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■ Abbreviation / Long Form : IRF3 / interferon regulatory factor 3

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Total Number of Papers: 591
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Abbreviation:   IRF3  (>> Co-occurring Abbreviation)
Long Form:   interferon regulatory factor 3
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2020 Oxidative stress, ion concentration change and immune response in gills of common carp (Cyprinus carpio) under long-term exposure to bisphenol A. AKP, BPA, c-lyz, CAT, GST, HO-1, IL-10, IL-1beta, IL-6, MDA, myd88, Nrf2, SOD, T-AOC, tlr2, TLRs
2020 Suppressive effects of dehydrocostus lactone on the toll-like receptor signaling pathways. MyD88, NF-kappaB, PRRs, TLRs, TRIF
2020 The kinase inhibitor BX795 suppresses the inflammatory response via multiple kinases. AP-1, JAK2, JNK, LPS, MKK4, NF, PDK1, STAT1, TAK, TBK1
2020 The U-Rich Untranslated Region of the Hepatitis E Virus Induces Differential Type I and Type III Interferon Responses in a Host Cell-Dependent Manner. HEV, IFN, PAMPs, RIG-I, UTR
2020 Thioredoxin 2 negatively regulates innate immunity to RNA viruses by disrupting the assembly of VISA complex. IFNB1, ROS, Trx2, VISA
2019 1-Palmitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol (PLAG) Rapidly Resolves LPS-Induced Acute Lung Injury Through the Effective Control of Neutrophil Recruitment. ALI, IFN, LPS, MIP, NADPH, PLAG, ROS, TIR, TLR4
2019 A Preclinical Model for Studying Herpes Simplex Virus Infection. HSV
2019 Activation of Toll-Like Receptor 3 Induces Interleukin-1 Receptor Antagonist Expression by Activating the Interferon Regulatory Factor 3. IL, TLR3
2019 Anti-Inflammatory Effects of Catalpalactone Isolated from Catalpa ovata in LPS-Induced RAW264.7 Cells. IFN-beta, iNOS, LPS, NF-kappaB, NO, STAT-1
10  2019 CHID1 positively regulates RLR antiviral signaling by targeting the RIG-I/VISA signalosome. CHID1, IFNs, RIG-I, RLRs, SeV, VISA
11  2019 Combination of STING Pathway Agonist With Saponin Is an Effective Adjuvant in Immunosenescent Mice. cGAMP
12  2019 Corilagin Interferes With Toll-Like Receptor 3-Mediated Immune Response in Herpes Simplex Encephalitis. HE, HSE, HSV, IL-6, NF-kappaB, TLR3, TNF, TRADD, TRAF, TRIF
13  2019 DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKepsilon-IRF3 Interactions and Promoting TBK1 and IKKepsilon Degradation. DDX19, IFN, IKKepsilon, RIG-I, TALENs, TBK1
14  2019 Development and characterization of a new cell line derived from European eel Anguilla anguilla kidney. CPE, CYP450, EK, irf7, PCR, qRT-PCR
15  2019 Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations. 2'3'CDNs, cGAS, IkappaB, NF-kappaB, NTP, PBMCs, QM/MM, TBK1
16  2019 Exosomal Interferon-Induced Transmembrane Protein 2 Transmitted to Dendritic Cells Inhibits Interferon Alpha Pathway Activation and Blocks Anti-Hepatitis B Virus Efficacy of Exogenous Interferon Alpha. CHB, DCs, ERK, GEO, IFITM2, IFN, PBMCs, TBK1
17  2019 Feline Infectious Peritonitis Virus Nsp5 Inhibits Type I Interferon Production by Cleaving NEMO at Multiple Sites. FIP, FIPV, IFN-beta, ISG, NF-kappaB, SeV, TANK, type I IFN
18  2019 Functional Characterization of Dark Sleeper (Odontobutis obscura) TBK1 on IFN Regulation. CCD, IFN, ISGs, O. obscura, S_TKc, TBK1
19  2019 Grouper viperin acts as a crucial antiviral molecule against iridovirus. ER, IFN, IFP35, ISG15, ISRE, MXI, NF-kappaB, SGIV, TRAF6
20  2019 Herpes Simplex Virus 1 Tegument Protein UL46 Inhibits TANK-Binding Kinase 1-Mediated Signaling. HSV-1, TBK1, WT HSV-1
21  2019 Histone Deacetylase Inhibitors Enhance Cell Killing and Block Interferon-Beta Synthesis Elicited by Infection with an Oncolytic Parainfluenza Virus. HDAC
22  2019 Human Cytomegalovirus DNA Polymerase Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3- and NF-kappaB-Mediated Transcription. HCMV, IFNs
23  2019 IFN-beta secretion is through TLR3 but not TLR4 in human gingival epithelial cells. HGECs, PRRs
24  2019 Immunobiotic Strains Modulate Toll-Like Receptor 3 Agonist Induced Innate Antiviral Immune Response in Human Intestinal Epithelial Cells by Modulating IFN Regulatory Factor 3 and NF-kappaB Signaling. IECs, IFN-beta, IL-10, IL-1beta, IL-6, IL-8, LAB, MxA, NF-kappaB, OSA1, RIG-I, TLR3, TNF-alpha
25  2019 Induction of pro-inflammatory cytokines by 29-kDa FN-f via cGAS/STING pathway. cGAS, IkappaBalpha, OA, STING, TBK1, TLR2
26  2019 Inhibition of TLR4/TRIF/IRF3 Signaling Pathway by Curcumin in Breast Cancer Cells. IFN, LPS, TLR4
27  2019 Interferon Regulatory Factor 3 Deficiency Induces Age-Related Alterations of the Retina in Young and Old Mice. ERG, ONL, OPL, PML, WT
28  2019 Interferon-beta induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier. FRT, GECs, IFN-beta
29  2019 Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication. FKBP5, IFN, IkappaB, KO, siRNAs
30  2019 Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation. lncRNA, PME-1
31  2019 Interleukin-1beta Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING. GMP, IFN, IL-1beta, STING
32  2019 Irf3 from mandarin fish thymus initiates interferon transcription. IFN, IRFs, ISRE, Sc-Irf3
33  2019 KAT8 selectively inhibits antiviral immunity by acetylating IRF3. PTMs
34  2019 Kinetics of Early Innate Immune Activation during HIV-1 Infection of Humanized Mice. HIV-1, IFN, ISG, NF-kappaB, SAMHD1, SIV, TBK1, TLR
35  2019 MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling. AECs, IFN, ISGs, MEK
36  2019 Negative regulation of the interferon response by finTRIM82 in the orange spotted grouper. CP, GS, IFN, ISG15, MAVS, MCP, MDA5, MXI, RdRp, RGNNV, SGIV, TRIM
37  2019 Nickel induces inflammatory activation via NF-kappaB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages. BMDMs, IL-1beta, INF-beta, MAPKs, mtDNA, mtROS, NF-kappaB, Ni, NLRP3, TNF-alpha
38  2019 Nontranscriptional Activity of Interferon Regulatory Factor 3 Protects Mice From High-Fat Diet-Induced Liver Injury. HFD, IFN, IKKbeta, NF-kappaB
39  2019 Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral Responses. dsRNA, FKBP5, IFN, IkappaB, NF-kappaB
40  2019 Nuclear localization of Zika virus NS5 contributes to suppression of type I interferon production and response. NLS, STAT2, ZIKV
41  2019 Nucleic Acid Sensing in Mammals and Plants: Facts and Caveats. DAMPs, ds, IFN, NF, ss, STING, TLRs
42  2019 Overexpression of Toll-like receptor 4 enhances LPS-induced inflammatory response and inhibits Salmonella Typhimurium growth in ovine macrophages. TLR4
43  2019 P-MAPA and Interleukin-12 Reduce Cell Migration/Invasion and Attenuate the Toll-Like Receptor-Mediated Inflammatory Response in Ovarian Cancer SKOV-3 Cells: A Preliminary Study. hrIL-12, MyD88, OC, PTX, RANTES, TLR
44  2019 Peste des Petits Ruminants Virus Nucleocapsid Protein Inhibits Beta Interferon Production by Interacting with IRF3 To Block Its Activation. IFN, ISG, RLR
45  2019 Prestimulation of Microglia Through TLR4 Pathway Promotes Interferon Beta Expression in a Rat Model of Alzheimer's Disease. AD, IFN-beta, LPS, MPL, TRIF
46  2019 Protective Effects of Aqueous Extract of Radix Isatidis on Lipopolysaccharide-Induced Sepsis in C57BL/6J Mice. LPS, NF-kappaB
47  2019 Quantitative Proteome Analysis of Atg5-Deficient Mouse Embryonic Fibroblasts Reveals the Range of the Autophagy-Modulated Basal Cellular Proteome. dsRNA, IL-6, LPS, MEFs, PAMPs, TGF-beta, TLR2, TMT
48  2019 Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist. HDAC5, IFN, NF-kappaB, VACV
49  2019 RACK1 attenuates RLR antiviral signaling by targeting VISA-TRAF complexes. IFN-beta, ISRE, NF-kappaB, RACK1, RIG-I, TBK1, TRAF2, VISA
50  2019 SLC19A1 transports immunoreactive cyclic dinucleotides. CDN, cGAS, NF-kappaB
51  2019 Study on Schizochytrium sp. improving the growth performance and non-specific immunity of golden pompano (Trachinotus ovatus) while not affecting the antioxidant capacity. AEM, CAT, FCR, GSH-Px, HO-1, HSP70, IRAK4, MDA, MyD88, Nrf2, PPARalpha, SOD, T-AOC
52  2019 Systemic LPS induces toll-like receptor 3 (TLR3) expression and apoptosis in testicular mouse tissue. dsRNA, IFN-beta, IL-6, LPS, TLR3
53  2019 The correlation of BER protein, IRF3 with CD8+ T cell and their prognostic significance in upper tract urothelial carcinoma. BER, DFS, OS, STING, TILs, UTUC
54  2019 The Megalocytivirus RBIV Induces Apoptosis and MHC Class I Presentation in Rock Bream (Oplegnathus fasciatus) Red Blood Cells. CASP6, CASP9, dpi, DSP, FAS, FLNB, KPNA3, NUP35, RBCs, RBIV, TRIM25
55  2019 The non-transcriptional activity of IRF3 modulates hepatic immune cell populations in acute-on-chronic ethanol administration in mice. RIPA
56  2019 THO Complex Subunit 7 Homolog Negatively Regulates Cellular Antiviral Response against RNA Viruses by Targeting TBK1. IFNs, MAVS, NF, RLR, TBK1, THOC7
57  2019 Transcription profiles of skin and head kidney from goldfish suffering hemorrhagic septicemia with an emphasis on the TLR signaling pathway. IFN, ISRE, TLRs
58  2019 Transducin beta-like 1 X-linked receptor 1 (TBLR1) affects RGNNV infection through negative regulation of interferon immune response in orange-spotted grouper, Epinephelus coioides. CP, ISG15, NCoR, ORF, qPCR, RdRp, RGNNV, RNAi, TBLR1
59  2019 Type I interferon protects neurons from prions in in vivo models. ---
60  2019 Unique Interferon Pathway Regulation by the Andes Virus Nucleocapsid Protein Is Conferred by Phosphorylation of Serine 386. ANDV, HPS, HVD, MAPV
61  2019 Vitamin D Alleviates Rotavirus Infection through a Microrna-155-5p Mediated Regulation of the TBK1/IRF3 Signaling Pathway In Vivo and In Vitro. miR-155-5p, p-IRF3, RV, TBK1, VD
62  2019 Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression. FGFR, IFN, RIG-I, SVCV, TBK1
63  2019 Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon. IFN, ZIKV
64  2019 [Effect of Human Adipose Mesenchymal Stem Cells on Phenotype Polarization of Mice Microglia via TLR3/TRIF Signal Pathway]. hADMSCs, pIRF3, TLR4
65  2019 [Protective Role of the Host Innate Immune System in Prion Pathogenesis]. I-IFN, PrP, TLR
66  2018 Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D. ADAM17, IFN, STING, TBK1
67  2018 Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease. FFA, HFD, NAFLD, NF-kappaB, STING
68  2018 Agaricus blazei Murill Polysaccharides Protect Against Cadmium-Induced Oxidative Stress and Inflammatory Damage in Chicken Spleens. ABP, Cd, GSH-Px, HSPs, IL-1beta, IL-6, IPS-1, MDA, MDA5, NF-kappaB, SOD, TNF-alpha
69  2018 Andrographolide suppresses TRIF-dependent signaling of toll-like receptors by targeting TBK1. IP-10, TLRs, TRIF
70  2018 Association of Respiratory Syncytial Virus Toll-Like Receptor 3-Mediated Immune Response with COPD Exacerbation Frequency. AECOPD, FEV1, IFN-beta, IL-6, RSV, TLR3
71  2018 Bufalin Suppresses Migration and Invasion of Hepatocellular Carcinoma Cells Elicited by Poly (I:C) Therapy. HCC, TBK1, TLR3
72  2018 C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response. C6orf106, CBP, IFN, TNF
73  2018 Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade. CatH, EAE, IFN-beta, MOG, TLR3
74  2018 Cytoplasmic Translocation of Nucleolar Protein NOP53 Promotes Viral Replication by Suppressing Host Defense. HIV, HSV-1, NES, RIG-I, VSV
75  2018 Cytosolic sensing of immuno-stimulatory DNA, the enemy within. cGAS, IFN-I, mtDNA, STING, TBK1
76  2018 Differential Delivery of Genomic Double-Stranded RNA Causes Reovirus Strain-Specific Differences in Interferon Regulatory Factor 3 Activation. MAVS, SV40
77  2018 Dingchuan tang essential oil inhibits the production of inflammatory mediators via suppressing the IRAK/NF-kappaB, IRAK/AP-1, and TBK1/IRF3 pathways in lipopolysaccharide-stimulated RAW264.7 cells. AP-1, COX-2, DCEO, ELISA, ERK, IL-1beta, IL-6, iNOS, IRAK, IRAK1, JNK, LPS, MCP-1, MIP, NF-kappaB, NO, PGE2, PI3K, qRT-PCR, TAK1, TBK1, TNF-alpha
78  2018 Fascin1 suppresses RIG-I-like receptor signaling and interferon-beta production by associating with IkappaB kinase ϵ (IKKϵ) in colon cancer. MDA5
79  2018 Herpes Simplex Virus 1 gamma134.5 Protein Inhibits STING Activation That Restricts Viral Replication. HSV-1, STING, TBK1
80  2018 Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses. HCMV, MAVS, STING
81  2018 Hypothiocyanous Acid Suppresses PolyI:C-Induced Antiviral Responses by Modulating IRF3 Phosphorylation in Human Airway Epithelial Cells. HOSCN, IFN, TBK1
82  2018 Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation. Bid, LPS, MAPK, MyD88, Peli1, TLRs, TRAF6, TRIF, WT
83  2018 InsP3R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca2+ elevation and TBK1 activity. C. albicans, TBK1
84  2018 Interferon regulatory factor3 mediates Poly(I:C)-induced innate immune response and apoptosis in non‑small cell lung cancer. MDA5, NSCLC, STAT1
85  2018 Involvement of interferon regulatory factor 3 from the barbel chub Squaliobarbus curriculus in the immune response against grass carp reovirus. bp, GCRV, IFN
86  2018 IRF3 signaling pathway serves an important role in poly(I:C)-induced procollagen reduction in human skin fibroblasts. dsRNA, PAMPs, PRRs, TLRs
87  2018 MicroR-9-5p suppresses EV71 replication through targeting NFkappaB of the RIG-I-mediated innate immune response. EV71, miR-9, NF-kappaB, VP1
88  2018 NLRP2 negatively regulates antiviral immunity by interacting with TBK1. IFN, NOD, PRRs, TBK1
89  2018 NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3. IFN, SFSV
90  2018 Oral cancer-derived exosomal NAP1 enhances cytotoxicity of natural killer cells via the IRF-3 pathway. IFN, NAP1, NK, NTA, OC, OCEXs
91  2018 Oxidative stress modulates the expression of toll‑like receptor 3 during respiratory syncytial virus infection in human lung epithelial A549 cells. NAC, NO, RSV, SOD1, TLR3
92  2018 PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria. IFN-beta, MAVS, TBK1
93  2018 Reduced-HMGB1 suppresses poly(I:C)-induced inflammation in keratinocytes. DAMPs, ERK, HMGB1, JNK, MAPK, MDA5, NF, NHKs, PAMPs, RIG-I
94  2018 Regulation and biological role of the peptide/histidine transporter SLC15A3 in Toll-like receptor-mediated inflammatory responses in macrophage. BMDMs, MAPK, PMs
95  2018 Retrospective screening of microarray data to identify candidate IFN-inducible genes in a HTLV-1 transformed model. ATL, HTLV-1, TAK1
96  2018 Saponin Quil A up-regulates type I interferon-regulated gene and type I and II interferon expressions which are suppressed by porcine reproductive and respiratory syndrome virus. IFN, IL-2, LPS, Mx1, OAS1, OPN, PBMC, PRRSV, STING, TGF-beta, TNF-alpha
97  2018 Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways. DAMPs, IFNs, NF-kappaB, PAMPs, PRRs
98  2018 STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation. ORMDL3, STAT6, STING, TBK1
99  2018 Synthetic RNA derived from the foot-and-mouth disease virus genome elicits antiviral responses in bovine and porcine cells through IRF3 activation. 3NCR, FMDV, IFN
100  2018 The Anti-Inflammatory Effects of Shinbaro3 Is Mediated by Downregulation of the TLR4 Signalling Pathway in LPS-Stimulated RAW 264.7 Macrophages. JAK1, JNK, MAPK, NF-kappaB, SAPK, STAT1