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■ Abbreviation / Long Form : GK / glucokinase

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Total Number of Papers: 471
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Abbreviation:   GK  (>> Co-occurring Abbreviation)
Long Form:   glucokinase
 Abbreviation Variation
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No. Year Title Co-occurring Abbreviation
2020 Angiotensin-(1-7) improves Islet Function in a Rat Model of Streptozotocin-induced Diabetes Mellitus by Up-regulating the Expression of Pdx1/Glut2. DM, GLUT2, HOMA-IR, Pdx1
2020 Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator. GKA
2020 Effects of dietary exogenous xylanase supplementation on growth performance, intestinal health, and carbohydrate metabolism of juvenile large yellow croaker, Larimichthys crocea. G6PD
2020 Glucokinase Activators for Type 2 Diabetes: Challenges and Future Developments. GKAs, T2DM
2020 Glucose in the hypothalamic paraventricular nucleus regulates GLP-1 release. GLP-1, PVN
2020 Molecular insight into conformational transformation of human glucokinase: conventional and targeted molecular dynamics. ---
2020 Nanocurcumin improved glucose metabolism in streptozotocin-induced diabetic rats: a comparison study with Gliclazide. FBG, GLUT2, GLZ, GS, INS, IRA, nanoCUR, STZ
2020 P2Y12 shRNA normalizes inflammatory dysfunctional hepatic glucokinase activity in type 2 diabetic rats. shRNA, SND, T2DM
2020 Recent Developments in Medicinal Chemistry of Allosteric Activators of Human Glucokinase for Type 2 Diabetes Mellitus Therapeutics. T2DM
10  2020 The effect of candesartan on chronic stress induced imbalance of glucose homeostasis. G6P, GLUT2, GR, GS, HK, ISR, LDH, RAS, SDH
11  2020 The role of a new insulin-like peptide in the pearl oyster Pinctada fucata martensii. GSK-3beta, MAPK, PCNA, PI3K, PP1
12  2019 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and small chemical activators affect enzyme activity of activating glucokinase mutants by distinct mechanisms. FBPase-2, GKAs, PFK-2
13  2019 A potential probiotic Chromobacterium aquaticum with bacteriocin-like activity enhances the expression of indicator genes associated with nutrient metabolism, growth performance and innate immunity against pathogen infections in zebrafish (Danio rerio). G6Pase, GHR, HK, IGF-1
14  2019 Activating Effects of Phenolics from Apache Red Zea mays L. on Free Fatty Acid Receptor 1 and Glucokinase Evaluated with a Dual Culture System with Epithelial, Pancreatic, and Liver Cells. ---
15  2019 Amelioration by quercetin of insulin resistance and uterine GLUT4 and ERalpha gene expression in rats with polycystic ovary syndrome (PCOS). DHEA, ERalpha, GLUT4, HK, HOMA-IR, IR, PCOS
16  2019 Assessing Cofactor Usage in Pseudoclostridium thermosuccinogenes via Heterologous Expression of Central Metabolic Enzymes. XK
17  2019 Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice. BBR, GC-MS, GKRP, PK-PD
18  2019 Combination of honey with metformin enhances glucose metabolism and ameliorates hepatic and nephritic dysfunction in STZ-induced diabetic mice. G6Pase, PC, PDK, PEPCK
19  2019 Comparative analysis of glucose metabolism responses of large yellow croaker Larimichthys crocea fed diet with fish oil and palm oil. FO, GLUT2, GYS, IR1, IR2, IRS-1, NEFA, PEPCK, PO, TG
20  2019 Design, synthesis and evaluation of novel 3,5-disubstituted benzamide derivatives as allosteric glucokinase activators. ---
21  2019 Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala. ACC, FAS, G6Pase, G6PDH, GLUT2, GS, IRS-1, PEPCK, PI3K, PK, S6K1, SREBP1, TC, TG, TOR
22  2019 Forkhead box O1 in turbot Scophthalmus maximus: Molecular characterization, gene structure, tissue distribution and the role in glucose metabolism. foxo1, g6pase1, g6pase2
23  2019 How Heterogeneity in Glucokinase and Gap-Junction Coupling Determines the Islet [Ca2+] Response. ---
24  2019 N-pyridin-2-yl benzamide analogues as allosteric activators of glucokinase: Design, synthesis, in vitro, in silico and in vivo evaluation. OGTT
25  2019 Panax ginseng improves glucose metabolism in streptozotocin-induced diabetic rats through 5' adenosine monophosphate kinase up-regulation. AMPK, GLUT-2, GS, IRA, STZ
26  2019 Sensing Glucose in the Central Melanocortin Circuits of Rainbow Trout: A Morphological Study. AgRP, POMC
27  2019 Targeting hepatic glucokinase to treat diabetes with TTP399, a hepatoselective glucokinase activator. GKA, GKRP
28  2019 The regulatory effect of saffron stigma on the gene expression of the glucose metabolism key enzymes and stress proteins in streptozotocin-induced diabetic rats. G6Pase, RT-PCR, SSE
29  2019 Therapeutic effects of ethanolic extract from the green cocoon shell of silkworm Bombyx mori on type 2 diabetic mice and its hypoglycaemic mechanism. AMPK, EE, G6Pase, GLUT4, GSH-Px, IL-6, IR, IRS, NF-kappaB, p-GSK3beta, PEPCK, PI3K, SOD, T2DM, TNF-alpha
30  2019 TTP399: an investigational liver-selective glucokinase (GK) activator as a potential treatment for type 2 diabetes. ---
31  2019 When a Little Bit More Makes the Difference: Expression Levels of GKRP Determines the Subcellular Localization of GK in Tanycytes. G6P, GKRP
32  2018 Anthocyanins from purple corn activate free fatty acid-receptor 1 and glucokinase enhancing in vitro insulin secretion and hepatic glucose uptake. ANC, C3G, C3G, D3G, FFAR1, GSIS
33  2018 Conformational transition pathway of R308K mutant glucokinase in the presence of the glucokinase activator YNKGKA4. ---
34  2018 Design, synthesis and biological evaluation of novel thiazol-2-yl benzamide derivatives as glucokinase activators. OGTT
35  2018 Determinants of human glucokinase activation and implications for small molecule allosteric control. MD, SAXS
36  2018 Discovery of a potent glucokinase activator with a favorable liver and pancreas distribution pattern for the treatment of type 2 diabetes mellitus. OGTT
37  2018 Effect of high dietary starch levels on growth, hepatic glucose metabolism, oxidative status and immune response of juvenile largemouth bass, Micropterus salmoides. ALP, AST, CAT, FBPase, FCR, iNOS, MDA, NO, PC, PER, PFK, PK, SGR, SOD
38  2018 Glucosensing capacity of rainbow trout telencephalon. AMPK, CREB, LXR, SGLT1
39  2018 Glutamate dehydrogenase: role in regulating metabolism and insulin release in pancreatic beta-cells. ---
40  2018 Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis. ARC
41  2018 Molecular characterization and identification of facilitative glucose transporter 2 (GLUT2) and its expression and of the related glycometabolism enzymes in response to different starch levels in blunt snout bream (Megalobrama amblycephala). G6P, GLUT, GLUT2, MFS, PEPCK, PK, qRT, UTR
42  2018 Octanoic acid potentiates glucose-stimulated insulin secretion and expression of glucokinase through the olfactory receptor in pancreatic beta-cells. CaMKK, GSIS, IP3R, OA, ORs
43  2018 Scutellariae Radix and Coptidis Rhizoma Improve Glucose and Lipid Metabolism in T2DM Rats via Regulation of the Metabolic Profiling and MAPK/PI3K/Akt Signaling Pathway. CR, ERK, FBPase, G6Pase, GLUT2, GP, GS, HFD, HSC, IRS-1, JNK, LSC, MAPK, p-Akt, p-PI3K, PEPCK, PFK, PI3K, PK, SR, STZ, T2DM
44  2018 Tucum-do-cerrado (Bactris setosa Mart.) may enhance hepatic glucose response by suppressing gluconeogenesis and upregulating Slc2a2 via AMPK pathway, even in a moderate iron supplementation condition. G6Pase, PFK-1, Tuc
45  2017 Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior. AgRP, AN, CART, NPY, POMC
46  2017 Blood glycemia-modulating effects of melanian snail protein hydrolysates in mice with typeII diabetes. G6Pase, HDL, HFD, MPh, PEPCK
47  2017 Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation. OGTT, T2DM
48  2017 Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus. FINS, GKA, SD, T2DM
49  2017 Hypoglycemic and hypolipidemic effects of a polysaccharide from Lachnum YM240 and its derivatives in mice, induced by a high fat diet and low dose STZ. AMPK, FBG, FFA, FINS, G6P, GLUT4, HbA1c, STZ, T2DM, TG
50  2017 Increased glucose metabolism and alpha-glucosidase inhibition in Cordyceps militaris water extract-treated HepG2 cells. CMW, GLUT2, GSK-3beta, HNF-1alpha, pAMPK, PDH, PI3K
51  2017 LncRNA NONRATT021972 siRNA normalized the dysfunction of hepatic glucokinase through AKT signaling in T2DM rats. GSK-3, lncRNAs, p-AKT, pGSK-3beta, siRNA, T2DM
52  2017 Structure based design, synthesis and biological evaluation of amino phosphonate derivatives as human glucokinase activators. GKAs
53  2017 TMG-123, a novel glucokinase activator, exerts durable effects on hyperglycemia without increasing triglyceride in diabetic animal models. ---
54  2016 Comparison of Regulation Mechanisms of Five Mulberry Ingredients on Insulin Secretion under Oxidative Stress. C3G, C3R, DNJ, GLP-1R, OXY, RES
55  2016 Dietary supplementation with xylanase-expressing B.amyloliquefaciens R8 improves growth performance and enhances immunity against Aeromonas hydrophila in Nile tilapia (Oreochromis niloticus). CF, FE, G6Pase, G6PD, IGF-1, SOD, WG
56  2016 DNA damage and differential gene expression associated with physical stress in gilthead seabream (Sparus aurata). ---
57  2016 Glucosensing in liver and Brockmann bodies of rainbow trout through glucokinase-independent mechanisms. BB, HSD, LXR, NSD, SIRT-1
58  2016 In type 1 diabetics, high-dose biotin may compensate for low hepatic insulin exposure, promoting a more normal expression of glycolytic and gluconeogenic enyzymes and thereby aiding glycemic control. CIIIT
59  2016 In vitro evidence in rainbow trout supporting glucosensing mediated by sweet taste receptor, LXR, and mitochondrial activity in Brockmann bodies, and sweet taste receptor in liver. BB, LXR, ROS, SGLT1, UCP2
60  2016 Influence of fermentation conditions on polysaccharide production and the activities of enzymes involved in the polysaccharide synthesis of Cordyceps militaris. IPS, PGI, PGM, UGD, UGP
61  2016 Investigational insulin secretagogues for type 2 diabetes. FFAR, GPR, T2D
62  2016 Leaf Extract from Lithocarpus polystachyus Rehd. Promote Glycogen Synthesis in T2DM Mice. G6P, GLUT2, IR, IRS, PEPCK, STZ
63  2016 MiR-206 is expressed in pancreatic islets and regulates glucokinase activity. GSIS, HFD, KO, miR
64  2016 Multiple Comparisons of Glucokinase Activation Mechanisms of Five Mulberry Bioactive Ingredients in Hepatocyte. C3G, C3R, DNJ, GKRP, OXY, RES
65  2016 Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394. ---
66  2016 Phycocyanin ameliorates alloxan-induced diabetes mellitus in mice: Involved in insulin signaling pathway and GK expression. FINS, GHb, GKRP, GSP
67  2016 ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes. LDH, PDH, PDK, PFK-1, PK, ROS, STZ-HFD
68  2016 Safety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study. AUC0-t, PD, PK
69  2016 Structural insight into the glucokinase-ligands interactions. Molecular docking study. ---
70  2016 The "metabolic sensor" function of rat supraoptic oxytocin and vasopressin neurons is attenuated during lactation but not in diet-induced obesity. DIO, HFD, OT, SON, VP
71  2016 The potential beneficial effects of phenolic compounds isolated from A. pilosa Ledeb on insulin-resistant hepatic HepG2 cells. AP, G6Pase, PEPCK
72  2016 Theoretical investigations on the interactions of glucokinase regulatory protein with fructose phosphates. F1P, F6P, GKRP
73  2016 Trigonella foenum-graecum Seed Extract, 4-Hydroxyisoleucine, and Metformin Stimulate Proximal Insulin Signaling and Increase Expression of Glycogenic Enzymes and GLUT2 in HepG2 Cells. FSE, GLUT2, GS, IR-beta, SREBP-1c
74  2015 Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity. GKRP, T2DM
75  2015 Antidiabetic potential of a novel dual-target activator of glucokinase and peroxisome proliferator activated receptor-gamma. PPARgamma
76  2015 Assessment of benzene induced oxidative impairment in rat isolated pancreatic islets and effect on insulin secretion. ---
77  2015 Effect of High Dietary Carbohydrate on the Growth Performance, Blood Chemistry, Hepatic Enzyme Activities and Growth Hormone Gene Expression of Wuchang Bream (Megalobrama amblycephala) at Two Temperatures. GH, HSI
78  2015 Effects of dietary glucose and dextrin on activity and gene expression of glucokinase and fructose-1,6-bisphosphatase in liver of turbot Scophthalmus maximus. FBPase, ORF
79  2015 Evidence for the Presence of Glucosensor Mechanisms Not Dependent on Glucokinase in Hypothalamus and Hindbrain of Rainbow Trout (Oncorhynchus mykiss). LXR, NSD, SGLT1
80  2015 Fermentation of Green Tea with 2% Aquilariae lignum Increases the Anti-Diabetic Activity of Green Tea Aqueous Extracts in the High Fat-Fed Mouse. fGT, G6Pase, GT, PEPCK, TC, TG
81  2015 Glucokinase activation is beneficial or toxic to cultured rat pancreatic islets depending on the prevailing glucose concentration. GSIS, Ro
82  2015 Hypoglycaemic activity of culinary Pleurotus ostreatus and P. cystidiosus mushrooms in healthy volunteers and type 2 diabetic patients on diet control and the possible mechanisms of action. GSK, PC, PO, SFDP
83  2015 Hypoglycemic and hypolipidemic properties of polysaccharides from Enterobacter cloacae Z0206 in KKAy mice. AMPK, ATGL, CPT1-alpha, FAS, G6P, GLUT2, HSL, LDL-C, SIRT1, TG
84  2015 Ischemic preconditioning maintains the immunoreactivities of glucokinase and glucokinase regulatory protein in neurons of the gerbil hippocampal CA1 region following transient cerebral ischemia. CA1, GKRP, IPC, SP
85  2015 Ligand-based modeling followed by in vitro bioassay yielded new potent glucokinase activators. NCI
86  2015 Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity. ChREBP, LXR, O-GlcNAc, OGT, SREBP
87  2015 Long-acting hypoglycemic effects of PEGylated FGF21 and insulin glargine in mice with type 1 diabetes. G6Pase, GLUT1, GLUT4, PEG-FGF21, PEPCK
88  2015 Molecular modeling and identification of novel glucokinase activators through stepwise virtual screening. GKA, MODY
89  2015 Molecular targeting of the GK-GKRP pathway in diabetes. GKA
90  2015 Mutations in exons 10 and 11 of human glucokinase result in conformational variations in the active site of the structure contributing to poor substrate binding - explains hyperglycemia in type 2 diabetic patients. ---
91  2015 Production of a mouse strain with impaired glucose tolerance by systemic heterozygous knockout of the glucokinase gene and its feasibility as a prediabetes model. CD
92  2015 Regulation of postnatal pancreatic Pdx1 and downstream target genes after gestational exposure to protein restriction in rats. BW
93  2015 Synthesis and Biological Evaluation of Novel Ursolic acid Derivatives as Potential Anticancer Prodrugs. Cyc-D1, GLUT1, UA
94  2015 Synthesis and biological evaluation of [C]AZ12504948; a novel tracer for imaging of glucokinase in pancreas and liver. ARG
95  2015 The dietary monounsaturated to saturated fatty acid ratio modulates the genetic effects of GCKR on serum lipid levels in children. GCKR, LDL, MUFA, MUFA
96  2015 The molecular mechanisms of liver and islets of Langerhans toxicity by benzene and its metabolite hydroquinone in vivo and in vitro. FBS, G6Pase, PEPCK
97  2015 UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma. 2-DG, GLUT1, UA
98  2015 Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities. GKA, SD, ZDF
99  2015 [Glucokinase and glucokinase regulatory proteins as molecular targets for novel antidiabetic drugs]. GKRP