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■ Abbreviation / Long Form : HSC / hepatic stellate cells

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Total Number of Papers: 1380
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Abbreviation:   HSC  (>> Co-occurring Abbreviation)
Long Form:   hepatic stellate cells
 Abbreviation Variation
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No. Year Title Co-occurring Abbreviation
2020 A network pharmacology approach to investigating the mechanism of Tanshinone IIA for the treatment of liver fibrosis. alpha-SMA, PPIs, TIIA
2020 Aberrant von Willebrand Factor Expression of Sinusoidal Endothelial Cells and Quiescence of Hepatic Stellate Cells in Nodular Regenerative Hyperplasia and Obliterative Portal Venopathy. ASMA, IHC, INCPH, NRH, OPV, vWF
2020 Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver. alpha-SMA, eNOS, hLSEC, TGF-beta
2020 CD8+ T cells regulate liver injury in obesity-related nonalcoholic fatty liver disease. NASH
2020 Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR-146a-5p. circRNA, circRSF1, miR, Rac1, RILD
2020 Circular RNA TUBD1 Acts as the miR-146a-5p Sponge to Affect the Viability and Pro-Inflammatory Cytokine Production of LX-2 Cells through the TLR4 Pathway. IRAK1, LPS, p-NF-kappaB, RILD, TLR4, TRAF6
2020 ClassC1 decoy oligodeoxynucleotide inhibits profibrotic genes expression in rat hepatic stellate cells. ODNs, TGF, TIMP
2020 Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver; Association with retinoic acid activity during fetal development. Cyp1b1, RA, STM
2020 Dynamic Changes in Function and Proteomic Composition of Extracellular Vesicles from Hepatic Stellate Cells during Cellular Activation. EV, hHSC, mHSC
10  2020 Epigenetic silencing of LncRNA ANRIL enhances liver fibrosis and HSC activation through activating AMPK pathway. alpha-SMA, AMPK, DNMT3A, LncRNAs
11  2020 Exogenous 8-hydroxydeoxyguanosine ameliorates liver fibrosis through the inhibition of Rac1-NADPH oxidase signaling. BDL, NOX, ROS, SMA, TGF
12  2020 Focal Adhesion Kinase Promotes Hepatic Stellate Cell Activation by Regulating Plasma Membrane Localization of TGFbeta Receptor 2. FAK, TGF-beta, TGFbetaR2
13  2020 Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis. GCDCA
14  2020 Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12. NRP-1
15  2020 Hepatocyte TNF Receptor-Associated Factor 6 Aggravates Hepatic Inflammation and Fibrosis by Promoting Lysine 6-Linked Polyubiquitination of Apoptosis Signal-Regulating Kinase 1. ASK1, Lys6, NASH, TRAF6
16  2020 Leptin promotes methionine adenosyltransferase 2A expression in hepatic stellate cells by the downregulation of E2F-4 via the beta-catenin pathway. MAT
17  2020 Liquiritigenin suppresses the activation of hepatic stellate cells via targeting miR-181b/PTEN axis. LQ, miR-181b, PTEN
18  2020 Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis. ATX, CFs
19  2020 Rat multicellular 3D liver microtissues to explore TGF-beta1 induced effects. AOP, HEP, KC
20  2020 STMN1 upregulation mediates hepatocellular carcinoma and hepatic stellate cell crosstalk to aggravate cancer by triggering the MET pathway. CAF, GEO, HCC, HGF
21  2020 SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis. FXR, NASH, OCA
22  2020 Taming the Savage Beast from Within - Tcf21, a Novel Regulator of Stellate Cell Deactivation. ---
23  2020 Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma. anti-PD-L1, HCC, ICB, M-MDSCs, MDSC, TILs
24  2020 Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivo. SFK
25  2020 TIM-4 interference in Kupffer cells against CCL4-induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway. APCs, KCs, LT, TIM-4
26  2020 Ursodeoxycholic acid alleviates experimental liver fibrosis involving inhibition of autophagy. HCQ, PBC, ptfLC3, UDCA
27  2019 (-)-Catechin-7-O-beta-d-Apiofuranoside Inhibits Hepatic Stellate Cell Activation by Suppressing the STAT3 Signaling Pathway. C7A, ECM, STAT3, TAA
28  2019 4 in 1: Antibody-free protocol for isolating the main hepatic cells from healthy and cirrhotic single rat livers. HMPhi, LSEC
29  2019 A cAbl-MRTF-A Feedback Loop Contributes to Hepatic Stellate Cell Activation. ERK, KO, MRTF-A, WT
30  2019 A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target. HFD, KCs, MCD, NASH, sAXL
31  2019 A non-autonomous role of MKL1 in the activation of hepatic stellate cells. CM, CTGF, ECM, HG
32  2019 A novel STAT3 inhibitor, STX-0119, attenuates liver fibrosis by inactivating hepatic stellate cells in mice. TAA
33  2019 A Nutraceutical Rich in Docosahexaenoic Acid Improves Portal Hypertension in a Preclinical Model of Advanced Chronic Liver Disease. ACLD, DHA, PH
34  2019 Activation of YAP attenuates hepatic damage and fibrosis in liver ischemia-reperfusion injury. IRI, OLT
35  2019 Adipose tissue-derived stem cells prevent fibrosis in murine steatohepatitis by suppressing IL-17-mediated inflammation. ADSCs, HICs, NASH
36  2019 Adoptive transfer of regulatory T cells stimulated by Allogeneic Hepatic Stellate Cells mitigates liver injury in mice with concanavalin A-induced autoimmune hepatitis. AIH, Con A
37  2019 Akt1 and Akt2 Isoforms Play Distinct Roles in Regulating the Development of Inflammation and Fibrosis Associated with Alcoholic Liver Disease. ALD, EBL, LPS, mTORC2, PDK1, PI3K
38  2019 Alogliptin alleviates liver fibrosis via suppression of activated hepatic stellate cell. DPP4, TGF-beta
39  2019 An aqueous extract of Stevia rebaudiana variety Morita II prevents liver damage in a rat model of cirrhosis that mimics the human disease. AES, NF-kappaB, Nrf2
40  2019 Astaxanthin inhibits proliferation and induces apoptosis of LX‑2 cells by regulating the miR‑29b/Bcl‑2 pathway. AST, Bcl
41  2019 Carvedilol improves liver cirrhosis in rats by inhibiting hepatic stellate cell activation, proliferation, invasion and collagen synthesis. PHT, TGF-beta1
42  2019 Carvedilol Inhibits Angiotensin II-Induced Proliferation and Contraction in Hepatic Stellate Cells through the RhoA/Rho-Kinase Pathway. ACE, alpha-SMA, CCK-8
43  2019 Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis. BA, OCA
44  2019 Comparison of Carotenoids for Their Antifibrogenic Effects in Hepatic Stellate Cells. ASTX, LT, mRNA, ROS, SMAD3
45  2019 Costunolide reduces glycolysis-associated activation of hepatic stellate cells via inhibition of hexokinase-2. HK2
46  2019 CTHRC1 expression in primary biliary cholangitis. CHB, CTHRC1, HC, PBC, PSC
47  2019 Curcumin and alpha/beta-Adrenergic Antagonists Cotreatment Reverse Liver Cirrhosis in Hamsters: Participation of Nrf-2 and NF-kappaB. AR, NF-kappaB, Nrf2
48  2019 Danshensu, a novel indoleamine 2,3-dioxygenase1 inhibitor, exerts anti-hepatic fibrosis effects via inhibition of JAK2-STAT3 signaling. DSS, HF, IDO1
49  2019 Design, synthesis, and antifibrosis evaluation of 4-(benzo-[c][1,2,5]thiadiazol-5-yl)-3(5)-(6-methyl- pyridin-2-yl)pyrazole and 3(5)-(6-methylpyridin- 2-yl)-4-(thieno-[3,2,-c]pyridin-2-yl)pyrazole derivatives. ALK5, MAP
50  2019 Disruption of crosstalk between LX-2 and liver cancer stem-like cells from MHCC97H cells by DFOG via inhibiting FOXM1. DFOG, FOXM1, HCC, HGF, LCSLCs
51  2019 Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPARgamma-dependent manner. DHA, PPARgamma
52  2019 Effects of duodenal-jejunal bypass surgery in ameliorating nonalcoholic steatohepatitis in diet-induced obese rats. DJB, MCD, NASH, PGZ
53  2019 Exogenous expression of caveolin-1 is sufficient for hepatic stellate cell activation. Cav-1
54  2019 Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling. ALK5, alpha-SMA, GDNF, GFRalpha1, SPR
55  2019 Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis. 2-AG, ALD, CB1R, mGluR5
56  2019 H19/miR-148a/USP4 axis facilitates liver fibrosis by enhancing TGF-beta signaling in both hepatic stellate cells and hepatocytes. EMT, TGF-beta, USP4
57  2019 Hormone-sensitive lipase is a retinyl ester hydrolase in human and rat quiescent hepatic stellate cells. REH
58  2019 IL-10-secreting human MSCs generated by TALEN gene editing ameliorate liver fibrosis through enhanced anti-fibrotic activity. AMMs, CM, IL-10, MSCs, qRT-PCR, RT-PCR, TAA, TALENs
59  2019 Immunopathogenesis of Hepatic Brucellosis. ---
60  2019 In vivo effects of PCB-126 and genistein on vitellogenin expression in zebrafish. PCB126, VTG
61  2019 Interaction Mechanisms Between the NOX4/ROS and RhoA/ROCK1 Signaling Pathways as New Anti- fibrosis Targets of Ursolic Acid in Hepatic Stellate Cells. ---
62  2019 Interleukin-1 Receptor Antagonist Modulates Liver Inflammation and Fibrosis in Mice in a Model-Dependent Manner. BDL, IL-1, IL-1ra
63  2019 Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-beta1/Smad3 and TGF-beta1/p38 MAPK Pathways. BDL, ECM, MAPK, TGF-beta1
64  2019 linc-SCRG1 accelerates liver fibrosis by decreasing RNA-binding protein tristetraprolin. alpha-SMA, lncRNAs, MMP-2, si- lincSCRG1, TTP
65  2019 Lipoprotein Lipase Up-regulation in Hepatic Stellate Cells Exacerbates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice. LPL, NASH
66  2019 Liver-Targeted Angiotensin Converting Enzyme 2 Therapy Inhibits Chronic Biliary Fibrosis in Multiple Drug-Resistant Gene 2-Knockout Mice. ACE2, Ang, Mdr2-KO, PSC, RAS
67  2019 lncRNA GAS5 restrains CCl4-induced hepatic fibrosis by targeting miR-23a through the PTEN/PI3K/Akt signaling pathway. GAS5, lncRNA, miR-23a, PTEN
68  2019 Loss of lncRNA-SNHG7 Promotes the Suppression of Hepatic Stellate Cell Activation via miR-378a-3p and DVL2. DVL2, lncRNA, SNHG7, TCF
69  2019 Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans. MPI
70  2019 Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis. ECM, MMPs
71  2019 Mediator MED23 regulates inflammatory responses and liver fibrosis. CXCL10, EHMT2, MED23, RORalpha
72  2019 Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma. HCC
73  2019 MicroRNA-101 suppresses liver fibrosis by downregulating PI3K/Akt/mTOR signaling pathway. CCN2, COL1alpha1, ECM, HCC, miR-101
74  2019 MicroRNA-326 attenuates hepatic stellate cell activation and liver fibrosis by inhibiting TLR4 signaling. NF-kappaB
75  2019 Moesin, an ERM family member, regulates hepatic fibrosis. ERM, MRTF-A, SRF
76  2019 Multitranscriptome analyses reveal prioritized genes specifically associated with liver fibrosis progression independent of etiology. HSCs
77  2019 Myofibroblast-specific YY1 promotes liver fibrosis. ECM, YY1
78  2019 Nanoparticle mediated silencing of tenascin C in hepatic stellate cells: effect on inflammatory gene expression and cell migration. MSNs, TN-C
79  2019 Non-coding RNA Associated Competitive Endogenous RNA Regulatory Network: Novel Therapeutic Approach in Liver Fibrosis. ceRNAs, circRNAs, ECM, lncRNAs, miRNAs, ncRNAs
80  2019 Obeticholic acid prevents carbon tetrachloride-induced liver fibrosis through interaction between farnesoid X receptor and Smad3. ECM, FXR, OCA
81  2019 Oroxylin A induces apoptosis of activated hepatic stellate cells through endoplasmic reticulum stress. ERS, OA
82  2019 p300 Acetyltransferase Is a Cytoplasm-to-Nucleus Shuttle for SMAD2/3 and TAZ Nuclear Transport in Transforming Growth Factor beta-Stimulated Hepatic Stellate Cells. NLS, TGF-beta
83  2019 P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation. ART, Fer-1
84  2019 PI3-kinase/Akt pathway-regulated membrane transportation of acid-sensing ion channel 1a/Calcium ion influx/endoplasmic reticulum stress activation on PDGF-induced HSC Activation. ASIC1a, ERS
85  2019 Pien-Tze-Huang ameliorates hepatic fibrosis via suppressing NF-kappaB pathway and promoting HSC apoptosis. ELISA, NF-kappaB, PZH
86  2019 PRC1 promotes GLI1-dependent osteopontin expression in association with the Wnt/beta-catenin signaling pathway and aggravates liver fibrosis. AST, GLI1, LF, PRC1
87  2019 Prevention of hepatic stellate cell activation using JQ1- and atorvastatin-loaded chitosan nanoparticles as a promising approach in therapy of liver fibrosis. alpha-SMA, RT
88  2019 Probucol ameliorates hepatic stellate cell activation and autophagy is associated with farnesoid X receptor. FXR
89  2019 Procyanidin B2 inhibits the activation of hepatic stellate cells and angiogenesis via the Hedgehog pathway during liver fibrosis. ECM, Hh, PB2, SAG
90  2019 Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases. alpha-SMA, BDL, BM, NOX, PTP1B
91  2019 Puerarin alleviates liver fibrosis via inhibition of the ERK1/2 signaling pathway in thioacetamide-induced hepatic fibrosis in rats. alpha-SMA, TAA, TGF-beta1
92  2019 Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells. SNARE
93  2019 Relevance of Autophagy in Parenchymal and Non-Parenchymal Liver Cells for Health and Disease. HCC
94  2019 Restoration of liver sinusoidal cell phenotypes by statins improves portal hypertension and histology in rats with NASH. ATO, CD, HFGFD, LSEC, NASH, PH, SIM
95  2019 Reversion of in vivo fibrogenesis by novel chromone scaffolds. BLM, DHLFs, HLECs, IPF, LTBP-1
96  2019 Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats. HSA, MLC, PDGFRbeta, pPB, PTH
97  2019 Role of AGAP2 in the profibrogenic effects induced by TGFbeta in LX-2 hepatic stellate cells. FAK, TGF-beta1, TGFR2
98  2019 Role of hepatic stellate cell (HSC)-derived cytokines in hepatic inflammation and immunity. HSCs
99  2019 Serum response factor (SRF) promotes ROS generation and hepatic stellate cell activation by epigenetically stimulating NCF1/2 transcription. cKO, MCD, ROS, SRF, TAA
100  2019 Silencing of EPCAM suppresses hepatic fibrosis and hepatic stellate cell proliferation in mice with alcoholic hepatitis via the PI3K/Akt/mTOR signaling pathway. AH, EpCAM