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■ Abbreviation / Long Form : GDF5 / growth differentiation factor 5

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Total Number of Papers: 250
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Abbreviation:   GDF5  (>> Co-occurring Abbreviation)
Long Form:   growth differentiation factor 5
 Abbreviation Variation
 Long Form Variation
 Pair(Abbreviation/Long Form) Variation
No. Year Title Co-occurring Abbreviation
2020 Cells from a GDF5 origin produce zonal tendon-to-bone attachments following anterior cruciate ligament reconstruction. ACL
2020 GDF5 induces TBX3 in a concentration dependent manner - on a gold nanoparticle gradient. iPSCs, TBX3
2020 Increasing the Medium Osmolarity Reduces the Inflammatory Status of Human OA Chondrocytes and Increases Their Responsiveness to GDF-5. OA
2020 Long Noncoding RNA GAS5 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Regulating GDF5 and p38/JNK Signaling Pathway. ALP, ARS, ECM, GAS5, hPDLSCs, lncRNA
2020 Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis. DMM, OA, YAP
2020 The GDF-5 mutant M1673 exerts robust anabolic and anti-catabolic effects in chondrocytes. ECM, MSCs, OA
2019 3D-bioprinting a genetically inspired cartilage scaffold with GDF5-conjugated BMSC-laden hydrogel and polymer for cartilage repair. BMSCs, GWAS
2019 An embryonic CaVbeta1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse. CaVbeta1, ECC
2019 Assessment of structurally and functionally high-risk nsSNPs impacts on human bone morphogenetic protein receptor type IA (BMPR1A) by computational approach. ALK3, nsSNPs, TGF-beta
10  2019 Comparison of the effect of growth factors on chondrogenesis of canine mesenchymal stem cells. BM-PACs, BMP-2, IGF-1, MSCs, TGF-beta1
11  2019 GDF5 Promotes White Adipose Tissue Thermogenesis via p38 MAPK Signaling Pathway. ATF2, FABP4, HFD, MAPK, sWAT, Tg
12  2019 Genetic Association Between Growth Differentiation Factor 5 Single Nucleotide Polymorphism and Primary Knee Osteoarthritis in a Group of Egyptian Patients: A Pilot Study. HAQ, K/L, OA, RFLP-PCR, SNP, WOMAC
13  2019 Identification of a novel mutation of NOG in family with proximal symphalangism and early genetic counseling. NOG, SYM1A, SYM1B
14  2019 Identification of a Novel NOG Missense Mutation in a Chinese Family With Symphalangism and Tarsal Coalitions. NOG, WES
15  2019 Interaction between GDF5 gene polymorphisms and environment factors increased the risk of knee osteoarthritis: a case-control study. CI, KOA, MI, OA, OR, SNPs
16  2019 Intradiscal Injection of Induced Pluripotent Stem Cell-Derived Nucleus Pulposus-Like Cell-Seeded Polymeric Microspheres Promotes Rat Disc Regeneration. GM, iPSCs, IVDs, NP-lCs
17  2019 Long Non-Coding RNA Myoparr Regulates GDF5 Expression in Denervated Mouse Skeletal Muscle. BMP, lncRNA, TA
18  2019 Low-intensity pulsed ultrasound combination with induced pluripotent stem cells-derived neural crest stem cells and growth differentiation factor 5 promotes sciatic nerve regeneration and functional recovery. iPSCs-NCSCs, LIPUS, PFTBA
19  2019 microRNA-132 inhibits osteogenic differentiation of periodontal ligament stem cells via GDF5 and the NF-kappaB signaling pathway. ALP, ARS, BMP2, miRs, NF-kappaB, OCN, PDLSCs
20  2019 Sustained release of GDF5 from a designed coacervate attenuates disc degeneration in a rat model. Co, ECM, hADSCs, NP, PEAD
21  2019 The role of microRNA-16 in the pathogenesis of autoimmune diseases: A comprehensive review. A2AR, ACVR, miRNAs
22  2018 Association between GDF5 single nucleotide polymorphism rs143383 and lumbar disc degeneration. DNA, LDD, OR, qPCR, SNP
23  2018 Association Between the SNP rs143383 + 104T/C in the GDF5 Gene and the Risk of Knee Osteoarthritis in a Population from Northern Mexico-A Case-Control Study. KOA
24  2018 Changes in the appendicular skeleton during metamorphosis in the axolotl salamander (Ambystoma mexicanum). ACAN
25  2018 Extracellular matrix protein production in human adipose-derived mesenchymal stem cells on three-dimensional polycaprolactone (PCL) scaffolds responds to GDF5 or FGF2. ECM, MSCs, PCL, PL, TN-C
26  2018 Genetic correction of adipose tissue-derived mesenchymal stem cells mediated by TALEN targeting the GDF5 gene. MSCs, OA, TALENs
27  2018 Growth Differentiation Factor 5 Improves Neurogenesis and Functional Recovery in Adult Mouse Hippocampus Following Traumatic Brain Injury. BrdU, DG, pCREB, TBI
28  2018 Heparin functionalization increases retention of TGF-beta2 and GDF5 on biphasic silk fibroin scaffolds for tendon/ligament-to-bone tissue engineering. AdMCs, TGF-beta2
29  2018 Impact of broad regulatory regions on Gdf5 expression and function in knee development and susceptibility to osteoarthritis. bp
30  2018 MicroRNA-449a upregulation promotes chondrocyte extracellular matrix degradation in osteoarthritis. ECM, miRNAs, OA
31  2018 microRNA-665 promotes the proliferation and matrix degradation of nucleus pulposus through targeting GDF5 in intervertebral disc degeneration. IDD, miRNAs
32  2018 Novel nano-microspheres containing chitosan, hyaluronic acid, and chondroitin sulfate deliver growth and differentiation factor-5 plasmid for osteoarthritis gene therapy. CCK-8, ECM, NMPs, OA
33  2018 Orthotopic Transplantation of Achilles Tendon Allograft in Rats: With or without Incorporation of Autologous Mesenchymal Stem Cells. MSCs
34  2018 Overexpression of growth and differentiation factor-5 inhibits inflammatory factors released by intervertebral disc cells. COX-2, IDD, IL, iNOS, LBP, NO, NP, PGE2, RT-qPCR, TNF
35  2018 Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration. DNMT3A, Dnmt3a-KO
36  2017 Genetic influence of growth and differentiation factor 5 gene polymorphism (+104T/C) on the development of knee osteoarthritis and its association with disease severity. KL, KOA, SNP, VAS, WOMAC
37  2017 Growth Differentiation Factor 5 Accelerates Wound Closure and Improves Skin Quality During Repair of Full-Thickness Skin Defects. ---
38  2017 Growth Differentiation Factor 5-Mediated Enhancement of Chondrocyte Phenotype Is Inhibited by Heparin: Implications for the Use of Heparin in the Clinic and in Tissue Engineering Applications. GAG, HS, TE
39  2017 Growth/differentiation factor-5 promotes in vitro/vivo periodontal specific differentiation of induced pluripotent stem cell-derived mesenchymal stem cells. BMSCs, HA, iPSC-MSCs, iPSCs, MSCs, rhGDF-5
40  2017 Intra-articular therapy with recombinant human GDF5 arrests disease progression and stimulates cartilage repair in the rat medial meniscus transection (MMT) model of osteoarthritis. MMT, OA, rhGDF5
41  2017 Is GDF5 gene promoter polymorphism +104T/C associated with osteoarthritis in the Eastern of Turkey population? OA, SNP
42  2017 MicroRNA-132 upregulation promotes matrix degradation in intervertebral disc degeneration. IDD, miRNAs, NP
43  2017 Novel homozygous sequence variants in the GDF5 gene underlie acromesomelic dysplasia type-grebe in consanguineous families. AMDG
44  2017 Preparation and Evaluation of Dexamethasone (DEX)/Growth and Differentiation Factor-5 (GDF-5) Surface-Modified Titanium Using beta-Cyclodextrin-Conjugated Heparin (CD-Hep) for Enhanced Osteogenic Activity In Vitro and In Vivo. ALP, CCK-8, CD-Hep, DEX, SEM, Ti, XPS
45  2017 Signaling by growth/differentiation factor 5 through the bone morphogenetic protein receptor type IB protects neurons against kainic acid-induced neurodegeneration. CA1, KA, TdT, TGF-beta
46  2017 The use of heparin chemistry to improve dental osteogenesis associated with implants. PDLSC
47  2017 [Comparative study of proliferative and periodontal differentiation propensity of induced pluripotent stem cells at different passages]. BSP, CAP, CEMP1, iPSCs, OCN
48  2016 Adenovirus-mediated GDF-5 promotes the extracellular matrix expression in degenerative nucleus pulposus cells. Ad-GDF-5, BM, DNA, ECM, GFP, Hyp, IDD, NP, sGAG
49  2016 Association between GDF5 +104T/C polymorphism and knee osteoarthritis in Caucasian and Asian populations: a meta-analysis based on case-control studies. OA, RA
50  2016 Characterization of an acromesomelic dysplasia, Grebe type case: novel mutation affecting the recognition motif at the processing site of GDF5. ---
51  2016 Generation and periodontal differentiation of human gingival fibroblasts-derived integration-free induced pluripotent stem cells. EMD, ESCs, HGFs, iPSCs
52  2016 Heads, Shoulders, Elbows, Knees, and Toes: Modular Gdf5 Enhancers Control Different Joints in the Vertebrate Skeleton. ---
53  2016 Human Adipose Stem Cells Differentiated on Braided Polylactide Scaffolds Is a Potential Approach for Tendon Tissue Engineering. hASCs, MM, PLA, PLCL, TM
54  2016 Identification of plasma microRNA expression profile in radiographic axial spondyloarthritis-a pilot study. BASDI, miRNA, rad-axial SpA
55  2016 In Vitro Osteogenic Differentiation Enhanced by Zirconia Coated with Nano-Layered Growth and Differentiation Factor-5. OC, Osx, SEM, XPS, Zr
56  2016 MicroRNA-7 regulates IL-1beta-induced extracellular matrix degeneration by targeting GDF5 in human nucleus pulposus cells. IDD, IL-1beta, miRNAs, NP
57  2016 MiR-132-3p Regulates the Osteogenic Differentiation of Thoracic Ligamentum Flavum Cells by Inhibiting Multiple Osteogenesis-Related Genes. FOXO1, LF, SOX6
58  2016 Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-induced Smad1/5/8 phosphorylation. BMPs
59  2016 Preferential tendon stem cell response to growth factor supplementation. IGF-1, TGF-beta1, TSCs
60  2016 Prospective cohort study of the risk factors for stress fractures in Chinese male infantry recruits. ---
61  2016 Protection of cultured dopamine neurons from MPP(+) requires a combination of neurotrophic factors. BDNF, DA, GDNF, SN, TGF-beta, VTA
62  2016 Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation. NGF, SCG, TGF-beta
63  2015 Association study between growth differentiation factor 5 polymorphism and non-contact anterior cruciate ligament rupture in Chinese Han population. ACL
64  2015 Growth and differentiation factor-5 contributes to the structural and functional maintenance of the intervertebral disc. FGF, IDD, IGF-1, IVD, LBP, MSC, NP, TGF-beta
65  2015 Identification of Pathways Mediating Growth Differentiation Factor5-Induced Tenogenic Differentiation in Human Bone Marrow Stromal Cells. hMSCs
66  2015 Improved bone defect healing by a superagonistic GDF5 variant derived from a patient with multiple synostoses syndrome. BMP, NOG
67  2015 Role of growth differentiation factor-5 and bone morphogenetic protein type II receptor in the development of lumbar intervertebral disc degeneration. BMPR-II, IDD
68  2015 TGF-beta1, GDF-5, and BMP-2 stimulation induces chondrogenesis in expanded human articular chondrocytes and marrow-derived stromal cells. BMP-2, GAGs, HACs, hMSCs, TGF-beta1
69  2014 A comparative study of the effects of growth and differentiation factor 5 on muscle-derived stem cells and bone marrow stromal cells in an in vitro tendon healing model. BMSCs, MDSCs
70  2014 A novel strategy of spine defect repair with a degradable bioactive scaffold preloaded with adipose-derived stromal cells. ADS, MSC, PLGA, VB
71  2014 Comparison of GDF5 and GDNF as neuroprotective factors for postnatal dopamine neurons in ventral mesencephalic cultures. GDNF
72  2014 Dynamic profile and adipogenic role of growth differentiation factor 5 (GDF5) in the differentiation of 3T3-L1 preadipocytes. ---
73  2014 Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors. eSZ, EWS-ETS, EZH2
74  2014 Freeze-dried allograft-mediated gene or protein delivery of growth and differentiation factor 5 reduces reconstructed murine flexor tendon adhesions. ELISA, FDL, rAAV, RT-PCR
75  2014 GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition. DKK1, ECM, ELISA, MMP13, OA, qPCR
76  2014 Growth and differentiation factor-5 (GDF-5) in the human intervertebral annulus cells and its modulation by IL-1ss and TNF-alpha in vitro. ---
77  2014 Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure. BMPR, PGC-1alpha
78  2014 Growth/differentiation factor-5: pre-clinical and clinical evaluations of periodontal regeneration and alveolar augmentation--review. ACS, beta-TCP, PLGA
79  2014 MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes. ---
80  2014 Molecular analysis of two novel missense mutations in the GDF5 proregion that reduce protein activity and are associated with brachydactyly type C. ---
81  2014 Photo-cured hyaluronic acid-based hydrogels containing growth and differentiation factor 5 (GDF-5) for bone tissue regeneration. HA
82  2014 PI3K/Akt is involved in brown adipogenesis mediated by growth differentiation factor-5 in association with activation of the Smad pathway. BMP, DN, PGC-1alpha, PI3K
83  2014 Tendon proper- and peritenon-derived progenitor cells have unique tenogenic properties. ---
84  2014 The effect of a bioactive collagen membrane releasing PDGF or GDF-5 on bone regeneration. ALP, CMs, PDGF
85  2013 A GDF5 point mutation strikes twice--causing BDA1 and SYNS2. BDA1, BMP, NOG, OA
86  2013 A modified aggregate culture for chondrogenesis of human adipose-derived stem cells genetically modified with growth and differentiation factor 5. Ad-GDF5, ADSCs, hADSCs, sGAG
87  2013 A rare variant in the osteoarthritis-associated locus GDF5 is functional and reveals a site that can be manipulated to modulate GDF5 expression. OA, SNP
88  2013 Analysis of association between IL-1beta, CASP-9, and GDF5 variants and low-back pain in Chinese male soldier: clinical article. CASP-9, LBP, SNPs
89  2013 Association between the +104T/C polymorphism in the 5'UTR of GDF5 and susceptibility to knee osteoarthritis: a meta-analysis. CIs, ORs, UTR
90  2013 Association study of candidate genes for the progression of hand osteoarthritis. ASPN, BMP5, GARP, JSN, OA, OR, SNPs
91  2013 BMP2 and GDF5 induce neuronal differentiation through a Smad dependant pathway in a model of human midbrain dopaminergic neurons. BMP, DA
92  2013 Composite growth factor supplementation strategies to enhance tenocyte bioactivity in aligned collagen-GAG scaffolds. bFGF, IGF-1, PDGF-BB, SDF-1alpha
93  2013 Construction of self-assembled cartilage tissue from bone marrow mesenchymal stem cells induced by hypoxia combined with GDF-5. CM, DMMB, GAG, hMSCs
94  2013 Effect of gene polymorphisms on the mechanical properties of human tendon structures. MMP3
95  2013 Genetic polymorphisms associated with intervertebral disc degeneration. CILP, COX2, DD, HAPLN1, PARK2, PSMB9, TIMP
96  2013 Growth and differentiation factor-5 regulates the growth and differentiation of human dental pulp cells. ALP
97  2013 Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development. BMP
98  2013 Growth differentiation factor 5 regulation in bone regeneration. BMP
99  2013 Growth differentiation factor-5 enhances in vitro mesenchymal stromal cell chondrogenesis and hypertrophy. EO, GAG, MSCs, TGF
100  2013 Negative mutation screening of the NOG, BMPR1B, GDF5, and FGF9 genes indicates further genetic heterogeneity of the facioaudiosymphalangism syndrome. ---