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■ Abbreviation / Long Form : IRF3 / interferon regulatory factor 3

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Total Number of Papers: 529
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Abbreviation:   IRF3  (>> Co-occurring Abbreviation)
Long Form:   interferon regulatory factor 3
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 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2018 A preclinical model for studying herpes simplex virus infection. HSV
2018 Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D. ADAM17, IFN, STING, TBK1
2018 Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease. FFA, HFD, NAFLD, NF-kappaB, STING
2018 Agaricus blazei Murill Polysaccharides Protect Against Cadmium-Induced Oxidative Stress and Inflammatory Damage in Chicken Spleens. ABP, Cd, GSH-Px, HSPs, IL-1beta, IL-6, IPS-1, MDA, MDA5, NF-kappaB, SOD, TNF-alpha
2018 Andrographolide suppresses TRIF-dependent signaling of toll-like receptors by targeting TBK1. IP-10, TLRs, TRIF
2018 Association of Respiratory Syncytial Virus Toll-Like Receptor 3-Mediated Immune Response with COPD Exacerbation Frequency. AECOPD, FEV1, IFN-beta, IL-6, RSV, TLR3
2018 Bufalin Suppresses Migration and Invasion of Hepatocellular Carcinoma Cells Elicited by Poly (I:C) Therapy. HCC, TBK1, TLR3
2018 C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response. C6orf106, CBP, IFN, TNF
2018 Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade. Cath, EAE, IFN-beta, MOG, TLR3
10  2018 Cytoplasmic Translocation of Nucleolar Protein NOP53 Promotes Viral Replication by Suppressing Host Defense. HIV, HSV-1, NES, RIG-I, VSV
11  2018 Cytosolic sensing of immuno-stimulatory DNA, the enemy within. cGAS, IFN-I, mtDNA, STING, TBK1
12  2018 Differential Delivery of Genomic Double-Stranded RNA Causes Reovirus Strain-Specific Differences in Interferon Regulatory Factor 3 Activation. MAVS, SV40
13  2018 Dingchuan tang essential oil inhibits the production of inflammatory mediators via suppressing the IRAK/NF-kappaB, IRAK/AP-1, and TBK1/IRF3 pathways in lipopolysaccharide-stimulated RAW264.7 cells. AP-1, COX-2, DCEO, ELISA, ERK, IL-1beta, IL-6, iNOS, IRAK, IRAK1, JNK, LPS, MCP-1, MIP, NF-kappaB, NO, PGE2, PI3K, qRT-PCR, TAK1, TBK1, TNF-alpha
14  2018 Fascin1 suppresses RIG-I-like receptor signaling and interferon-beta production by associating with IkappaB kinase ϵ (IKKϵ) in colon cancer. MDA5
15  2018 Herpes Simplex Virus 1 gamma134.5 Protein Inhibits STING Activation That Restricts Viral Replication. HSV-1, STING, TBK1
16  2018 Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses. HCMV, MAVS, STING
17  2018 Hypothiocyanous Acid Suppresses PolyI:C-Induced Antiviral Responses by Modulating IRF3 Phosphorylation in Human Airway Epithelial Cells. HOSCN, IFN, TBK1
18  2018 Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation. Bid, LPS, MAPK, MyD88, Peli1, TLRs, TRAF6, TRIF, WT
19  2018 InsP3R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca2+ elevation and TBK1 activity. C. albicans, TBK1
20  2018 Interferon regulatory factor3 mediates Poly(I:C)-induced innate immune response and apoptosis in non‑small cell lung cancer. MDA5, NSCLC, STAT1
21  2018 Interferon-beta induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier. FRT, GECs, IFN-beta
22  2018 Involvement of interferon regulatory factor 3 from the barbel chub Squaliobarbus curriculus in the immune response against grass carp reovirus. bp, GCRV, IFN
23  2018 Irf3 from mandarin fish thymus initiates interferon transcription. IFN, IRFs, ISRE, Sc-Irf3
24  2018 IRF3 signaling pathway serves an important role in poly(I:C)-induced procollagen reduction in human skin fibroblasts. dsRNA, PAMPs, PRRs, TLRs
25  2018 MicroR-9-5p suppresses EV71 replication through targeting NFkappaB of the RIG-I-mediated innate immune response. EV71, miR-9, NF-kappaB, VP1
26  2018 NLRP2 negatively regulates antiviral immunity by interacting with TBK1. IFN, NOD, PRRs, TBK1
27  2018 NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3. IFN, SFSV
28  2018 Oral cancer-derived exosomal NAP1 enhances cytotoxicity of natural killer cells via the IRF-3 pathway. IFN, NAP1, NK, NTA, OC, OCEXs
29  2018 Overexpression of Toll-like receptor 4 enhances LPS-induced inflammatory response and inhibits Salmonella Typhimurium growth in ovine macrophages. TLR4
30  2018 Oxidative stress modulates the expression of toll‑like receptor 3 during respiratory syncytial virus infection in human lung epithelial A549 cells. NAC, NO, RSV, SOD1, TLR3
31  2018 PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria. IFN-beta, MAVS, TBK1
32  2018 RACK1 attenuates RLR antiviral signaling by targeting VISA-TRAF complexes. IFN-beta, ISRE, NF-kappaB, RACK1, RIG-I, TBK1, TRAF2, VISA
33  2018 Reduced-HMGB1 suppresses poly(I:C)-induced inflammation in keratinocytes. DAMPs, ERK, HMGB1, JNK, MAPK, MDA5, NF, NHKs, PAMPs, RIG-I
34  2018 Regulation and biological role of the peptide/histidine transporter SLC15A3 in Toll-like receptor-mediated inflammatory responses in macrophage. BMDMs, MAPK, PMs
35  2018 Retrospective screening of microarray data to identify candidate IFN-inducible genes in a HTLV-1 transformed model. ATL, HTLV-1, TAK1
36  2018 Saponin Quil A up-regulates type I interferon-regulated gene and type I and II interferon expressions which are suppressed by porcine reproductive and respiratory syndrome virus. IFN, IL-2, LPS, Mx1, OAS1, OPN, PBMC, PRRSV, STING, TGF-beta, TNF-alpha
37  2018 STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation. ORMDL3, STAT6, STING, TBK1
38  2018 Synthetic RNA derived from the foot-and-mouth disease virus genome elicits antiviral responses in bovine and porcine cells through IRF3 activation. 3NCR, FMDV, IFN
39  2018 The Anti-Inflammatory Effects of Shinbaro3 Is Mediated by Downregulation of the TLR4 Signalling Pathway in LPS-Stimulated RAW 264.7 Macrophages. JAK1, JNK, MAPK, NF-kappaB, SAPK, STAT1
40  2018 The cGas-Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus. cGAMP, cGAS, ECTV, IFNs, STING, Tbk1
41  2018 The Role of p38 and CK2 Protein Kinases in the Response of RAW 264.7 Macrophages to Lipopolysaccharide. HSPs, LPS, NF-kappaB, SAPK/JNK, TLR4
42  2018 Thymoquinone alleviates the experimentally induced Alzheimer's disease inflammation by modulation of TLRs signaling. AD, d-gal, IL-1beta, NF-kappaB, TLRs, TNF-alpha, TQ
43  2018 USP4 positively regulates RLR-induced NF-kappaB activation by targeting TRAF6 for K48-linked deubiquitination and inhibits enterovirus 71 replication. EV71, IFNs, NF-kappaB, RLR, TRAF6, USP4
44  2017 A Histological Study of Fulminant Type 1 Diabetes Mellitus Related to Human Cytomegalovirus Reactivation. DIHS, EBV, HCMV, HHV-6, RIG-I, T1DM, ZBP1
45  2017 A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection. DENV, GSK3beta, IFN, JEV, miRNAs, WNV, ZIKV
46  2017 A naturally truncated NS1 protein of influenza A virus impairs its interferon-antagonizing activity and thereby confers attenuation in vitro. KG11, MA63
47  2017 A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response. HTS, RLR
48  2017 Ablation of Interferon Regulatory Factor 3 Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice. VCAM-1
49  2017 ALK is a therapeutic target for lethal sepsis. ALK, EGFR, NF-kappaB, STING
50  2017 An Engineered Herpesvirus Activates Dendritic Cells and Induces Protective Immunity. DC, HSV, TBK1
51  2017 ArfGAP Domain-Containing Protein 2 (ADAP2) Integrates Upstream and Downstream Modules of RIG-I Signaling and Facilitates Type I Interferon Production. ADAP2, PRR
52  2017 Bis(monoacylglycero)phosphate inhibits TLR4-dependent RANTES production in macrophages. BMP, LPS, TLR4
53  2017 Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells. ALI, AP-1, M. ovipneumoniae, NF-kappaB
54  2017 Chloroquine attenuates lipopolysaccharide-induced inflammatory responses through upregulation of USP25. CQ, LPS, MAPKs, TLR4
55  2017 Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA. 2',3'-cGAMP, GMP, TBK1
56  2017 Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. IFN-beta, NF-kappaB, STAT3, STAT6, STING, TBK1
57  2017 Detection of Cyclic Dinucleotides by STING. CDNs, STING
58  2017 Dissecting Glioma Invasiveness in a 3D-Organotypic Model. ---
59  2017 Down-regulated GATA-1 up-regulates interferon regulatory factor 3 in lung adenocarcinoma. ---
60  2017 Fish TRIM32 functions as a critical antiviral molecule against iridovirus and nodavirus. GS, IFP35, ISG15, MDA5, RGNNV, SGIV, STING, TRIF, TRIM32
61  2017 Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure. cGAMP, EBV, IFI16, STING, TBK1
62  2017 Identification of a Druggable Pathway Controlling Glioblastoma Invasiveness. CK2, ECM, GBM
63  2017 Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon beta. BMDMs, IFN-beta, KO, LPS, OPTN, TANK, TLR3
64  2017 Influenza A Virus PA Antagonizes Interferon-beta by Interacting with Interferon Regulatory Factor 3. IAV, IFN-beta, IKKepsilon, NF-kappaB, NS1, PA, RIG-I
65  2017 Innate immune responses induced by lipopolysaccharide and lipoteichoic acid in primary goat mammary epithelial cells. CXCL6, IFIT3, IL-6, IL1B, LPS, LTA, LTF, MEC, Myd88, pgMEC, PTGS2, qPCR, TLR2, TLR4, TNF, TOLLIP
66  2017 Invitro antioxidative and anti-inflammatory effects of the compound K-rich fraction BIOGF1K, prepared from Panax ginseng. DPPH, MyD88, NF, TBK1, TRIF
67  2017 IRF3 and type I interferons fuel a fatal response to myocardial infarction. cGAS, IFNICs, IFNs, ISG, MI, SAVI
68  2017 IRF3 Inhibits Neutrophil Recruitment in Mice Infected with Pseudomonas aeruginosa. BM, KO, WT
69  2017 Knockdown of IRF3 inhibits extracellular matrix expression in keloid fibroblasts. alpha-SMA, ECM, IRF, KFs
70  2017 Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms. BMDC, EAU, IL-6, NF-kappaB, NFATc, TNF-alpha
71  2017 Mechanisms and roles by which IRF-3 mediates the regulation of ORMDL3 transcription in respiratory syncytial virus infection. ChIP, EMSA, ORMDL3, RSV
72  2017 Molecular characterization, expression of chicken TBK1 gene and its effect on IRF3 signaling pathway. ALV-J, bp, CEFs, chTBK1, IFN, NC, ORF, qRT-PCR, TANK
73  2017 NSs protein of severe fever with thrombocytopenia syndrome virus suppresses interferon production through different mechanism than Rift Valley fever virus. RVFV, SFTSV, TBK1
74  2017 Pro-apoptotic signaling induced by Retinoic acid and dsRNA is under the control of Interferon Regulatory Factor-3 in breast cancer cells. dsRNA, IFNs, RA, TLR3, TRAIL
75  2017 Reovirus inhibits interferon production by sequestering IRF3 into viral factories. MRV
76  2017 RIG-1 and MDA-5 signaling pathways contribute to IFN-beta production and viral replication in porcine circovirus virus type 2-infected PK-15 cells in vitro. IFNs, MAVS, MDA5, NF-kappaB, p-IRF3, PCV2
77  2017 Role of Herpes Simplex Virus 1 gamma34.5 in the Regulation of IRF3 Signaling. BBD, HSV-1, IFNs, IFNs, PRRs, TBD, TBK1
78  2017 Roles of TRIM32 in Corneal Epithelial Cells After Infection with Herpes Simplex Virus. HSK, HSV-1, STING, TRIM32
79  2017 Silencing of IRF3 alleviates chronic neuropathic pain following chronic constriction injury. CCI, DRG, shRNA
80  2017 STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity. STING
81  2017 Surface Toll-like receptor 3 expression in metastatic intestinal epithelial cells induces inflammatory cytokine production and promotes invasiveness. IECs, NF-kappaB, TIR, TLRs
82  2017 Synthesis and biological activity of new phthalimides as potential anti-inflammatory agents. iNOS, LPS, NO, TLR
83  2017 The C-Terminal Effector Domain of Non-Structural Protein 1 of Influenza A Virus Blocks IFN-beta Production by Targeting TNF Receptor-Associated Factor 3. ED, MAVS, NS1, TRAF3
84  2017 The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3. NSD3
85  2017 Transmissible Gastroenteritis Virus Papain-Like Protease 1 Antagonizes Production of Interferon-beta through Its Deubiquitinase Activity. CoVs, DUB, HCoV-NL63, MERS-CoV, MHV, PEDV, PL, SARS-CoV, TGEV
86  2017 TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis. CoA, HFD, NAFLD, TLR, TRIF
87  2017 TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity. EMCV, TLR3
88  2017 Up-regulation of IRF-3 expression through GATA-1 acetylation by histone deacetylase inhibitor in lung adenocarcinoma A549 cells. TSA, VPA
89  2017 West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5. IFN, IFN-beta, MDA5, NS1, RIG-I, RLR, WNV
90  2016 1,8-Cineole potentiates IRF3-mediated antiviral response in human stem cells and in an ex vivo model of rhinosinusitis. ITSCs, LPS, NF
91  2016 Attenuation of cerebral ischemic injury in interferon regulatory factor 3-deficient rat. I/R
92  2016 Bacterial Muramyl Dipeptide (MDP) Restricts Human Cytomegalovirus Replication via an IFN-beta-Dependent Pathway. HCMV, MDP, RIPK2, TBK1
93  2016 beta-Catenin Upregulates the Constitutive and Virus-Induced Transcriptional Capacity of the Interferon Beta Promoter through T-Cell Factor Binding Sites. GSK-3, IFN-beta, RVFV, TCF
94  2016 c-Cbl-mediated ubiquitination of IRF3 negatively regulates IFN-beta production and cellular antiviral response. RIG-I, TLR
95  2016 cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection. cGAS, CMV, CRISPR, TLR
96  2016 Cloning and characterizing of the murine IRF-3 gene promoter region. mIRF-3
97  2016 Critical Role of IRF-3 in the Direct Regulation of dsRNA-Induced Retinoic Acid-Inducible Gene-I (RIG-I) Expression. IFNs, IRF-E, ISG, RIG-I
98  2016 Effects of TLR4 gene silencing on the proliferation and apotosis of hepatocarcinoma HEPG2 cells. ERK, JNK, MyD88, NF, p-IkappaBalpha, si, TLRs, TRIF
99  2016 Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes. ER, STING, TIR, TLR4, TRAM
100  2016 Equine herpesvirus-1 infection disrupts interferon regulatory factor-3 (IRF-3) signaling pathways in equine endothelial cells. EECs, EHV-1, IFN