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■ Abbreviation / Long Form : IGF-IR / insulin-like growth factor-I receptor

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Total Number of Papers: 644
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Abbreviation:   IGF-IR  (>> Co-occurring Abbreviation)
Long Form:   insulin-like growth factor-I receptor
 Abbreviation Variation
 Long Form Variation
 Pair(Abbreviation/Long Form) Variation
No. Year Title Co-occurring Abbreviation
2021 2021 update on thyroid-associated ophthalmopathy. ---
2021 Identification of a Resistance Mechanism to IGF-IR Targeting in Human Triple Negative MDA-MB-231 Breast Cancer Cells. FGFR1, TNBC
2021 Lessons Learned from Targeting IGF-I Receptor in Thyroid-Associated Ophthalmopathy. TAO
2021 Targeting the IGF-Axis Potentiates Immunotherapy for Pancreatic Ductal Adenocarcinoma Liver Metastases by Altering the Immunosuppressive Microenvironment. PDAC
2021 Teprotumumab: The Dawn of Therapies in Moderate-to-Severe Thyroid-Associated Ophthalmopathy. TAO, TMB, TSHR
2021 Therapeutic IGF-I receptor inhibition alters fibrocyte immune phenotype in thyroid-associated ophthalmopathy. MHC-II, PD-L1, TAO
2020 Glioma Cells With Genetically Engineered IGF-I Receptor Downregulation Can Persist in the Brain in a Dormant State. ---
2020 Leucine Improved Growth Performance, Muscle Growth, and Muscle Protein Deposition Through AKT/TOR and AKT/FOXO3a Signaling Pathways in Hybrid Catfish Pelteobagrus vachelli Leiocassis longirostris. FE, FI, IGF-I, Leu, PCNA, PER, PWG, SGR
2020 MiR-148a inhibits oral squamous cell carcinoma progression through ERK/MAPK pathway via targeting IGF-IR. miR-148a, OSCC, qRT-PCR, TNM
10  2020 Teprotumumab for the Treatment of Active Thyroid Eye Disease. GO-QOL
11  2020 Teprotumumab in Thyroid-Associated Ophthalmopathy: Rationale for Therapeutic Insulin-Like Growth Factor-I Receptor Inhibition. TAO
12  2020 Teprotumumab: a novel therapeutic monoclonal antibody for thyroid-associated ophthalmopathy. FDA, TAO
13  2020 Teprotumumab: First Approval. ---
14  2019 Cell-specific expression of insulin/insulin-like growth factor-I receptor hybrids in the mouse brain. PLA
15  2019 Dual inhibition of IGF-IR and ALK as an effective strategy to eradicate NPM-ALK+ T-cell lymphoma. ---
16  2019 IGFBP-2 Signaling in the Brain: From Brain Development to Higher Order Brain Functions. CSF, HBD, IGFBP-2, IGFs
17  2019 Picropodophyllin inhibits type I endometrial cancer cell proliferation via disruption of the PI3K/Akt pathway. PPP
18  2019 Protective Effect of Pyropia yezoensis Peptide on Dexamethasone-Induced Myotube Atrophy in C2C12 Myotubes. DEX, FoxO, IGF-I, mTOR
19  2019 TAE226, a dual inhibitor of focal adhesion kinase and insulin-like growth factor-I receptor, is effective for Ewing sarcoma. EWS, FAK
20  2019 Targeting mTOR for cancer therapy. mTOR, PKC, S6K1
21  2018 Challenges in Orphan Drug Development: Identification of Effective Therapy for Thyroid-Associated Ophthalmopathy. TAO
22  2018 Insulin-like growth factor I receptor regulates the radiation-induced G2/M checkpoint in HeLa cells. DSB, PI3K
23  2018 Insulin-like Growth Factor-I Receptor and Thyroid-Associated Ophthalmopathy. GD, TAO, TSHR
24  2018 IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling. IRS
25  2018 Mutant KRAS promotes liver metastasis of colorectal cancer, in part, by upregulating the MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR signaling pathway. CRC, YB
26  2018 New advances in understanding thyroid-associated ophthalmopathy and the potential role for insulin-like growth factor-I receptor. TAO
27  2018 Potential role of insulin receptor isoforms and IGF receptors in plaque instability of human and experimental atherosclerosis. alpha-SMA, IGF-IIR, IR, IR-A, IR-B, IRA, IRB, VSMCs
28  2018 [Expression of Insulin-like Growth Factor Recepter Type I in CD34+ Cells of Patients with Myelodysplastic Syndromes]. MDS
29  2017 A bispecific antibody targeting IGF-IR and EGFR has tumor and metastasis suppressive activity in an orthotopic xenograft osteosarcoma mouse model. EGFR
30  2017 A high level of estrogen-stimulated proteins selects breast cancer patients treated with adjuvant endocrine therapy with good prognosis. DFS, ER, OS, PR
31  2017 Building the Case for Insulin-Like Growth Factor Receptor-I Involvement in Thyroid-Associated Ophthalmopathy. GD, TAO
32  2017 Cell surface GRP78 facilitates hepatoma cells proliferation and migration by activating IGF-IR. EGCG, ER, MAPK, PI3K
33  2017 IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights. EMT, IGF-I
34  2017 Site-Directed Mutagenesis of the Fibronectin Domains in Insulin Receptor-Related Receptor. FNIII, IR, IRR
35  2017 Somatostatin protects photoreceptor cells against high glucose-induced apoptosis. DR, HG, PTP1B, SST
36  2017 Teprotumumab for Thyroid-Associated Ophthalmopathy. ---
37  2017 TSHR as a therapeutic target in Graves' disease. GD, TAO
38  2016 Acute Ethanol Increases IGF-I-Induced Phosphorylation of ERKs by Enhancing Recruitment of p52-Shc to the Grb2/Shc Complex. ERKs, FRAP
39  2016 Antiproliferative and apoptotic effects of a specific anti-insulin-like growth factor I receptor single chain antibody on breast cancer cells. mAbs, scFv
40  2016 beta1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation. FAK, JNK, TRAMP
41  2016 BMS-754807 is cytotoxic to non-small cell lung cancer cells and enhances the effects of platinum chemotherapeutics in the human lung cancer cell line A549. NSCLC
42  2016 Correlations of insulin-like growth factor I and insulin-like growth factor I receptor with the clinicopathological features and prognosis of patients with colon cancer. IGF-I
43  2016 Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor. AD, CNS, TTR
44  2016 Expression and Clinical Significance of Sushi Domain- Containing Protein 3 (SUSD3) and Insulin-like Growth Factor-I Receptor (IGF-IR) in Breast Cancer. SUSD3
45  2016 Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis. IR, IR-A, IRA, IRB, VSMCs
46  2016 GPER, IGF-IR, and EGFR transduction signaling are involved in stimulatory effects of zinc in breast cancer cells and cancer-associated fibroblasts. CAFs, EGFR, ER, Zn
47  2016 IGF-I receptor as an emerging potential molecular-targeted for hepatocellular carcinoma in vitro and in vivo. HCC, shRNA
48  2016 Inhibition of Protein Tyrosine Phosphatase 1B Improves IGF-I Receptor Signaling and Protects Against Inflammation-Induced Gliosis in the Retina. DR, GFAP, IRS-1, PTP1B
49  2016 Insulin-Like Growth Factor I Receptor (IGF-IR) Ligands and BMI in Squamous Intra-Epithelial Lesion (SIL) of Cervix. BEMR, BMI, CI, ELISA, IGFBP-3, OR, SIL, SIL
50  2016 miR-223-IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach. ---
51  2016 Novel role of cannabinoid receptor 2 in inhibiting EGF/EGFR and IGF-I/IGF-IR pathways in breast cancer. CNR2 or CB2, EGFR, MMPs
52  2016 The insulin-like growth factor I receptor regulates glucose transport by astrocytes. GLUT1
53  2016 The insulin-like growth factor-I receptor (IGF-IR) in breast cancer: biology and treatment strategies. EMT
54  2016 [Abnormal expression of insulin-like growth factor-I receptor and inhibitory effect of its transcription intervention on nude mice xenograft tumor]. ---
55  2015 A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation. bi-AbCap, BsAbs, VEGFR1
56  2015 A framework for the in vitro evaluation of cancer-relevant molecular characteristics and mitogenic potency of insulin analogues. IGF-I, IR
57  2015 Aflatoxin B1 induces Src phosphorylation and stimulates lung cancer cell migration. AFB1, IRS
58  2015 Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts. CHO, HEK, LPA
59  2015 Chimaphilin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines through insulin-like growth factor-I receptor (IGF-IR) signaling. ---
60  2015 Crosstalk between the TNF and IGF pathways enhances NF-kappaB activation and signaling in cancer cells. MEKK3
61  2015 Expression of insulin-like growth factor I receptor as a biomarker for predicting prognosis in biliary tract cancer patients. mTOR, Raf-1
62  2015 High levels of dietary soy decrease mammary tumor latency and increase incidence in MTB-IGFIR transgenic mice. ---
63  2015 Inhibition of lung adenocarcinoma cells by insulin-like growth factor-I receptor and Kirsten rat sarcoma mutations: A mutation analysis with antisense oligodeoxynucleotide. ASODN, KRAS, mRNA, PCR-SSP
64  2015 Intrinsic Resistance to Cixutumumab Is Conferred by Distinct Isoforms of the Insulin Receptor. IR
65  2015 mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR. INSR, IRS, mTOR
66  2015 Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses. DDR1
67  2015 Prolidase-dependent mechanism of (Z)-8,9-epoxyheptadeca-1,11,14-triene-induced inhibition of collagen biosynthesis in cultured human skin fibroblasts. EHT, HIF-1alpha, NF-kappaB
68  2015 Purification of Bone Marrow Clonal Cells from Patients with Myelodysplastic Syndrome via IGF-IR. MDS
69  2015 Role of extracellular matrix in development of skeletal muscle and postmortem aging of meat. ECM, IMCTs
70  2015 Safety, tolerability, and pharmacokinetics of single and multiple doses of intravenous cixutumumab (IMC-A12), an inhibitor of the insulin-like growth factor-I receptor, administered weekly or every 2 weeks in patients with advanced solid tumors. AE, PK
71  2015 SWOG S0925: A Randomized Phase II Study of Androgen Deprivation Combined With Cixutumumab Versus Androgen Deprivation Alone in Patients With New Metastatic Hormone-Sensitive Prostate Cancer. AD, CTC, PSA
72  2015 TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells. FAK, NSCLC
73  2015 The mechanism of oxythiamine-induced collagen biosynthesis in cultured fibroblasts. OXY, PEP, PEPCK
74  2015 The Protective Effects of Exclusive Enteral Nutrition Formulas on Growth Factor Expression and the Proximal Tibial Epiphyseal Growth Plate in a TNBS-Induced IBD Rat Model. BMP, GHR, IGFBP3
75  2015 The role of selenium in insulin-like growth factor I receptor (IGF-IR) expression and regulation of apoptosis in mouse osteoblasts. Se
76  2015 The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK⁺ T-cell lymphoma. MZF1, NPM-ALK
77  2014 Co-localization of TRPV2 and insulin-like growth factor-I receptor in olfactory neurons in adult and fetal mouse. OB, OSNs
78  2014 Delineation of the IGF-II C domain elements involved in binding and activation of the IR-A, IR-B and IGF-IR. IGF-I and -II
79  2014 Expression of insulin-like growth factor-1 receptor in keloid and hypertrophic scar. HS
80  2014 GSK3 protein positively regulates type I insulin-like growth factor receptor through forkhead transcription factors FOXO1/3/4. GSK-3
81  2014 Hypoxia inducible factor 2alpha/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells. HIF-2alpha, PGC
82  2014 IGF-I receptor 275124A>C (rs1464430) polymorphism and athletic performance. ---
83  2014 IGF-IR mediated mammary tumorigenesis is enhanced during pubertal development. ---
84  2014 Increased mRNA levels of apolipoprotein M and apolipoprotein AI in the placental tissues with fetal macrosomia. apoAI, apoM, BMI, IGF-I
85  2014 Insulin analogs and cancer: a note of caution. IR-A, IRs
86  2014 Insulin-like growth factor receptor-1 (IGF-IR) as a target for prostate cancer therapy. ---
87  2014 Metformin displays anti-myeloma activity and synergistic effect with dexamethasone in in vitro and in vivo xenograft models. AMPK, mTOR, PI3K, T2DM
88  2014 MicroRNA-145 directly targets the insulin-like growth factor receptor I in human bladder cancer cells. miR-145, siRNA, UTR
89  2014 SP600125 induces Src and type I IGF receptor phosphorylation independent of JNK. JNK, MAPK
90  2014 Transthyretin Induces Insulin-like Growth Factor I Nuclear Translocation Regulating Its Levels in the Hippocampus. AD, CNS, RBP, TTR
91  2014 Vav2 protein overexpression marks and may predict the aggressive subtype of ductal carcinoma in situ. BM, CIS, DCIS, ER, HER2, IBC, PR, Rap1
92  2013 Abnormal expression of insulin-like growth factor-I receptor in hepatoma tissue and its inhibition to promote apoptosis of tumor cells. ---
93  2013 Antisense oligonucleotide suppression of human IGF-1R inhibits the growth and survival of in vitro cultured epithelial ovarian cancer cells. AS, EOC
94  2013 beta-Catenin/POU5F1/SOX2 transcription factor complex mediates IGF-I receptor signaling and predicts poor prognosis in lung adenocarcinoma. ALDH1A1, CSLC, LACSLC
95  2013 beta1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1. JNK1, PrCa, TRAMP
96  2013 Characterization of anti-Tn-antigen MLS128 binding proteins involved in inhibiting the growth of human colorectal cancer cells. GP
97  2013 Cross-talk between GPER and growth factor signaling. EGFR, GPCRs
98  2013 Cross-talk between integrin receptor and insulin-like growth factor receptor in regulation of collagen biosynthesis in cultured fibroblasts. IGFBP-1
99  2013 Decorin activates Akt downstream of IGF-IR and promotes myoblast differentiation. ---
100  2013 Designing novel therapies against sarcomas in the era of personalized medicine and economic crisis. ---