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■ Abbreviation / Long Form : NEP / neprilysin

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Total Number of Papers: 322
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Abbreviation:   NEP  (>> Co-occurring Abbreviation)
Long Form:   neprilysin
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2019 Alzheimer's Abeta1-40 peptide degradation by thermolysin: evidence of inhibition by a C-terminal Abeta product. TLN
2019 Clinical and genetic analysis in a large Chinese cohort of patients with X-linked hypophosphatemia. MLPA, XLH
2019 Comparing Gly11/dAla11-Replacement vs. the in-Situ Neprilysin-Inhibition Approach on the Tumor-targeting Efficacy of the 111In-SB3/111In-SB4 Radiotracer Pair. PA
2019 Dendrobium polysaccharides attenuate cognitive impairment in senescence-accelerated mouse prone 8 mice via modulation of microglial activation. AD, DOP, IDE, IL-10, IL-1beta, IL-6, SAMP8, TNF-alpha
2019 Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI). ACE, ARNIs, TPE
2019 HIV-1 increases extracellular amyloid-beta levels through neprilysin regulation in primary cultures of human astrocytes. ---
2019 Localization of 99mTc-GRP Analogs in GRPR-Expressing Tumors: Effects of Peptide Length and Neprilysin Inhibition on Biological Responses. BBN, GRPRs, PA
2019 Management of a patient with heart failure by sacubitril/valsartan: improvement of functional capacity. ARB, ARNIs, HF, HFrEF, NYHA
2019 N-Terminal Truncated Abeta4-42 Is a Substrate for Neprilysin Degradation in vitro and in vivo. AD
10  2019 Neprilysin levels at the acute phase of ST-elevation myocardial infarction. IQR, IS, LVEF, STEMI
11  2019 Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents. ACE2, PEGylation
12  2019 Retrograde transport of masseter muscle-derived neprilysin to hippocampus. AD, HPC, MM, TGN
13  2019 Sacubitril/valsartan (LCZ696) significantly reduces aldosterone and increases cGMP circulating levels in a canine model of RAAS activation. NP, RAAS
14  2019 Targeting amyloid clearance in Alzheimer's disease as a therapeutic strategy. ACE, AD, ADEs
15  2019 The circulating form of neprilysin is not a general biomarker for overall survival in treatment-naive cancer patients. cNEP
16  2019 Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review. AbetaO, AD, BBB, GLP-1R, IDE, LB, LRP-1, NFT, NFTs, P-gp, PD, SNpc
17  2018 5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease. 5-HIAA, AD
18  2018 Activation of alpha7 nicotinic acetylcholine receptor alleviates Abeta1-42-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways. Abeta1-42, AD, alpha7nAChR, CAT, IDE, MDA, SOD
19  2018 Angiotensin converting enzyme and neprilysin inhibition alter pain response in dexhamethasone-induced hypertensive rats. ---
20  2018 Biological and In silico Studies on Synthetic Analogues of Tyrosine Betaine as Inhibitors of Neprilysin - A Drug Target for the Treatment of Heart Failure. BBB
21  2018 Chronic intermittent hypoxia induces changes on the expression and activity of neprilysin (EC in the brain of rats. CIH, OSA
22  2018 Cigarette smoke condensate could promote human bronchial epithelial BEAS-2B cell migration through shifting neprilysin trafficking. CSC, p120ctn
23  2018 Degradation of amyloid beta peptide by neprilysin expressed from Borna disease virus vector. AD, BoDV
24  2018 Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice. AD, APP, BACE1, DHM
25  2018 DNA methylation level of the neprilysin promoter in Alzheimer's disease brains. AD
26  2018 Effects of sacubitril/valsartan on neprilysin targets and the metabolism of natriuretic peptides in chronic heart failure: a mechanistic clinical study. ANP, BNP, HF, NT-proBNP, sNEP
27  2018 Increased urinary angiotensin converting enzyme 2 and neprilysin in patients with type 2 diabetes. ACE2, ADAM17, CKD, ND
28  2018 Insulin-signaling Pathway Regulates the Degradation of Amyloid beta-protein via Astrocytes. AD, ERK, IDE
29  2018 Interplay between Copper, Neprilysin, and N-Truncation of beta-Amyloid. AD
30  2018 Intra-Renal Angiotensin Levels Are Increased in High-Fructose Fed Rats in the Extracorporeal Renal Perfusion Model. ACE, Ang 1-7, Ang I, Ang II, RAS
31  2018 miR-103 Promotes Neurite Outgrowth and Suppresses Cells Apoptosis by Targeting Prostaglandin-Endoperoxide Synthase 2 in Cellular Models of Alzheimer's Disease. AD, ADAM10, CSF, PTGS2
32  2018 Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design. ACE
33  2018 Neprilysin Deficiency Is Associated With Expansion of Islet beta-Cell Mass in High Fat-Fed Mice. T2D
34  2018 Neprilysin in the Cerebrospinal Fluid and Serum of Patients Infected With HIV1-Subtypes C and B. CSF
35  2018 Neprilysin inhibition promotes corneal wound healing. WT
36  2018 New Insights of a Neuronal Peptidase DINE/ECEL1: Nerve Development, Nerve Regeneration and Neurogenic Pathogenesis. DINE, ECE, ECEL1
37  2018 Radiometal-Dependent Biological Profile of the Radiolabeled Gastrin-Releasing Peptide Receptor Antagonist SB3 in Cancer Theranostics: Metabolic and Biodistribution Patterns Defined by Neprilysin. GRPR
38  2018 Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice. ET-1, PASMCs
39  2018 The antioxidant xanthorrhizol prevents amyloid-beta-induced oxidative modification and inactivation of neprilysin. AD, HNE, ROS, Xan
40  2018 Treadmill Exercise Ameliorates Spatial Learning and Memory Deficits Through Improving the Clearance of Peripheral and Central Amyloid-Beta Levels. AD, IDE, LRP-1, sAbeta1-42, sLRP-1
41  2018 Umbilical Cord Mesenchymal Stem Cells Conditioned Medium Promotes Abeta25-35 phagocytosis by Modulating Autophagy and Abeta-Degrading Enzymes in BV2 Cells. AD, IDE, MSC, ucMSCs-CM
42  2018 [Effect of Electroacupuncture on Levels of beta-amyloid and Neprilysin Proteins in the Cerebral Cortex of Alzheimer's Disease Mice Based on "Mutual Assistance of Kidney and Brain" Theory]. AD, EA, WB
43  2018 [Effects of benzo(a)pyrene on expressions of insulin-degrading enzyme and neprilysin in neuroglia cells]. BaP, CCK-8, IDE, qRT-PCR
44  2017 Biochemistry, Therapeutics, and Biomarker Implications of Neprilysin in Cardiorenal Disease. BNP, cGMP, HF, NPs, NT-proBNP, RAAS
45  2017 CART modulates beta-amyloid metabolism-associated enzymes and attenuates memory deficits in APP/PS1 mice. CART, IDE, LRP-1, RAGE
46  2017 Degradation Paradigm of the Gut Hormone, Pancreatic Polypeptide, by Hepatic and Renal Peptidases. DPP-IV, PP
47  2017 Elucidating Pathogenic Mechanisms of Early-onset Alzheimer's Disease in Down Syndrome Patients. AD, APP, DS, DYRK1A
48  2017 Epigallocatechin gallate induces extracellular degradation of amyloid beta-protein by increasing neprilysin secretion from astrocytes through activation of ERK and PI3K pathways. EGCG, ERK, IDE, PI3K
49  2017 Expression of neprilysin in periodontitis-affected gingival tissues. AD, APP, IHC, qRT-PCR
50  2017 HIV-1 Transactivator Protein Induces ZO-1 and Neprilysin Dysfunction in Brain Endothelial Cells via the Ras Signaling Pathway. BBB, FTS, ROS
51  2017 Meta-analysis of expression and function of neprilysin in Alzheimer's disease. AD
52  2017 Neprilysin facilitates adipogenesis through potentiation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway. PI3K, PPARgamma
53  2017 Neprilysin inhibitors: A new hope to halt the diabetic cardiovascular and renal complications? ACE, ARNi, CKD, CVD, RAS
54  2017 Neprilysin Inhibitors: Emerging Therapy for Heart Failure. NPs
55  2017 Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-beta in APP/PS1 mice. AD, BACE1, BJJS, IDE
56  2017 Pharmacogenomics of angiotensin receptor/neprilysin inhibitor and its long-term side effects. AD, ARNI, CAA, HF, HFpEF, HFrEF
57  2017 Protective effect of valproic acid in streptozotocin-induced sporadic Alzheimer's disease mouse model: possible involvement of the cholinergic system. ACh, AChE, HDACi, i.c.v, MWM, SAD, STZ, VPA
58  2017 Role of Ageing and Oxidative Stress in Regulation of Amyloid-Degrading Enzymes and Development of Neurodegeneration. AD, ADEs, APP, IDE
59  2017 Sacubitril/valsartan: beyond natriuretic peptides. BNP, HF, NPS, RAAS
60  2017 Sarsasapogenin-AA13 ameliorates Abeta-induced cognitive deficits via improving neuroglial capacity on Abeta clearance and antiinflammation. AD, ECE, i.c.v, IDE
61  2017 Sustained Activation of Guanylate Cyclase-A with TDT, a Natriuretic Peptide Derivative, Exhibits Cardiorenal Protection in Dahl Salt-Sensitive Hypertensive Rats. DS, GC-A, hANP, NP
62  2017 Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain. APN, UHP
63  2017 Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation. ---
64  2017 Systemic Administration of Sialorphin Attenuates Experimental Colitis in Mice via Interaction With Mu and Kappa Opioid Receptors. APN, DSS, IBD, MPO
65  2017 The Association of MME microRNA Binding Site Polymorphism with the Risk of Late Onset Alzheimer's Disease in Northern Han Chinese. 3'UTR, APOE, CI, LOAD, miRNAs, OR, SNPs
66  2017 The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-beta concentrations and clearance in the cynomolgus monkey. CSF
67  2017 The renal and cardiovascular effects of natriuretic peptides. ANP, BNP, CNP
68  2017 Urinary neprilysin in the critically ill patient. AKI
69  2016 Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-beta Alterations in a Monkey Model of Type 1 Diabetes. AD, DM
70  2016 Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice. AD, BACE1, IDE, IRX3, ROS
71  2016 Design of Peptide Substrate for Sensitively and Specifically Detecting Two Abeta-Degrading Enzymes: Neprilysin and Angiotensin-Converting Enzyme. ACE, AD, IDE
72  2016 Endostatin and irradiation modifies the activity of ADAM10 and neprilysin in breast cancer cells. ADAM10, ES, RT
73  2016 Endothelin-1: Biosynthesis, Signaling and Vasoreactivity. ECE, ET-1, ETA, ETB
74  2016 Green tea reduces body fat via upregulation of neprilysin. NPY
75  2016 Hypertension in Patients with Heart Failure with Reduced Ejection Fraction. HF, HFrEF, HTN, NPS, RAAS, SNS
76  2016 Icariside II, a novel phosphodiesterase-5 inhibitor, attenuates streptozotocin-induced cognitive deficits in rats. AD, APP, BACE1, COX-2, ICS II, ICV-STZ, IL-1beta, PDE5, TGF-beta1, TNF
77  2016 Identification of the sites of 4-hydroxy-2-nonenal and neprilysin adduction using a linear trap quadrapole Velos Pro-Orbitrap Elite mass spectrometer. AD, HNE, LTQ
78  2016 Major amyloid-beta-degrading enzymes, endothelin-converting enzyme-2 and neprilysin, are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex. ECE
79  2016 Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles. AD, APP, i.c.v
80  2016 MME mutation in dominant spinocerebellar ataxia with neuropathy (SCA43). ---
81  2016 Mutations in MME cause an autosomal-recessive Charcot-Marie-Tooth disease type 2. AR, CMT, MME
82  2016 N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin. AC50, ECE-1
83  2016 Neprilysin Confers Genetic Susceptibility to Alzheimer's Disease in Han Chinese. AD, IDE, MMP-9, mRNA, SNPs
84  2016 Neprilysin Inhibits Coagulation through Proteolytic Inactivation of Fibrinogen. AD, APTT, CAT, HSA-NEPv, PT
85  2016 Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney. ACE2, Ang II, RAS
86  2016 Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model. AD, NRG1
87  2016 Neuropeptide Levels as well as Neprilysin Activity Decrease in Renal Cell Carcinoma. CGRP, RCC, SP, VIP
88  2016 Neuropeptide Y (NPY) in cerebrospinal fluid from patients with Huntington's Disease: increased NPY levels and differential degradation of the NPY1-30 fragment. CSF, Dyn-A1-13, hCSF, HD, IL-NPY, MALDI-TOF MS, MSNs, NPY, TOP
89  2016 Neuroprotective effects of Caralluma tuberculata on ameliorating cognitive impairment in a d-galactose-induced mouse model. BACE1, CTME, GSH-Px, MDA, NO, NOS, PS1, SOD, T-AOC
90  2016 New Insights into Epigenetic and Pharmacological Regulation of Amyloid-Degrading Enzymes. AD, AICD, IDE
91  2016 Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer's disease. ---
92  2016 Protection against vascular leak in neprilysin transgenic mice with complexoverexpressionpattern. DT
93  2016 Protective effect of recombinant soluble neprilysin against beta-amyloid induced neurotoxicity. AD, sNEP
94  2016 Sacubitril/valsartan in heart failure: latest evidence and place in therapy. Ang II, CV, HF, NYHA
95  2016 Simvastatin and atorvastatin facilitates amyloid beta-protein degradation in extracellular spaces by increasing neprilysin secretion from astrocytes through activation of MAPK/Erk1/2 pathways. AD, ERK, IDE
96  2016 Structure of neprilysin in complex with the active metabolite of sacubitril. ---
97  2016 The characteristics of astrocyte on Abeta clearance altered in Alzheimer's disease were reversed by anti-inflammatory agent (+)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate. AD
98  2016 The natriuretic peptides system in the pathophysiology of heart failure: from molecular basis to treatment. ACE, Ang, ARNI, HF, NP, SNS
99  2016 The role of PDGF-B/TGF-beta1/neprilysin network in regulating endothelial-to-mesenchymal transition in pulmonary artery remodeling. EndoMT, PAECs, PAH, PAR, PDGF, TGF-beta1
100  2016 Therapeutic Potential of Dental Pulp Stem Cell Secretome for Alzheimer's Disease Treatment: An In Vitro Study. AD, DPSCs