonic acid release and eicosanoid biosynthesis by mast cells. 5-LO, AA, sPLA2
34  1994 In vivo characterization of zymosan-induced mouse peritoneal inflammation. 5-LO, 6-KPA, LT, MPO
35  1994 Inhibition of leukotriene production by N-[4-[4-(diphenylmethyl)-1- piperazinyl]butyl]-3-(6-methyl-3-pyridyl) acrylamide (AL-3264), a new antiallergic agent. 5-LO, LT
36  1994 Interleukin-1 beta and interleukin-6 stimulate neurohypophysial hormone release in vitro. AVP, CRH, IL-1, IL-6, LO
37  1994 Lipoxygenase inhibitory activity of U-66,858 and its deacetylated metabolite U-68,244 in human whole blood. 5-LO, LTB4, NS, WB
38  1994 Modulation of superoxide generation in in vivo lipopolysaccharide-primed Kupffer cells by staurosporine, okadaic acid, manoalide, arachidonic acid, genistein and sodium orthovanadate. 5-LO, AA, LPS, PKC, PLA2, PMA
39  1994 Piperazinealkanol ester derivatives of indomethacin as dual inhibitors of 5-lipoxygenase and cyclooxygenase. 5-HETE, 5-LO, TXB2
40  1994 Pyridinyl imidazoles inhibit the inflammatory phase of delayed type hypersensitivity reactions without affecting T-dependent immune responses. 5-LO, DTH
41  1994 Studies on anti-platelet agents. IV. A series of 2-substituted 4,5-bis(4-methoxyphenyl)pyrimidines as novel anti-platelet agents. AA
42  1994 Studies on anti-platelet agents. V. Synthesis and structure-activity relationship of 3-substituted 5,6-bis(4-methoxyphenyl)-1,2,4-triazines. ---
43  1994 Tepoxalin: a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. HPBL, LO, LTB4, PG, TXB2
44  1994 The role of prostanoids in the complications of extracorporeal shock wave lithotripsy (ESWL) in children. ESWL, LO, LTC4, PGE2, UTSD
45  1993 1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities. 5-LO, CFE, NSAIDs
46  1993 Antiplatelet principles from a food spice clove (Syzygium aromaticum L) [corrected]. AA
47  1993 Aspirin effect on early and late changes in acute lung injury in sheep. OA, TXB2
48  1993 Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents. LO
49  1993 Effects of interleukin-1 alpha on arachidonic acid metabolism in human osteosarcoma osteoblastic cells. AA, HETE, IL-1alpha, LO, PGE2
50  1993 Inhibition of endotoxin-induced hypothermia and serum TNF-alpha levels in CD-1 mice by various pharmacological agents. LO, LPS
51  1993 Involvement of phospholipase A2 activation and arachidonic acid metabolism in the cytotoxic functions of rat NK cells. AA, Ab, LO, LTB4, lysoPC, NDGA, p-BPB, PLA2
52  1993 Renal function conscious one kidney-one clip hypertensive rats. Effect of indomethacin. BP, PGE2
53  1993 Role of eicosanoids in hyperpnea-induced airway responses in guinea pigs. 5-LO, HIB, HIBVH
54  1993 Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors. 5-LO, DA, i.v
55  1993 The effects of anti-inflammatory and antiallergic drugs on the release of IL-1 beta and TNF-alpha in the human whole blood assay. ---
56  1993 Transforming growth factor-beta is a renin secretagogue at picomolar concentrations. LO, TGF-beta s
57  1992 Comparative pharmacological investigations of Allium ursinum and Allium sativum. ACE, LO, TA
58  1992 Cytotoxic action of cis-unsaturated fatty acids on human cervical carcinoma (HeLa) cells: relationship to free radicals and lipid peroxidation and its modulation by calmodulin antagonists. CPZ, DGLA, DHA, EPA, GLA, HeLa, HeLa, LA, LO, NDGA, TFP
59  1992 Effect of dihomogammalinolenic acid and its 15-lipoxygenase metabolite on eicosanoid metabolism by human mononuclear leukocytes in vitro: selective inhibition of the 5-lipoxygenase pathway. 15-HETrE, AA, HPML, LO, PGE1, RP-HPLC
60  1992 Effect of extracellular magnesium on platelet activation and intracellular calcium mobilization. 12-HETE, LO, TXA2
61  1992 Effects of lipoxygenase and cyclooxygenase inhibitors on murine antibody-dependent cellular cytotoxicity (ADCC). AA, ADCC, ASA, ES, Imi, INDO, LO, NDGA, PHE
62  1992 Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders. 5-LO
63  1992 Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors. 5-LPO, LTC4
64  1992 Modulation of macrophage procoagulant activity by arachidonic acid metabolites. 5-LO, INDO, NDGA, PCA
65  1992 Prostaglandin synthesis and accumulation by porcine ciliary epithelium. NPE, PE
66  1992 The mixed lipoxygenase/cyclooxygenase inhibitor SK&F 105809 reduces cerebral edema after closed head injury in rat. 5-LO
67  1992 [Analysis of platelet shape change, inositol metabolism, and Ca mobilization in patients with platelet dysfunction]. ---
68  1992 [Anti-inflammatory activity of sabal fruit extracts prepared with supercritical carbon dioxide. In vitro antagonists of cyclooxygenase and 5-lipoxygenase metabolism]. 5-LO, BPH
69  1991 Analgetic activity of SK&F 105809, a dual inhibitor of arachidonic acid metabolism. 5-LO, PBQ, RS
70  1991 Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. 5-LPO, MHb
71  1991 Pharmacology of the pyrroloimidazole, SK&F 105809--II. Antiinflammatory activity and inhibition of mediator production in vivo. 5-LO, IL-1, LTB4, PMN
72  1991 Possible implication of arachidonic acid metabolism in the decrease of chemiluminescence production after exposure of murine peritoneal macrophages to diethylnitrosamine and tumour promoter, 12-O-tetradecanoylphorbol-13-acetate. AA, DEN, LTs, PGs, PKC, PLA2, TPA
73  1991 Rapid increase in the activity of enzymes of eicosanoid synthesis in hepatic and extrahepatic tissues after experimental liver transplantation. 5-LO, PCS, TXS, Vmax
74  1991 Role of corticosterone in modulation of eicosanoid biosynthesis and antiinflammatory activity by 5-lipoxygenase (5-LO) and cyclooxygenase (CO) inhibitors. 5-LO, AA, LO, TXB2
75  1991 The role of prostaglandin E2 in immune suppression following injury. IL-2, PBMC, PGE2, PHA, SUP
76  1991 Therapeutic intervention in a rat model of adult respiratory distress syndrome: III. Cyclooxygenase pathway inhibition. BAL, Hb, Hct, TP, TXA2
77  1991 Transcription, translation and secretion of interleukin 1 and tumor necrosis factor: effects of tebufelone, a dual cyclooxygenase/5-lipoxygenase inhibitor. IL, LO, LPS, LT, PBMC, PG, TNF
78  1991 Treatment of S antigen uveoretinitis with lipoxygenase and cyclo-oxygenase inhibitors. AA, LO, NDGA
79  1991 [Evaluation of platelet malondialdehyde and 12-hydroperoxyeicosatetraenoic acid in type I and II diabetic patients with ketoacidosis and after clinical complications]. 12-HPETE, AA, LO, MDA
80  1991 [Synthesis and antiinflammatory and anticancer activities of 2-(E)-(un)substituted benzylidene cyclopentanones and their Mannich base hydro chlorides]. 5-LO, NSAIDs
81  1990 1-naphthyl N-methyl carbamate effect on intra- and extracellular concentrations of arachidonic acid metabolites, and on the chemiluminescence generation by mouse peritoneal macrophages. 5-HETE, AA, CL, LO, OZ, PGs, TPA
82  1990 5-Hydroxytryptamine and the metabolism of arachidonic acid by the lipoxygenase and cyclooxygenase of washed human platelets. 12-HETE, 5-HT, AA, TXB2
83  1990 Alterations in the pattern of arachidonate metabolism accompany rat macrophage differentiation in the lung. 5-LO, AA, IM, PM
84  1990 Cyclooxygenase and lipoxygenase metabolite synthesis by polymorphonuclear neutrophils: in vitro effect of dipyrone. AA, LO, LTC4, PGE2, PMN, TXA2
85  1990 Effect of dopamine on renal blood flow, prostaglandins, renin and electrolyte excretion in normal and hypertensive humans. DA
86  1990 Effect of structure on potency and selectivity in 2,6-disubstituted 4-(2-arylethenyl)phenol lipoxygenase inhibitors. 5-LO
87  1990 Effects of indomethacin on neural and myogenic components in equine airway smooth muscle. ATR, INDO, LO, PGE2, S-R, TTX
88  1990 Gastric inhibitory polypeptide mechanisms of augmenting insulin secretion. GIP, LPX, PLA2
89  1990 IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators. ELGV, PAF
90  1990 Influence of extracellular calcium on the metabolism of arachidonic acid in alveolar macrophages. AA, LO, PLA2, PMA
91  1990 Oxygen free radical producing leukocytes cause functional depression of isolated rat hearts: role of leukotrienes. CF, CL, DCM, LO, LVDP, OFR, PMA
92  1990 Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors. 5-LO, AA
93  1990 Possible involvement of arachidonic acid metabolites of cytochrome P450 monooxygenase pathway in vasopressin-stimulated glycogenolysis in isolated rat hepatocytes. AA, EET, ETYA, LO, MO
94  1990 Tumor necrosis factor and interleukin-1 may regulate renin secretion. AII, hIL-1, IL-1, rhIL-i beta, TNF
95  1989 Arabinogalactan- and dextran-induced ear inflammation in mice: differential inhibition by H1-antihistamines, 5-HT-serotonin antagonists and lipoxygenase blockers. LO
96  1989 Changes in cyclooxygenase metabolites in experimental periodontitis in Macaca mulatta. ALOSS, BLOSS, CF, Fb, PGE2, TXB2
97  1989 Different patterns of arachidonate metabolism in autologous human blood monocytes and alveolar macrophages. 5-LO, AA, AM, PBM
98  1989 Dysregulation of arachidonic acid release and metabolism by atopic mononuclear cells. AA, HPLC, LO
99  1989 Effect of a 5-lipoxygenase (5-LO)/cyclooxygenase (CO) inhibitor, WY-47, 288, on cutaneous models of inflammation. 5-LO, TPA
100  1989 Effect of heparin-PVA hydrogel on platelets in a chronic canine arterio-venous shunt. PVA