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â–  Abbreviation / Long Form : MP / methapyrilene

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Abbreviation:   MP  (>> Co-occurring Abbreviation)
Long Form:   methapyrilene
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No. Year Title Co-occurring Abbreviation
2015 A novel transcriptomics based in vitro method to compare and predict hepatotoxicity based on mode of action. BNF, CLO, CPZ, DINP, MOAs, PB, VPA
2014 Changes in the expression of miRNAs at the pericentral and periportal regions of the rat liver in response to hepatocellular injury: comparison with the changes in the expression of plasma miRNAs. miRNAs
2014 Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats. GST-P, PB, TAA
2012 In vitro - in vivo correlation of gene expression alterations induced by liver carcinogens. 2-NF, AB1, PBO
2012 In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsymâ„¢: a mechanistic, mathematical model of DILI. ADME, DILI
2011 The genotoxic potential of methapyrilene using the alkaline Comet assay in vitro and in vivo. ABT
2008 A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats. PAM, TAA
2008 Gene expression profiling of methapyrilene-induced hepatotoxicity in rat. ---
2008 Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore. ---
10  2006 Gene expression analysis of the hepatotoxicant methapyrilene in primary rat hepatocytes: an interlaboratory study. ---
11  2004 Cross-site comparison of gene expression data reveals high similarity. ---
12  2004 Interlaboratory evaluation of rat hepatic gene expression changes induced by methapyrilene. ---
13  2002 Methapyrilene toxicity: anchorage of pathologic observations to gene expression alterations. ---
14  1998 Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil. ---
15  1994 Dose-responses in rat hepatic protein modification and expression following exposure to the rat hepatocarcinogen methapyrilene. ---
16  1994 Effects of some non-genotoxic chemicals on DNA synthesis in rat hepatocytes. AAF, CA, DMSO, EGF, PB
17  1994 Mutation spectrum of a binary mixture of mutagens (methapyrilene and sodium azide) in strain TA1535 of Salmonella. ---
18  1993 Comparisons of protein changes in human and rodent hepatocytes induced by the rat-specific carcinogen, methapyrilene. ---
19  1993 The evaluation of methapyrilene for bacterial mutation with metabolic activation by Aroclor-induced, methapyrilene-induced and noninduced rat-liver S9. ---
20  1992 Covalent protein modifications and gene expression changes in rodent liver following administration of methapyrilene: a study using two-dimensional electrophoresis. ---
21  1992 Effects of methapyrilene measured in mitochondria isolated from naive and methapyrilene-treated rat and mouse hepatocytes. ---
22  1992 Effects of methapyrilene on DNA synthesis in mice and rats following continuous dietary exposure. ---
23  1992 Metabolism of methapyrilene by Fischer-344 rat and B6C3F1 mouse hepatocytes. ---
24  1991 DNA methylation and oncogene expression in methapyrilene-induced rat liver tumors and in treated hepatocytes in culture. 5MC
25  1991 Modulation of rat hepatic cytochromes P450 by chronic methapyrilene treatment. ---
26  1989 Glutathione and lipid peroxide levels in rat liver following administration of methapyrilene and analogs. MDA, MF, TD
27  1989 Rat liver carcinogen methapyrilene (MP) induced mutants of chromosomal origin in the L5178Y/TK+/- ----TK-/- mouse lymphoma. ---
28  1988 Examination of genotoxicity, toxicity and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene. SDH, SGOT, SGPT, SPS, UDS
29  1987 Methapyrilene is a genotoxic carcinogen: studies on methapyrilene and pyrilamine in the L5178Y/TK +/- mouse lymphoma assay. MLA, PYR
30  1985 Carcinogenesis by nonmutagenic chemicals: early response of rat liver cells induced by methapyrilene. ---
31  1984 Neoplastic conversion in rat liver by the antihistamine methapyrilene demonstrated by a sequential syncarcinogenic effect with N-2-fluorenylacetamide. DEN, FAA
32  1983 An enhancing effect of the antihistaminic drug methapyrilene on rat liver carcinogenesis by previously administered N-2-fluorenylacetamide. FAA, PB