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■ Abbreviation / Long Form : GCL / glutamate-cysteine ligase

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Total Number of Papers: 329
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Abbreviation:   GCL  (>> Co-occurring Abbreviation)
Long Form:   glutamate-cysteine ligase
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2019 Cytoprotective Effect of Ligustrum robustum Polyphenol Extract against Hydrogen Peroxide-Induced Oxidative Stress via Nrf2 Signaling Pathway in Caco-2 Cells. CAT, GR, GSH-Px, HO-1, MDA, NQO1, Nrf2, ROS, SOD
2019 Down-regulation of GCLC is involved in microcystin-LR-induced malignant transformation of human liver cells. MC-LR
2019 Effects of sulphur-containing mineral water intake on oxidative status and markers for inflammation in healthy subjects. SMW
2019 ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress. ARE, CA, HO-1, Nrf2, TBHP
2019 First evidence of glutathione metabolism in Leptospira interrogans. gamma-GC, GS
2019 Glutamine starvation inhibits snakehead vesiculovirus replication via inducing autophagy associated with the disturbance of endogenous glutathione pool. BSO, ROS, SHVV
2019 Influence of seasonality on the natural modulation of oxidative stress biomarkers in mangrove crab Ucides cordatus (Brachyura, Ucididae). ACAP, GST, LPO
2019 Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in Vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis. HMOX1, NQO1, OS
2019 l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats. CAT, GPx, GR, GS, GST, Nrf2-ARE, ROS, SOD
10  2019 Multiple pathways for the formation of the gamma-glutamyl peptides gamma-glutamyl-valine and gamma- glutamyl-valyl-glycine in Saccharomyces cerevisiae. GGT, GS, VG
11  2019 Plant glutathione biosynthesis revisited: redox-mediated activation of glutamylcysteine ligase does not require homo-dimerization. WT
12  2019 Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway. ALP, ALT/AST, Keap1, MDA, Nrf2, ROS, TBIL, TSN
13  2019 The Precursor to Glutathione (GSH), gamma-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Abeta40 Oligomers in Human Astrocytes. AD, GGC, GPx, MMP, SOD, TAC
14  2019 Theaflavins alleviate sevoflurane-induced neurocytotoxicity via Nrf2 signaling pathway. CCK-8, HO-1, NQO1, Nrf2, Prx1, qPCR, ROS, TFs
15  2019 Thiol redox-regulation for efficient adjustment of sulfur metabolism in acclimation to abiotic stress. APR, APSK
16  2019 Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia. AFN, BPD, BSO, GPx, mtCCs, TXNRD1
17  2018 Assessment of the effects of graphene exposure in Danio rerio: A molecular, biochemical and histological approach to investigating mechanisms of toxicity. GST, i.p
18  2018 gamma-Glutamyl Cysteine Ligase of Lactobacillus reuteri Synthesizes gamma-Glutamyl Dipeptides in Sourdough. gamma-GPs
19  2018 Glioprotective Effect of Resveratrol: an Emerging Therapeutic Role for Oligodendroglial Cells. BDNF, CNS, GDNF, HIF-1alpha, HO-1, LPS, NF-kappaB, Nrf2, OPC, ROS, TGF-beta, TLR4
20  2018 Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. EAE, Gclc, GSSG
21  2018 Glutathione homeostasis is significantly altered by quercetin via the Keap1/Nrf2 and MAPK signaling pathways in rats. ERK, GR, GST, MAPKs, Nrf2
22  2018 Induction of oxidative stress by chlorothalonil in the estuarine polychaete Laeonereis acuta. ACAP, AChE, CAT, GST, LPO, PChE, SOD
23  2018 Inhibition of Glutathione Synthesis via Decreased Glucose Metabolism in Stored RBCs. RBCs
24  2018 Lactic Acid Bacteria With Antioxidant Activities Alleviating Oxidized Oil Induced Hepatic Injury in Mice. DPPH, HO-1, LAB, Nrf2
25  2018 Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors. BSO
26  2018 Lower antioxidant capacity in the prefrontal cortex of individuals with schizophrenia. GPx, mRNA, RT-PCR
27  2018 Modulated Gene Expression of Toxoplasma gondii Infected Retinal Pigment Epithelial Cell Line (ARPE-19) via PI3K/Akt or mTOR Signal Pathway. CK2, GST, PEDF, qRT-PCR, RPE, RT-PCR, VEGF
28  2018 Oxidative Stress in the Visceral Fat Is Elevated in Postmenopausal Women with Gynecologic Cancer. HO-1, NQO1, Nrf2, ROS
29  2018 Retinol but not retinoic acid can enhance the glutathione level, in a manner similar to beta-carotene, in a murine cultured macrophage cell line. RA, RAR, RXR
30  2018 Role of glutathione biosynthesis in endothelial dysfunction and fibrosis. MLEC, WT
31  2018 S-Alk(en)ylmercaptocysteine suppresses LPS-induced pro-inflammatory responses in murine macrophages through inhibition of NF-kappaB pathway and modulation of thiol redox status. BSO, IKK, LPS, NF-kappaB, Nrf2
32  2018 Sulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism. GSR, GST, MDR, SM
33  2018 The AMPK-PGC-1alpha signaling axis regulates the astrocyte glutathione system to protect against oxidative and metabolic injury. AMPK, CNS, GCLM
34  2017 Alteration of Nrf2 and Glutamate Cysteine Ligase expression contribute to lesions growth and fibrogenesis in ectopic endometriosis. NRF2
35  2017 Association of GCLM -588C/T and GCLC -129T/C Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population. IHD
36  2017 C1q/TNF-Related Protein-9 Ameliorates Ox-LDL-Induced Endothelial Dysfunction via PGC-1alpha/AMPK-Mediated Antioxidant Enzyme Induction. AMPK, CTRP9, eNOS, HO-1, HUVECs, NO, oxLDL, PGC-1alpha, ROS
37  2017 CHAC2 is essential for self-renewal and glutathione maintenance in human embryonic stem cells. hESCs, ROS
38  2017 Clinical and molecular characterization of 6 children with glutamate-cysteine ligase deficiency causing hemolytic anemia. ---
39  2017 Delayed Nrf2-regulated antioxidant gene induction in response to silica nanoparticles. GCLM, HO-1, NQO1, Nrf2
40  2017 Effects of increasing temperature on antioxidant defense system and oxidative stress parameters in the Antarctic fish Notothenia coriiceps and Notothenia rossii. ACAP, ADS, CAT, GPx, GST, LPO, MTLP, PC, SOD
41  2017 Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells. ER, GRP78, HO, MAPKs, ROS, SIRT1, TM, TRB3, UPR
42  2017 Gclc deficiency in mouse CNS causes mitochondrial damage and neurodegeneration. CNS, ROS, SLICK
43  2017 Omega-3 polyunsaturated fatty acids improve the antioxidative defense in rat astrocytes via an Nrf2-dependent mechanism. GPX4, GS, omega-3 PUFA
44  2017 Opportunistic Pathogen Porphyromonas gingivalis Modulates Danger Signal ATP-Mediated Antibacterial NOX2 Pathways in Primary Epithelial Cells. eATP, GECs, HOCl, MPO, NOX, ROS
45  2017 Oral administration of gamma-glutamylcysteine increases intracellular glutathione levels above homeostasis in a randomised human trial pilot study. gamma-GC
46  2017 Post-translational Activation of Glutamate Cysteine Ligase with Dimercaprol: A NOVEL MECHANISM OF INHIBITING NEUROINFLAMMATION IN VITRO. ---
47  2017 Protective effect of rutaecarpine against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via the CaMKII-Akt and Nrf2/ARE pathways. CaMKII, HO-1, NQO1, Nrf2, ROS, TBHP
48  2017 Resveratrol modulates GSH system in C6 astroglial cells through heme oxygenase 1 pathway. BSO, CNS, GPx, GR, HO-1, ROS/RNS
49  2017 Temporal changes in glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response of THP-1 macrophages. ---
50  2017 Transformation of liver cells by 3-methylcholanthrene potentiates oxidative stress via the downregulation of glutathione synthesis. 3-MC, AhR, PAHs
51  2016 Effects of hypoxia and reoxygenation on the antioxidant defense system of the locomotor muscle of the crab Neohelice granulata (Decapoda, Varunidae). ADS, GPx
52  2016 Effects of S-Adenosylmethionine and Its Combinations With Taurine and/or Betaine on Glutathione Homeostasis in Ethanol-induced Acute Hepatotoxicity. AST, SAMe
53  2016 Evaluation of coexposure to inorganic arsenic and titanium dioxide nanoparticles in the marine shrimp Litopenaeus vannamei. ---
54  2016 Glutamate cysteine ligase and the age-related decline in cellular glutathione: The therapeutic potential of gamma-glutamylcysteine. gamma-GC, ROS
55  2016 Insulin-like growth factor 1 specifically up-regulates expression of modifier subunit of glutamate-cysteine ligase and enhances glutathione synthesis in SH-SY5Y cells. IGF-1, Nrf2
56  2016 Lycopene inhibits ICAM-1 expression and NF-kappaB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells. AMD, ROS, RPE
57  2016 Mechanism of acute endosulfan intoxication-induced neurotoxicity in Sprague-Dawley rats. HO-1, IL-1beta, NF-kappaB, SD, SOD, TNF-alpha
58  2016 Mountain-Cultivated Ginseng Attenuates Phencyclidine-Induced Abnormal Behaviors in Mice by Positive Modulation of Glutathione in the Prefrontal Cortex of Mice. GPx, GSSG, MG, PFC
59  2016 Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma. HN, SCC
60  2016 Protective Effects of Maillard Reaction Products of Whey Protein Concentrate against Oxidative Stress through an Nrf2-Dependent Pathway in HepG2 Cells. ERK, Glc-WPC, HO-1, JNK, MRPs, Nrf2, SDS-PAGE, TBHP
61  2016 Protective Effects of Melatonin on Retinal Inflammation and Oxidative Stress in Experimental Diabetic Retinopathy. DR, i.p, iNOS
62  2016 Quercetin affects glutathione levels and redox ratio in human aortic endothelial cells not through oxidation but formation and cellular export of quercetin-glutathione conjugates and upregulation of glutamate-cysteine ligase. HAEC, LPS, MRP1
63  2016 SIRT2 mediates NADH-induced increases in Nrf2, GCL, and glutathione by modulating Akt phosphorylation in PC12 cells. ---
64  2016 The proteasome inhibitor lactacystin enhances GSH synthesis capacity by increased expression of antioxidant components in an Nrf2-independent, but p38 MAPK-dependent manner in rat colorectal carcinoma cells. GGT, ROS
65  2015 A novel compound VSC2 has anti-inflammatory and antioxidant properties in microglia and in Parkinson's disease animal model. HO-1, iNOS, NQO1, PD
66  2015 A protective mechanism of licorice (Glycyrrhiza uralensis): isoliquiritigenin stimulates detoxification system via Nrf2 activation. BSEP, MRP2, Nrf2, Nrf2 KO, Nrf2 WT, UGT1A1
67  2015 Activation of NRF2 pathway in spleen, thymus as well as peripheral blood mononuclear cells by acute arsenic exposure in mice. GR, GST, HO-1, NQO1, Nrf2, PBMCs
68  2015 Aging alters circadian regulation of redox in Drosophila. Gclc
69  2015 An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly. NAC, NHANES, ROS
70  2015 Arsenic responsive microRNAs in vivo and their potential involvement in arsenic-induced oxidative stress. miRNA, SD
71  2015 Effect of full flavor and denicotinized cigarettes exposure on the brain microvascular endothelium: a microarray-based gene expression study using a human immortalized BBB endothelial cell line. ARE, BBB, CSE, HMOX1, IR, MRP4, NF-kappabeta, NQO1, Nrf2, P-gp, TS
72  2015 Involvement of decreased neuroglobin protein level in cognitive dysfunction induced by 1-bromopropane in rats. 1-BP, 4-HNE, CNS, HEL, MWM, Ngb, ODS, PL
73  2015 Involvement of glutathione and glutathione metabolizing enzymes in human colorectal cancer cell lines and tissues. GSS
74  2015 Protective effect of Wuzhi tablet (Schisandra sphenanthera extract) against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response. HO-1, Nrf2, ROS
75  2015 Targeting of Gamma-Glutamyl-Cysteine Ligase by miR-433 Reduces Glutathione Biosynthesis and Promotes TGF-beta-Dependent Fibrogenesis. HUVEC, miRNAs, TGF-beta1, UTRs
76  2015 The chalcone compound isosalipurposide (ISPP) exerts a cytoprotective effect against oxidative injury via Nrf2 activation. AMPK, ERK, ISPP, MAPKs, Nrf2, PKC, ROS
77  2015 Therapeutic approaches to modulating glutathione levels as a pharmacological strategy in Alzheimer's disease. AD, GGC
78  2015 Therapeutic Approaches to ModulatingGlutathione Levels as a Pharmacological strategy in Alzheimer's Disease. AD, GGC
79  2015 Upregulation of cellular glutathione levels in human ABCB5- and murine Abcb5-transfected cells. BSO
80  2015 Water availability influences morphology, mycorrhizal associations, PSII efficiency and polyamine metabolism at early growth phase of Scots pine seedlings. ADC, CAT, DAO, GS, LEA, PA, PAO, PDC, Put, SPDS
81  2014 17alpha-Estradiol down-regulates glutathione synthesis in serum deprived PC-12 cells. ---
82  2014 Altered glutamate cysteine ligase activity in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. PBMCs, SLE, Trx
83  2014 Altered glutamate cysteine ligase expression and activity in renal cell carcinoma. RCC
84  2014 Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats. HO, SOD
85  2014 Certain carotenoids enhance the intracellular glutathione level in a murine cultured macrophage cell line by inducing glutamate-cysteine-ligase. JNK
86  2014 Effect of licorice on the induction of phase II metabolizing enzymes and phase III transporters and its possible mechanism. GST, MRP2, Nrf2, UGT1A1, XMEs
87  2014 Genomic and non-genomic regulation of PGC1 isoforms by estrogen to increase cerebral vascular mitochondrial biogenesis and reactive oxygen species protection. PGC-1alpha, PI3K, PRC
88  2014 Glutathione metabolism enzymes in brain and liver of hyperphenylalaninemic rats and the effect of lipoic acid treatment. G6PD, GR, GSH-Px, GST, HPA, LA, Phe, PKU
89  2014 Immunolocalization of glutathione biosynthesis enzymes in Arabidopsis thaliana. GS
90  2014 Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes. ARE
91  2014 Key proteins in the polyamine-trypanothione pathway as drug targets against Trypanosoma cruzi. TR
92  2014 Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential. ERK, Nrf2
93  2014 Molecular cloning and analysis of Ancylostoma ceylanicum glutamate-cysteine ligase. ---
94  2014 Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice. ARE, LPS, Nrf2, Ubc9
95  2014 Oxidative stress and mitochondrial dysfunction in Kindler syndrome. FERMT1, KS
96  2014 Protection of Flos Lonicerae against acetaminophen-induced liver injury and its mechanism. ALT/AST, AP, CGA, FL, HPLC, TB, TUNEL
97  2014 Resveratrol affects the expression of glutamate cysteine ligase in the kidneys of aged rats. RSV
98  2014 Saponins from Aralia taibaiensis attenuate D-galactose-induced aging in rats by activating FOXO3a and Nrf2 pathways. AGEs, CAT, FOXO3a, GR, HO-1, MDA, Nrf2, ROS, SAbeta-gal, SOD2
99  2014 Sulforaphane reduces the alterations induced by quinolinic acid: modulation of glutathione levels. GPx, GR, QUIN, SULF
100  2013 A functional trinucleotide repeat polymorphism in the 5'-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers. GCLC, OR