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■ Abbreviation / Long Form : HSV-TK / herpes simplex virus thymidine kinase

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Total Number of Papers: 748
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Abbreviation:   HSV-TK  (>> Co-occurring Abbreviation)
Long Form:   herpes simplex virus thymidine kinase
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2022 Efficacy of HSV-TK/GCV system suicide gene therapy using SHED expressing modified HSV-TK against lung cancer brain metastases. GCV, NSCLC, SHED
2022 Hypoxia-directed tumor targeting of CRISPR-Cas9 and HSV-TK suicide gene therapy using lipid nanoparticles. CMV, HIF-1, HRE, LNPs
2022 Improving the Safety of Mesenchymal Stem Cell-Based Ex Vivo Therapy Using Herpes Simplex Virus Thymidine Kinase. GCV, MSCs, SAEs, VGCV
2022 In vitro assessment of an engineered tBID-based safety switch system in human T lymphocytes. iCasp9, TMP
2022 Potent bystander effect and tumor tropism in suicide gene therapy using stem cells from human exfoliated deciduous teeth. GCV, SHED, SHEDTK
2022 Preclinical gene therapy in glioblastoma multiforme: Using olfactory ensheathing cells containing a suicide gene. GBM, GCV, OEC-tks, OECs
2022 Selective Depletion of Adult GFAP-Expressing Tanycytes Leads to Hypogonadotropic Hypogonadism in Males. GCV, GFAP, GnRH, NSPCs, SGZ, SVZ
2022 Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells. GCV
2021 An AAV gene therapy computes over multiple cellular inputs to enable precise targeting of multifocal hepatocellular carcinoma in mice. AAV
10  2021 An Efficient Strategy for Obtaining Mutants by Targeted Gene Deletion in Ophiostoma novo-ulmi. DED, HR, NHEJ, TFs, WT
11  2021 Cytopathic effects and local immune responses in repeated neoadjuvant HSV-tk + ganciclovir gene therapy for prostate cancer. GCV, GT, LI, PCa, ssDNA
12  2021 Depletion of T cells via Inducible Caspase 9 Increases Safety of Adoptive T-Cell Therapy Against Chronic Hepatitis B. HBV, iC9, S-CAR, TCR
13  2021 Engineered TCR-T Cell Immunotherapy in Anticancer Precision Medicine: Pros and Cons. ImmTAC, TCRs
14  2021 Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP). ABC, BCRP, GCV, MRPs, MTX
15  2021 Improved safety of induced pluripotent stem cell-derived antigen-presenting cell-based cancer immunotherapy. GCV, GM-CSF, iCasp9, iPSCs
16  2021 Intracerebral Administration of Autologous Mesenchymal Stem Cells as HSV-TK Gene Vehicle for Treatment of Glioblastoma Multiform: Safety and Feasibility Assessment. GBM, MSCs, OS, PFS
17  2021 Iron Oxide Nanoparticles Promote Cx43-Overexpression of Mesenchymal Stem Cells for Efficient Suicide Gene Therapy during Glioma Treatment. Cx43, GCV, GJIC, MFIONs, MSCs
18  2021 Neural Progenitor Cells Expressing Herpes Simplex Virus-Thymidine Kinase for Ablation Have Differential Chemosensitivity to Brivudine and Ganciclovir. BVDU, GCV, NPC, SCI
19  2021 Poly(ethylene glycol)-Poly(beta-amino ester)-Based Nanoparticles for Suicide Gene Therapy Enhance Brain Penetration and Extend Survival in a Preclinical Human Glioblastoma Orthotopic Xenograft Model. ePBAE, GBM, NPs, PEG-PBAE
20  2021 Polymeric Nanovectors Incorporated with Ganciclovir and HSV-tk Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy. epsilon-CL, GCV, GCV-PCL, GDEPT
21  2020 A human Myogenin promoter modified to be highly active in alveolar rhabdomyosarcoma drives an effective suicide gene therapy. ARMS
22  2020 Complete regression of metastatic de-differentiated liposarcoma with engineered mesenchymal stromal cells with dTRAIL and HSV-TK. DDLPS, dTRAIL, GCV, MSC, PDCs
23  2020 Demonstration of anti-tumour bystander killing with prodrug-preloaded suicide gene-engineered tumour cells: a potential improvement for cancer therapeutics. GCV
24  2020 Engineering and Characterization of Oncolytic Vaccinia Virus Expressing Truncated Herpes Simplex Virus Thymidine Kinase. OVV
25  2020 Gene Therapy Using Neural Stem/Progenitor Cells Derived from Human Induced Pluripotent Stem Cells: Visualization of Migration and Bystander Killing Effect. GCV, hiPSCs
26  2020 Implication of in vivo circulating fibrocytes ablation in experimental pulmonary hypertension murine model. alpha-SMA, CF, PH
27  2020 Improvement of the dP-nucleoside-mediated herpes simplex virus thymidine kinase negative-selection system by manipulating dP metabolism genes. ---
28  2020 Selective Elimination of NG2-Expressing Hair Follicle Stem Cells Exacerbates the Sensitization Phase of Contact Dermatitis in a Transgenic Rat Model. GCV, HFSCs, Tg
29  2020 Suicide Gene Therapy Mediated with Exosomes Produced by Mesenchymal Stem/Stromal Cells Stably Transduced with HSV Thymidine Kinase. GCV, MSCs
30  2019 Cell-based interferon gene therapy using proliferation-controllable, interferon-releasing mesenchymal stem cells. IFN-gamma
31  2019 Depletion of Bone Marrow-Derived Fibrocytes Attenuates TAA-Induced Liver Fibrosis in Mice. FC, TAA
32  2019 Epithelial ovarian cancer: feasibility of image-guided intratumoral radiofrequency hyperthermia-enhanced direct gene therapy. PBS, RFH
33  2019 Human embryonic stem cell-derived cardiomyocyte therapy in mouse permanent ischemia and ischemia-reperfusion models. ESC-CM, ESC-Rep-CMs, Fluc, GFP, IR, LAD, LVEF, LVFS, PI
34  2019 Human Genomic Safe Harbors and the Suicide Gene-Based Safeguard System for iPSC-Based Cell Therapy. GSHs, hiPSCs
35  2019 Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma. EGFR, GBM, GCV, GFP, valGCV
36  2019 Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies. AT/RT, MB, PBAE
37  2019 Preclinical Proof-of-Concept, Analytical Development, and Commercial Scale Production of Lentiviral Vector in Adherent Cells. LV, LV-TK
38  2019 Rapid Regulation of Human Mesenchymal Stem Cell Proliferation Using Inducible Caspase-9 Suicide Gene for Safe Cell-Based Therapy. GCV, iC9, Nluc
39  2019 Suicide Gene Therapy Against Malignant Gliomas by the Local Delivery of Genetically Engineered Umbilical Cord Mesenchymal Stem Cells as Cellular Vehicles. GBM, GCV, MSCs
40  2019 Targeted AAVP-based therapy in a mouse model of human glioblastoma: a comparison of cytotoxic versus suicide gene delivery strategies. AAVP, GCV, TNF
41  2018 A Herpes Simplex Virus Thymidine Kinase-Induced Mouse Model of Hepatocellular Carcinoma Associated with Up-Regulated Immune-Inflammatory-Related Signals. GCV, GO, GSEA, HCC
42  2018 Cancer Suicide Gene Therapy with TK.007. GCV, SGT
43  2018 Cholangiocarcinoma: molecular imaging-guided radiofrequency hyperthermia-enhanced intratumoral herpes simplex virus thymidine kinase gene therapy. CBD, GCV, GFP, RFH
44  2018 Engineering functional BMP-2 expressing teratoma-derived fibroblasts for enhancing osteogenesis. ALP, BMP-2, GCV, TDF
45  2018 Graphene oxide-hydroxyapatite nanocomposites effectively deliver HSV-TK suicide gene to inhibit human breast cancer growth. GO-HAp
46  2018 Inducible Caspase9-mediated suicide gene for MSC-based cancer gene therapy. MSC, TRAIL
47  2018 Introduction of Exogenous HSV-TK Suicide Gene Increases Safety of Keratinocyte-Derived Induced Pluripotent Stem Cells by Providing Genetic "Emergency Exit" Switch. ES, GCV, iPS
48  2018 Linking a cell-division gene and a suicide gene to define and improve cell therapy safety. ---
49  2018 New Plasmids for Fusarium Transformation Allowing Positive-Negative Selection and Efficient Cre-loxP Mediated Marker Recycling. FdU, PKI
50  2018 Noninvasive and Local Delivery of Adenoviral-Mediated Herpes Simplex Virus Thymidine Kinase to Treat Glioma Through Focused Ultrasound-Induced Blood-Brain Barrier Opening in Rats. Ad-EGFP, BBB, FUS, GCV
51  2018 Orthotopic hepatic cancer: radiofrequency hyperthermia-enhanced intratumoral herpes simplex virus-thymidine kinase gene therapy. GCV, PBS, RFH
52  2018 Osteonectin Promoter-Mediated Suicide Gene Therapy of Prostate Cancer. GCV
53  2018 Regulation of proliferation and functioning of transplanted cells by using herpes simplex virus thymidine kinase gene in mice. GCV
54  2018 Suicide Gene Therapy for Oral Squamous Cell Carcinoma. GCV
55  2017 A Modified Adenovirus Vector-Mediated Antibody Screening Method Identifies EphA2 as a Cancer Target. GCV, mAbs
56  2017 A Safety Checkpoint to Eliminate Cancer Risk of the Immune Evasive Cells Derived from Human Embryonic Stem Cells. hESCs, hu-mice
57  2017 Engineering of Systematic Elimination of a Targeted Chromosome in Human Cells. GCV
58  2017 Genetic studies in mice directly link oocytes produced during adulthood to ovarian function and natural fertility. GCV, OSCs, Stra8
59  2017 Genetically Engineered Multilineage-Differentiating Stress-Enduring Cells as Cellular Vehicles against Malignant Gliomas. GCV, Muse
60  2017 HSVtk/GCV system on hepatoma carcinoma cells: Construction of the plasmid pcDNA3.1‑pAFP-TK and targeted killing effect. AFP, GCV
61  2017 Regulation of HSVtk gene by endogenous microRNA-122a in liver cell lines as suicide gene therapy. Ad, GCV
62  2017 Selective elimination of long INterspersed element-1 expressing tumour cells by targeted expression of the HSV-TK suicide gene. GCV
63  2017 STAT3/NF-kappaB-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer. CSCs, TNBC
64  2016 A non-viral suicide gene delivery system traversing the blood brain barrier for non-invasive glioma targeting treatment. BBB, GBM, PEG, PPA NPs
65  2016 A Positive Selection for Nucleoside Kinases in E. coli. AZT
66  2016 Antitumor activity of combined endostatin and thymidine kinase gene therapy in C6 glioma models. ES, GCV, HUVECs, IRES, MVD
67  2016 Combined delivery of temozolomide and the thymidine kinase gene for treatment of glioblastoma. R7L10, TMZ
68  2016 Development of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase. AZT, C-TAD, GDEPT, TICKLE
69  2016 Elimination of proliferating cells from CNS grafts using a Ki67 promoter-driven thymidine kinase. NPC, PSC
70  2016 Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene. GCV, hPSCs, iPSCs
71  2016 Exogenous p53 and ASPP2 expression enhances rAdV-TK/ GCV-induced death in hepatocellular carcinoma cells lacking functional p53. GCV, HCC, rAdv
72  2016 Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma. APOE, HCC, PEPCK, PRT, Rz
73  2016 Repression of telomerase gene promoter requires human-specific genomic context and is mediated by multiple HDAC1-containing corepressor complexes. BAC, HDAC, hTERT, NuRD
74  2016 Role of Equilibrative Nucleobase Transporter 1/SLC43A3 as a Ganciclovir Transporter in the Induction of Cytotoxic Effect of Ganciclovir in a Suicide Gene Therapy with Herpes Simplex Virus Thymidine Kinase. ENBT1, GCV, GFP, HeLa, MDCKII
75  2016 Screening glioma stem cells in U251 cells based on the P1 promoter of the CD133 gene. CD, GSCs
76  2016 Suppression of neointima formation by targeting beta-catenin/TCF pathway. GCV, TCF
77  2016 Targeted molecular-genetic imaging and ligand-directed therapy in aggressive variant prostate cancer. AAVP, AVPC, PDX
78  2016 The natural dietary genistein boosts bacteriophage-mediated cancer cell killing by improving phage-targeted tumor cell transduction. i.e. intravenous
79  2016 Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes. AAVP, IBC
80  2016 Tumor-specific promoter-driven adenoviral therapy for insulinoma. INSM1, NE, NRSEs
81  2015 A GSDMB enhancer-driven HSV thymidine kinase-expressing vector for controlling occult peritoneal dissemination of gastric cancer cells. GC, PD
82  2015 A New Approach in Gene Therapy of Glioblastoma Multiforme: Human Olfactory Ensheathing Cells as a Novel Carrier for Suicide Gene Delivery. GBM, MAP2, OECs, S100beta
83  2015 Combined antitumor gene therapy with herpes simplex virus-thymidine kinase and short hairpin RNA specific for mammalian target of rapamycin. GCV, mTOR, rAAV, shRNA
84  2015 Combined enzyme/prodrug treatment by genetically engineered AT-MSC exerts synergy and inhibits growth of MDA-MB-231 induced lung metastases. 5-FC, AT-MSC, CD, GCV, MSC
85  2015 Enhanced central memory cluster of differentiation 8+ and tumor antigen-specific T cells in prostate cancer patients receiving repeated in situ adenovirus-mediated suicide gene therapy. CM, GCV, IFN
86  2015 Evidence for transcriptional interference in a dual-luciferase reporter system. 3'UTR, CMV, EZH2, SV40
87  2015 Improving the safety of cell therapy with the TK-suicide gene. GVHD, GVT, HSCT
88  2015 Liquid-based iterative recombineering method tolerant to counter-selection escapes. ---
89  2015 Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo. CED, GCV, PBAE
90  2015 Rapid and liquid-based selection of genetic switches using nucleoside kinase fused with aminoglycoside phosphotransferase. aph
91  2015 Tumor Restrictive Suicide Gene Therapy for Glioma Controlled by the FOS Promoter. ---
92  2014 2,3-Dihydroxy-quinoxaline induces ATPase activity of Herpes Simplex Virus thymidine kinase. ---
93  2014 A fiber-modified adenovirus co-expressing HSV-TK and Coli.NTR enhances antitumor activities in breast cancer cells. Ad5, CAR, Coli.NTR
94  2014 A novel cancer vaccine strategy with combined IL-18 and HSV-TK gene therapy driven by the hTERT promoter in a murine colorectal cancer model. hTERT, IL
95  2014 An autologous in situ tumor vaccination approach for hepatocellular carcinoma. 1. Flt3 ligand gene transfer increases antitumor effects of a radio-inducible suicide gene therapy in an ectopic tumor model. Adeno-Flt3L, DC, HCC, PFU, RT
96  2014 Brain pharmacokinetics of ganciclovir in rats with orthotopic BT4C glioma. ECF, GCV
97  2014 Inhibitory effects of the ultrasound-targeted microbubble destruction-mediated herpes simplex virus-thymidine kinase/ganciclovir system on ovarian cancer in mice. GCV, MBs, OC, US, UTMD
98  2014 Prognostic utility of gene therapy with herpes simplex virus thymidine kinase for patients with high-grade malignant gliomas: a systematic review and meta analysis. GBM, HGGs, HR, MST, OR, OS
99  2014 Suicide HSVtk gene delivery by neurotensin-polyplex nanoparticles via the bloodstream and GCV Treatment specifically inhibit the growth of human MDA-MB-231 triple negative breast cancer tumors xenografted in athymic mice. GCV, GFP, NTS, NTSR1, TNBC
100  2014 Targeted expression of suicide gene by tissue-specific promoter and microRNA regulation for cancer gene therapy. EGP2-TK, EpCAM, Rb