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■ Abbreviation / Long Form : MOA / mode of action

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Total Number of Papers: 451
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Abbreviation:   MOA  (>> Co-occurring Abbreviation)
Long Form:   mode of action
 Abbreviation Variation
 Long Form Variation
 Pair(Abbreviation/Long Form) Variation
No. Year Title Co-occurring Abbreviation
2020 A toxicogenomic approach for the risk assessment of the food contaminant acetamide. BMD, BMDL10, POD
2020 Aclonifen targets solanesyl diphosphate synthase, representing a novel mode of action for herbicides. HRAC
2020 An evaluation of the human relevance of the liver tumors observed in female mice treated with permethrin based on mode of action. PPARalpha
2020 Application of the adverse outcome pathway framework to genotoxic modes of action. AOP, AOs
2020 Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept. AOPs, BDNF, CKEs, DNT, hiPSC, MRA
2020 Berberine in the treatment of metabolism-related chronic diseases: A drug cloud (dCloud) effect to target multifactorial disorders. AMPK, BBR, CDs, dCloud, INSR, LDLR, MTD
2020 Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro. MN
2020 Development of the transcriptome for a sediment ecotoxicological model species, Chironomus dilutus. ---
2020 Dioxin Male Rat Reproductive Toxicity Mode of Action and Relative Potency of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and 2,3,7,8-Tetrachlorodibenzofuran Characterized by Fetal Pituitary and Testis Transcriptome Profiling. TCDD, TCDF
10  2020 Dose addition in chemical mixtures inducing craniofacial malformations in zebrafish (Danio rerio) embryos. ---
11  2020 The relative rate of kill of the MMV Malaria Box compounds provides links to the mode of antimalarial action and highlights scaffolds of medicinal chemistry interest. BRRoK, MMV, RoK, SERCaP, TCP1
12  2020 Toggling Preassembly with Single-Site Mutation Switches the Cytotoxic Mechanism of Cationic Amphipathic Peptides. CAP
13  2020 Town-scale microbial sewer community and H2S emissions response to common chemical and biological dosing treatments. FOGs, QS
14  2020 [The association between mode of action and adverse outcome pathway and its application in risk assessment]. AA, AOP
15  2019 Advance of Seriniquinone Analogues as Melanoma Agents. SARs
16  2019 An in vitro developmental neurotoxicity screening assay for retinoic acid-induced neuronal differentiation using the human NT2/D1 cell line. 4-HPR, DNT, non-RA, RA
17  2019 Application of Modeling Approaches to Explore Vaccine Adjuvant Mode-of-Action. ---
18  2019 Arsenite interrupts neurodevelopmental processes of human and rat neural progenitor cells: The role of reactive oxygen species and species-specific antioxidative defense. DNT, ROS
19  2019 Comparison of Target Features for Predicting Drug-Target Interactions by Deep Neural Network Based on Large-Scale Drug-Induced Transcriptome Data. ADR, DNN, DR, DTIs, LINCS, PM, PPI network
20  2019 Cross-species comparison of CAR-mediated procarcinogenic key events in a 3D liver microtissue model. CAR, IPA, NPCs, PB
21  2019 Deciphering the mode of action of pollutants impairing the fish larvae escape response with the vibrational startle response assay. CPO, MCA, VSRA
22  2019 Developing context appropriate toxicity testing approaches using new alternative methods (NAMs). NAMs, NAMs
23  2019 Differential metabolic activity and discovery of therapeutic targets using summarized metabolic pathway models. KO
24  2019 Ecotoxicity of nanomaterials in amphibians: A critical review. NMs, ROS
25  2019 Environmental hazard and risk assessment of thiochemicals. Application of integrated testing and intelligent assessment strategies (ITS) to fulfil the REACH requirements for aquatic toxicity. ITS, PECs, PNECs
26  2019 Histopathology re-examination of the NTP toxicity/carcinogenicity studies of tert-butyl alcohol to identify renal tumor and toxicity modes of action. alpha2u-gN, CPN, TBA
27  2019 In silico drug repositioning: from large-scale transcriptome data to therapeutics. FDA
28  2019 Increase in stable isotope ratios driven by metabolic alterations in amphipods exposed to the beta-blocker propranolol. ---
29  2019 Involvement of Peroxisome Proliferator-Activated Receptor-Alpha in Liver Tumor Production by Permethrin in the Female Mouse. PPARalpha
30  2019 Machine learning-powered antibiotics phenotypic drug discovery. BPF
31  2019 Metazachlor: Mode of action analysis for rat liver tumour formation and human relevance. CAR, CAR KO, RDS, WT
32  2019 Mode of Action Classifications in the EnviroTox Database: Development and Implementation of a Consensus MOA Classification. ---
33  2019 Mode-of-action analysis of the effects induced by nicotine in the in vitro micronucleus assay. MN
34  2019 Multitarget Approach for the Treatment of Alzheimer's Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles. AD, ADME, CREB, HDAC, HDACs, PDE9
35  2019 Nanomaterials induce DNA-protein crosslink and DNA oxidation: A mechanistic study with RTG-2 fish cell line and Comet assay modifications. NMs
36  2019 Pilot studies evaluating the nongenotoxic rodent carcinogens phenobarbital and clofibrate in the rat Pig-a assay. ---
37  2019 Plant chemical genetics reveals colistin sulphate as a SA and NPR1-independent PR1 inducer functioning via a p38-like kinase pathway. CLPs, CS, MAPK, NPR1, PR1, ROS, SA, SAR
38  2019 Predictions of genotoxic potential, mode of action, molecular targets, and potency via a tiered multiflow assay data analysis strategy. GEFs, ML
39  2019 PROteolysis TArgeting Chimeras (PROTACs) - Past, present and future. PROTAC, PROTACs
40  2019 QSAR for baseline toxicity and classification of specific modes of action of ionizable organic chemicals in the zebrafish embryo toxicity test. FET, IOC, QSAR, TR
41  2019 Review of transcriptomic responses to hexavalent chromium exposure in lung cells supports a role of epigenetic mediators in carcinogenesis. ---
42  2019 Statistical Approach to Identify Threshold and Point of Departure in Dose-Response Data. HS, HS-Arc, POD
43  2019 STING Activation and its Application in Immuno-Oncology. CDN
44  2019 Styryl-cinnamate hybrid inhibits glioma by alleviating translation, bioenergetics and other key cellular responses leading to apoptosis. PPI
45  2019 Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability. MRSA, SAR
46  2019 Target site model: Application of the polyparameter target lipid model to predict aquatic organism acute toxicity for various modes of action. ---
47  2019 Tetrahydrofuran-induced tumors in rodents are not relevant to humans: Quantitative weight of evidence analysis of mode of action information does not support classification of tetrahydrofuran as a possible human carcinogen. CAR, CPN, QWoE, THF
48  2019 The new age of insecticide discovery-the crop protection industry and the impact of natural products. ---
49  2019 Toxicity of some prevalent organic chemicals to tadpoles and comparison with toxicity to fish based on mode of toxic action. ELUMO, NHDA, QSAR
50  2019 Transcriptomic analysis reveals dose-dependent modes of action of benzo(a)pyrene in polar cod (Boreogadus saida). BaP, PAHs
51  2019 Use of GC-MS based metabolic fingerprinting for fast exploration of fungicide modes of action. GC-MS
52  2019 UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries. cGMP, CVD, EDCs, OMC, PCPs, PCSA, sGC, UV
53  2019 xCELLanalyzer: A Framework for the Analysis of Cellular Impedance Measurements for Mode of Action Discovery. ---
54  2018 A human relevance investigation of PPARalpha-mediated key events in the hepatocarcinogenic mode of action of propaquizafop in rats. KO, PPARalpha, WT
55  2018 A Leveraged Signal-to-Noise Ratio (LSTNR) Method to Extract Differentially Expressed Genes and Multivariate Patterns of Expression From Noisy and Low-Replication RNAseq Data. DEGs, GLM, LSTNR
56  2018 A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation. HTT
57  2018 Application of the adverse outcome pathway (AOP) approach to inform mode of action (MOA): A case study with inorganic arsenic. AOP, AOPs, iAs
58  2018 Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing. HaCaT, UPR, VEGF-A
59  2018 Assessment of the mutagenic potential of para-chloroaniline and aniline in the liver, spleen, and bone marrow of Big Blue rats with micronuclei analysis in peripheral blood. ABRET, MetHb, MF, PCA, TGR
60  2018 Bacterial ribonuclease binase exerts an intra-cellular anti-viral mode of action targeting viral RNAs in influenza a virus-infected MDCK-II cells. IAV
61  2018 Changes in the proteome of the problem weed blackgrass correlating with multiple-herbicide resistance. HS, MDR, MHR
62  2018 Combined effects of antifouling biocides on the growth of three marine microalgal species. CA, IA, ZnPT
63  2018 Comparative behavioral toxicology with two common larval fish models: Exploring relationships among modes of action and locomotor responses. PTZ
64  2018 Comparison of modes of action between fish and zebrafish embryo toxicity for baseline, less inert, reactive and specifically-acting compounds. ---
65  2018 Complex Interplay between Sphingolipid and Sterol Metabolism Revealed by Perturbations to the Leishmania Metabolome Caused by Miltefosine. PLs, SLs, WT
66  2018 Development of a data-processing method based on Bayesian k-means clustering to discriminate aneugens and clastogens in a high-content micronucleus assay. MN
67  2018 Development of a robust reporter gene based assay for the bioactivity determination of IL-5-targeted therapeutic antibodies. RGA
68  2018 Development of an adverse outcome pathway for chemically induced hepatocellular carcinoma: case study of AFB1, a human carcinogen with a mutagenic mode of action. AFB1, AOPs, HCC, KERs, KEs, MIE
69  2018 Development of an in vitro potency assay for human skeletal muscle derived cells. AChE, ATMP, MAA, MACS, SMDCs
70  2018 Effect of polyhexamethylene biguanide on rat liver. PHMB
71  2018 Effects of carbamazepine and cetirizine under an ocean acidification scenario on the biochemical and transcriptome responses of the clam Ruditapes philippinarum. CBZ, CTZ, OA
72  2018 From the Cover: Fenretinide, Troglitazone, and Elmiron Add to Weight of Evidence Support for Hemangiosarcoma Mode-of-Action From Studies in Mice. EC, HS
73  2018 Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna. ROS
74  2018 Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators. CAR, PB, RDS
75  2018 Human-relevant potency threshold (HRPT) for ERalpha agonism. EDCs, HRPT
76  2018 Identifying the gaps: Resources and perspectives on the use of nuclear receptor based-assays to improve hazard assessment of emerging contaminants. EDCs, NRs
77  2018 In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats. MF
78  2018 Insights into antitrypanosomal drug mode-of-action from cytology-based profiling. HAT
79  2018 Linking mode of action of the model respiratory and photosynthesis uncoupler 3,5-dichlorophenol to adverse outcomes in Lemna minor. 3,5-DCP, AOPs, ETR, LPO, OXPHOS, PSII, ROS
80  2018 Mesenchymal stromal/stem cells as potential therapy in diabetic retinopathy. DR, EC, MSC, PDR, VEGF
81  2018 Minimum datasets to establish a CAR-mediated mode of action for rodent liver tumors. CAR
82  2018 Mode of action characterization for adverse effect of propranolol in Daphnia magna based on behavior and physiology monitoring and metabolite profiling. NMR, PCA
83  2018 Multibiomarker interactions to diagnose and follow-up chronic exposure of a marine crustacean to Hazardous and Noxious Substances (HNS). ACN, ANL, HNS
84  2018 Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells. ---
85  2018 Screening for human urinary bladder carcinogens: two-year bioassay is unnecessary. ---
86  2018 Sedaxane-Use of Nuclear Receptor Transactivation Assays, Toxicogenomics, and Toxicokinetics as Part of a Mode of Action Framework for Rodent Liver Tumors. ---
87  2018 Self-association and conformational variation of NS5A domain 1 of hepatitis C virus. DAAs, DCV, HCV, NS5A
88  2018 The PPARalpha-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions. KE, PPARalpha
89  2018 The role of ethyl acrylate induced GSH depletion in the rodent forestomach and its impact on MTD and in vivo genotoxicity in developing an adverse outcome pathway (AOP). AOP, EA, MTD
90  2018 Transcriptional profiling of male CD-1 mouse lungs and Harderian glands supports the involvement of calcium signaling in acrylamide-induced tumors. AA, CS, PODs
91  2018 Unexpected Effects of Propiconazole, Tebuconazole, and Their Mixture on the Receptors CAR and PXR in Human Liver Cells. CAR, PXR, Te
92  2017 An Evaluation of the Human Relevance of the Lung Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action. ---
93  2017 An updated analysis of respiratory tract cells at risk for formaldehyde carcinogenesis. ---
94  2017 Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target. CoA, PanAms
95  2017 Biological responses to phenylurea herbicides in fish and amphibians: New directions for characterizing mechanisms of toxicity. ---
96  2017 Characterizing combined effects of antiestrogenic chemicals on vitellogenin production in rainbow trout (Oncorhynchus mykiss) hepatocytes. AhR, BNF, CYP1A, EDC, ER, ERalpha, VTG, vtg-1, Zrp
97  2017 Chromosomal aberrations, clastogens vs aneugens. ---
98  2017 Classification of in vitro genotoxicants using a novel multiplexed biomarker assay compared to the flow cytometric micronucleus test. ---
99  2017 Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver. CO, DCM
100  2017 Comment on "Mode of Action (MOA) Assignment Classifications for Ecotoxicology: An Evaluation of Approaches". ---