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■ Abbreviation / Long Form : MPO / multiparameter optimization

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Total Number of Papers: 9
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Abbreviation:   MPO  (>> Co-occurring Abbreviation)
Long Form:   multiparameter optimization
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No. Year Title Co-occurring Abbreviation
2018 Contribution assessment of multiparameter optimization descriptors in CNS penetration. CNS
2018 Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases. CNS, Keap1, Keap1-Nrf2, Nrf2, PPI
2018 Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)-7-Hydroxy- N-[(1 S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic). CNS, SAR
2017 Applications of parallel synthetic lead hopping and pharmacophore-based virtual screening in the discovery of efficient glycine receptor potentiators. CNS, GlyRs
2017 Assessing molecular scaffolds for CNS drug discovery. CNS
2017 Updating molecular properties during early drug discovery. ---
2016 Probabilistic Approach to Generating MPOs and Its Application as a Scoring Function for CNS Drugs. pMPO
2014 Advances in multiparameter optimization methods for de novo drug design. ---
2012 Multi-parameter optimization: identifying high quality compounds with a balance of properties. ADME