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■ Abbreviation / Long Form : GSM / gamma-secretase modulator

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Total Number of Papers: 23
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Abbreviation:   GSM  (>> Co-occurring Abbreviation)
Long Form:   gamma-secretase modulator
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No. Year Title Co-occurring Abbreviation
2020 Radiosynthesis of a carbon-11 labeled tetrahydrobenzisoxazole derivative as a new PET probe for gamma-secretase imaging in Alzheimer's disease. Am
2017 Generation and Partial Characterization of Rabbit Monoclonal Antibody to Amyloid-beta Peptide 1-37 (Abeta37). Abeta37, Abeta37, AD, CSF, RabmAb
2017 Pharmacological and Toxicological Properties of the Potent Oral gamma-Secretase Modulator BPN-15606. AD
2017 Structural and Chemical Biology of Presenilin Complexes. APH1, APP
2017 Synergistic inhibition of Abeta production by combinations of gamma-secretase modulators. ---
2017 Trifluoromethyl Oxetanes: Synthesis and Evaluation as a tert-Butyl Isostere. LipE
2016 Beyond Chemoselectivity: Catalytic Site-Selective Aldolization of Diketones and Exploitation for Enantioselective Alzheimer's Drug Candidate Synthesis. ---
2016 Pharmacological properties of a novel and potent gamma-secretase modulator as a therapeutic option for the treatment of Alzheimer's disease. APP, GSIs, PAS
2016 Single administration of a novel gamma-secretase modulator ameliorates cognitive dysfunction in aged C57BL/6J mice. AD, APP, MCI, mRNA, PS1, PS2
10  2016 The gamma-Secretase Modulator, BMS-932481, Modulates Abeta Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers. CSF
11  2015 Modulation of Abeta42 in vivo by gamma-secretase modulator in primates and humans. ---
12  2014 Effect of potent gamma-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. PS1
13  2014 Identification and Preclinical Pharmacology of the gamma-Secretase Modulator BMS-869780. PD, PK
14  2014 Potent gamma-secretase inhibitors/modulators interact with amyloid-beta fibrils but do not inhibit fibrillation: a high-resolution NMR study. APP, GSI, STD
15  2013 An improved cell-based method for determining the gamma-secretase enzyme activity against both Notch and APP substrates. AD, GSIs, NICD
16  2013 gamma-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin. GSMs
17  2013 Orally bioavailable and brain-penetrant pyridazine and pyridine-derived gamma-secretase modulators reduced amyloidogenic Abeta peptides in vivo. AD, APP
18  2013 R-flurbiprofen improves tau, but not Ass pathology in a triple transgenic model of Alzheimer's disease. MRS, NSAID, RAWM
19  2012 Cerebrospinal fluid amyloid-beta (Abeta) as an effect biomarker for brain Abeta lowering verified by quantitative preclinical analyses. BACEi, CSF, GSI, PD, PK
20  2012 gamma-Secretase modulator in Alzheimer's disease: shifting the end. AbetaPP
21  2010 Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Abeta42, APP, TMS
22  2010 Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. AD, GSIs
23  2008 [Amyloid-beta 42 generating process may have a biological role in regulation of Notch signaling intensity]. gamma40, PS