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■ Abbreviation / Long Form : KLF4 / Kruppel-like factor 4

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Total Number of Papers: 724
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Abbreviation:   KLF4  (>> Co-occurring Abbreviation)
Long Form:   Kruppel-like factor 4
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2021 3,3'-Diindolylmethane Enhances Paclitaxel Sensitivity by Suppressing DNMT1-Mediated KLF4 Methylation in Breast Cancer. DIM, DNMT1, PTX
2021 A biomechanical switch regulates the transition towards homeostasis in oesophageal epithelium. YAP
2021 A model of atherosclerosis using nicotine with balloon overdilation in a porcine. CD68, SMA
2021 A Pioneer Transcription Factor and Type I Nuclear Hormone Receptors Synergistically Activate the Bovine Herpesvirus 1 Infected Cell Protein 0 (ICP0) Early Promoter. bICP0, BoHV-1, ChIP, ICP0, NHR, NHRs
2021 Acetyl oxygen benzoate engeletin ester promotes KLF4 degradation leading to the attenuation of pulmonary fibrosis via inhibiting TGFbeta1-smad/p38MAPK-lnc865/lnc556-miR-29b-2-5p-STAT3 signal pathway. AOBEE, FVC, lncRNA, STAT3
2021 Aging disrupts circadian gene regulation and function in macrophages. TF
2021 AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation. HCC, IHC, MS, SOX2, Spd, Spm
2021 ATF4-mediated histone deacetylase HDAC1 promotes the progression of acute pancreatitis. AP, ATF4, HDACs, NEP
2021 Baihui (DU20)-penetrating-Qubin (GB7) acupuncture regulates microglia polarization through miR-34a-5p/Klf4 signaling in intracerebral hemorrhage rats. ICH
10  2021 Bioinformatics analysis of key genes and potential mechanism in cadmium-induced breast cancer progression. CALM3, CASP8, Cd, CDK6, DEGs, EMT, ESPL1, HNF1B, IPA, KRAS, MKI67, NEUROG3, NUPR1, Plk1, PPI, PTPN11, SIRT1, TP53, TWIST1
11  2021 C1q/TNF-Related Protein 9 Attenuates Atherosclerosis by Inhibiting Hyperglycemia-Induced Endothelial Cell Senescence Through the AMPKα/KLF4 Signaling Pathway. AMPK, ApoE KO, CTRP9, HUVECs, Lv-CTRP9, TERT
12  2021 Cellular reprogramming with multigene activation by the delivery of CRISPR/dCas9 ribonucleoproteins via magnetic peptide-imprinted chitosan nanoparticles. gRNA, HEK, OCT4, VPR
13  2021 circRNAome profiling reveals circFgfr2 regulates myogenesis and muscle regeneration via a feedback loop. circRNAs, FGFR2, G3BP1
14  2021 CRISPR/cas9-mediated overexpression of long non-coding RNA SRY-box transcription factor 21 antisense divergent transcript 1 regulates the proliferation of osteosarcoma by increasing the expression of mechanistic target of rapamycin kinase and Kruppel like factor 4. lncRNA, mTOR, SOX21-AS1
15  2021 Curcumin nicotinate suppresses abdominal aortic aneurysm pyroptosis via lncRNA PVT1/miR-26a/KLF4 axis through regulating the PI3K/AKT signaling pathway. AAA, CUR, CurTn, PVT1, qPCR, VSMCs
16  2021 E3 Ubiquitin Ligase March1 Facilitates OX40L Expression in Allergen-Stimulated Dendritic Cells Through Mediating the Ubiquitination of HDAC11. DCs, HDAC11, HDMs, March 1, OX40L
17  2021 EPHA5 Enhances the Stemness of Non-small cell lung cancer Cells Through Activating the Wnt Signaling Pathway. CD133, EPHA5, OCT4, SOX2
18  2021 Expressions and related mechanisms of miR-212 and KLF4 in rats with acute kidney injury. AKI, IL-6, MDA, MOF, SOD, TNF-alpha
19  2021 Functional Analysis of the Promoter Regions of Two Apoptosis-Related Genes (Bcl-2 and Cycs) and Their Regulation by Zn in Yellow Catfish. Bcl-2, FOXO, HNF-1alpha, MRE, MTF-1, STAT3, TFBSs, Zn
20  2021 Gene expression of type II collagen is regulated by direct interaction with Kruppel-like factor 4 and AT-rich interactive domain 5B. ARID5B
21  2021 Generation of High-Yield, Functional Oligodendrocytes from a c-myc Immortalized Neural Cell Line, Endowed with Staminal Properties. EGF, Gal-C, GFAP, MBP, NG2, NS, RIP
22  2021 H. pylori infection induces CXCL8 expression and promotes gastric cancer progress through downregulating KLF4. CagA, GC, H. pylori
23  2021 HOXA10 promotion of HDAC1 underpins the development of lung adenocarcinoma through the DNMT1-KLF4 axis. DNMT1, HDAC1, HOXA10, LAD
24  2021 Inflammation in an Animal Model of Multiple Sclerosis Leads to MicroRNA-25-3p Dysregulation Associated with Inhibition of Pten and Klf4. CNS, EAE, IL, LPS, miRs, PTEN, TNF-alpha
25  2021 Inhibition of Bruton's tyrosine kinase as a therapeutic strategy for chemoresistant oral squamous cell carcinoma and potential suppression of cancer stemness. ALDH, BTK, CCRT, OSCC, TIM-3
26  2021 ITIH5, a p53-responsive gene, inhibits the growth and metastasis of melanoma cells by downregulating the transcriptional activity of KLF4. ITI
27  2021 KLF4 inhibition by Kenpaullone induces cytotoxicity and chemo sensitization in B-NHL cell lines via YY1 independent. ---
28  2021 KLF4 Promotes Diabetic Chronic Wound Healing by Suppressing Th17 Cell Differentiation in an MDSC-Dependent Manner. MDSCs, PU
29  2021 KLF4 Regulates Metabolic Homeostasis in Response to Stress. GLUT1, ROS
30  2021 KLF4 transactivates TRIM29 expression and modulates keratin network. ---
31  2021 KLF4, DAPK1 and SPG20 promoter methylation is not affected by DNMT1 silencing and hypomethylating drugs in lymphoma cells. DLBCL, DNMT, SPG20
32  2021 KLF4, Slug and EMT in Head and Neck Squamous Cell Carcinoma. EMT, EMT-TFs, HNSCC, HPV, TGF-beta1
33  2021 Kruppel-Like Factor 4 and Its Activator APTO-253 Induce NOXA-Mediated, p53-Independent Apoptosis in Triple-Negative Breast Cancer Cells. Bcl-2, ERK, TNBC, UV
34  2021 LINC00852 is associated with poor prognosis in non-small cell lung cancer patients and its inhibition suppresses cancer cell proliferation and chemoresistance via the hsa-miR-145-5p/KLF4 axis. lncRNAs, NSCLC, qRT-PCR
35  2021 LncRNA MEG3 Protects Chondrocytes From IL-1beta-Induced Inflammation via Regulating miR-9-5p/KLF4 Axis. IL-1beta, lncRNA, OA
36  2021 Long non-coding RNA NEAT1 mediates MPTP/MPP+-induced apoptosis via regulating the miR-124/KLF4 axis in Parkinson's disease. cleaved-casp-3, NEAT1, PD
37  2021 Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function. AMPK, ED, eNOS, FOXO1, KLF2, LKB1, NF-kappaB, PI3K-Akt, SIRT1
38  2021 Methyl CpG binding protein 2 promotes colorectal cancer metastasis by regulating N6 -methyladenosine methylation through methyltransferase-like 14. CRC, MeCP2, METTL14
39  2021 Microglia secrete miR-146a-5p-containingexosomes to regulate neurogenesis in depression. DG
40  2021 miR-145 attenuates phenotypic transformation of aortic vascular smooth muscle cells to prevent aortic dissection. AD, VSMC
41  2021 MiR-25 and KLF4 relationship has early prognostic significance in the development of cervical cancer. DE, miRNAs, SCC
42  2021 MiR-506-3p Promotes the Proliferation and Migration of Vascular Smooth Muscle Cells via Targeting KLF4. AS, VSMCs
43  2021 MYOD1 inhibits avian adipocyte differentiation via miRNA-206/KLF4 axis. MYOD1
44  2021 NEAT1 silencing alleviates pulmonary arterial smooth muscle cell migration and proliferation under hypoxia through regulation of miR‑34a‑5p/KLF4 in vitro. miR, NEAT1, PAH, PASMCs
45  2021 Nobiletin Alleviates Non-alcoholic Steatohepatitis in MCD-Induced Mice by Regulating Macrophage Polarization. MCD, NASH, NOB, RORalpha
46  2021 Oxytocin Protects Against Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting PI3K/AKT Pathway via a lncRNA GAS5/miR-375-3p/KLF4-Dependent Mechanism. ISO, LcRNA, OT
47  2021 Palmitic acid up regulates Gal-3 and induces insulin resistance in macrophages by mediating the balance between KLF4 and NF-kappaB. Gal-3, PA, TLR4
48  2021 Piperlongumine attenuates angiotensin-II-induced cardiac hypertrophy and fibrosis by inhibiting Akt-FoxO1 signalling. Ang II, NRCMs, PLG
49  2021 Pluripotency inducing Yamanaka factors: role in stemness and chemoresistance of liver cancer. CSCs, MYC, OCT4, SRY
50  2021 Protein deglycase DJ-1 deficiency induces phenotypic switching in vascular smooth muscle cells and exacerbates atherosclerotic plaque instability. VSMCs
51  2021 Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner. AR, PCa
52  2021 RNA Splicing of the Abi1 Gene by MBNL1 contributes to macrophage-like phenotype modulation of vascular smooth muscle cell during atherogenesis. Abi1, MBNL1, VSMC
53  2021 Roles of KLF4 and AMPK in the inhibition of glycolysis by pulsatile shear stress in endothelial cells. AMPK, ECs, GCKR, OS, PS
54  2021 Salidroside inhibits endothelial‑mesenchymal transition via the KLF4/eNOS signaling pathway. AS, EndMT, Hcy, NO, Sal, si
55  2021 Sevoflurane Inhibits Traumatic Brain Injury-Induced Neuron Apoptosis via EZH2-Downregulated KLF4/p38 Axis. BBB, EZH2, MAPK, TBI
56  2021 Six Shades of Vascular Smooth Muscle Cells Illuminated by KLF4 (Kruppel-Like Factor 4). VSMCs
57  2021 Telmisartan relieves liver fibrosis and portal hypertension by improving vascular remodeling and sinusoidal dysfunction. alpha-SMA, BDL, Col1a1, eNOS, IL, LPS, MMP, PDGF-beta, PHT, PP, TEL, TGF-beta, TNF-alpha, VEGF, vWF
58  2021 The role of C/EBP homologous protein (CHOP) in regulating macrophage polarization in RAW264.7 cells. CHOP, IL-13Ralpha, p-STAT6, SEA
59  2021 Transcription factors Kruppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes. GRHL, PAX5
60  2021 USP11 degrades KLF4 via its deubiquitinase activity in liver diseases. HCC
61  2021 [The Mechanism of GREM1's Effect on Osteogenic/Odontogenic Differentiation of Stem Cells from Apical Papilla]. ALP, BMP, BSP, DLX2, DMP1, DSPP, GREM1, OCN, OPN, Osx, SCAPs, SOX2, Waf1
62  2020 A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation. AMPK, PCs
63  2020 A Preliminary Study of miR-144 Inhibiting the Stemness of Colon Cancer Stem Cells by Targeting Kruppel-Like Factor 4. CRC, CSCs
64  2020 Acquisition of cancer stem cell properties in osteosarcoma cells by defined factors. ANOVA, CSCs, OS, SOX2
65  2020 Benzophenone and Benzoylphloroglucinol Derivatives from Hypericum sampsonii with Anti-Inflammatory Mechanism of Otogirinin A. iNOS, LPS, NO, TNF-alpha
66  2020 BMI1-KLF4 axis deficiency improves responses to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer. BMI1, CCRT, MSS
67  2020 BMP6 Regulates Corneal Epithelial Cell Stratification by Coordinating Their Proliferation and Differentiation and Is Upregulated in Pterygium. BMP6, CE, HCLE, PN-12
68  2020 Cellular Functions of OCT-3/4 Regulated by Ubiquitination in Proliferating Cells. ESCs, iPSCs, SOX2, UPS
69  2020 circARRDC3 contributes to interleukin‑13‑induced inflammatory cytokine and mucus production in nasal epithelial cells via the miR‑375/KLF4 axis. AR, circARRDC3, circRNA, miR, MUC5AC
70  2020 CircEHMT1 inhibits metastatic potential of breast cancer cells by modulating miR-1233-3p/KLF4/MMP2 axis. MMP-2
71  2020 CircRNA CDR1as promotes hepatoblastoma proliferation and stemness by acting as a miR-7-5p sponge to upregulate KLF4 expression. CCK-8, circRNAs, CSCs, HB
72  2020 Cross‑validation of genes potentially associated with neoadjuvant chemotherapy and platinum‑based chemoresistance in epithelial ovarian carcinoma. AEOC, GEO, HGF, NACT, NAFTc1, NR4A3
73  2020 Cyanidin-3-O-glucoside inhibits epithelial-to-mesenchymal transition, and migration and invasion of breast cancer cells by upregulating KLF4. ACNs, Cy3G, EMT
74  2020 Deletion of Kruppel-like factor-4 promotes axonal regeneration in mammals. ---
75  2020 Differential Regulatory Roles of MicroRNAs in Porcine Intramuscular and Subcutaneous Adipocytes. IM, miRNA, s.c, SDE
76  2020 Downregulation of miR-34a ameliorates inflammatory response and apoptosis induced by renal ischemia-reperfusion by promoting Kruppel-like factor 4 expression. Bcl-2, IL-10, miR, qRT-PCR, SD, TNF-alpha
77  2020 Effects of Sesame Oil Aroma on Mice after Exposure to Water Immersion Stress: Analysis of Behavior and Gene Expression in the Brain. Dusp-1
78  2020 Effects of treatment with a microRNA mimic or inhibitor on the developmental competence, quality, epigenetic status and gene expression of buffalo (Bubalus bubalis) somatic cell nuclear transfer embryos. miRNAs, NT, OCT4
79  2020 EOFAZ inhibits endothelial‑to‑mesenchymal transition through downregulation of KLF4. EndMT, EOFAZ, HUVECs, TGF
80  2020 Epigallocatechin-3-Gallate (EGCG), an Active Compound of Green Tea Attenuates Acute Lung Injury Regulating Macrophage Polarization and Krupple-Like-Factor 4 (KLF4) Expression. ALI, ARDS, EGCG, i.p, MPO, TLC
81  2020 Evaluation of toxicity of halloysite nanotubes and multi-walled carbon nanotubes to endothelial cells invitro and blood vessels invivo. HNTs, HUVECs, MWCNTs, NMs, sVCAM-1
82  2020 Exosomal LINC01005 derived from oxidized low-density lipoprotein-treated endothelial cells regulates vascular smooth muscle cell phenotypic switch. AS, HUVECs, MTT, ox-LDL, VSMCs
83  2020 Exosomal miR-103-3p from LPS-activated THP-1 macrophage contributes to the activation of hepatic stellate cells. HSCs, LPS
84  2020 FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency. EpiSCs, ESCs, FGF, FGFRs, iPSC, MAPK, Oct, PI3K, PLCgamma, PSCs, RA, Sox-2, STAT, TGF
85  2020 Functional Analysis of Two Zinc (Zn) Transporters (ZIP3 and ZIP8) Promoters and Their Distinct Response to MTF1 and RREB1 in the Regulation of Zn Metabolism. CREB, EMSA, MTF-1, RREB1, ZIP, Zn
86  2020 GINS complex subunit 4, a prognostic biomarker and reversely mediated by Kruppel-like factor 4, promotes the growth of colorectal cancer. CRC, GINS4
87  2020 Helicobacter pylori infection leads to KLF4 inactivation in gastric cancer through a TET1-mediated DNA methylation mechanism. CagA, GC
88  2020 High Level of Palmitic Acid Induced Over-Expressed Methyltransferase Inhibits Anti-Inflammation Factor KLF4 Expression in Obese Status. BSP, DNMTs, FFA, PA
89  2020 Immune checkpoint inhibitor induces cardiac injury through polarizing macrophages via modulating microRNA-34a/Kruppel-like factor 4 signaling. ICIs, miR-34a, PD-1
90  2020 Increased Serum KLF4 in Severe Atheromatosis and Extensive Aneurysmal Disease. MD
91  2020 Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies. iPS, SOX2
92  2020 Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL. B-ALL, MRD, PDX
93  2020 Inhibition of miRNA-34a Promotes M2 Macrophage Polarization and Improves LPS-Induced Lung Injury by Targeting Klf4. ARDS, LPS, miR-34a
94  2020 Integrated Analysis of lncRNAs and mRNAs Identifies a Potential Driver lncRNA FENDRR in Lung Cancer in Xuanwei, China. CCNB1, CDKN1A, CDKN1C, FENDRR, LCXW, lncRNAs
95  2020 Interplay among p21Waf1/Cip1, MUSASHI-1 and Kruppel-like factor 4 in activation of Bmi1-CreER reserve intestinal stem cells after gamma radiation-induced injury. GI, ISCs, Msi1
96  2020 KLF4 (Kruppel-Like Factor 4)-Dependent Perivascular Plasticity Contributes to Adipose Tissue inflammation. AT, DIO
97  2020 KLF4 Coordinates Corneal Epithelial Apical-Basal Polarity and Plane of Cell Division and Is Downregulated in Ocular Surface Squamous Neoplasia. ABP, CE, EMT, OSSN
98  2020 KLF4 defines the efficacy of the epidermal growth factor receptor inhibitor, erlotinib, in triple-negative breast cancer cells by repressing the EGFR gene. EGFR, TNBC
99  2020 KLF4 down-regulation resulting from TLR4 promotion of ERK1/2 phosphorylation underpins inflammatory response in sepsis. CLP, LPS
100  2020 KLF4 is required for suppression of histamine synthesis by polyamines during bone marrow-derived mast cell differentiation. 5'-UTR, BMMCs, DFMO, HDC