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■ Abbreviation / Long Form : FOXO1 / forkhead box protein O1

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Total Number of Papers: 239
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Abbreviation:   FOXO1  (>> Co-occurring Abbreviation)
Long Form:   forkhead box protein O1
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2020 AKT2 regulates endothelial-mediated coagulation homeostasis and promotes intrathrombotic recanalization and thrombus resolution in a mouse model of venous thrombosis. IVC, TF, TM, VTE, WT
2020 Angiotensin II-upregulated MAP kinase phosphatase-3 modulates FOXO1 and p21 in adrenocortical H295R cells. Ang II, MAPK, MKP
2020 Caffeine Upregulates Hepatic Sex Hormone-Binding Globulin Production by Increasing Adiponectin Through AKT/FOXO1 Pathway in White Adipose Tissue. AKT, SHBG
2020 Comparative Analyses of mTOR/Akt and Muscle Atrophy-Related Signaling in Aged Respiratory and Gastrocnemius Muscles. ---
2020 Epigallocatechin-3-Gallate (EGCG)-Inducible SMILE Inhibits STAT3-Mediated Hepcidin Gene Expression. EGCG, IL-6, SMILE, STAT3
2020 Fluoxetine regulates glucose and lipid metabolism via the PI3K‑AKT signaling pathway in diabetic rats. G6PC, PEPCK, STZ
2020 FOXO1 contributes to diabetic cardiomyopathy via inducing imbalanced oxidative metabolism in type 1 diabetes. ---
2020 FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma. ChIP, CSF-1, ESCC, qRT-PCR, TME
2020 FOXO1 regulates developmental lymphangiogenesis by upregulating CXCR4 in the mouse-tail dermis. CXCL12, CXCR4, LECs
10  2020 FOXO1 suppresses PGC-1beta gene expression in skeletal muscles. PGC-1beta
11  2020 Genomic Binding Patterns of Forkhead Box Protein O1 Reveal Its Unique Role in Cardiac Hypertrophy. Pol II
12  2020 GLP-1/GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation Sites. GCs, PCOS
13  2020 Hyperoside exhibits anticancer activity in non‑small cell lung cancer cells with T790M mutations by upregulating FoxO1 via CCAT1. CCAT1, EGFR, lncRNA, NSCLC
14  2020 Knockdown of SGK1 alleviates the IL-1beta-induced chondrocyte anabolic and catabolic imbalance by activating FoxO1-mediated autophagy in human chondrocytes. IL-1beta, OA, SGK1
15  2020 Lignan from Alnus japonica Inhibits Adipocyte Differentiation via Cell Cycle and FOXO1 Regulation. ---
16  2020 LncRNA GUSBP5-AS promotes EPC migration and angiogenesis and deep vein thrombosis resolution by regulating FGF2 and MMP2/9 through the miR-223-3p/FOXO1/Akt pathway. DVT, EPCs, FGF-2, lncRNAs
17  2020 Luteolin-loading of Her-2-poly (lactic-co-glycolic acid) nanoparticles and proliferative inhibition of gastric cancer cells via targeted regulation of forkhead box protein O1. Her-2-NPs, NPs
18  2020 Matrix Metalloproteinase-11 Promotes Early Mouse Mammary Gland Tumor Growth through Metabolic Reprogramming and Increased IGF1/AKT/FoxO1 Signaling Pathway, Enhanced ER Stress and Alteration in Mitochondrial UPR. ECM, HR-MAS, IGF-1, MMP11, MMTV, PyMT
19  2020 MSC-Secreted Exosomal H19 Promotes Trophoblast Cell Invasion and Migration by Downregulating let-7b and Upregulating FOXO1. Akt, MSCs, PE
20  2020 Multi-omics analysis identifies FoxO1 as a regulator of macrophage function through metabolic reprogramming. ---
21  2020 N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation. MNAM, PA, SIRT1, T2DM
22  2020 PDK4-Deficiency Reprograms Intrahepatic Glucose and Lipid Metabolism to Facilitate Liver Regeneration in Mice. AMPK, PDK4
23  2020 Red Pepper (Capsicum annuum L.) Seed Extract Improves Glycemic Control by Inhibiting Hepatic Gluconeogenesis via Phosphorylation of FOXO1 and AMPK in Obese Diabetic db/db Mice. AMPK, G6Pase, IL-6, ObD, PEPCK, RPSE, TNF-alpha
24  2020 Resveratrol improves left ventricular remodeling in chronic kidney disease via Sirt1-mediated regulation of FoxO1 activity and MnSOD expression. CKD, MnSOD, RSV, SIRT1
25  2020 Role and mechanism of PI3K/AKT/FoxO1/PDX-1 signaling pathway in functional changes of pancreatic islets in rats after severe burns. ELISA, PDX-1, PI3K, TBSA, TEM
26  2020 Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue. BAT, GGPP, IRF4
27  2020 Supplementary Oral Anamorelin Mitigates Anorexia and Skeletal Muscle Atrophy Induced by Gemcitabine Plus Cisplatin Systemic Chemotherapy in a Mouse Model. 5-ALA, GC
28  2020 Targeting Histone Deacetylase 6 Reprograms Interleukin-17-Producing Helper T Cell Pathogenicity and Facilitates Immunotherapies for Hepatocellular Carcinoma. HCC, HDAC6, IL-17, RORgammat
29  2020 Targeting the PLK1-FOXO1 pathway as a novel therapeutic approach for treating advanced prostate cancer. PCa, Plk1
30  2020 The cleft palate candidate gene BAG6 supports FoxO1 acetylation to promote FasL-mediated apoptosis during palate fusion. BAG6, FasL, MEE, WES
31  2020 The role and molecular mechanism of FoxO1 in mediating cardiac hypertrophy. ---
32  2020 Up-regulation of FoxO1 contributes to adverse vascular remodelling in type 1 diabetic rats. STZ, T1DM
33  2019 AKT as a Therapeutic Target for Cancer. AKT, GSK3beta, PDK
34  2019 Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression. AH, ALD, miRNAs, TXNIP
35  2019 AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins. AMPK
36  2019 AMPK/FOXO1 signaling pathway is indispensable in visfatin-regulated myosin heavy chain expression in C2C12 myotubes. AMP, MHC
37  2019 Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways. AMPK, CPT1, GRE, INSR, IRS-1 and IRS-2, OBIR
38  2019 Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway. CUMS, IL-1beta, IL-6, LPS, PI3K, TLR4, TNF-alpha
39  2019 Biochemical and molecular evidence on the role of vaspin in early detection of the insulin resistance in a rat model of high-fat diet and use of diazinon. ChE, DZN, FBG, HFD, HOMA-IR, OGTT, PTEN, ROS, TNF-alpha
40  2019 Combination of Soy Protein, Amylopectin, and Chromium Stimulates Muscle Protein Synthesis by Regulation of Ubiquitin-Proteasome Proteolysis Pathway after Exercise. FOXO3, FSR, IGF-1, MAFbx, SAC
41  2019 Decreased PKG transcription mediated by PI3K/Akt/FoxO1 pathway is involved in the development of nitroglycerin tolerance. NTG, PI3K, ROS
42  2019 Differential Control of iNKT Cell Effector Lineage Differentiation by the Forkhead Box Protein O1 (Foxo1) Transcription Factor. iNKT
43  2019 Expression of REGgamma in atherosclerotic plaques and promotes endothelial cells apoptosis via the cyclophilin A pathway indicates functional implications in atherogenesis. CyPA, ECs, HUVECs, PKAcalpha
44  2019 Fibroblast growth factor 21 protects the heart from angiotensin II-induced cardiac hypertrophy and dysfunction via SIRT1. AMPK, Ang II, CAT, FGF21, i.p, LKB1, NRCMs, ROS, SIRT1, SIRT1-iKO
45  2019 Fisetin supplementation prevents high fat diet-induced diabetic nephropathy by repressing insulin resistance and RIP3-regulated inflammation. FIS, GSK, HFD, IL-6, KIM-1, NCD, NF-kappaB, NLRP3, PAL, TNF-alpha
46  2019 Forkhead box protein O1 (FOXO1) and paired box gene 3 (PAX3) overexpression is associated with poor prognosis in patients with cervical cancer. IHC, PAX3, TMA
47  2019 Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion. LIRKO, serpinB1
48  2019 FOXO1 associated with sensitivity to chemotherapy drugs and glial-mesenchymal transition in glioma. GBM, GMT
49  2019 FoxO1 localizes to mitochondria of adipose tissue and is affected by nutrient stress. ROS
50  2019 FoxO1 Overexpression Ameliorates TNF-alpha-Induced Oxidative Damage and Promotes Osteogenesis of Human Periodontal Ligament Stem Cells via Antioxidant Defense Activation. ECM, hPDLSCs, MDA, ROS
51  2019 FoxO1 regulates leptin-induced mood behavior by targeting tyrosine hydroxylase. DA, STAT3, TH
52  2019 FoxO1 Suppresses Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication and Controls Viral Latency. KS, KSHV, NAC, ROS
53  2019 HDAC4 mutations cause diabetes and induce beta-cell FoxO1 nuclear exclusion. ---
54  2019 Hypoxia-Activated PI3K/Akt Inhibits Oxidative Stress via the Regulation of Reactive Oxygen Species in Human Dental Pulp Cells. hDPCs, PI3K, ROS
55  2019 Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. FTO
56  2019 KY-226 Protects Blood-brain Barrier Function Through the Akt/FoxO1 Signaling Pathway in Brain Ischemia. BBB, ERK, PTP1B, TJ, tMCAO
57  2019 LINC01018 confers a novel tumor suppressor role in hepatocellular carcinoma through sponging microRNA-182-5p. HCC, lncRNAs, miR-182-5p
58  2019 Liver kinase B1 overexpression controls mycobacterial infection in macrophages via FOXO1/Wnt5a signaling. IL, LKB1, Mtb, TB
59  2019 LncRNA ADAMTS9-AS2 inhibits cell proliferation and decreases chemoresistance in clear cell renal cell carcinoma via the miR-27a-3p/FOXO1 axis. ccRCC
60  2019 lncRNA MEG3 promotes hepatic insulin resistance by serving as a competing endogenous RNA of miR-214 to regulate ATF4 expression. ATF4, ceRNA, HFD, MEG3, miR
61  2019 Lysophosphatidylcholine-induced mitochondrial fission contributes to collagen production in human cardiac fibroblasts. COX-2, Drp1, HCFs, LPC, mitoROS, PGE2, PKC
62  2019 Menin Upregulates FOXO1 Protein Stability by Repressing Skp2-Mediated Degradation in beta Cells. Skp2
63  2019 Methylphenidate alters Akt-mTOR signaling in rat pheochromocytoma cells. ADHD, CREB, GSK-3beta, MPH
64  2019 MicroRNA-145 Regulates the Differentiation of Adipose Stem Cells Toward Microvascular Endothelial Cells and Promotes Angiogenesis. ASCs, ECs, vWF
65  2019 miR-486-5p Inhibits Inflammatory Response, Matrix Degradation and Apoptosis of Nucleus Pulposus Cells through Directly Targeting FOXO1 in Intervertebral Disc Degeneration. ECM, IDD, LPS, miR-486-5p, NP
66  2019 Paclitaxel alleviates monocrotaline-induced pulmonary arterial hypertension via inhibition of FoxO1-mediated autophagy. MCT, PAH, PASMCs, RVSP
67  2019 PAR2 promotes M1 macrophage polarization and inflammation via FOXO1 pathway. BMDM, PAR2, qRT-PCR
68  2019 Polydatin inhibits hepatocellular carcinoma via the AKT/STAT3-FOXO1 signaling pathway. AKT, EMT, FITC, HCC, PI, STAT3
69  2019 Poorly controlled diabetes during pregnancy and lactation activates the Foxo1 pathway and causes glucose intolerance in adult offspring. G6PC, PCK1, STZ
70  2019 Prognostic implications of forkhead box protein O1 (FOXO1) and paired box 3 (PAX3) in epithelial ovarian cancer. EOC, PAX3
71  2019 Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-kappab Signal. ALT, AML12, AST, BAX, BCL-2, DOX, GSH-Px, HO-1, IL-1beta, IL-6, Keap1, MDA, NF-kappaB, Nrf2, ROS, SIRT1, SOD, TNF-alpha
72  2019 Radix Tetrastigma flavonoid ameliorates inflammation and prolongs the lifespan of Caenorhabditis elegans through JNK, p38 and Nrf2 pathways. C. elegans, COX-2, iNOS, JNK, NO, Nrf2, PQ
73  2019 Regulation of programmed cell death ligand 1 expression by atypical protein kinase C lambda/iota in cutaneous angiosarcoma. aPKClamda, CAS, pSer218 FoxO1
74  2019 Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4. G6PC, HDAC4, PA, PCK1, REV
75  2019 SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPARalpha/FoxO1 signaling pathway. NAFLD, NAS, PPAR, Qki5, SIRT1, TG
76  2019 The effects of SIRT1/FoxO1 on LPS induced INS-1 cells dysfunction. ac-FoxO1, LPS, MDA, RSV, SIRT1, SOD, TLR4
77  2019 Tomatidine Reduces Palmitate-Induced Lipid Accumulation by Activating AMPK via Vitamin D Receptor-Mediated Signaling in Human HepG2 Hepatocytes. ACC1, AMPK, ATGL, FAS, NAFLD, SREBP-1c
78  2019 Young Blood Rescues the Cognition of Alzheimer's Model Mice by Restoring the Hippocampal Cholinergic Circuit. AD, REST
79  2018 ADAR1 attenuates allogeneic graft rejection by suppressing miR-21 biogenesis in macrophages and promoting M2 polarization. ---
80  2018 Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling. CEP55, Egr4, ESCRT, Gfra1, PLZF, Sohlh1, TEX14
81  2018 CK2 Controls Th17 and Regulatory T Cell Differentiation Through Inhibition of FoxO1. ---
82  2018 Dendrobium mixture regulates hepatic gluconeogenesis in diabetic rats via the phosphoinositide-3-kinase/protein kinase B signaling pathway. ALT, AST, DMix, FBG, G6Pase, GSP, INSR, PEPCK, PI3K, TCH, TG
83  2018 Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp. ACC, AMPK, aPKC, ERK, FBP1, G6Pase, GLUT4, INSR, IRS-1, PEPCK, PGC1alpha, SHP
84  2018 Exosome-mediated transfer of lncRNA RP11‑838N2.4 promotes erlotinib resistance in non-small cell lung cancer. lncRNAs, NSCLC
85  2018 Expression and phosphorylation of FOXO1 influences cell proliferation and apoptosis in the gastrointestinal stromal tumor cell line GIST-T1. Bcl-2, GISTs, MAPK, PI3K
86  2018 FoxO1 Is Required for Most of the Metabolic and Hormonal Perturbations Produced by Hepatic Insulin Receptor Deletion in Male Mice. ---
87  2018 FoxO1, A2M, and TGF-beta1: three novel genes predicting depression in gene X environment interactions are identified using cross-species and cross-tissues transcriptomic and miRNomic analyses. A2M, PNS, TGF-beta1
88  2018 Fusion status in patients with lymph node-positive (N1) alveolar rhabdomyosarcoma is a powerful predictor of prognosis: Experience of the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG). ARMS, EpSSG
89  2018 Galangin Inhibits Thrombin-Induced MMP-9 Expression in SK-N-SH Cells via Protein Kinase-Dependent NF-kappaB Phosphorylation. Akt, JNK, MAPK, MMPs, mTOR, PKC, Pyk2
90  2018 High-intensity eccentric training ameliorates muscle wasting in colon 26 tumor-bearing mice. CNT, ECC, ES, mTORC, MuRF-1, REDD
91  2018 Inhibition of BRD4 suppresses tumor growth in prostate cancer via the enhancement of FOXO1 expression. Bcl-2, BRD4, PCa
92  2018 Inhibitory Effect of Idelalisib, a Selective Phosphatidylinositol 3-Kinase delta Inhibitor, on Adipogenesis in an In Vitro Model of Graves' Orbitopathy. C/EBP, GO, mTOR, PI3K, PPARgamma
93  2018 Insulin suppresses the production of fibroblast growth factor 23 (FGF23). FGF23, IGF-1, PI3K, PKB, PTH
94  2018 Intermittent Hypoxia Disrupts Glucose Homeostasis in Liver Cells in an Insulin-Dependent and Independent Manner. GSK-3beta, IH, JNK, PEPCK
95  2018 Leptin suppresses microRNA-122 promoter activity by phosphorylation of foxO1 in hepatic stellate cell contributing to leptin promotion of mouse liver fibrosis. HSC, miR-122
96  2018 Liraglutide ameliorates early renal injury by the activation of renal FoxO1 in a type 2 diabetic kidney disease rat model. BUN, FN, GBM, MnSOD, SCr, STZ, TGF-beta1
97  2018 Long Noncoding RNA LINC01619 Regulates MicroRNA-27a/Forkhead Box Protein O1 and Endoplasmic Reticulum Stress-Mediated Podocyte Injury in Diabetic Nephropathy. DN, ER, lncRNAs, miR-27a
98  2018 miR15a regulates NLRP3 inflammasome proteins in the retinal vasculature. IL-1beta, NLRP3, REC
99  2018 Pulsed electromagnetic fields alleviate streptozotocin‑induced diabetic muscle atrophy. Akt, DM, DP, DT, MSTN, mTOR, NC, PEMFs, SD, STZ
100  2018 Qing Gan Zi Shen Tang alleviates adipose tissue dysfunction with up-regulation of SIRT1 in spontaneously hypertensive rat. eWAT, FABP4, HFD, MAP, PPARgamma, PTP1B, QGZST, SBP, SHR, SIRT1