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■ Abbreviation / Long Form : ETP / epipolythiodioxopiperazine

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Total Number of Papers: 54
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Abbreviation:   ETP  (>> Co-occurring Abbreviation)
Long Form:   epipolythiodioxopiperazine
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No. Year Title Co-occurring Abbreviation
2020 Chetocochliodins A-I, Epipoly(thiodioxopiperazines) from Chaetomium cochliodes. ---
2020 Disulfide Cleavage in a Dimeric Epipolythiodioxopiperazine Natural Product Diminishes Its Apoptosis-Inducing Effect but Enhances Autophagy in Tumor Cells. ---
2020 Epipolythiodiketopiperazine and trichothecene derivatives from the NaI-containing fermentation of marine-derived Trichoderma cf. brevicompactum. ECD
2020 N-Heterocyclization in Gliotoxin Biosynthesis is Catalyzed by a Distinct Cytochrome P450 Monooxygenase. ---
2019 Dithiodiketopiperazine derivatives from endophytic fungi Trichoderma harzianum and Epicoccum nigrum. ---
2019 Novel epidithiodiketopiperazines as anti-viral zinc ejectors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein as a model for HIV infection. FIV
2019 Verticillin A suppresses HGF-induced migration and invasion via repression of the c-Met/FAK/Src pathway in human gastric and cervical cancer cells. AGS, HGF
2018 De Novo Transcriptome Sequencing of the Deep-Sea-Derived Fungus Dichotomomyces cejpii and Analysis of Gliotoxin Biosynthesis Genes. qRT-PCR
2018 Dysregulated gliotoxin biosynthesis attenuates the production of unrelated biosynthetic gene cluster-encoded metabolites in Aspergillus fumigatus. BmGT
10  2018 Genome-based deletion analysis in Aspergillus terreus reveals the acetylaranotin bis-thiomethyltransferase gene. ---
11  2018 Reconstitution of Enzymatic Carbon-Sulfur Bond Formation Reveals Detoxification-Like Strategy in Fungal Toxin Biosynthesis. CYP450, DKP, GST
12  2017 Enantioselective Synthesis of (-)-Acetylapoaranotin. ---
13  2017 Penicisulfuranols A-F, Alkaloids from the Mangrove Endophytic Fungus Penicillium janthinellum HDN13-309. ---
14  2017 Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus. ---
15  2016 Gliotoxin--bane or boon? GT
16  2016 Sequential Inactivation of Gliotoxin by the S-Methyltransferase TmtA. ---
17  2016 The Epipolythiodiketopiperazine Gene Cluster in Claviceps purpurea: Dysfunctional Cytochrome P450 Enzyme Prevents Formation of the Previously Unknown Clapurines. ---
18  2015 A Unified Strategy to 6-5-6-5-6-Membered Epipolythiodiketopiperazines: Studies towards the Total Synthesis of Scabrosin Diacetate and Haematocin. ---
19  2015 Biogenetically-inspired total synthesis of epidithiodiketopiperazines and related alkaloids. ---
20  2015 Tricyclic Analogues of Epidithiodioxopiperazine Alkaloids with Promising In Vitro and In Vivo Antitumor Activity. i.p, SAR
21  2014 Antibacterial epipolythiodioxopiperazine and unprecedented sesquiterpene from Pseudallescheria boydii, a beetle (coleoptera)-associated fungus. ECD
22  2014 Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion. ---
23  2014 Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1alpha/p300 complex in a preclinical model of prostate cancer. ETPs, HIF-1alpha
24  2014 Opposed effects of enzymatic gliotoxin N- and S-methylations. MTs
25  2014 Stereoselective construction of a key hydroindole precursor of epidithiodiketopiperazine (ETP) natural products. IEDDA
26  2013 Cloning and sequencing of the chaetocin biosynthetic gene cluster. ---
27  2013 Concise Total Synthesis of (+)-Bionectins A and C. ---
28  2013 Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: reducing cytotoxicity by structural simplification. SAR
29  2013 General approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors: enantioselective total syntheses of (+)- and (-)-gliocladine C, (+)-leptosin D, (+)-T988C, (+)-bionectin A, and (+)-gliocladin A. ---
30  2013 On the histone lysine methyltransferase activity of fungal metabolite chaetocin. ---
31  2013 Reconstitution of the early steps of gliotoxin biosynthesis in Aspergillus nidulans reveals the role of the monooxygenase GliC. ---
32  2013 Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids. SAR
33  2013 [Genetic transformation of the fungus Gliocladium sp. mediated by Agrobacterium tumefaciens]. ATMT, EGFP
34  2012 Biosynthesis and function of gliotoxin in Aspergillus fumigatus. GT
35  2012 Enantioselective total synthesis of (-)-acetylaranotin, a dihydrooxepine epidithiodiketopiperazine. ---
36  2011 A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis. GST
37  2011 Antifungal activity of microbial secondary metabolites. ---
38  2011 Enantioselective total synthesis of (+)-gliocladine C: convergent construction of cyclotryptamine-fused polyoxopiperazines and a general approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors. ---
39  2011 Inhibition of hypoxia-inducible transcription factor complex with designed epipolythiodiketopiperazine. C-TAD, HIF-1alpha
40  2009 Direct inhibition of hypoxia-inducible transcription factor complex with designed dimeric epidithiodiketopiperazine. ---
41  2009 Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism. HIF, HIF-1alpha
42  2008 A Zn(II)2Cys6 DNA binding protein regulates the sirodesmin PL biosynthetic gene cluster in Leptosphaeria maculans. ---
43  2007 Origin and distribution of epipolythiodioxopiperazine (ETP) gene clusters in filamentous ascomycetes. ETPs
44  2005 Bioinformatic and expression analysis of the putative gliotoxin biosynthetic gene cluster of Aspergillus fumigatus. ---
45  2005 The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis. ETPs
46  2004 The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans. ---
47  2003 Evidence that the lichen-derived scabrosin esters target mitochondrial ATP synthase in P388D1 cells. SEs
48  2002 Influx of calcium through a redox-sensitive plasma membrane channel in thymocytes causes early necrotic cell death induced by the epipolythiodioxopiperazine toxins. ---
49  1998 DNA damage by gliotoxin from Aspergillus fumigatus. An occupational and environmental propagule: adduct detection as measured by 32P DNA radiolabelling and two-dimensional thin-layer chromatography. dCMP, dNDP, dTMP
50  1991 Clinical isolates of yeast produce a gliotoxin-like substance. MEM
51  1991 Langerhans cell depletion in gliotoxin-treated murine epidermis. LC
52  1990 Apoptosis induced in macrophages and T blasts by the mycotoxin sporidesmin and protection by Zn2+ salts. ---
53  1990 Effects of gliotoxin on Langerhans' cell function: contact hypersensitivity responses and skin graft survival. CHS, LC, MHC
54  1988 Gliotoxin induces apoptosis in macrophages unrelated to its antiphagocytic properties. ---