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■ Abbreviation / Long Form : DR5 / death receptor 5

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Total Number of Papers: 461
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Abbreviation:   DR5  (>> Co-occurring Abbreviation)
Long Form:   death receptor 5
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No. Year Title Co-occurring Abbreviation
2022 AF8c, a Multi-Kinase Inhibitor Induces Apoptosis by Activating DR5/Nrf2 via ROS in Colorectal Cancer Cells. CRC, ER, Nrf2, ROS
2022 CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade. ---
2022 Co-overexpression of TRAIL and Smac sensitizes MDA-MB-231 cells to radiation through apoptosis depending on mitochondrial pathway. cyt c, Smac, TRAIL
2022 Elevated soluble death receptor 5 can predict poor prognosis in patients with acute respiratory distress syndrome. ARDS, BALF, sRAGE, TNF
2022 Enhanced expression of death receptor 5 is responsible for increased cytotoxicity of theophylline in combination with recombinant human TRAIL in MDA-MB-231 breast cancer cells. MMP, rhTRAIL, ROS
2022 Exosomes derived from γδ-T cells synergize with radiotherapy and preserve antitumor activities against nasopharyngeal carcinoma in immunosuppressive microenvironment. CSCs, FasL, NPC, TRAIL
2022 Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy. ACT, CAR, COX-2, INDO, NSAID, PGE2, TCR, TRAIL
2022 Inhibition of histone demethylase KDM4 by ML324 induces apoptosis through the unfolded protein response and Bim upregulation in hepatocellular carcinoma cells. ATF3, ChIP, HCC, UPR
2022 MicroRNA-148a Inhibits Hepatocellular Carcinoma Cell Growth via Epithelial-to-Mesenchymal Transition and PI3K/AKT Signaling Pathways by Targeting Death Receptor-5. EMT, HCC, miR-148a
10  2022 Molecular Targets of Nimbolide for Anti-Cancer Therapy: An Updated Review. EGF, IGF, JNK, MAPK, NF-kappaBeta, PI3K, TNF-alpha, VEGF, Wnt
11  2022 Sensitizing TRAIL response via differential modulation of anti- and pro-apoptotic factors by AZD5582 combined with ER nanosomal TRAIL in neuroblastoma. ERN-T, IAPs, NSFs, TRAIL
12  2022 Tubular epithelial cell-to-macrophage communication forms a negative feedback loop via extracellular vesicle transfer to promote renal inflammation and apoptosis in diabetic nephropathy. BMDMs, DN, EVs, LPC, LRG1, TECs, TRAIL
13  2021 A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors. PPCR
14  2021 BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma. BAP1, DR4, MPM, TRAIL, YY1
15  2021 BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade. BET, CRC, ICD, PROTAC, SPOP
16  2021 Bioymifi, a novel mimetic of TNF-related apoptosis-induced ligand (TRAIL), stimulates eryptosis. BMF, COX, RBCs, TRAIL, WB
17  2021 Citrus-derived DHCP inhibits mitochondrial complex II to enhance TRAIL sensitivity via ROS-induced DR5 upregulation. DHCP, SQR, TRAIL
18  2021 Combination of oridonin and TRAIL induces apoptosis in uveal melanoma cells by upregulating DR5. TRAIL, XIAP
19  2021 Death Receptor 5 (TNFRSF10B) Is Upregulated and TRAIL Resistance Is Reversed in Hypoxia and Normoxia in Colorectal Cancer Cell Lines after Treatment with Skyrin, the Active Metabolite of Hypericum spp. RT-qPCR, SKR, TRAIL
20  2021 Designed proteins assemble antibodies into modular nanocages. ACE2, SARS-CoV-2
21  2021 DR-5 and DLL-4 mAb Functionalized SLNs of Gamma-Secretase Inhibitors- An Approach for TNBC Treatment. BCSCs, DLL4, GSIs, mAb, SLNs, TNBC
22  2021 DR5 antibody conjugated lipid-based nanocarriers of gamma-secretase inhibitor for the treatment of triple negative breast cancer. DAPT, DR5-DAPT-SLNs, TNBC
23  2021 Enhanced extrinsic apoptosis of therapy-induced senescent cancer cells using a death receptor 5 (DR5) selective agonist. DcR, DR, OPG, TRAIL
24  2021 First-in-human DR5 PET reveals insufficient DR5 expression in patients with gastrointestinal cancer. GI, PET
25  2021 Glucose deprivation-induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity. ATF4, Bax, CHOP, ER, TRAIL
26  2021 LCT-3d Induces Oxidative Stress-Mediated Apoptosis by Upregulating Death Receptor 5 in Gastric Cancer Cells. NAC, Nrf2, ROS
27  2021 Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199. ---
28  2021 Potent preclinical sensitivity to imipridone-based combination therapies in oncohistone H3K27M-mutant diffuse intrinsic pontine glioma is associated with induction of the integrated stress response, TRAIL death receptor DR5, reduced ClpX and apoptosis. CI, DIPG, HDACi
29  2021 Preclinical evaluation of a novel antibody-drug conjugate targeting DR5 for lymphoblastic leukemia therapy. ADC, ALL, CDX, MMAE, PDX
30  2021 Sodium fluoride activates the extrinsic apoptosis via regulating NOX4/ROS-mediated p53/DR5 signaling pathway in lung cells both in vitro and in vivo. NOX4, ROS, siRNA
31  2021 Splicing reprogramming of TRAIL/DISC-components sensitizes lung cancer cells to TRAIL-mediated apoptosis. c-FLIP, DISC, HSP70, TRAIL
32  2021 The Synergistic Activity of Bortezomib and TIC10 against A2058 Melanoma Cells. BOZ, TRAIL
33  2021 TRAIL induces proliferation in rodent pancreatic beta cells via AKT activation. DcR1, sTRAIL, TRAIL
34  2021 Unexpected PD-L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies. ---
35  2021 Vanillin oxime inhibits lung cancer cell proliferation and activates apoptosis through JNK/ERK-CHOP pathway. CHOP, TRAIL
36  2020 Artemisinin Derivatives Stimulate DR5-Specific TRAIL-Induced Apoptosis by Regulating Wildtype P53. ART, ATS, DHA, TRAIL
37  2020 Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats. MI, TNF
38  2020 CUDC-907 enhances TRAIL-induced apoptosis through upregulation of DR5 in breast cancer cells. HDAC, PI3K, TRAIL
39  2020 Dexamethasone Inhibits TRAIL-Induced Apoptosis through c-FLIP(L) Upregulation and DR5 Downregulation by GSK3beta Activation in Cancer Cells. DEX, TRAIL
40  2020 Dissecting Programmed Cell Death with Small Molecules. Hsp90, MLKL, PCD
41  2020 DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models. CPT, NP
42  2020 Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism. ---
43  2020 Epigallocatechin-3-Gallate Induces Apoptosis as a TRAIL Sensitizer via Activation of Caspase 8 and Death Receptor 5 in Human Colon Cancer Cells. EGCG, TRAIL, TUNEL
44  2020 HIF-1alpha Mediates TRAIL-Induced Neuronal Apoptosis via Regulating DcR1 Expression Following Traumatic Brain Injury. DcR1, HIF, sDR5, TBI, TRAIL
45  2020 Imipridone enhances vascular relaxation via FOXO1 pathway. ACh, ERK, PI3K
46  2020 Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation. DSS, IBD, TNF, TRAIL
47  2020 Inhibition of autophagy flux by sertraline attenuates TRAIL resistance in lung cancer via death receptor5 upregulation. TRAIL
48  2020 Lestaurtinib potentiates TRAIL-induced apoptosis in glioma via CHOP-dependent DR5 induction. ---
49  2020 Luteolin enhances TRAIL sensitivity in non-small cell lung cancer cells through increasing DR5 expression and Drp1-mediated mitochondrial fission. Drp1, JNK, NSCLC, TRAIL
50  2020 Microcystin-leucine arginine exposure contributes to apoptosis and follicular atresia in mice ovaries by endoplasmic reticulum stress-upregulated Ddit3. 4-PBA, DDIT3, ER, IRE1, MC-LR, PP2A
51  2020 Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress. ER, UPR
52  2020 Molecular mechanisms underlying the effects of the small molecule AMC-04 on apoptosis: Roles of the activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway. ATF4, eIF2alpha, p38 MAPK, ROS, UPR
53  2020 Noncompetitive Allosteric Antagonism of Death Receptor 5 by a Synthetic Affibody Ligand. TRAIL
54  2020 ONC201 and imipridones: Anti-cancer compounds with clinical efficacy. ClpP, DRD2, GPCR, TRAIL
55  2020 Quinovic acid purified from medicinal plant Fagonia indica mediates anticancer effects via death receptor 5. QA
56  2020 RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer. CRIS, DISC, mCRC, MT
57  2020 ROS-mediated PERK-eIF2alpha-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling. ATF4, CHOP, DISC, ER, NAC, PERK, ROS
58  2020 Self-assembled peptide nanostructures targeting death receptor 5 and encapsulating paclitaxel as a multifunctional cancer therapy. PA
59  2020 Targeting of keloid with TRAIL and TRAIL-R2/DR5. TRAIL
60  2020 Tianma Gouteng Decoction Exerts Cardiovascular Protection by Upregulating OPG and TRAIL in Spontaneously Hypertensive Rats. SHR, TGD, WKY
61  2020 TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic. NK, rhTRAIL, TNBC, TRAIL
62  2020 Up-regulation of Death Receptor 5/TRAIL-R2 Mediates Apoptosis Induced by N,N'-[(3,4-dimethoxyphenyl)methylene] Biscinnamide in Cancer Cells. DPMBC
63  2020 YM155 sensitizes HeLa cells to TRAIL-mediated apoptosis via cFLIP and survivin downregulation. cFLIP, TRAIL
64  2019 Apoptotic effect of fluoxetine through the endoplasmic reticulum stress pathway in the human gastric cancer cell line AGS. ER, FLX, ROS
65  2019 Apoptotic Resistance of Metastatic Tumor Cells in Triple Negative Breast Cancer: Roles of Death Receptor-5. TNBC
66  2019 Artonin E sensitizes TRAIL-induced apoptosis by DR5 upregulation and cFLIP downregulation in TRAIL-refractory colorectal cancer LoVo cells. CRC
67  2019 Auriculasin sensitizes primary prostate cancer cells to TRAIL-mediated apoptosis through up-regulation of the DR5-dependent pathway. AC, mTOR, PI3K, TRAIL
68  2019 BET Inhibitors Potentiate Chemotherapy and Killing of SPOP-Mutant Colon Cancer Cells via Induction of DR5. BET, BETi, SPOP
69  2019 Caudatin potentiates the anti-tumor effects of TRAIL against human breast cancer by upregulating DR5. TRAIL
70  2019 Celastrol enhances TRAIL-induced apoptosis in human glioblastoma via the death receptor pathway. TRAIL
71  2019 Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells. DDLPS, FACS, LPS, PDCs, TRAIL
72  2019 DR5 related autophagy can promote apoptosis in gliomas after irradiation. RAP, TMZ
73  2019 Farnesoid X receptor induces cell death and sensitizes to TRAIL-induced inhibition of growth in colorectal cancer cells throughthe up-regulation of death receptor 5. FXR, SQSTM
74  2019 Galbanic acid potentiates TRAIL induced apoptosis in resistant non-small cell lung cancer cells via inhibition of MDR1 and activation of caspases and DR5. Bcl-2, Bcl-xL, DcR1, GBA, MDR1, NSCLCs, TRAIL, TUNEL, XIAP
75  2019 Glucosamine Enhances TRAIL-Induced Apoptosis in the Prostate Cancer Cell Line DU145. GlcN, TNF
76  2019 Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. TMH
77  2019 Identification of New DR5 Agonistic Nanobodies and Generation of Multivalent Nanobody Constructs for Cancer Treatment. Nbs, TRAIL
78  2019 Inhibition of N-myc expression sensitizes human neuroblastoma IMR-32 cells expressing caspase-8 to TRAIL. IFN
79  2019 Involvement of ERK1/2-mediated ELK1/CHOP/DR5 pathway in 6-(methylsulfinyl)hexyl isothiocyanate-induced apoptosis of colorectal cancer cells. CHOP
80  2019 Methyloleanolate Induces Apoptotic And Autophagic Cell Death Via Reactive Oxygen Species Generation And c-Jun N-terminal Kinase Phosphorylation. 3-MA, ATG5, CQ, LC3BII, MEF
81  2019 p53-Mediated Oxidative Stress Enhances Indirubin-3'-Monoxime-Induced Apoptosis in HCT116 Colon Cancer Cells by Upregulating Death Receptor 5 and TNF-Related Apoptosis-Inducing Ligand Expression. CHOP, ER, I3M, ROS, TNF
82  2019 Prognostic significance of serum soluble DR5 levels in small-cell lung cancer. SCLC, sDR5, VALSG
83  2019 Pseudolaric Acid B Induces Growth Inhibition and Caspase-Dependent Apoptosis on Head and Neck Cancer Cell lines through Death Receptor 5. HNC, PAB
84  2019 Quercetin enhances the antitumor activity of trichostatin A through up-regulation of p300 protein expression in p53 null cancer cells. TSA
85  2019 Reversine induces cell cycle arrest and apoptosis via upregulation of the Fas and DR5 signaling pathways in human colorectal cancer cells. siRNA
86  2019 Targeting of CD133+ Cancer Stem Cells by Mesenchymal Stem Cell Expressing TRAIL Reveals a Prospective Role of Apoptotic Gene Regulation in Non-Small Cell Lung Cancer. CSC, MSCs, NSCLC, TNF
87  2019 The Rolipram-Perillyl Alcohol Conjugate (NEO214) Is A Mediator of Cell Death through the Death Receptor Pathway. BBB, BER, ER, GBM, POH
88  2019 TRAIL-Inspired Multivalent Dextran Conjugates Efficiently Induce Apoptosis upon DR5 Receptor Clustering. DISC, Fc
89  2019 Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL. sDR5-Fc
90  2019 Tubulin couples death receptor 5 to regulate apoptosis. TNF
91  2019 Xanthohumol increases death receptor 5 expression and enhances apoptosis with the TNF-related apoptosis-inducing ligand in neuroblastoma cell lines. DR4, NB, TRAIL, XN
92  2018 3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5. AMPK, CHOP, ER, GRP78, TRAIL
93  2018 4-HPR Is an Endoplasmic Reticulum Stress Aggravator and Sensitizes Breast Cancer Cells Resistant to TRAIL/Apo2L. 4-HBR, 4-HPR, ER, qPCR, RA, TNF
94  2018 A Single-Agent Dual-Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian Cancer. FOLR1, OvCa
95  2018 Antihypertensive drug-candesartan attenuates TRAIL resistance in human lung cancer via AMPK-mediated inhibition of autophagy flux. NSCLC, TRAIL
96  2018 Bile acid-induced apoptosis and bile acid synthesis are reduced by over-expression of Augmenter of Liver Regeneration (ALR) in a STAT3-dependent mechanism. ALR, FOXA2, GCDCA
97  2018 Calmodulin antagonist enhances DR5-mediated apoptotic signaling in TRA-8 resistant triple negative breast cancer cells. CaM, TNBC
98  2018 Chimeric Mice With Humanized Livers Demonstrate Human-Specific Hepatotoxicity Caused by a Therapeutic Antibody Against TRAIL-Receptor 2/Death Receptor 5. ALT, TNF, TUNEL
99  2018 Chrysanthemulide A induces apoptosis through DR5 upregulation via JNK-mediated autophagosome accumulation in human osteosarcoma cells. CA, JNK, siRNA, TRAIL
100  2018 Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate. ER, RIDD, RPAP2, UPR