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■ Abbreviation / Long Form : DDR2 / discoidin domain receptor 2

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Total Number of Papers: 136
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Abbreviation:   DDR2  (>> Co-occurring Abbreviation)
Long Form:   discoidin domain receptor 2
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2019 Biomarkers for the identification of cardiac fibroblast and myofibroblast cells. ---
2019 Discoidin domain receptor 2: An emerging pharmacological drug target for prospective therapy against osteoarthritis. MMP, MMPs, OA
2019 ECM signaling in cartilage development and endochondral ossification. ECM
2019 Role of discoidin domain receptor 2 (DDR2) and microRNA-182 in survival of women with high-grade serous ovarian cancer. HGSOC
2018 Collagen Type 1 Accelerates Healing of Ruptured Fetal Membranes. PPROM
2018 Corrigendum to "Spatial localisation of Discoidin Domain Receptor 2 (DDR2) signalling is dependent on its collagen binding and kinase activity" [Biochem. Biophys. Res. Commun. 501 (1) (18 June 2018) 124-130]. ---
2018 Coupling of a specific photoreactive triple-helical peptide to crosslinked collagen films restores binding and activation of DDR2 and VWF. THP, vWF
2018 Discoidin Domain Receptor 2 Signaling Regulates Fibroblast Apoptosis through PDK1/Akt. ---
2018 Incorporation of DDR2 clusters into collagen matrix via integrin-dependent posterior remnant tethering. ECD, ECM, RTK
10  2018 Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain. RTK
11  2018 Inhibitor of apoptosis proteins (IAPs) mediate collagen type XI alpha 1-driven cisplatin resistance in ovarian cancer. IAPs
12  2018 Mutational Landscape of DDR2 Gene in Lung Squamous Cell Carcinoma Using Next-generation Sequencing. SCC
13  2018 Selective Role of Discoidin Domain Receptor 2 in Murine Temporomandibular Joint Development and Aging. slie, TMJ
14  2018 Spatial localisation of Discoidin Domain Receptor 2 (DDR2) signalling is dependent on its collagen binding and kinase activity. ---
15  2018 Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins. alpha-SMA, CCC, CFs, ST
16  2018 TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis. RTK
17  2017 DDR2 controls the epithelial-mesenchymal-transition-related gene expression via c-Myb acetylation upon matrix stiffening. ECM, EMT
18  2017 DDR2 Expression Is Associated with a High Frequency of Peritoneal Dissemination and Poor Prognosis in Colorectal Cancer. CRC, PD
19  2017 Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts. MT1-MMP
20  2017 Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth. BC, MSC
21  2017 Role of a novel immune modulating DDR2-expressing population in silica-induced pulmonary fibrosis. CFPs, MHC-II
22  2016 DDR2 Induces Gastric Cancer Cell Activities via Activating mTORC2 Signaling and Is Associated with Clinicopathological Characteristics of Gastric Cancer. EMT, GC
23  2016 DDR2 overexpression in urothelial carcinoma indicates an unfavorable prognosis: a large cohort study. ---
24  2016 Discoidin Domain Receptor 2 as a Potential Therapeutic Target for Development of Disease-Modifying Osteoarthritis Drugs. DMM, OA
25  2016 Discoidin Receptor 2 Controls Bone Formation and Marrow Adipogenesis. BMSCs, BV/TV, ECM, Tb.N, Tb.Sp, Tb.Th, WT
26  2016 Integrated Molecular Profiling of Human Gastric Cancer Identifies DDR2 as a Potential Regulator of Peritoneal Dissemination. GC
27  2016 May the fibrosis be with you: Is discoidin domain receptor 2 the receptor we have been looking for? Ang II, NF-kappaB, p38 MAPK
28  2016 Molecular basis and functional significance of Angiotensin II-induced increase in Discoidin Domain Receptor 2 gene expression in cardiac fibroblasts. ---
29  2016 Prognostic significance of discoidin domain receptor 2 (DDR2) expression in ovarian cancer. ---
30  2016 Targeting of Discoidin Domain Receptor 2 (DDR2) Prevents Myofibroblast Activation and Neovessel Formation During Pulmonary Fibrosis. IPF, TGF, VEGF
31  2016 The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis. CAFs
32  2016 Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression. ---
33  2016 [The expression and significance of DDR2 and MMP-13in human middle ear cholesteatoma]. MMP-13
34  2015 Abnormal Accumulation of Collagen Type I Due to the Loss of Discoidin Domain Receptor 2 (Ddr2) Promotes Testicular Interstitial Dysfunction. LH
35  2015 Beyond adenocarcinoma: current treatments and future directions for squamous, small cell, and rare lung cancer histologies. FGFR, mTOR, NSCLC, PI3K
36  2015 Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer. NSCLCs
37  2015 DDR2 (discoidin domain receptor 2) suppresses osteoclastogenesis and is a potential therapeutic target in osteoporosis. NRP-1
38  2015 Effect of Bushenhuoxue formula on interleukin-1 beta and discoidin domain receptor 2 levels in a rat model of osteoarthritis. BHF, GS, IL-1beta, MMP-1, OA, TGF-beta1
39  2015 Evaluation of correlation of articular cartilage staining for DDR2 and proteoglycans with histological tissue damage and the results of radiographic assessment in patients with early stages of knee osteoarthritis. OA, PF, TF
40  2015 Evaluation of discoidin domain receptor-2 (DDR2) expression level in normal, benign, and malignant human prostate tissues. BPH, DDR, PSA
41  2015 Expression of beclin-1 in the microenvironment of invasive ductal carcinoma of the breast: correlation with prognosis and the cancer-stromal interaction. ---
42  2015 Hematopoietic Origin of Murine Lung Fibroblasts. CFPs, HSC
43  2015 Inhibition of discoidin domain receptor 2-mediated lung cancer cells progression by gold nanoparticle-aptamer-assisted delivery of peptides containing transmembrane-juxtamembrane 1/2 domain. ---
44  2015 Networks of protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6J mouse. CFC, PI3K, PP2A
45  2015 Nrp1, a Neuronal Regulator, Enhances DDR2-ERK-Runx2 Cascade in Osteoblast Differentiation via Suppression of DDR2 Degradation. NRP-1
46  2015 NSCLC Driven by DDR2 Mutation Is Sensitive to Dasatinib and JQ1 Combination Therapy. ---
47  2015 The anti-angiogenic role of discoidin domain receptor 2 (DDR2) in laser-induced choroidal neovascularization. CNV, qPCR, RPE, siRNA
48  2015 [The attachment manner of ubiquitin to proinflammatory molecule discoidin domain receptor 2]. Ub
49  2014 A host deficiency of discoidin domain receptor 2 (DDR2) inhibits both tumour angiogenesis and metastasis. ECs, HUVECs, RTK
50  2014 A novel mutation in DDR2 causing spondylo-meta-epiphyseal dysplasia with short limbs and abnormal calcifications (SMED-SL) results in defective intra-cellular trafficking. ER, SMED-SL
51  2014 Assessment of DDR2, BRAF, EGFR and KRAS mutations as therapeutic targets in non-adenocarcinoma lung cancer patients. EGFR, KRAS, non-AdLC, SCC
52  2014 Collagen advanced glycation inhibits its Discoidin Domain Receptor 2 (DDR2)-mediated induction of lysyl oxidase in osteoblasts. CML-collagen, RAGE
53  2014 Delayed progression of condylar cartilage degeneration, by reduction of the discoidin domain receptor 2, in the temporomandibular joints of osteoarthritic mouse models. OA, TMJ
54  2014 Discoidin domain receptor 2 (DDR2) promotes breast cancer cell metastasis and the mechanism implicates epithelial-mesenchymal transition programme under hypoxia. EMT
55  2014 Discoidin domain receptor 2 (DDR2) regulates body size and fat metabolism in mice. ---
56  2014 Discoidin domain receptor 2 facilitates prostate cancer bone metastasis via regulating parathyroid hormone-related protein. PTHrP, RTK
57  2014 Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse. ---
58  2014 Discoidin domain receptor 2 signaling networks and therapy in lung cancer. ---
59  2014 Experimental chondrocyte hypertrophy is promoted by the activation of discoidin domain receptor 2. ECM, OA, qPCR
60  2014 From platinum compounds to targeted therapies in advanced thoracic malignancies. ALK, EGFR, NSCLC, SCLC, TKI
61  2014 Identification of novel driver mutations of the discoidin domain receptor 2 (DDR2) gene in squamous cell lung cancer of Chinese patients. NSCLC, SCC
62  2014 Overexpression of DDR2 contributes to cell invasion and migration in head and neck squamous cell carcinoma. EMT, HNSCC, RTK
63  2014 Sensitive methods for detection of the S768R substitution in exon 18 of the DDR2 gene in patients with central nervous system metastases of non-small cell lung cancer. ADSCC, CNS, NSCLC
64  2014 The discoidin domain receptor 2/annexin A2/matrix metalloproteinase 13 loop promotes joint destruction in arthritis through promoting migration and invasion of fibroblast-like synoviocytes. CIA, FLS, MMP, RA, siRNA
65  2014 The intracellular juxtamembrane domain of discoidin domain receptor 2 (DDR2) is essential for receptor activation and DDR2-mediated cancer progression. DDRs, DS, JM2, RTKs
66  2014 Ubiquitin ligase Cbl-b acts as a negative regulator in discoidin domain receptor 2 signaling via modulation of its stability. ---
67  2014 [Application of high-content screening and flow cytometry analysis techniques to evaluation of myocardial fibroblasts proliferation]. CFs, FBS, FCM, HCS
68  2014 [Research status on molecular targeted therapy for squamous-cell lung cancer]. EGFR, FGFR1, IGF-1R, PIK3CA, PTEN, SqCLC
69  2013 Discoidin domain receptor 2 regulates neutrophil chemotaxis in 3D collagen matrices. ---
70  2013 Discoidin domain receptor 2-microRNA 196a-mediated negative feedback against excess type I collagen expression is impaired in scleroderma dermal fibroblasts. SSc, TGF-beta
71  2013 Discoipyrroles A-D: isolation, structure determination, and synthesis of potent migration inhibitors from Bacillus hunanensis. ---
72  2013 ECM: chemoattraction but not adhesion. MMP
73  2013 Increased expression of discoidin domain receptor 2 (DDR2): a novel independent prognostic marker of worse outcome in breast cancer patients. ---
74  2013 Induction of IL-12 production by the activation of discoidin domain receptor 2 via NF-kappaB and JNK pathway. IL-12, JNK, MAPK
75  2013 Molecular biology of lung cancer. ADC, EGFR, FGFR1, KRAS, PI3K, RET, SCC
76  2013 New findings in osteoarthritis pathogenesis: therapeutic implications. Hh, OA
77  2013 RNA interference against discoidin domain receptor 2 ameliorates alcoholic liver disease in rats. ---
78  2013 Targeted therapies in development for non-small cell lung cancer. ALK, EGFR, EML4, Eph, FGFR, MAPK, NSCLC, RAS, RET, ROS1
79  2013 The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. EMT, RTK
80  2013 [Advances of molecular targeted therapy in squamous cell lung cancer]. ALK, EGFR, EML4, FGFR1, SqCLC
81  2012 DDR2 plays a role in fibroblast migration independent of adhesion ligand and collagen activated DDR2 tyrosine kinase. ---
82  2012 Discoidin domain receptor 2 (DDR2) regulates proliferation of endochondral cells in mice. KD, miDdr2
83  2012 Discoidin domain receptor 2 deficiency predisposes hepatic tissue to colon carcinoma metastasis. HSCs, IL, LSECs, TGF, VEGF
84  2012 Dual action of a selective cyclooxygenase-2 inhibitor on vascular endothelial growth factor expression in human hepatocellular carcinoma cells: novel involvement of discoidin domain receptor 2. COX-2, HCC, VEGF
85  2012 [Primary culture and biological characteristics of cardiac fibroblasts of adult mice]. ---
86  2011 Amyloid protein-mediated differential DNA methylation status regulates gene expression in Alzheimer's disease model cell line. AD
87  2011 An essential role of discoidin domain receptor 2 (DDR2) in osteoblast differentiation and chondrocyte maturation via modulation of Runx2 activation. ERK, RTK
88  2011 Collagen-induced expression of collagenase-3 by primary chondrocytes is mediated by integrin α1 and discoidin domain receptor 2: a protein kinase C-dependent pathway. FAK, ITGalpha1, PKC, siRNA
89  2011 Discoidin domain receptor 2 is a critical regulator of epithelial-mesenchymal transition. EMT, TGF-beta1
90  2011 Impaired dermal wound healing in discoidin domain receptor 2-deficient mice associated with defective extracellular matrix remodeling. alpha-SMA, ECM, LH1, LOX, MMP2
91  2011 Intact pericellular matrix of articular cartilage is required for unactivated discoidin domain receptor 2 in the mouse model. MMP, OA
92  2011 Loss of discoidin domain receptor 2 promotes hepatic fibrosis after chronic carbon tetrachloride through altered paracrine interactions between hepatic stellate cells and liver-associated macrophages. HSCs
93  2011 The colorectal tumor microenvironment: the next decade. ---
94  2010 Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice. OA
95  2010 Discoidin domain receptor 2 (DDR2) is required for maintenance of spermatogenesis in male mice. RTK
96  2010 Expression of discoidin domain receptors (DDR2) in alcoholic liver fibrosis in rats. CON
97  2010 Inhibition of collagen fibrillogenesis by cells expressing soluble extracellular domains of DDR1 and DDR2. ECD
98  2010 Role of HTRA1, a serine protease, in the progression of articular cartilage degeneration. HtrA1, TM
99  2010 The collagen receptor DDR2 is expressed during early cardiac development. EMT
100  2009 Actinomycin D identified as an inhibitor of discoidin domain receptor 2 interaction with collagen through an insect cell based screening of a drug compound library. ---