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■ Abbreviation / Long Form : DOR / delta-opioid receptor

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Total Number of Papers: 420
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Abbreviation:   DOR  (>> Co-occurring Abbreviation)
Long Form:   delta-opioid receptor
 Abbreviation Variation
 Long Form Variation
 Pair(Abbreviation/Long Form) Variation
No. Year Title Co-occurring Abbreviation
2020 Aromatic-Amine Pendants Produce Highly Potent and Efficacious Mixed Efficacy mu-Opioid Receptor (MOR)/delta-Opioid Receptor (DOR) Peptidomimetics with Enhanced Metabolic Stability. AASA, MLMs, MOR
2020 Determination of structural factors affecting binding to mu, kappa and delta opioid receptors. MOR, OR
2020 Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic. KOR, MOR
2020 Enkephalinergic Circuit Involved in Nociceptive Modulation in the Spinal Dorsal Horn. ENK, HRP, IB4, mEPSC, PBN, PPE, SDH, TMR
2020 Genetic polymorphisms in the opioid receptor delta 1 (OPRD1) gene are associated with methadone dose in methadone maintenance treatment for heroin dependence. MMT, OPRD1, SNPs
2019 A Novel Mu-Delta Opioid Agonist Demonstrates Enhanced Efficacy With Reduced Tolerance and Dependence in Mouse Neuropathic Pain Models. CIPN, MOR
2019 Activation of HIF-1alpha by delta-Opioid Receptors Induces COX-2 Expression in Breast Cancer Cells and Leads to Paracrine Activation of Vascular Endothelial Cells. BCa, COX-2, DADLE, END, HIF-1alpha, PGE2, PI3K, VEGF
2019 Agonist-dependent development of delta opioid receptor tolerance in the colon. MOR
2019 Bold zebrafish (Danio rerio) express higher levels of delta opioid and dopamine D2 receptors in the brain compared to shy fish. ---
10  2019 Characterization of 17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6alpha-(indole-7-carboxamido)morphinan (NAN) as a Novel Opioid Receptor Modulator for Opioid Use Disorder Treatment. KOR, MOR
11  2019 Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids. CB1, KOR, MOR, NOP, sigma1R
12  2019 Delta Opioid Peptide [d-Ala2, d-Leu5] Enkephalin (DADLE) Exerts a Cytoprotective Effect in Astrocytes Exposed to Oxygen-Glucose Deprivation by Inducing Autophagy. OGD
13  2019 delta Opioid Receptor Agonism Preserves the Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates the Retinopathy in Experimental Diabetes. DR, shRNA, TU
14  2019 Delta opioid receptor agonists are effective for multiple types of headache disorders. MOH, OIH, PTH
15  2019 delta-Opioid Receptor Activation Attenuates Hypoxia/MPP+-Induced Downregulation of PINK1: a Novel Mechanism of Neuroprotection Against Parkinsonian Injury. PD, PINK1
16  2019 delta-Opioid Receptor Activation Attenuates the Oligomer Formation Induced by Hypoxia and/or alpha-Synuclein Overexpression/Mutation Through Dual Signaling Pathways. ---
17  2019 delta-Opioid Receptor-Nrf-2-Mediated Inhibition of Inflammatory Cytokines in Neonatal Hypoxic-Ischemic Encephalopathy. HI, HIE
18  2019 Development of Novel delta Opioid Receptor Inverse Agonists without a Basic Nitrogen Atom and Their Antitussive Effects in Mice. BNTX, NTB, NTI
19  2019 Discovery of delta Opioid Receptor Full Inverse Agonists and Their Effects on Restraint Stress-Induced Cognitive Impairment in Mice. ---
20  2019 Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design. MOR, SAR
21  2019 Dual RXR motifs regulate nerve growth factor-mediated intracellular retention of the delta opioid receptor. COPI, NGF
22  2019 Involvement of opioid system in behavioral despair induced by social isolation stress in mice. KOR, MOR, NLT, NLX, OR, SIS
23  2019 Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward. INs, MOR, PrL, PV, SST
24  2019 Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon. ENS, MOR
25  2019 Neuroprotective role of delta opioid receptors in hypoxic preconditioning DPDPE, NT, PC, PS, SH
26  2019 New discoveries in migraine mechanisms and therapeutic targets. ASICs, CGRP
27  2019 Novel Dimethyltyrosine-Tetrahydroisoquinoline Peptidomimetics with Aromatic Tetrahydroisoquinoline Substitutions Show in Vitro Kappa and Mu Opioid Receptor Agonism. Dmt-Tiq, KOR, MOR
28  2019 Novel miRNA expression in the delta opioid signaling pathway mediated cell survivability in an in vitro model of ER stress. ER, miRNAs
29  2019 Oxycodone suppresses the apoptosis of hippocampal neurons induced by oxygen-glucose deprivation/recovery through caspase-dependent and caspase-independent pathways via kappa- and delta-opioid receptors in rats. CIRI, KOR, OGD/R, PND, ROS
30  2019 Progress in the development of more effective and safer analgesics for pain management. KOR, MOR
31  2019 Regulation of CRF mRNA in the rat extended amygdala following chronic cocaine: sex differences and effect of delta opioid receptor agonism. BNST, CeA, PVN
32  2019 Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain. CCI, CNS, Cx43, MOR
33  2019 Structural Simplification of a Tetrahydroquinoline-Core Peptidomimetic mu-Opioid Receptor (MOR) Agonist/delta-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability. MOR, SAR
34  2019 Structure-Activity Relationships of 7-Substituted Dimethyltyrosine-Tetrahydroisoquinoline Opioid Peptidomimetics. Dmt-Tiq, KOR, MOR
35  2019 Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. ACC, MOR, MSNs, MThal
36  2019 Targeting Cannabinoid 1 and Delta Opioid Receptor Heteromers Alleviates Chemotherapy-Induced Neuropathic Pain. CIPN
37  2019 The delta-Opioid Receptor Differentially Regulates MAPKs and Anti-inflammatory Cytokines in Rat Kidney Epithelial Cells Under Hypoxia. BCL6, IL-10, MAPKs, TTP
38  2019 Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated. HO-1, JNK, MAPK, Nrf2, PI3K, SFN
39  2018 Can crosstalk between DOR and PARP reduce oxidative stress mediated neurodegeneration? AD, OS, PARP1, PD
40  2018 Chronic Increases in Daily Neuromuscular Activity Promote Changes in Gene Expression in Small and Large Dorsal Root Ganglion Neurons in Rat. ---
41  2018 Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors. KOR
42  2018 Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept. NTI
43  2018 Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons. DRG, VGCCs
44  2018 Delta Opioid Receptors and Modulation of Mood and Emotion. ---
45  2018 Delta Opioid Receptors: Learning and Motivation. ---
46  2018 Delta-opioid receptor inhibition prevents remifentanil-induced post-operative hyperalgesia via regulating GluR1 trafficking and AMPA receptor function. AMPAR, GluR1
47  2018 DOR agonist (SNC-80) exhibits anti-parkinsonian effect via downregulating UPR/oxidative stress signals and inflammatory response in vivo. HO-1
48  2018 microRNA-874 suppresses tumor proliferation and metastasis in hepatocellular carcinoma by targeting the DOR/EGFR/ERK pathway. EGF, EGFR, ERK, HCC, UTR
49  2018 Neuroprotection Against Hypoxic/Ischemic Injury: delta-Opioid Receptors and BDNF-TrkB Pathway. ---
50  2018 Opioid receptor and beta-arrestin2 densities and distribution change after sexual experience in the ventral tegmental area of male rats. MLS, VTA
51  2018 Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran. KOR, MOR, SNP
52  2018 Oxycodone regulates incision-induced activation of neurotrophic factors and receptors in an acute post-surgery pain rat model. BDNF, KOR, MOR, NGF, NTs, PI, Trk
53  2018 Prolonged DADLE exposure epigenetically promotes Bcl-2 expression and elicits neuroprotection in primary rat cortical neurons via the PI3K/Akt/NF-kappaB pathway. ---
54  2018 Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists. AR, TSPO
55  2018 SNC80 and naltrindole modulate voltage-dependent sodium, potassium and calcium channels via a putatively delta opioid receptor-independent mechanism. dbcAMP
56  2018 Synthesis and Pharmacological Evaluation of Novel C-8 Substituted Tetrahydroquinolines as Balanced-Affinity Mu/Delta Opioid Ligands for the Treatment of Pain. MOR
57  2018 Synthesis and Structure-Activity Relationships of (-)-cis-N-Normetazocine-Based LP1 Derivatives. KOR, MOR
58  2018 The Delta Opioid Peptide DADLE Represses Hypoxia-Reperfusion Mimicked Stress Mediated Apoptotic Cell Death in Human Mesenchymal Stem Cells in Part by Downregulating the Unfolded Protein Response and ROS along with Enhanced Anti-Inflammatory Effect. hMSCs, ROS, UPR
59  2018 The delta-opioid receptor and Parkinson's disease. PD
60  2018 The non-peptidic delta-opioid receptor agonist Tan-67 mediates neuroprotection post-ischemically and is associated with altered amyloid precursor protein expression, maturation and processing in mice. APP, I/R
61  2017 Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands. MOR
62  2017 Characteristic MicroRNA Expression Induced by delta-Opioid Receptor Activation in the Rat Liver Under Prolonged Hypoxia. miRNAs, TLDA
63  2017 d-Alanine 2, Leucine 5 Enkephaline (DADLE)-mediated DOR activation augments human hUCB-BFs viability subjected to oxidative stress via attenuation of the UPR. hMSCs, hUCB-BFs, ROS, UPR
64  2017 Design and synthesis of novel delta opioid receptor agonists with an azatricyclodecane skeleton for improving blood-brain barrier penetration. BBB
65  2017 Effect of Sinomenine on the Morphine-Dependence and Related Neural Mechanisms in Mice. CPP, MOR, NR2B, TH
66  2017 Endogenous opioids regulate moment-to-moment neuronal communication and excitability. ITCs, MOR
67  2017 Identification of a signaling cascade that maintains constitutive delta-opioid receptor incompetence in peripheral sensory neurons. GRK2, MOR, PKA
68  2017 Identification of Crucial Amino Acid Residues Involved in Agonist Signaling at the GPR55 Receptor. LPI, SRE, SRF
69  2017 Insights into the Role of Opioid Receptors in the GI Tract: Experimental Evidence and Therapeutic Relevance. KORs, MORs
70  2017 Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronal apoptosis in the hypothalamus: effects of neonatal alcohol. MOR, POMC
71  2017 Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities. ---
72  2017 One-step generation of mice carrying a conditional allele together with an HA-tag insertion for the delta opioid receptor. GPCRs
73  2017 Rationally designed benzopyran fused isoxazolidines and derived beta2,3,3-amino alcohols as potent analgesics: Synthesis, biological evaluation and molecular docking analysis. ---
74  2017 Regulation of delta Opioid Receptor-Mediated Signaling and Antinociception in Peripheral Sensory Neurons by Arachidonic Acid-Dependent 12/15-Lipoxygenase Metabolites. AA, CHO, HETE, KOR, LOX, PGE2
75  2017 Role of beta endorphin in pain relief following high rate repetitive transcranial magnetic stimulation in migraine. BE, rTMS
76  2017 Role of DOR in neuronal plasticity changes promoted by food-seeking behaviour. FR1, HCP, KO, NAc, PFC, PR
77  2017 Synthesis and evaluation of a ligand targeting the mu and delta opioid receptors for drug delivery to lung cancer. FDA, HEK-mu, MOR, NSCLC
78  2017 Targeting delta opioid receptors for pain treatment: drugs in phase I and II clinical development. MOR
79  2017 The induction of the transcription factor Nrf2 enhances the antinociceptive effects of delta-opioid receptors in diabetic mice. HO-1, NQO1, SFN
80  2017 The Inhibitory Effects of Cobalt Protoporphyrin IX and Cannabinoid 2 Receptor Agonists in Type 2 Diabetic Mice. CB2R, CoPP, JNK, NQO1, SFN
81  2016 A randomized, placebo-controlled pilot trial of the delta opioid receptor agonist AZD2327 in anxious depression. AMDD, EEG, HAM-A, HAM-D, VEGF
82  2016 Antidepressant-like Effects of Buprenorphine are Mediated by Kappa Opioid Receptors. BPN, FST, KORs, ORL-1, UCMS
83  2016 Attenuating Ischemic Disruption of K+ Homeostasis in the Cortex of Hypoxic-Ischemic Neonatal Rats: DOR Activation vs. Acupuncture Treatment. HI, OGD
84  2016 Cellular localization and adaptive changes of the cardiac delta opioid receptor system in an experimental model of heart failure in rats. ACF, CHF, LV, PENK, RyR
85  2016 Cytoprotection against Hypoxic and/or MPP⁺ Injury: Effect of delta-Opioid Receptor Activation on Caspase 3. PD, PINK1
86  2016 delta-Opioid receptor (DOR) signaling and reactive oxygen species (ROS) mediate intermittent hypoxia induced protection of canine myocardium. ROS
87  2016 delta-Opioid Receptor Activation and MicroRNA Expression in the Rat Heart Under Prolonged Hypoxia. miRNAs, TLDA
88  2016 Discovery of Potent and Selective Agonists of delta Opioid Receptor by Revisiting the "Message-Address" Concept. ---
89  2016 Downregulation of delta opioid receptor by RNA interference enhances the sensitivity of BEL/FU drug‑resistant human hepatocellular carcinoma cells to 5‑FU. HCC
90  2016 Effects of N-Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacy mu-Opioid Receptor (MOR)/delta-Opioid Receptor (DOR) Ligands. ip, MOR, THQ
91  2016 Local analgesic effect of tramadol is mediated by opioid receptors in late postoperative pain after plantar incision in rats. MOR, POD
92  2016 Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist. ---
93  2016 Morphine sulfate concomitantly decreases neuronal differentiation and opioid receptor expression in mouse embryonic stem cells. EB, GFAP, KOR, mES, MOR, MS, Mtap2, NP
94  2016 The antinociceptive effects of a delta-opioid receptor agonist in mice with painful diabetic neuropathy: Involvement of heme oxygenase 1. STZ
95  2016 Upregulation and activation of delta‑opioid receptors promotes the progression of human breast cancer. ERKs, GPCRs, PKC
96  2015 A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons. Dlx-DOR
97  2015 A novel mechanism for cytoprotection against hypoxic injury: delta-opioid receptor-mediated increase in Nrf2 translocation. ROS
98  2015 Activation of mu or delta opioid receptors in the lumbosacral spinal cord is essential for ejaculatory reflexes in male rats. DPN, GRP, LSt
99  2015 Asymmetric synthesis and in vitro and in vivo activity of tetrahydroquinolines featuring a diverse set of polar substitutions at the 6 position as mixed-efficacy mu opioid receptor/delta opioid receptor ligands. KOR, MOR
100  2015 Chronic exposure to morphine decreases the expression of EAAT3 via opioid receptors in hippocampal neurons. EAAT3, KOR