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■ Abbreviation / Long Form : IRF / IFN regulatory factor

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Total Number of Papers: 250
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Abbreviation:   IRF  (>> Co-occurring Abbreviation)
Long Form:   IFN regulatory factor
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No. Year Title Co-occurring Abbreviation
2019 15-Epi-LXA4 and MaR1 counter inflammation in stromal cells from patients with Achilles tendinopathy and rupture. ALOX, AR, AT, MaR, SPM, STAT
2018 Ctenopharyngodon idella TBK1 activates innate immune response via IRF7. CIKs, LPS, TBK1
2018 Defective RNA sensing by RIG-I in severe influenza virus infection. CARD, DDX58, IAV, IFN
2018 Differential and Overlapping Immune Programs Regulated by IRF3 and IRF5 in Plasmacytoid Dendritic Cells. pDCs, RLR
2018 Duck interferon regulatory factor 1 acts as a positive regulator in duck innate antiviral response. DEFs, duIRF1, duMyD88, ISGs, RIG-I
2018 High-throughput screening for small molecule inhibitors of the type-I interferon signaling pathway. HTS, IFN-alpha, IFN-beta, IFNs, JAK-STAT, SEAP
2018 IRF and STAT Transcription Factors - From Basic Biology to Roles in Infection, Protective Immunity, and Primary Immunodeficiencies. CMC, HIES, HSE, IFN, MSMD, PID, STAT
2018 IRF-2 haploinsufficiency causes enhanced imiquimod-induced psoriasis-like skin inflammation. IMQ, TNF
2018 IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection. IAV, NLRP3, ZBP1
10  2018 On taking the STING out of immune activation. ER, STING
11  2018 Production of IL-35 by Bregs is mediated through binding of BATF-IRF-4-IRF-8 complex to il12a and ebi3 promoter elements. AICEs, ChIP, EAU, LNs
12  2018 Respiratory syncytial virus activates epidermal growth factor receptor to suppress interferon regulatory factor 1-dependent interferon-lambda and antiviral defense in airway epithelium. EGFR, IFN, RSV
13  2018 Role of interferon regulatory factor 1 in governing Treg depletion, Th1 polarization, inflammasome activation and antitumor efficacy of cyclophosphamide. IFN, Treg
14  2018 Signal Propagation in Sensing and Reciprocating Cellular Systems with Spatial and Structural Heterogeneity. IFN, SARs, SST
15  2018 The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment. CIIta, Gbp2, IFN, Pol II, TAD
16  2018 The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family. IFN, IFNs
17  2018 The Molecular Basis of Viral Inhibition of IRF- and STAT-Dependent Immune Responses. HIV, HSV, IFNs, ISGs, STAT, ZIKV
18  2018 The Protein Expression of PDL1 Is Highly Correlated with Those of eIF2alpha and ATF4 in Lung Cancer. ATF4, IFN, ISR, PD-1, PDL1, STAT, UPR
19  2018 Toll-Like Receptor 3 Signaling Contributes to Regional Neutrophil Recruitment in Cultured Human Glomerular Endothelial Cells. GECs, GN, IFN, NF, PN, TLR3
20  2017 CCL5 is induced by TLR 3 signaling in HuCCT1 human biliary epithelial cells: possible involvement in the pathogenesis of biliary atresia. BA, dsRNA, ELISA, IFN, qRT-PCR, siRNA, TLR3
21  2017 DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS. DDX3, IFN, IKKepsilon, MAVS, SeV, TRAF3
22  2017 Endoplasmic Reticulum Transmembrane Proteins ZDHHC1 and STING Both Act as Direct Adaptors for IRF3 Activation in Teleost. STING, ZDHHC1
23  2017 Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection. DENV, IFN-beta, IFNAR, ISGs, PMEFs, shRNA, SK, WT
24  2017 MDA5 Induces a Stronger Interferon Response than RIG-I to GCRV Infection through a Mechanism Involving the Phosphorylation and Dimerization of IRF3 and IRF7 in CIK Cells. CIK, GCRV, IFNs, MDA5, RIG-I
25  2017 MiR-525-3p mediates antiviral defense to rotavirus infection by targeting nonstructural protein 1. IFN, miRNAs, nsp1, qRT-PCR, RVs, UTR
26  2017 miRNA-451a Targets IFN Regulatory Factor 8 for the Progression of Systemic Lupus Erythematosus. miR-451a, SLE
27  2017 Smac mimetics and type II interferon synergistically induce necroptosis in various cancer cell lines. cIAP, CIs, IFN, MLKL, Nec-1, NSA, RIP, TNF, TRAIL, XIAP
28  2017 STING and TRIF Contribute to Mouse Sepsis, Depending on Severity of the Disease Model. CLP, STING, TRIF
29  2017 The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production. GPs, MDSCs, PMN
30  2016 A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines. cGAS
31  2016 Effects of IRF1 and IFN-beta interaction on the M1polarization of macrophages and its antitumor function. IFN, IL, LPS, TNF
32  2016 Essential Requirement for IFN Regulatory Factor 7 in Autoantibody Production but Not Development of Nephritis in Murine Lupus. SLE
33  2016 Esterase D enhances type I interferon signal transduction to suppress foot-and-mouth disease virus replication. ESD, FMDV, IFN, ISGs
34  2016 Identification and functional characterization of miiuy croaker IRF3 as an inducible protein involved regulation of IFN response. ISGs
35  2016 Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks. dpi, IBV, IFN, IKK, ILs, LGP2, MAVS, MDA5, MIP-1beta, MyD88, NF-B, STING, TBK1, TLR, TRAF
36  2016 Transcriptional Repression of IFN Regulatory Factor 7 by MYC Is Critical for Type I IFN Production in Human Plasmacytoid Dendritic Cells. pDCs
37  2016 Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFNPhi1 and IFNPhi3 Expression through Assembly of Homo- or Heteroprotein Complexes. ---
38  2015 Activation of Vago by interferon regulatory factor (IRF) suggests an interferon system-like antiviral mechanism in shrimp. IFN, ISRE
39  2015 Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3. NLS
40  2015 Casein kinase II controls TBK1/IRF3 activation in IFN response against viral infection. ---
41  2015 CCL7 and IRF-7 Mediate Hallmark Inflammatory and IFN Responses following Rhinovirus 1B Infection. AHR, RV
42  2015 Characterization of Amphioxus IFN Regulatory Factor Family Reveals an Archaic Signaling Framework for Innate Immune Response. bbt, ISRE
43  2015 Cutting Edge: Synchronization of IRF1, JunB, and C/EBPbeta Activities during TLR3-TLR7 Cross-Talk Orchestrates Timely Cytokine Synergy in the Proinflammatory Response. ---
44  2015 Cutting Edge: The Orphan Nuclear Receptor Nr4a1 Regulates CD8+ T Cell Expansion and Effector Function through Direct Repression of Irf4. ---
45  2015 EGFR kinase activity is required for TLR4 signaling and the septic shock response. EGFR, IFN-beta, LPS, TLR
46  2015 Ex vivo and in vitro effect of serum amyloid a in the induction of macrophage M2 markers and efferocytosis of apoptotic neutrophils. SAA
47  2015 Functional Analysis of Chicken IRF7 in Response to dsRNA Analog Poly(I:C) by Integrating Overexpression and Knockdown. dsRNA, IFNs
48  2015 Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2. TICAM, TIRAP
49  2015 IFN Regulatory Factor-1 Modulates the Function of Dendritic Cells in Patients with Acute Coronary Syndrome. ACS, APCs, CAD, DCs
50  2015 IRF4 Is a Critical Gene in Retinoic Acid-Mediated Plasma Cell Formation and Is Deregulated in Common Variable Immunodeficiency-Derived B Cells. AID, RA
51  2015 Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages. IFNs, IKK, Keap1, TBK1
52  2015 Phosphatidylinositol-3-kinase and Akt are required for RIG-I-mediated anti-viral signalling through cross-talk with IPS-1. IFN-beta, PI3K, RIG-I
53  2015 Sca-1+Lin-CD117- mesenchymal stem/stromal cells induce the generation of novel IRF8-controlled regulatory dendritic cells through Notch-RBP-J signaling. HSCs, MSCs, regDCs, sBM-DCs
54  2015 Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-alpha Production in Women. ESR1, pDCs
55  2015 TGF-beta1 inhibits the production of IFN in response to CpG DNA via ubiquitination of TNF receptor-associated factor (TRAF) 6. TRAF
56  2015 Toll-like receptor 3 signaling contributes to the expression of a neutrophil chemoattractant, CXCL1 in human mesangial cells. IFN, IgAN, LN, MCs, MDA5, NF, RIG-I, RT-PCR, TLR
57  2015 Zebrafish IRF1 regulates IFN antiviral response through binding to IFNϕ1 and IFNϕ3 promoters downstream of MyD88 signaling. DrIRF
58  2014 Common genetic variants modulate pathogen-sensing responses in human dendritic cells. IFN-beta
59  2014 EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. EGFR, RSV
60  2014 IFN regulatory factor 10 is a negative regulator of the IFN responses in fish. DrIFN1
61  2014 Inflammatory response to Porphyromonas gingivalis partially requires interferon regulatory factor (IRF) 3. MO, PD, TRIF
62  2014 IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice. hMPV, IFN
63  2014 MAVS-dependent IRF3/7 bypass of interferon beta-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells. BMDCs, IFN, MDA5, MV, RIG-I
64  2014 Measurement of the innate immune response in the airway. IIR, MS, NF-kappaB, PKR, PPRs, qRT-PCR, RIG, SRM, STAT, TLRs
65  2014 The role of endogenous IFN-beta in the regulation of Th17 responses in patients with relapsing-remitting multiple sclerosis. RRMS
66  2014 Toll-like receptor 3 stimulation promotes Ro52/TRIM21 synthesis and nuclear redistribution in salivary gland epithelial cells, partially via type I interferon pathway. IFN, LPS, SGEC, SS, TLR, TRIM21, TROVE2
67  2014 Type I interferon-mediated immune response against influenza A virus is attenuated in the absence of p53. IAV, IFN, ISGs
68  2013 Estradiol promotes functional responses in inflammatory and steady-state dendritic cells through differential requirement for activation function-1 of estrogen receptor alpha. AFs, DC, ER, pDC
69  2013 IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-alpha secretion and LPS-induced endotoxin shock. BMDMs, IFIT2, LPS
70  2013 Inhibition of histone deacetylase activity suppresses IFN-gamma induction of tripartite motif 22 via CHIP-mediated proteasomal degradation of IRF-1. HDAC, HSP, TRIM, TSA
71  2013 Inhibitory effect of 10-hydroxydecanoic acid on lipopolysaccharide-induced nitric oxide production via translational downregulation of interferon regulatory factor-1 in RAW264 murine macrophages. 10H2DA, 10HDA, IFN, IL, LPS, NO, TLRs
72  2013 Interferon regulatory factor 3 controls interleukin-17 expression in CD8 T lymphocytes. ---
73  2013 IRF7-dependent IFN-beta production in response to RANKL promotes medullary thymic epithelial cell development. AIRE, IFNAR, mTECs, RANK
74  2013 Negative regulation of Nmi on virus-triggered type I IFN production by targeting IRF7. Nmi
75  2013 Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon lamda and antiviral defense in airway epithelium. EGFR, IFN, RV
76  2013 Role of IRF4 in IFN-stimulated gene induction and maintenance of Kaposi sarcoma-associated herpesvirus latency in primary effusion lymphoma cells. ISGs, KSHV, vFLIP
77  2013 The roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus. DENV, hpi
78  2012 CD40 stimulates a "feed-forward" NF-kappaB-driven molecular pathway that regulates IFN-beta expression in carcinoma cells. ---
79  2012 Characterization of retinoic acid-inducible gene-I (RIG-I) expression corresponding to viral infection and UVB in human keratinocytes. IFN, RIG-I
80  2012 Defective antiviral responses of induced pluripotent stem cells to baculoviral vector transduction. BV, IL-6, iPSCs, TLR, TNF-alpha
81  2012 Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction. RLRs, TLRs, TSLP
82  2012 IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS. ---
83  2012 Monocytes from Irf5-/- mice have an intrinsic defect in their response to pristane-induced lupus. SLE
84  2012 MyD88 drives the IFN-beta response to Lactobacillus acidophilus in dendritic cells through a mechanism involving IRF1, IRF3, and IRF7. Syk
85  2012 Transcriptional regulation of type I interferon gene expression by interferon regulatory factor-3 in Japanese flounder, Paralichthys olivaceus. IFN
86  2011 Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-beta signaling. ---
87  2011 Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells. MDDCs
88  2011 IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools. cKO, FO, MZ
89  2011 Negative regulation of IRF7 activation by activating transcription factor 4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses. ATF
90  2011 p53-paralog DNp73 oncogene is repressed by IFNalpha/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor. HCCs, HDACs, IFN, PHHs
91  2011 Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta. Bb, IRSs, TLR
92  2011 Suppression of IRF4 by IRF1, 3, and 7 in Noxa expression is a necessary event for IFN-gamma-mediated tumor elimination. BMK, LPS
93  2011 Suppression of TLR4-mediated inflammatory response by macrophage class A scavenger receptor (CD204). IFN, IL, LPS, MAPK, NF-kappaB, TLR4, TNF
94  2011 Targeting interferon regulatory factors to inhibit activation of the type I IFN response: implications for treatment of autoimmune disorders. IFN
95  2011 The potential role of interferon-regulatory factor 7 among Taiwanese patients with systemic lupus erythematosus. IFN, mRNA, SLE, SNP
96  2010 Characterization of fish IRF3 as an IFN-inducible protein reveals evolving regulation of IFN response in vertebrates. ISGs
97  2010 Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process. ---
98  2010 Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. HATs, HDACs
99  2010 E2F3a is critically involved in epidermal growth factor receptor-directed proliferation in ovarian cancer. EGFR
100  2010 Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells. MAVS