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■ Abbreviation / Long Form : EP / ethyl pyruvate

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Total Number of Papers: 205
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Abbreviation:   EP  (>> Co-occurring Abbreviation)
Long Form:   ethyl pyruvate
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No. Year Title Co-occurring Abbreviation
2019 Anti-Inflammatory and Neuroprotective Effects of DIPOPA (N,N-Diisopropyl-2-Oxopropanamide), an Ethyl Pyruvate Bioisoster, in the Postischemic Brain. MCAO
2019 Ethyl pyruvate (EP) suppressed post-harvest blue mold of sweet cherry fruit by inhibiting the growth of Penicillium oxalicum. MDA, ROS
2019 Ethyl pyruvate and analogs as potential treatments for acute pancreatitis: A review of invitro and invivo studies. AP, MODS
2019 Ethyl Pyruvate Induces Tolerogenic Dendritic Cells. DC, tolDC
2019 Ethyl Pyruvate Modulates Murine Dendritic Cell Activation and Survival Through Their Immunometabolism. DC, DCs, NO
2019 Ethyl pyruvate protects against Salmonella intestinal infection in mice through down-regulation of pro-inflammatory factors and inhibition of TLR4/MAPK pathway. ---
2019 Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling. HMGB1, ODE
2019 Ethyl pyruvate treatment ameliorates pancreatic damage: evidence from a rat model of acute necrotizing pancreatitis. ANP
2019 HMGB1-RAGE Signaling Plays a Role in Organic Dust-Induced Microglial Activation and Neuroinflammation. ---
10  2019 Icariin and icaritin ameliorated hippocampus neuroinflammation via inhibiting HMGB1-related pro-inflammatory signals in lipopolysaccharide-induced inflammation model in C57BL/6 J mice. HMGB1, ICA, ICT
11  2019 Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats. AQP4, GFAP, GL, HMGB1, SCI
12  2019 Protective Effect of Ethyl Pyruvate against Myocardial Ischemia Reperfusion Injury through Regulations of ROS-Related NLRP3 Inflammasome Activation. I/R, IRC, NLRP3, ROS, TXNIP
13  2019 Pyruvic acid/ethyl pyruvate inhibits melanogenesis in B16F10 melanoma cells through PI3K/AKT, GSK3beta, and ROS-ERK signaling pathways. ERK, GSK, PA, PI3K, ROS, TRP, UV
14  2018 Ethyl pyruvate ameliorates hepatic injury following blunt chest trauma and hemorrhagic shock by reducing local inflammation, NF-kappaB activation and HMGB1 release. RL
15  2018 Ethyl Pyruvate Attenuates CaCl2-Induced Tubular Epithelial Cell Injury by Inhibiting Autophagy and Inflammatory Responses. CaOx, HMGB1, LDH, TLR4
16  2018 Ethyl pyruvate attenuates myocardial ischemia-reperfusion injury exacerbated by hyperglycemia via retained inhibitory effect on HMGB1. HG, HMGB1, I/R, NG
17  2018 Ethyl pyruvate can alleviate alcoholic liver disease through inhibiting Nrf2 signaling pathway. AST, FFA, Nrf2, SOD, TG, VLDLR
18  2018 Ethyl Pyruvate Improves Pulmonary Function in Mice with Bleomycin-induced Lung Injury as Monitored with Hyperpolarized 129Xe MR Imaging. ALG, BLM, HMGB1
19  2018 Ethyl pyruvate inhibits oxidation of LDL in vitro and attenuates oxLDL toxicity in EA.hy926 cells. ATP, LPO, MDA, nLDL, REMs
20  2018 Ethyl pyruvate is renoprotective against ischemia-reperfusion injury under hyperglycemia. HG, HMGB1, I/R, NG, TLRs
21  2018 Ethyl pyruvate prevents from chronic cerebral hypoperfusion via preserving cognitive function and decreasing oxidative stress, caspase 3 activation and IL-1beta level. CCH, MDA, MWM
22  2018 Ethyl pyruvate reduces acute lung damage following trauma and hemorrhagic shock via inhibition of NF-kappaB and HMGB1. BAL, PMNL, RL
23  2018 Ethyl Pyruvate Stimulates Regulatory T Cells and Ameliorates Type 1 Diabetes Development in Mice. HMGB1, MLDS, T1D
24  2018 Hepatoprotective effects of ethyl pyruvate against CCl4-induced hepatic fibrosis via inhibition of TLR4/NF-kappaB signaling and up-regulation of MMPs/TIMPs ratio. ECM, HMGB1, MMPs, NF-kappaB, TIMPs, TLR4
25  2018 HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway. CUMS, HMGB1, IDO, KMO, KP, KYN, KYNU, SIRT1, Trp
26  2018 Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity. HMGB1, mtROS
27  2018 Intermittent high glucose-induced oxidative stress modulates retinal pigmented epithelial cell autophagy and promotes cell survival via increased HMGB1. DCFH-DA, HMGB1, MDA, NAC, ROS, RPE, SOD
28  2018 Modulation of diabetes-related liver injury by the HMGB1/TLR4 inflammatory pathway. DAMPs, HMGB1
29  2018 Suppressed epithelial-mesenchymal transition and cancer stem cell properties mediate the anti-cancer effects of ethyl pyruvate via regulation of the AKT/nuclear factor-kappaB pathway in prostate cancer cells. CRPC, PCa
30  2018 The role of HMGB1 in BMSC transplantation for treating MODS in rats. BMSCs, HMGB1, MODS
31  2018 [High mobility group box 1 contributes to the endoplasmic reticulum stress of liver in rats with trauma]. AST, CHOP, ERS, GRP78, HE, HMGB1, IRE1alpha, SB, SD
32  2017 Anti-apoptotic and myocardial protective effects of ethyl pyruvate after regional ischaemia/reperfusion myocardial damage in an in vivo rat model. Bcl-2, I/R, TUNEL
33  2017 Anti-inflammatory and anti-excitoxic effects of diethyl oxopropanamide, an ethyl pyruvate bioisoster, exert robust neuroprotective effects in the postischemic brain. DEOPA, MCAO
34  2017 CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma. CMA, HCC, Lamp-2a
35  2017 Ethyl pyruvate alleviates radiation-induced lung injury in mice. RILI
36  2017 Ethyl pyruvate ameliorates inflammatory arthritis in mice. CIA, HMGB1, Th17
37  2017 Ethyl Pyruvate Attenuates Early Brain Injury Following Subarachnoid Hemorrhage in the Endovascular Perforation Rabbit Model Possibly Via Anti-inflammation and Inhibition of JNK Signaling Pathway. EBI, FJB, SAH, TNF-alpha, TUNEL
38  2017 Ethyl pyruvate does not require microglia for mediating neuroprotection after excitotoxic injury. OHSC
39  2017 Ethyl pyruvate protects PC12 cells from oxygen-glucose deprivation: A potential role in ischemic cerebrovascular disease. BDNF, MCAO, NF-kappaB, NGF, OGD
40  2017 Ethyl pyruvate reverses development of Pseudomonas aeruginosa pneumonia during sepsis-induced immunosuppression. CLP, PA
41  2017 Expression of glyoxalase-I is reduced in cirrhotic livers: A possible mechanism in the development of cirrhosis. AGEs, Glo-I, MGO, pHSC
42  2017 HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma. HMGB1, MM
43  2017 Inhibitory effects of ethyl pyruvate on platelet aggregation and phosphatidylserine exposure. LDH, PKC
44  2017 Metabolic fate of glucose in rats with traumatic brain injury and pyruvate or glucose treatments: A NMR spectroscopy study. CCI, Glc, NMR, PC, SAL, SP
45  2017 Para-hydroxyphenylpyruvate inhibits the pro-inflammatory stimulation of macrophage preventing LPS-mediated nitro-oxidative unbalance and immunometabolic shift. iNOS, LPS, PAMPs, pHPP
46  2017 Roles of nitric oxide and ethyl pyruvate after peripheral nerve injury. NO, WD
47  2017 Treatment response of ethyl pyruvate in a mouse model of chronic obstructive pulmonary disease studied by hyperpolarized 129 Xe MRI. COPD, CS, LPS, MRI
48  2017 Trypsinogen Activation Peptide Induces HMGB1 Release from Rat Pancreatic Acinar Cells. AP, qPCR, TAP
49  2016 Attenuation of Methotrexate-Induced Embryotoxicity and Oxidative Stress by Ethyl Pyruvate. CAT, i.p, IVF, MDA, MTX
50  2016 Effects of Ethyl Pyruvate in Preventing the Development of Diet-induced Atherosclerosis by Blocking the HMGB1 Expression in ApoE-Deficient Mice. HMGB1, MCP-1, oxLDL, TLR2, TNF-alpha
51  2016 Effects of insulin combined with ethyl pyruvate on inflammatory response and oxidative stress in multiple-organ dysfunction syndrome rats with severe burns. CK, Cre, HMGB-1, MDA, MODS, TAC, TNF-alpha
52  2016 Effects of N-acetylcysteine and ethyl pyruvate on ischemia-reperfusion injury in experimental electrical burn model. NAC
53  2016 Ethyl Pyruvate Ameliorates The Damage Induced by Cyclophosphamide on Adult Mice Testes. ALP, CP, i.p, PAS, TAC
54  2016 Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1/RAGE/NF-KappaB pathway. AVMC, CVB3, HMGB1, NF, RAGE
55  2016 Ethyl pyruvate inhibits the acetylation and release of HMGB1 via effects on SIRT1/STAT signaling in LPS-activated RAW264.7 cells and peritoneal macrophages. HMGB1, LPS
56  2016 Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries. ARDS, ROS
57  2016 Ethyl pyruvate modulates delayed paralysis following thoracic aortic ischemia reperfusion in mice. Iba-1, IL-6, KC, LR, TAR, TUNEL
58  2016 Ethyl pyruvate protects against sepsis by regulating energy metabolism. IL
59  2016 Impact of ethyl pyruvate on Adriamycin-induced cardiomyopathy in rats. ADR, SD
60  2016 Intestinal anti-inflammatory activity of calcium pyruvate in the TNBS model of rat colitis: Comparison with ethyl pyruvate. CPM, TNBS
61  2016 Intratracheal instillation of ethyl pyruvate nanoparticles prevents the development of shunt-flow-induced pulmonary arterial hypertension in a rat model. PAH
62  2016 Neuroprotective effect of ethyl pyruvate against Zn(2+) toxicity via NAD replenishment and direct Zn(2+) chelation. HMGB1
63  2016 Protective effect of ethyl pyruvate on mice sperm parameters in phenylhydrazine induced hemolytic anemia. i.p, MDA, PHZ
64  2016 Pyruvate treatment attenuates cerebral metabolic depression and neuronal loss after experimental traumatic brain injury. CCI, SP, TBI
65  2016 The potential beneficial effects of ethyl pyruvate on diabetic nephropathy: an experimental and ultrastructural study. DM, i.p, MDA
66  2015 A comparative analysis of multiple sclerosis-relevant anti-inflammatory properties of ethyl pyruvate and dimethyl fumarate. DMF, MS
67  2015 Combination treatment with ethyl pyruvate and IGF-I exerts neuroprotective effects against brain injury in a rat model of neonatal hypoxic-ischemic encephalopathy. BrdU, HI, LDH, OGD
68  2015 Ethyl pyruvate ameliorates experimental colitis in mice by inhibiting the HMGB1-Th17 and Th1/Tc1 responses. HMGB1, MLN, TNBS
69  2015 Ethyl pyruvate attenuates murine allergic rhinitis partly by decreasing high mobility group box 1 release. AR, HMGB1, NLF, OVA
70  2015 Ethyl pyruvate inhibits HMGB1 phosphorylation and release by chelating calcium. HMGB1
71  2015 Ethyl pyruvate protects against blood-brain barrier damage and improves long-term neurological outcomes in a rat model of traumatic brain injury. BBB, MMP, TBI
72  2015 Ethyl pyruvate reduces hepatic mitochondrial swelling and dysfunction in a rat model of sepsis. AQP8, CLP, Cyt C
73  2015 HMGB1 may act via RAGE to promote angiogenesis in the later phase after intracerebral hemorrhage. HMGB1, ICH, RAGE, VEGF
74  2015 Overexpression of HMGB1 A-box reduced lipopolysaccharide-induced intestinal inflammation via HMGB1/TLR4 signaling in vitro. HMGB, IL, LPS, MyD88, pNF-kappaB, TLR, TNF
75  2015 Protective effects of ethyl pyruvate on sperm quality in cyclophosphamide treated mice. CP
76  2015 Reactivity of pyruvic acid and its derivatives towards reactive oxygen species. CL, PA, ROS, SP
77  2015 Role of high-mobility group box-1 in myocardial ischemia/reperfusion injury and the effect of ethyl pyruvate. HMGB1, I/R, IL-6, IS, PBS, rhHMGB1, TNF-alpha
78  2015 Short term exposure to ethyl pyruvate has long term anti-inflammatory effects on microglial cells. ---
79  2015 Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. cAMP, EAO, ERK, HMGB1, IL-6, MAPK, NF-B, PTC, RAGE, SC, TLR4, TM, TNF-alpha
80  2014 Effects of ethyl pyruvate on cardiac function recovery and apoptosis reduction after global cold ischemia and reperfusion. ATP, KHB, MDA
81  2014 Endoplasmic reticulum stress mediates the anti-inflammatory effect of ethyl pyruvate in endothelial cells. EC, ERS, HUVECs, TNF-alpha
82  2014 Ethyl pyruvate ameliorates 3-nitropropionic acid-induced striatal toxicity through anti-neuronal cell death and anti-inflammatory mechanisms. 3-NP, HD, IL, MAPKs, NF-kappaB
83  2014 Ethyl pyruvate ameliorates monocrotaline-induced pulmonary arterial hypertension in rats. ET-1, IL-6, PAH, TNF-alpha
84  2014 Ethyl pyruvate decreases airway neutrophil infiltration partly through a high mobility group box 1-dependent mechanism in a chemical-induced murine asthma model. BAL, HMGB1, MIP-2, TDI
85  2014 Ethyl pyruvate inhibits HMGB1 phosphorylation and secretion in activated microglia and in the postischemic brain. CSF, HMGB1, MCAO
86  2014 Ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the HMGB1-RAGE and AKT pathways. HMGB1, MMP9
87  2014 Ethyl pyruvate pretreatment attenuates concanavalin a-induced autoimmune hepatitis in mice. Con A, NF-kappaB
88  2014 Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury. ALI, BALF, HMGB1, rHMGB1
89  2014 Preventing intraperitoneal adhesions with ethyl pyruvate and hyaluronic acid/carboxymethylcellulose: a comparative study in an experimental model. ---
90  2014 Protective effect of ethyl pyruvate on ischemia-reperfusion injury in rat ovary: biochemical and histopathological evaluation. ADMA, MDA
91  2014 Protective effects of ethyl pyruvate in cisplatin-induced nephrotoxicity. MDA, OSI, REPS, TAS, TOS
92  2014 Role of ethyl pyruvate in systemic inflammatory response and lung injury in an experimental model of ruptured abdominal aortic aneurysm. IL-6, MDA, MPO, rAAA, S/C, TNF-alpha
93  2013 Effect of ethyl pyruvate on Paclitaxel-induced neuropathic pain in rats. DRG, IR
94  2013 Ethyl pyruvate ameliorates intracerebral hemorrhage-induced brain injury through anti-cell death and anti-inflammatory mechanisms. ICH, IL-1beta, NF-kappaB, TNF-alpha
95  2013 Ethyl pyruvate diminishes the inflammatory response to lipopolysaccharide infusion in horses. FM, IL-6, LPS, LRS, TNF-alpha
96  2013 Ethyl pyruvate inhibits retinal pathogenic neovascularization by downregulating HMGB1 expression. HMGB1, OIR
97  2013 Ethyl pyruvate prevents inflammatory factors release and decreases intestinal permeability in rats with D-galactosamine-induced acute liver failure. ALF, DAO, HMGB1, IFN-gamma, TNF-alpha
98  2013 Ethyl pyruvate prevents methyglyoxal-induced retinal vascular injury in rats. BRB
99  2013 Ethyl pyruvate protects against lipopolysaccharide-induced white matter injury in the developing rat brain. IL-1beta, TNF-alpha
100  2013 Ethyl pyruvate protects rats from phosgene-induced pulmonary edema by inhibiting cyclooxygenase2 and inducible nitric oxide synthase expression. COX-2, iNOS, MAPKs, NO