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■ Abbreviation / Long Form : GK / Goto-Kakizaki

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Total Number of Papers: 722
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Abbreviation:   GK  (>> Co-occurring Abbreviation)
Long Form:   Goto-Kakizaki
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No. Year Title Co-occurring Abbreviation
2020 A sea cucumber (Holothuria leucospilota) polysaccharide improves the gut microbiome to alleviate the symptoms of type 2 diabetes mellitus in Goto-Kakizaki rats. CD36, GLUT4, HLP, PI3K, PPAR-alpha, PPARgamma, T2DM
2020 A second-generation glucagon-like peptide-1 receptor agonist mitigates vomiting and anorexia while retaining glucoregulatory potency in lean diabetic and emetic mammalian models. B12-Ex4, Ex-4, GLP-1R
2020 ApolipoproteinM overexpression through adeno-associated virus gene transfer improves insulin secretion and insulin sensitivity in Goto-Kakizaki rats. AAV, ApoM, HEC, OGTT
2020 Characteristics of Gastric Microbiota in GK Rats with Spontaneous Diabetes: A Comparative Study. BG, LEfSe, SPF, T2DM
2020 Comprehensive analysis of long non-coding RNAs and mRNAs in skeletal muscle of diabetic Goto-Kakizaki rats during the early stage of type 2 diabetes. DELs, lncRNAs, T2D
2020 Danggui Buxue decoction ameliorates lipid metabolic defects involved in the initiation of diabetic atherosclerosis; identification of active compounds. ABCs, Chol, DA, DBD, HDL-C, HOMA- IR, LDL-C, TG, TNF-alpha
2020 Diabetes-Induced Inflammation and Vascular Alterations in the Goto-Kakizaki Rat Retina. B1R, VEGF
2020 Dominant gut Prevotella copri in gastrectomised non-obese diabetic Goto-Kakizaki rats improves glucose homeostasis through enhanced FXR signalling. FXR, VSG
2020 Effect of Diquafosol Ophthalmic Solution on Airflow-Induced Ocular Surface Disorder in Diabetic Rats. DQS
10  2020 Examination of nicotine and saccharin reward in the Goto-Kakizaki diabetic rat model. CPP, SD
11  2020 GSTO1 regulates insulin biosynthesis in pancreatic beta cells. GSTO1, Pdx1
12  2020 Implication of glycogen synthase kinase 3 in diabetes-associated islet inflammation. GSK-3, T2D
13  2020 Increased inflammation, oxidative stress and a reduction in antioxidant defense enzymes in perivascular adipose tissue contribute to vascular dysfunction in type 2 diabetes. PVAT
14  2020 Major Improvement in Wound Healing Through Pharmacologic Mobilization of Stem Cells in Severely Diabetic Rats. DFU
15  2020 Osmotic diuresis by SGLT2 inhibition stimulates vasopressin-induced water reabsorption to maintain body fluid volume. AQP, BFV
16  2020 Resveratrol ameliorates inflammatory and oxidative stress in type 2 diabetic Goto-Kakizaki rats. IL-1beta, IL-6, NF-kappaB, SD, TNF-alpha
17  2020 Single-Anastomosis Duodenal Jejunal Bypass Improve Glucose Metabolism by Regulating Gut Microbiota and Short-Chain Fatty Acids in Goto-Kakisaki Rats. DJB-sa, FBG, FSI, GLP-1, GPR109A, GPR41, GPR43, IPGTT, SCFAs
18  2020 The insulin resistance is reversed by exogenous 3,5,3'triiodothyronine in type 2 diabetic Goto-Kakizaki rats by an inflammatory-independent pathway. DM, T2DM
19  2020 The Leading Role of Peptide Tyrosine Tyrosine in Glycemic Control After Roux-en-Y Gastric Bypass in Rats. AUCs, PYY, RYGB
20  2020 Type II diabetes accentuates diaphragm blood flow increases during submaximal exercise in the rat. BF, CON, T2DM
21  2020 Yu Nu Compound Regulates Autophagy and Apoptosis Through mTOR in vivo and vitro. CCK-8, DN
22  2019 1,25-Dihydroxy vitamin D3 treatment attenuates osteopenia, and improves bone muscle quality in Goto-Kakizaki type 2 diabetes model rats. T2DM, TXNIP
23  2019 Activated PPARbeta/delta Protects Pancreatic beta Cells in Type 2 Diabetic Goto-Kakizaki Rats from Lipoapoptosis via GPR40. ERK, GPR, HFD, PAM, PPAR
24  2019 Alterations of Brain Energy Metabolism in Type 2 Diabetic Goto-Kakizaki Rats Measured In Vivo by 13C Magnetic Resonance Spectroscopy. T2D, TCA
25  2019 Anomalous bone changes in ovariectomized type 2 diabetic rats: inappropriately low bone turnover with bone loss in an estrogen-deficient condition. T2DM, WT
26  2019 Cardiac metabolic modulation upon low-carbohydrate low-protein ketogenic diet in diabetic rats studied in vivo using hyperpolarized 13 C pyruvate, butyrate and acetoacetate probes. 13 C-MRS, KD
27  2019 Characterization of the Goto-Kakizaki (GK) Rat Model of Type 2 Diabetes. ---
28  2019 Combination of metformin and p38 MAPK inhibitor, SB203580, reduced myocardial ischemia/reperfusion injury in non-obese type 2 diabetic Goto-Kakizaki rats. I/R, p38 MAPK, ROS
29  2019 Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance. BN, eQTLs, SHR
30  2019 Effects of 830 nm low-power laser irradiation on body weight gain and inflammatory cytokines in experimental diabetes in different animal models. LPLI, SD, STZ
31  2019 Effects of combined treatment with blood flow restriction and low-intensity electrical stimulation on diabetes mellitus-associated muscle atrophy in rats. AGEs, Bfr, DM, ERK, ES, RAGE, rpS6
32  2019 Effects of Resveratrol in Goto-Kakizaki Rat, a Model of Type 2 Diabetes. SD
33  2019 Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption. BBR, TB-2
34  2019 Extract of ice plant (Mesembryanthemum crystallinum) ameliorates hyperglycemia and modulates the gut microbiota composition in type 2 diabetic Goto-Kakizaki rats. AUC, RSM
35  2019 Fumarate accumulation involved in renal diabetic fibrosis in Goto-Kakizaki rats. HIF-1alpha, TGF-beta1
36  2019 FXR Mediates Adenylyl Cyclase 8 Expression in Pancreatic beta-Cells. ADCY8, FXR, SRC1
37  2019 GLP-1 mediated improvement of the glucose tolerance in the T2DM GK rat model after massive jejunal resection. GLP-1
38  2019 Glycogen metabolism is impaired in the brain of male type 2 diabetic Goto-Kakizaki rats. MRS, T2D
39  2019 Hypothesis and Theory: Circulating Alzheimer's-Related Biomarkers in Type 2 Diabetes. Insight From the Goto-Kakizaki Rat. AD, BDNF, CBS, T2D
40  2019 Influence of a Hyperglycemic Microenvironment on a Diabetic Versus Healthy Rat Vascular Endothelium Reveals Distinguishable Mechanistic and Phenotypic Responses. HG, MS/MS, RCMVECs, ROS, T2DM, WKY
41  2019 Integrated 16S rRNA Sequencing, Metagenomics, and Metabolomics to Characterize Gut Microbial Composition, Function, and Fecal Metabolic Phenotype in Non-obese Type 2 Diabetic Goto-Kakizaki Rats. COG, KEGG, T2DM
42  2019 Intestinal electrical stimulation attenuates hyperglycemia and prevents loss of pancreatic beta cells in type 2 diabetic Goto-Kakizaki rats. GLP-1, IES, ITT, OGTT
43  2019 Obesity and inactivity, not hyperglycemia, cause exercise intolerance in individuals with type 2 diabetes: Solving the obesity and inactivity versus hyperglycemia causality dilemma. ---
44  2019 Profiling and activity screening of Dammarane-type triterpen saponins from Gynostemma pentaphyllum with glucose-dependent insulin secretory activity. GP
45  2019 Progression of diabetic kidney disease in T2DN rats. DKD, T2DN
46  2019 Protective Effect of Resveratrol against Ischemia-Reperfusion Injury via Enhanced High Energy Compounds and eNOS-SIRT1 Expression in Type 2 Diabetic Female Rat Heart. ATP, PCr, RSV
47  2019 Retinal Deficits Precede Cognitive and Motor Deficits in a Rat Model of Type II Diabetes. ---
48  2019 Role of hepatic neuregulin 4 in the regulation of gluconeogenesis in mice. G6Pase, Nrg4, PEPCK, PGC-1alpha
49  2019 Roux-en-Y gastric bypass enhances insulin secretion in type 2 diabetes via FXR-mediated TRPA1 expression. AcH3, BAs, FXR, GSIS, IVGTT, RYGB, SRC1, TRPA1
50  2019 Skeletal muscle energetics are compromised only during high-intensity contractions in the Goto-Kakizaki rat model of type 2 diabetes. T2D, WC, WG
51  2019 Stem Cells from Human Exfoliated Deciduous Teeth Ameliorate Diabetic Nephropathy In Vivo and In Vitro by Inhibiting Advanced Glycation End Product-Activated Epithelial-Mesenchymal Transition. DN, EMT, GFP, IHC, MSCs, SHED
52  2019 Stem cells from human exfoliated deciduous teeth ameliorate type II diabetic mellitus in Goto-Kakizaki rats. BMSCs, DM, HE, IHC, IPITTs, IRTs, MSCs, PAS, SHED, T2DM
53  2019 The calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification. CaVgamma4
54  2019 The calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification. CaVgamma4
55  2019 The Changes of Serum Metabolites in Diabetic GK Rats after Ileal Transposition Surgery. HOMA-IR, IT, LC-MS
56  2019 The Chinese Herbal Formula Shenzhu Tiaopi Granule Results in Metabolic Improvement in Type 2 Diabetic Rats by Modulating the Gut Microbiota. CHF, FBG, STG, T2DM
57  2019 Transcriptome Changes of Skeletal Muscle RNA-Seq Speculates the Mechanism of Postprandial Hyperglycemia in Diabetic Goto-Kakizaki Rats During the Early Stage of T2D. RNA-Seq
58  2019 Transcriptomic responses of hypothalamus to acute exercise in type 2 diabetic Goto-Kakizaki rats. DEGs, T2D
59  2019 Transcriptomic Responses of Skeletal Muscle to Acute Exercise in Diabetic Goto-Kakizaki Rats. T2D
60  2019 Type 2 diabetes mellitus in the Goto-Kakizaki rat impairs microvascular function and contributes to premature skeletal muscle fatigue. TX
61  2019 [Mechanism of Danzhi Jiangtang Capsules in treatment of diabetic macrovascular disease in GK rats based on correlation between microRNAs and inflammatory factors]. DJC, L-NAME, NOS, TC
62  2018 A Glucagon-Like Peptide-1 Receptor Agonist Lowers Weight by Modulating the Structure of Gut Microbiota. ---
63  2018 Altered Purinergic Receptor Sensitivity in Type 2 Diabetes-Associated Endothelial Dysfunction and Up₄A-Mediated Vascular Contraction. T2D, WT
64  2018 Amaranthus caudatus Stimulates Insulin Secretion in Goto-Kakizaki Rats, a Model of Diabetes Mellitus Type 2. AC, AUC, LC-MS, NMR, OGTT
65  2018 Apelin‑13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high‑fat diet. cNOS, FINS, FPG, GLUT4, HFD, IR, NO, TC, TG
66  2018 Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats. AD, Ex-4, GLP-1, IGF-1, PI3K, PKA, s.c, T2D
67  2018 Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat. CVD, DM, T2DM
68  2018 Cell shortening and calcium dynamics in epicardial and endocardial myocytes from the left ventricle of Goto-Kakizaki type 2 diabetic rats. ENDO, EPI
69  2018 Chronic Stress Disturbs Metabolome of Blood Plasma and Urine in Diabetic Rats. CUMS, LC/MS
70  2018 Effect of hindlimb unloading and reloading on the soleus and plantaris muscles in diabetic rats. GC, GR, GS, WC, WR, WS
71  2018 Effects of Diet on Bile Acid Metabolism and Insulin Resistance in Type 2 Diabetic Rats after Roux-en-Y Gastric Bypass. BA, CH, RYGB
72  2018 Effects of pioglitazone on ventricular myocyte shortening and Ca(2+) transport in the Goto-Kakizaki type 2 diabetic rat. PIO
73  2018 Ellagic Acid Alleviates Hepatic Oxidative Stress and Insulin Resistance in Diabetic Female Rats. EA, HOMA-IR, NAFLD, Nrf2, T2DM
74  2018 Fermentation Products of Paenibacillus bovis sp. nov. BD3526 Alleviates the Symptoms of Type 2 Diabetes Mellitus in GK Rats. T2DM
75  2018 Ginsenoside Ameliorates Cognitive Dysfunction in Type 2 Diabetic Goto-Kakizaki Rats. CON, DM, MDA, SOD
76  2018 Ileal transposition rapidly improves glucose tolerance and gradually improves insulin resistance in non-obese type 2 diabetic rats. AUC, FINS, FPG, GLP-1, GLP-1R, HOMA-IR, OGTT, Sham group, T2DM
77  2018 Ileal Transposition Surgery Decreases Fat Mass and Improves Glucose Metabolism in Diabetic GK Rats: Possible Involvement of FGF21. eWAT, FBG, FGF21, FGFR1, IT, pWAT, Sham-IT group, sWAT, UCP1, WAT
78  2018 Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus. T2D
79  2018 Insulin does not rescue cortical and trabecular bone loss in type 2 diabetic Goto-Kakizaki rats. T2DM
80  2018 Integrative Analysis of Genome and Expression Profile Data Reveals the Genetic Mechanism of the Diabetic Pathogenesis in Goto Kakizaki (GK) Rats. GSIS, PASS, SAAC, T2D
81  2018 Liraglutide improves cognitive impairment via the AMPK and PI3K/Akt signaling pathways in type 2 diabetic rats. AMPK, mTOR, PI3K, T2DM
82  2018 Low molecular weight fucoidan ameliorates hindlimb ischemic injury in type 2 diabetic rats. DM, LMWF, PAD
83  2018 Lupinus mutabilis Extract Exerts an Anti-Diabetic Effect by Improving Insulin Release in Type 2 Diabetic Goto-Kakizaki Rats. AUC, LM, OGTT
84  2018 Mechanism of Astragalus polysaccharides in attenuating insulin resistance in Rats with type 2 diabetes mellitus via the regulation of liver microRNA‑203a‑3p. APS, CHOP, ERS, GRP, IR, mi, miR, p-JNK, T2DM
85  2018 Metformin restores electrophysiology of small conductance calcium-activated potassium channels in the atrium of GK diabetic rats. ---
86  2018 MicroRNA-216b actively modulates diabetic angiopathy through inverse regulation on FZD5. FZD5, MMECs
87  2018 Oral Glucose Tolerance and Tryptophan Metabolism in Non-Obese and Non-Insulin-Dependent Diabetic Goto-Kakizaki Rats Fed High-Tryptophan Diets. Trp
88  2018 Sitagliptin improved glucose assimilation in detriment of fatty-acid utilization in experimental type-II diabetes: role of GLP-1 isoforms in Glut4 receptor trafficking. 18FDG, FAT, GLP-1, GLUT4
89  2018 Starch synthase IIIa and starch branching enzyme IIb-deficient mutant rice line ameliorates pancreatic insulin secretion in rats: screening and evaluating mutant rice lines with antidiabetic functionalities. iAUC
90  2018 The Effects of Sleeve Gastrectomy on Glucose Metabolism and Glucagon-Like Peptide 1 in Goto-Kakizaki Rats. GLP-1, OGTT, SG
91  2018 The Favorable Effect of Empagliflozin on Erectile Function in an Experimental Model of Type 2 Diabetes. ED, T2DM
92  2018 The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto-Kakizaki Type 2 Diabetic Rat Heart. HCN1, SAN
93  2018 The pattern of plasma BCAA concentration and liver Bckdha gene expression in GK rats during T2D progression. BCAA, T2D
94  2018 Voltage dependence of the Ca2+ transient in endocardial and epicardial myocytes from the left ventricle of Goto-Kakizaki type 2 diabetic rats. CON, ENDO, EPI
95  2018 Weaning stage hyperglycemia induces glucose-insensitivity in arcuate POMC neurons and hyperphagia in type 2 diabetic GK rats. ARC, POMC
96  2018 [Protective effect of Yiqi Huoxue decoction on kidney in diabetic GK rats]. Chol, CREA, FBG, GSH-Px, PAS, U-CREA, U-GLU, UA
97  2017 A mini-network balance model for evaluating the progression of cardiovascular complications in Goto-Kakizaki rats. CVR, Sal A, T2DM
98  2017 Age-Related Reduction of Contractile Responses to Urotensin II Is Seen in Aortas from Wistar Rats but Not from Type 2 Diabetic Goto-Kakizaki Rats. MAPK, UII, UT
99  2017 Compromised Neurotrophic and Angiogenic Regenerative Capability during Tendon Healing in a Rat Model of Type-II Diabetes. DM-II, qRT-PCR, SCX, TNMD
100  2017 Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats. HFD, WKY