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■ Abbreviation / Long Form : MgTX / margatoxin

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Total Number of Papers: 42
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Abbreviation:   MgTX  (>> Co-occurring Abbreviation)
Long Form:   margatoxin
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No. Year Title Co-occurring Abbreviation
2022 GFP-Margatoxin, a Genetically Encoded Fluorescent Ligand to Probe Affinity of Kv1.3 Channel Blockers. GFP
2022 Modulating the Excitability of Olfactory Output Neurons Affects Whole-Body Metabolism. AP, DIO, DREADDs, EE, MHF, OB, RMP
2021 Optimization of Pichia pastoris Expression System for High-Level Production of Margatoxin. rMgTx, TrMgTx, UrMgTx
2020 Olfactory bulb-targeted quantum dot (QD) bioconjugate and Kv1.3 blocking peptide improve metabolic health in obese male mice. OB, QD
2016 Human immunodeficiency virus protein Tat induces oligodendrocyte injury by enhancing outward K+ current conducted by KV1.3. HIV-1, KV, OLs, PAP, Tat
2016 Margatoxin-bound quantum dots as a novel inhibitor of the voltage-gated ion channel Kv1.3. OB, QDs
2015 Inhibition of Kv channel expression by NSAIDs depolarizes membrane potential and inhibits cell migration by disrupting calpain signaling. GI, NSAIDs
2015 Nuclear localization and functional characteristics of voltage-gated potassium channel Kv1.3. CREB, Kv
2014 Binding modes of two scorpion toxins to the voltage-gated potassium channel kv1.3 revealed from molecular dynamics. HgTx, MD
10  2014 Components of action potential repolarization in cerebellar parallel fibres. DAP, TEA
11  2014 Effect of methamphetamine on the microglial damage: role of potassium channel Kv1.3. 4-AP, Meth, TEA
12  2014 Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels. ---
13  2013 Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers. AgTx2
14  2013 The role of potassium channel in silica nanoparticle-induced inflammatory effect in human vascular endothelial cells in vitro. 4-AP, HUVECs, IL-6, LDH, TEA, TNF-alpha
15  2011 Kv1.3 channels regulate synaptic transmission in the nucleus of solitary tract. EPSCs, NTS
16  2011 Pharmacological inhibition of Kv1.3 fails to modulate insulin sensitivity in diabetic mice or human insulin-sensitive tissues. SkMC
17  2010 Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo. shRNA
18  2010 Bursts and hyperexcitability in non-myelinated axons of the rat hippocampus. 4-AP, alpha-DTX
19  2010 Immunomodulation of voltage-dependent K+ channels in macrophages: molecular and biophysical consequences. ---
20  2009 Ca2+-dependent functions in peptidoglycan-stimulated mouse dendritic cells. DCs, IL-10, IL-12, Kv, PGN, PM, TLR2, TNF-alpha
21  2008 Kv1.3 channels in postganglionic sympathetic neurons: expression, function, and modulation. ---
22  2008 Voltage-gated potassium channel Kv1.3 in rabbit ciliary epithelium regulates the membrane potential via coupling intracellular calcium. Kv1.3, NPE
23  2006 Moderate hypoxia influences excitability and blocks dendrotoxin sensitive K+ currents in rat primary sensory neurones. AP, DRG, DTX, DTX-K, PNS, TsTX-K
24  2006 Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism. ---
25  2003 Immunosuppressive effects of a Kv1.3 inhibitor. ---
26  2003 Shaker-type Kv1 channel blockers increase the peristaltic activity of guinea-pig ileum by stimulating acetylcholine and tachykinins release by the enteric nervous system. alpha-DTX, ChTX, DTX-K, IbTX
27  2000 Correolide, a nor-triterpenoid blocker of Shaker-type Kv1 channels elicits twitches in guinea-pig ileum by stimulating the enteric nervous system and enhancing neurotransmitter release. ---
28  1999 Peptidyl inhibitors of shaker-type Kv1 channels elicit twitches in guinea pig ileum by blocking kv1.1 at enteric nervous system and enhancing acetylcholine release. ---
29  1998 Components of after-hyperpolarization in magnocellular neurones of the rat supraoptic nucleus in vitro. AHP, ChTX, DAP, IbTX
30  1998 Modulation of inhibitory post-synaptic currents (IPSCs) in mouse cerebellar Purkinje and basket cells by snake and scorpion toxin K+ channel blockers. AgTX-2, alpha-DTX, gamma-DTX, IPSCs, TEA
31  1997 Ion channels, Ca2+ signaling, and reporter gene expression in antigen-specific mouse T cells. CTX
32  1997 Margatoxin binds to a homomultimer of K(V)1.3 channels in Jurkat cells. Comparison with K(V)1.3 expressed in CHO cells. ---
33  1997 [125I]Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channels. ChTX, IbTX
34  1996 Observation of noncovalent complexes between margatoxin and the Kv1.3 peptide ligands: A model investigation using ion-spray mass spectrometry. ---
35  1996 Presence of the voltage-gated potassium channels sensitive to charybdotoxin in inhibitory presynaptic terminals of cultured rat hippocampal neurons. ChTX, IbTX, IPSCs, KTX
36  1996 Properties of K+ and Cl- channels and their involvement in proliferation of rat microglial cells. ChTX, CSF, NPPB, oxy
37  1995 Ca(2+)-activated K+ channels of human and rabbit erythrocytes display distinctive patterns of inhibition by venom peptide toxins. ChTX, IbTX, KTX, ScyTX
38  1995 [125I]margatoxin, an extraordinarily high affinity ligand for voltage-gated potassium channels in mammalian brain. ---
39  1994 A disposable-chamber temperature-regulation system for the study of intracellular calcium levels in single live T cells using fluorescence digital-imaging microscopy. DIM
40  1994 Chemical synthesis and structure-function studies of margatoxin, a potent inhibitor of voltage-dependent potassium channel in human T lymphocytes. ---
41  1993 Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels. ChTX
42  1993 Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation. ChTX, IL-2, NxTX