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■ Abbreviation / Long Form : LEC / Long-Evans Cinnamon

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Total Number of Papers: 217
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Abbreviation:   LEC  (>> Co-occurring Abbreviation)
Long Form:   Long-Evans Cinnamon
 Abbreviation Variation
 Long Form Variation
 Pair(Abbreviation/Long Form) Variation
No. Year Title Co-occurring Abbreviation
2019 Metabolic disposition of WTX101 (bis-choline tetrathiomolybdate) in a rat model of Wilson disease. LEA, Mo, WD
2019 Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson's disease. SHED, SHED-Heps, WD
2017 Animal models of Wilson disease. tx, WD
2017 Demonstrating Potential of Cell Therapy for Wilson's Disease with the Long-Evans Cinnamon Rat Model. WD
2017 Exogenous gene transfer of Rab38 small GTPase ameliorates aberrant lung surfactant homeostasis in Ruby rats. Ad-Rab38, HPS
2017 Mesoscopic Multimodal Imaging Provides New Insight to Tumor Tissue Evaluation: An Example of Macrophage Imaging of Hepatic Tumor using Organosilica Nanoparticles. FI, MNPs, MRI
2016 Rapid and reliable diagnosis of Wilson disease using X-ray fluorescence. WD, XRF
2014 Coffee consumption delays the hepatitis and suppresses the inflammation related gene expression in the Long-Evans Cinnamon rat. ---
2014 Determination of the serum metallothionein (MT)1/2 concentration in patients with Wilson's disease and Menkes disease. ELISA, MT, MT-1
10  2014 In vivo detection of a novel endogenous etheno-DNA adduct derived from arachidonic acid and the effects of antioxidants on its formation. DHHedA, gamma-OHPdG, PUFAs
11  2014 Redox regulation of apurinic/apyrimidinic endonuclease 1 activity in Long-Evans Cinnamon rats during spontaneous hepatitis. AP, APE1
12  2014 Transplantation of ATP7B-transduced bone marrow mesenchymal stem cells decreases copper overload in rats. ALT, AST, BM-MSCs, IRP, RT, RT-PCR, WD
13  2013 Evolution of exchangeable copper and relative exchangeable copper through the course of Wilson's disease in the Long Evans Cinnamon rat. ALF, CuEXC, LE, REC, WD
14  2013 Role of p38 Mapk in development of acute hepatic injury in Long-Evans Cinnamon (LEC) rats, an animal model of human Wilson's disease. SAPK
15  2013 The early molecular processes underlying the neurological manifestations of an animal model of Wilson's disease. SNCA, WD
16  2013 Visualizing hepatic copper release in Long-Evans cinnamon rats using single-photon emission computed tomography. LE, SPECT
17  2012 Dietary copper triggers onset of fulminant hepatitis in the Long-Evans cinnamon rat model. rCu, WD
18  2012 Longitudinal analysis of serum miR-122 in a rat model of Wilson's disease. AST, miR-122, WD
19  2012 Metallothionein (MT) 1/2 expression in MT 1/2 and MT 3 knock-out mice and Long-Evans Cinnamon (LEC) rats. ELISA, KO, MT, MW, WT
20  2012 PET with 64Cu-histidine for noninvasive diagnosis of biliary copper excretion in Long-Evans cinnamon rat model of Wilson disease. LEA
21  2011 Proteomic analysis of the hepatic tissue of Long-Evans Cinnamon (LEC) rats according to the natural course of Wilson disease. WD
22  2011 Quantification of oxidative DNA lesions in tissues of Long-Evans Cinnamon rats by capillary high-performance liquid chromatography-tandem mass spectrometry coupled with stable isotope-dilution method. ROS
23  2011 Radiofrequency radiation at 40 kHz induces hepatic injury in Long-Evans Cinnamon (LEC) rats, an animal model for human Wilson disease. RF
24  2010 Suppression of tumor suppressor Tsc2 and DNA repair glycosylase Nth1 during spontaneous liver tumorigenesis in Long-Evans Cinnamon rats. EBSs, LEA, TSC2, WD
25  2010 Transplantation of a fetal liver cell-loaded hyaluronic acid sponge onto the mesentery recovers a Wilson's disease model rat. FLCs, HA
26  2009 Bile salt-induced pro-oxidant liver damage promotes transplanted cell proliferation for correcting Wilson disease in the Long-Evans Cinnamon rat model. LEA, mRNA
27  2009 Low susceptibility to N-ethyl-N-nitrosourea-induced transplacental carcinogenesis in Long-Evans Cinnamon (LEC) rats. ENU, LEA, MT
28  2009 Potential feasibility of early bone marrow cell injection into the spleen for creating functional hepatocytes. BMCs, BMDHs
29  2008 Bovine lactoferrin potently inhibits liver mitochondrial 8-OHdG levels and retrieves hepatic OGG1 activities in Long-Evans Cinnamon rats. ---
30  2008 Development of cell therapy strategies to overcome copper toxicity in the LEC rat model of Wilson disease. ---
31  2008 Development of inflammatory bowel disease in Long-Evans Cinnamon rats based on CD4+CD25+Foxp3+ regulatory T cell dysfunction. IBD, MLNs, Treg
32  2008 Functional analysis of phenolsulfonphthalein transport system in Long-Evans Cinnamon rats. LEA, MRP2, PSP
33  2007 A new amphiphilic derivative, N-{[4-(lactobionamido)methyl]benzylidene}-1,1-dimethyl-2-(octylsulfanyl)ethylamine N-oxide, has a protective effect against copper-induced fulminant hepatitis in Long-Evans Cinnamon rats at an extremely low concentration compared with its original form alpha-phenyl-N-(tert-butyl) nitrone. PBN
34  2007 Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease. apo, CE, FC, MDA, MTP, TGs
35  2007 Characterization of hepatobiliary organic anion transporters in Long-Evans Cinnamon rats. ---
36  2007 Down-regulation of intestinal multidrug resistance-associated protein 2 in long-evans cinnamon rats. ABC, MRP2
37  2007 Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase kappa gene in LEC rats. thid
38  2007 Mild zinc deficiency and dietary phytic acid accelerates the development of fulminant hepatitis in LEC rats. ---
39  2006 Accumulation of copper induces DNA strand breaks in brain cells of Long-Evans Cinnamon (LEC) rats, an animal model for human Wilson Disease. SSBs
40  2006 Aldo-keto reductase 1 family B7 is the gene induced in response to oxidative stress in the livers of Long-Evans Cinnamon rats. AKR1B7, G6PDH, HO-1, NF-kappaB, Trx
41  2006 An improved diagnostic method for chronic hepatic disorder: analyses of metallothionein isoforms and trace metals in the liver of patients with hepatocellular carcinoma as determined by capillary zone electrophoresis and inductively coupled plasma-mass spectrometry. HCC, MDA, MT, Zn
42  2006 Defective repair of radiation-induced DNA damage is complemented by a CHORI-230-65K18 BAC clone on rat chromosome 4. BAC
43  2006 Development of liver regenerative therapy using glycoside-modified bone marrow cells. BMCs, GFP
44  2006 Effects of copper metabolism on neurological functions in Wistar and Wilson's disease model rats. PPI
45  2006 Inhibitory effects of fermented brown rice and rice bran on the development of acute hepatitis in Long-Evans Cinnamon rats. ---
46  2006 Lentiviral gene transfer ameliorates disease progression in Long-Evans cinnamon rats: an animal model for Wilson disease. ---
47  2006 Prevention of lethal hepatic injury in Long-Evans Cinnamon (LEC) rats by D-galactosamine hydrochloride. GalN, GPx
48  2006 Reactive oxygen species modify oligosaccharides of glycoproteins in vivo: a study of a spontaneous acute hepatitis model rat (LEC rat). ROS
49  2005 A new strain of rat for functional analysis of PINA. NAT, PINA, WD
50  2005 A novel H28Y mutation in LEC rats leads to decreased NAT protein stability in vivo and in vitro. ---
51  2005 Absence of nigrostriatal degeneration in LEC rats up to 20 weeks of age. LEA, SN, TH
52  2005 Apoptosis and age-dependant induction of nuclear and mitochondrial etheno-DNA adducts in Long-Evans Cinnamon (LEC) rats: enhanced DNA damage by dietary curcumin upon copper accumulation. LPO
53  2005 Effects of N-acetylcysteine, quercetin, and phytic acid on spontaneous hepatic and renal lesions in LEC rats. NAC, PA, QC
54  2005 Efficacy of zinc supplementation in preventing acute hepatitis in Long-Evans Cinnamon rats. MT, Zn
55  2005 Enhanced Mn-SOD immunoreactivity in the dopaminergic neurons of long-evans cinnamon rats. LEA
56  2005 Ferrous and ferric iron accumulates in the brain of aged Long-Evans Cinnamon rats, an animal model of Wilson's disease. SN
57  2005 In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase. BACE1
58  2005 Inhibitory effects of trientine, a copper-chelating agent, on induction of DNA strand breaks in kidney cells of Long-Evans Cinnamon (LEC) rats. SSBs
59  2005 Oxidative stress and pro-apoptotic conditions in a rodent model of Wilson's disease. LE, LE, PSH, SOD, WD
60  2005 Protection from spontaneous hepatocellular damage by N-benzyl-d-glucamine dithiocarbamate in Long-Evans Cinnamon rats, an animal model of Wilson's disease. BGD, D-Pen, TETA
61  2005 Whole animal copper flux assessed by positron emission tomography in the Long-Evans cinnamon rat--a feasibility study. ---
62  2005 [Liver regenerative therapy using glycoside-modified bone marrow]. ASGPR, BMCs, GFP, WD
63  2004 Comparison of the disposition behavior of organic anions in an animal model for Wilson's disease (Long-Evans Cinnamon rats) with that in normal Long-Evans Agouti rats. BSP, EHBR, LEA, PSP
64  2004 Comparison of urinary excretion of phenolsulfonphthalein in an animal model for Wilson's disease (Long-Evans Cinnamon rats) with that in normal Wistar rats: involvement of primary active organic anion transporter. BLMV, CYA, PSP, PTC
65  2004 Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats. HCC
66  2004 Evaluation of MT expression and detection of apoptotic cells in LEC rat kidneys. MT, MT
67  2004 Expression of G1 phase-related cell cycle molecules in naturally developing hepatocellular carcinoma of Long-Evans Cinnamon rats. CDK4, HCC, pRb
68  2004 Identification of the "missing domain" of the rat copper-transporting ATPase, atp7b: insight into the structural and metal binding characteristics of its N-terminal copper-binding domain. CD, HMA, WCBD
69  2004 Inhibitory effects of trientine, a copper-chelating agent, on induction of DNA strand breaks in hepatic cells of Long-Evans Cinnamon rats. SSBs
70  2004 Relationship between metallothionine and zinc in the protection against DNA damage in zinc-treated Long-Evans Cinnamon rat liver. MT, MT, Zn
71  2004 Restoration of copper metabolism and rescue of hepatic abnormalities in LEC rats, an animal model of Wilson disease, by expression of human ATP7B gene. WD
72  2004 Role of tumor necrosis factor-alpha in the development of spontaneous hepatic toxicity in Long-Evans Cinnamon rats. LE
73  2004 Tetrathiomolybdate in the treatment of acute hepatitis in an animal model for Wilson disease. TTM
74  2003 Effect and possible role of Zn treatment in LEC rats, an animal model of Wilson's disease. MT, Zn
75  2003 Evidence of alterations in base excision repair of oxidative DNA damage during spontaneous hepatocarcinogenesis in Long Evans Cinnamon rats. LEA
76  2003 Excess dietary histidine decreases the liver copper level and serum alanine aminotransferase activity in Long-Evans Cinnamon rats. ---
77  2003 Gene expression in the liver of Long-Evans cinnamon rats during the development of hepatitis. LEA
78  2003 Metallothionein-1 and metallothionein-2 gene expression and localisation of apoptotic cells in Zn-treated LEC rat liver. mAb, MT, Zn
79  2003 No prevention of liver and kidney tumors in Long-Evans Cinnamon rats by dietary curcumin, but inhibition at other sites and of metastases. ---
80  2003 Sestamibi is a substrate for MDR1 and MDR2 P-glycoprotein genes. LEA
81  2003 Tetrathiomolybdate causes formation of hepatic copper-molybdenum clusters in an animal model of Wilson's disease. ---
82  2002 99mTc-mebrofenin scintigraphy for evaluating liver disease in a rat model of Wilson's disease. LEA
83  2002 Deficiency in nuclear accumulation of G22p1 and Xrcc5 proteins in hyper-radiosensitive Long-Evans Cinnamon (LEC) rat cells after X irradiation. DNA-PK, DSBs
84  2002 DNA damage triggers imbalance of proliferation and apoptosis during development of preneoplastic foci in the liver of Long-Evans Cinnamon rats. GST-P, HCCs, LEA, PCNA
85  2002 Early cell transplantation in LEC rats modeling Wilson's disease eliminates hepatic copper with reversal of liver disease. ---
86  2002 Hepatic iron accumulation is not directly associated with induction of DNA strand breaks in the liver cells of Long-Evans Cinnamon (LEC) rats. ---
87  2002 Interactions between Zn and Cu in LEC rats, an animal model of Wilson's disease. MT
88  2002 Metallothionein and antioxidant enzymes in Long-Evans Cinnamon rats treated with zinc. MT, SOD
89  2001 Correction of liver disease following transplantation of normal rat hepatocytes into Long-Evans Cinnamon rats modeling Wilson's disease. ---
90  2001 Cu-metallothioneins (Cu(I)8-MTs) in LEC rat livers 13 weeks after birth still act as antioxidants. DMPO, MTs
91  2001 Effects of lycopene and Sho-saiko-to on hepatocarcinogenesis in a rat model of spontaneous liver cancer. GST-P, HCC
92  2001 In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis. ASA, SA, WD
93  2001 New rat model for attention deficit hyperactive disorder (ADHD). ADHD, Wig, WKAH
94  2001 No significant differences were observed in the amounts of DNA strand breaks produced by copper between male and female liver cells of long-evans cinnamon (LEC) strain rats. ---
95  2001 Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats. DEN, WKAH
96  2001 The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats. LA, LPO
97  2000 Accumulation of diacylglycerol in the liver membrane of the Long-Evans Cinnamon (LEC) rat with hepatitis: FT-IR spectroscopic and HPLC detection. ---
98  2000 Biliary copper excretion capacity in intact animals: correlation between ATP7B function, hepatic mass, and biliary copper excretion. LEA
99  2000 Competition between copper and silver in Fischer rats with a normal copper metabolism and in Long-Evans Cinnamon rats with an abnormal copper metabolism. Cp, MT
100  2000 Genomic DNA analyses of spontaneous hepatocellular carcinomas in LEC rat liver using a new technique. HCCs, RLGS