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■ Abbreviation / Long Form : NTN / neurturin

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Total Number of Papers: 118
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Abbreviation:   NTN  (>> Co-occurring Abbreviation)
Long Form:   neurturin
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No. Year Title Co-occurring Abbreviation
2017 A bicistronic vector with destabilized mRNA secondary structure yields scalable higher titer expression of human neurturin in E. coli. ---
2017 Neurotrophic Factors NGF, GDNF and NTN Selectively Modulate HSV1 and HSV2 Lytic Infection and Reactivation in Primary Adult Sensory and Autonomic Neurons. GDNF, NGF, NTFs, SCG, TG
2016 Perspective on the Road toward Gene Therapy for Parkinson's Disease. AAV, DA, GT, PD
2015 Enhanced delivery and bioactivity of the neurturin neurotrophic factor through focused ultrasound-mediated blood--brain barrier opening in vivo. BBB, CP, FUS, GDNF, PD, SN
2015 Neurturin influences inflammatory responses and airway remodeling in different mouse asthma models. ---
2013 Bone marrow-derived microglia-based neurturin delivery protects against dopaminergic neurodegeneration in a mouse model of Parkinson's disease. BBB, MPTP, TH
2013 Evidence for increased tissue androgen sensitivity in neurturin knockout mice. DHT, GDNF, Gfra2, GFRalpha2, NTNKO
2013 Recovery of behavioral symptoms in hemi-parkinsonian rhesus monkeys through combined gene and stem cell therapy. ASCs, ESCs, LMX1A, MPTP, TH
2013 [Pharmacotherapy of Parkinson's disease: progress or regress?]. CNS, DA, GAD, L-dopa, PD
10  2012 The delivery of tyrosine hydroxylase accelerates the neurorestoration of Macaca Rhesus model of Parkinson's disease provided by Neurturin. TH
11  2011 Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRalpha2 isoforms. cAMP, GDNF, GFRalpha2
12  2011 Increased Th2 cytokine secretion, eosinophilic airway inflammation, and airway hyperresponsiveness in neurturin-deficient mice. AHR
13  2010 Neurturin effects on nigrostriatal dopamine release and content: comparison with GDNF. DA, GDNF
14  2010 Neurturin protects against 6-hydroxydopamine-induced reductions in evoked dopamine overflow in rat striatum. GDNF
15  2010 Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain. CED, DA, GDNF, IHC
16  2010 The effects of docosahexaenoic acid on glial derived neurotrophic factor and neurturin in bilateral rat model of Parkinson's disease. DHA, DHA, GDNF, MPTP, PD, PUFA, SN
17  2009 Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's disease. ---
18  2009 Herpes simplex virus vector-mediated delivery of neurturin rescues erectile dysfunction of cavernous nerve injury. ED, FG, GDNF, HSV, HSV-LacZ, ICP/AP
19  2009 Increased expression of glial cell line-derived neurotrophic factor and neurturin in a case of colon adenocarcinoma associated with diffuse ganglioneuromatosis. ENS, GDNF, GFR-alpha 1, GN
20  2009 Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease. HD
21  2009 Nerve growth factor modulation of the cavernous nerve response to injury. BDNF, CN, GDF5, NGF
22  2009 Study on construction, expression, and biological activity of recombinant adenovirus of neurturin. Ad5, CM, PD
23  2008 Expression patterns of the glial cell line-derived neurotrophic factor, neurturin, their cognate receptors GFRalpha-1, GFRalpha-2, and a common signal transduction element c-Ret in the human skin hair follicles. GDNF, HF
24  2008 Intraputamenal infusion of exogenous neurturin protein restores motor and dopaminergic function in the globus pallidus of MPTP-lesioned rhesus monkeys. ---
25  2008 The upregulation of GLAST-1 is an indirect antiapoptotic mechanism of GDNF and neurturin in the adult CNS. CNS, GDNF, PI3K, RGCs
26  2008 Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum. AAV2, FB, PD, SN, TH
27  2007 AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease. AAV2, PD
28  2007 Differential expression of glial cell line-derived neurotrophic factor family receptor alpha-2 isoforms in rat urinary bladder and intestine. GPI
29  2007 Dopaminergic neuroprotection by neurturin-expressing c17.2 neural stem cells in a rat model of Parkinson's disease. NSC, PD, SN
30  2007 Dopaminergic regeneration by neurturin-overexpressing c17.2 neural stem cells in a rat model of Parkinson's disease. GDNF, NSC, PD
31  2007 Glial cell line-derived neurotrophic factor and neurturin inhibit neurite outgrowth and activate RhoA through GFR alpha 2b, an alternatively spliced isoform of GFR alpha 2. GDNF, GFRalpha2, MAPK, NCAM
32  2007 Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease. 3-NP, HD
33  2007 Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys. AAV2
34  2007 Striatal delivery of neurturin by CERE-120, an AAV2 vector for the treatment of dopaminergic neuron degeneration in Parkinson's disease. GDNF, PD
35  2007 Tissue distribution of neurturin, persephin and artemin in the human brainstem at fetal, neonatal and adult age. ART, GDNF, PSP
36  2007 Transplantation of bone marrow stromal cells containing the neurturin gene in rat model of Parkinson's disease. BMSCs, DA, GFAP, GFP, HPLC, NSE, PBS, PD, TH
37  2006 Analysis of the expression pattern of glial cell line-derived neurotrophic factor, neurturin, their cognate receptors GFRalpha-1 and GFRalpha-2, and a common signal transduction element c-Ret in the human scalp skin. GDNF
38  2006 Glial cell-line derived neurotrophic factor and neurturin regulate the expressions of distinct miRNA precursors through the activation of GFRalpha2. GDNF, GFRalpha2, miRNAs, RET
39  2006 Loss of nitrergic neurotransmission to mouse corpus cavernosum in the absence of neurturin is accompanied by increased response to acetylcholine. GFRalpha
40  2006 Nerve growth factor, glial cell line-derived neurotrophic factor and neurturin prevent semaphorin 3A-mediated growth cone collapse in adult sensory neurons. cGMP, DRG, GDNF, NGF, sema3A
41  2005 Efficient in vivo protection of nigral dopaminergic neurons by lentiviral gene transfer of a modified Neurturin construct. DA, GDNF, IgSP, PD, WT
42  2005 Expression and function of glial cell line-derived neurotrophic factor family ligands and their receptors on human immune cells. GDNF
43  2005 Neurturin has multiple neurotrophic effects on adult rat sacral parasympathetic ganglion neurons. CREB
44  2005 Neurturin, persephin, and artemin in the human pre- and full-term newborn and adult hippocampus and fascia dentata. ART, GDNF, PSP
45  2004 Blocked MAP kinase activity selectively enhances neurotrophic growth responses. BMPs, NT-3, SRE
46  2004 Expression of neurturin, glial cell line-derived neurotrophic factor, and their receptor components in light-induced retinal degeneration. GDNF, RET
47  2004 Patterns of developmental mRNA expression of neurturin and GFRalpha2 in the rat striatum and substantia nigra do not suggest a role in the regulation of natural cell death in dopamine neurons. DA, NCD, PND, SN
48  2004 Quantitative analyses of GFRalpha-1 and GFRalpha-2 mRNAs and tyrosine hydroxylase protein in the nigrostriatal system reveal bilateral compensatory changes following unilateral 6-OHDA lesions in the rat. GDNF, qRT-PCR, SN, ST, TH
49  2003 Expression of glial cell line-derived neurotrophic factor and neurturin in mature kidney, nephrogenic rests, and nephroblastoma: possible role as differentiating factors. GDNF
50  2003 Expression, purification, and characterization of recombinant human neurturin secreted from the yeast Pichia pastoris. hNTN
51  2003 Identification of a surface for binding to the GDNF-GFR alpha 1 complex in the first cadherin-like domain of RET. GDNF, GFRalpha
52  2003 Potential role of glial cell line-derived neurotrophic factor receptors in Muller glial cells during light-induced retinal degeneration. GDNF
53  2003 Protective action of recombinant neurturin on dopaminergic neurons in substantia nigra in a rhesus monkey model of Parkinson's disease. 5-HIAA, 5-HT, DA, MPTP, PD
54  2003 Real time PCR quantification of GFRalpha-2 alternatively spliced isoforms in murine brain and peripheral tissues. GDNF, GFR alpha-2
55  2003 Restorative effects of neurotrophin treatment on diabetes-induced cutaneous axon loss in mice. GDNF, STZ
56  2002 Expression patterns of neurotrophic factor mRNAs in developing human teeth. BDNF, GDNF, NGF, NT-3, NT-4, PGP
57  2002 Identification of GFR alpha-2 isoforms in myenteric plexus of postnatal and adult rat intestine. GDNF, RT-PCR
58  2002 Neurturin is a neuritogenic but not a survival factor for developing and adult central noradrenergic neurons. GDNF, LC, TH
59  2002 Quantification of mouse glial cell-line derived neurotrophic factor family receptor alpha 2 alternatively spliced isoforms by real time detection PCR using SYBR Green I. GDNF, GFR alpha-2, PCR
60  2001 A homozygous missense mutation in the tyrosine E kinase domain of the RET proto-oncogene in an infant with total intestinal aganglionosis. GDNF, RET
61  2001 Cultured olfactory ensheathing cells express nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor and their receptors. BDNF, CNS, ECs, ELISA, GDNF, NGF, ONs, RT-PCR
62  2001 Differential regulation of GDNF, neurturin, and their receptors in primary cultures of rat glial cells. GDNF, PKC
63  2001 Epitope-tagged recombinant AAV vectors for expressing neurturin and its receptor in retinal cells. rAAV
64  2001 Evidence for a ligand-specific signaling through GFRalpha-1, but not GFRalpha-2, in the absence of Ret. GDNF, GFR
65  2001 Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin. CED, GDNF
66  2001 Responsiveness to neurturin of subpopulations of embryonic rat spinal motoneuron does not correlate with expression of GFR alpha 1 or GFR alpha 2. GDNF
67  2001 Retinoic acid-induced apoptosis of the CHP134 neuroblastoma cell line is associated with nuclear accumulation of p53 and is rescued by the GDNF/Ret signal. GDNF, NBL, RA
68  2000 A dynamic regulation of GDNF-family receptors correlates with a specific trophic dependency of cranial motor neuron subpopulations during development. ART, GDNF, gfr
69  2000 Broad specificity of GDNF family receptors GFRalpha1 and GFRalpha2 for GDNF and NTN in neurons and transfected cells. DA, GDNF, GFR
70  2000 Characterization of novel neutralizing monoclonal antibodies specific to human neurturin. ELISA, GDNF, GPI, mAbs, MAPK
71  2000 Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas. GDNF, MEN 2A
72  2000 Expression of receptors for glial cell line-derived neurotrophic factor (GDNF) and neurturin in the inner blood-retinal barrier of rats. BBB, BRB, GDNF, GFAP
73  2000 Expression of RET and its ligand complexes, GDNF/GFRalpha-1 and NTN/GFRalpha-2, in medullary thyroid carcinomas. GDNF, MTCs, PTC
74  2000 GFRalpha 1 is required for development of distinct subpopulations of motoneuron. GDNF
75  2000 Glial cell line-derived neutrotrophic factor and neurturin can act as paracrine growth factors stimulating DNA synthesis of Ret-expressing spermatogonia. GDNF
76  2000 Mammalian-cell-produced neurturin (NTN) is more potent than purified Escherichia coli-produced NTN. DA
77  2000 Neurturin, RET, GFRalpha-1 and GFRalpha-2, but not GFRalpha-3, mRNA are expressed in mice gonads. GDNF, GFR
78  2000 New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control. GDNF, GFR alpha-2, GFRalpha1, HF
79  2000 Positive and negative interactions of GDNF, NTN and ART in developing sensory neuron subpopulations, and their collaboration with neurotrophins. ART, BDNF, DRG, GDNF, NGF, NT-3, NT4
80  2000 The RET receptor tyrosine kinase: activation, signalling and significance in neural development and disease. ART, ENS, GDNF, PSP
81  1999 A rapid and dynamic regulation of GDNF-family ligands and receptors correlate with the developmental dependency of cutaneous sensory innervation. GDNF
82  1999 Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons. GDNF
83  1999 Differential in vivo effects of neurturin and glial cell-line-derived neurotrophic factor. GDNF
84  1999 Distribution of neurturin mRNA and immunoreactivity in the peripheral tissues of adult rats. GDNF
85  1999 Expression patterns of neurturin and its receptor components in developing and degenerative mouse retina. RD
86  1999 GDNF family ligands and receptors are differentially regulated after brain insults in the rat. GDNF
87  1999 GDNF family members and their receptors: expression and functions in two oligodendroglial cell lines representing distinct stages of oligodendroglial development. GDNF, PSP, TGF-betas
88  1999 GDNF, RET and GFRalpha-1-3 mRNA expression in the developing human spinal cord and ganglia. GDNF, PSP
89  1999 Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons. ---
90  1999 Glial line-derived neurotrophic factor (GDNF): Biological activities. ARTN, GDNF, PSP
91  1999 Implication of expression of GDNF/Ret signalling components in differentiation of bone marrow haemopoietic cells. GDNF, RA, TPA
92  1999 Localization of GDNF/neurturin receptor (c-ret, GFRalpha-1 and alpha-2) mRNAs in postnatal rat brain: differential regional and temporal expression in hippocampus, cortex and cerebellum. GDNF
93  1999 Neurturin enhances the survival of intrastriatal fetal dopaminergic transplants. DA, GDNF, TH-ir
94  1999 Other neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF). ART, GDNF, GFRalpha, GPI, PSP, TGF-beta
95  1999 Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle. DA, GDNF, i.c.v, i.s, TH
96  1999 Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor. GDNF
97  1999 Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system. ENS, GDNF, NC, RTK
98  1998 Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. GDNF, PSP
99  1998 Calcium-dependent Ret activation by GDNF and neurturin. GDNF, GPI
100  1998 CNS glia are targets for GDNF and neurturin. GDNF, GFR