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■ Abbreviation / Long Form : OLETF / Otsuka Long-Evans Tokushima Fatty

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Total Number of Papers: 756
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Abbreviation:   OLETF  (>> Co-occurring Abbreviation)
Long Form:   Otsuka Long-Evans Tokushima Fatty
 Abbreviation Variation
 Long Form Variation
 Pair(Abbreviation/Long Form) Variation
No. Year Title Co-occurring Abbreviation
2023 Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus. SMCT1, T2DM
2022 Aerobic exercise training-induced follistatin-like 1 secretion in the skeletal muscle is related to arterial stiffness via arterial NO production in obese rats. cfPWV, eNOS, FSTL1, LETO
2022 Angiotensin receptor blockade with olmesartan alleviates brain pathology in obese OLETF rats. AD, ARB, MetS
2022 d-allulose protects against diabetic nephropathy progression in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes. ---
2022 Effects of long-term childhood exercise and detraining on lipid accumulation in metabolic-related organs. BAT, WAT
2022 Examination of Niddm20 candidate genes of OLETF rats in Drosophila melanogaster using inducible GeneSwitch GAL4 system. T2D
2022 Exercise training improves obesity-induced inflammatory signaling in rat brown adipose tissue. BAT, LETO
2022 Glucose Increases Hepatic Mitochondrial Antioxidant Enzyme Activities in Insulin Resistant Rats Following Chronic Angiotensin Receptor Blockade. 4-HNE, ARE, AT1, GCLC, GPX1, IL-1beta, LETO, NAFLD, Nrf2, SOD2
2022 Improved lipogenesis gene expression in liver is associated with elevated plasma angiotensin 1-7 after AT1 receptor blockade in insulin-resistant OLETF rats. Ang 1-7, Ang II, ARBs, AT1, FASN, FATP5, GCK, LETO, MetS, NAFLD, TAG
10  2022 Phosphodiesterase 5 inhibitor suppresses prostate weight increase in type 2 diabetic rats. bFGF, HIF-1alpha, IGF-1, IL, LETO, PDE5i, T2D, TGF-beta, TNF-alpha
11  2022 Simultaneous SGLT2 inhibition and caloric restriction improves insulin resistance and kidney function in OLETF rats. CR, IRI, LETO, SGLT2i
12  2022 Stimulation of Alpha-1-Adrenergic Receptor Ameliorates Obesity-Induced Cataracts by Activating Glycolysis and Inhibiting Cataract-Inducing Factors. ---
13  2022 Voluntary exercise reverses social behavior deficits and the increases in the densities of cholecystokinin-positive neurons in specific corticolimbic regions of diabetic OLETF rats. ---
14  2021 Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway. HFrD, LETO, NAFLD, UA
15  2021 Chronic AT1 blockade improves hyperglycemia by decreasing adipocyte inflammation and decreasing hepatic PCK1 and G6PC1 expression in obese rats. AT1, GLUT4, IR, LETO
16  2021 Decreased muscle-derived musclin by chronic resistance exercise is associated with improved insulin resistance in rats with type 2 diabetes. GLUT4
17  2021 Impact of Exercise and Detraining during Childhood on Brown Adipose Tissue Whitening in Obesity. BAT, LETO, UCP1
18  2021 Liraglutide inhibits the progression of prediabetes in rats by reducing Raf-1 kinase inhibitor protein. ChAT, CON, FINS, H-DAR, HCNP, Ins1, LETO, LIRA, M3R, PBO, qRT-PCR, RKIP, RPMI
19  2021 Long-term light and moderate exercise intervention similarly prevent both hippocampal and glycemic dysfunction in presymptomatic type 2 diabetic rats. BDNF, LETO, MCT2, T2DM
20  2021 Mass recovery following caloric restriction reverses lipolysis and proteolysis, but not gluconeogenesis, in insulin resistant OLETF rats. CR, GC, IR, LETO, MS, PR, TOF
21  2021 Medial prefrontal area reductions, altered expressions of cholecystokinin, parvalbumin, and activating transcription factor 4 in the corticolimbic system, and altered emotional behavior in a progressive rat model of type 2 diabetes. ---
22  2021 Reductions in Intestinal Taurine-Conjugated Bile Acids and Short-Chain Fatty Acid-Producing Bacteria Might be Novel Mechanisms of Type 2 Diabetes Mellitus in Otsuka Long-Evans Tokushima Fatty Rats. GLP, LETO, SCFAs, T-BAs, T2DM
23  2021 Retinal Neuropathy in IGT Stage of OLETF Rats: Another Characteristic Change of Diabetic Retinopathy. BRB, DKD, DM, IGT, NGT, RGCs
24  2021 Sevoflurane and isoflurane inhibit KCl-induced, Rho kinase-mediated, and PI3K-participated vasoconstriction in aged diabetic rat aortas. DM, ISO, LETO, PI3K, SEVO, VSM
25  2021 Subproteomic profiling from renal cortices in OLETF rats reveals mutations of multiple novel genes in diabetic nephropathy. DN, LETO
26  2021 Xanthine oxidoreductase-mediated injury is amplified by upregulated AMP deaminase in type 2 diabetic rat hearts under the condition of pressure overload. AMPD, XOR
27  2020 1-Kestose supplementation mitigates the progressive deterioration of glucose metabolism in type 2 diabetes OLETF rats. T2D
28  2020 Calorie restriction delays cardiac senescence and improves cardiac function in obese diabetic rats. AL, CR, HFD, LETO
29  2020 Correcting imbalance of sex hormones by a phosphodiesterase 5 inhibitor improves copulatory dysfunction in male rats with type 2 diabetes. LETO, LH, PDE5I
30  2020 Differential Contractile Reactivity to Nucleotides in Femoral Arteries of OLETF and LETO Rats. LETO, UDP, UTP
31  2020 Effect of the Sodium-Glucose Cotransporter 2 Inhibitor, Dapagliflozin, on Genitourinary Infection in an Animal Model of Type 2 Diabetes. IL-18, IL-1beta, LETO
32  2020 Electroacupuncture improves cognitive deficits and insulin resistance in an OLETF rat model of Al/D-gal induced aging model via the PI3K/Akt signaling pathway. AD, CP, CSF, EA, ELISA, FINS, IR, MWM, WB
33  2020 Exercise and Curcumin in Combination Improves Cognitive Function and Attenuates ER Stress in Diabetic Rats. ER, LETO, T2DM
34  2020 Hemodynamic response during hyperbaric treatment on skeletal muscle in a type 2 diabetes rat model. ATA, LETO
35  2020 In Situ Gel Incorporating Disulfiram Nanoparticles Rescues the Retinal Dysfunction via ATP Collapse in Otsuka Long-Evans Tokushima Fatty Rats. DDC, DIS, ERGs, MC
36  2020 Inhibition of gamma-glutamyltransferase ameliorates ischaemia-reoxygenation tissue damage in rats with hepatic steatosis. gamma-GT, IR
37  2020 Korean Red Ginseng attenuates type 2 diabetic cardiovascular dysfunction in Otsuka Long-Evans Tokushima Fatty rats. KRG
38  2020 Obesity preventive function of novel edible mushroom, Basidiomycetes-X (Echigoshirayukidake): Manipulations of insulin resistance and lipid metabolism. BDMP
39  2020 Partial Body Mass Recovery After Caloric Restriction Abolishes Improved Glucose Tolerance in Obese, Insulin Resistant Rats. BM, CR, LETO, OGTT, TG
40  2020 Region-specific brain area reductions and increased cholecystokininpositive neurons in diabetic OLETF rats: implication for anxiety-like behavior. CCK, LETO, PV
41  2020 Soy beta-Conglycinin Peptide Attenuates Obesity and Lipid Abnormalities in Obese Model OLETF Rats. beta-CG
42  2020 The angiotensin II receptor-neprilysin inhibitor LCZ696 attenuates the progression of proteinuria in type 2 diabetic rats. BUN
43  2020 The herbal extract ALS-L1023 from Melissa officinalis reduces weight gain, elevated glucose levels and beta-cell loss in Otsuka Long-Evans Tokushima fatty rats. ---
44  2019 Aerobic exercise training-induced irisin secretion is associated with the reduction of arterial stiffness via nitric oxide production in adults with obesity. AMPK, cfPWV, eNOS, FNDC5, NO
45  2019 Canagliflozin, a sodium-glucose cotransporter2 inhibitor, normalizes renal susceptibility to type1 cardiorenal syndrome through reduction of renal oxidative stress in diabetic rats. LETO, MI, NOX, SGLT2
46  2019 Dietary beta-Conglycinin Modulates Insulin Sensitivity, Body Fat Mass, and Lipid Metabolism in Obese Otsuka Long-Evans Tokushima Fatty (OLETF) Rats. AdipoR1, beta-CON, CAS, IRS, ITT, SOY
47  2019 Differential regulation of thyrotropin-releasing hormone mRNA expression in the paraventricular nucleus and dorsomedial hypothalamus in OLETF rats. DMH, OLETF-RW, PVN, TRH
48  2019 Effect of combination of chlorella intake and aerobic exercise training on glycemic control in type 2 diabetic rats. Akt, GLUT4, PI3K
49  2019 Effect of fosinopril on the renal cortex protein expression profile of Otsuka Long-Evans Tokushima Fatty rats. ACEIs, DN, FP, LETO
50  2019 Hyperbaric Normoxia Improved Glucose Metabolism and Decreased Inflammation in Obese Diabetic Rat. ATA, IL-10, LETO, TNF-alpha
51  2019 Inhibition of Ceramide Accumulation in Podocytes by Myriocin Prevents Diabetic Nephropathy. GFA, HFD, ROS
52  2019 Salsalate Prevents beta-Cell Dedifferentiation in OLETF Rats with Type 2 Diabetes through Notch1 Pathway. DAPT, IGT, SAL
53  2019 Simultaneous angiotensin receptor blockade and glucagon-like peptide-1 receptor activation ameliorate albuminuria in obese insulin-resistant rats. AT1, GLP-1, NOX4, NT, RAS
54  2019 The effects of resistance training on bone mineral density and bone quality in type 2 diabetic rats. BMD, CON, LETO, RT, T2DM
55  2018 A Controlled Fermented Samjunghwan Herbal Formula Ameliorates Non-alcoholic Hepatosteatosis in HepG2 Cells and OLETF Rats. FSJH, HS, LBB, LBP, LCL, LETO, PMM, SJH, VAT
56  2018 Acyclic retinoid and angiotensin-II receptor blocker exert a combined protective effect against diethylnitrosamine-induced hepatocarcinogenesis in diabetic OLETF rats. ACR, ARB, HCC, HUVECs, IR, LETO, PNL
57  2018 Angiotensin receptor and tumor necrosis factor-alpha activation contributes to glucose intolerance independent of systolic blood pressure in obese rats. ARB, AT1, CCB, LETO, MetS, SBP, TNF-alpha
58  2018 Changes in lipid metabolism and capillary density of the skeletal muscle following low-intensity exercise training in a rat model of obesity with hyperinsulinemia. LETO
59  2018 Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats. AT1, RAS
60  2018 Effect of combined farnesoid X receptor agonist and angiotensin II type 1 receptor blocker on hepatic fibrosis. Ac-HSC, CDAA, FXR, HSC, NASH, PS
61  2018 Effect of sodium-glucose cotransporter 2 inhibitor, empagliflozin, and α-glucosidase inhibitor, voglibose, on hepatic steatosis in an animal model of type 2 diabetes. ACC, AMPK, FAS, FBP1, G6Pase, LETO, PEPCK, SIRT1, SREBP-1c
62  2018 Effects of voluntary running exercise on bone histology in type 2 diabetic rats. LETO
63  2018 Empagliflozin, an SGLT2 Inhibitor, Reduced the Mortality Rate after Acute Myocardial Infarction with Modification of Cardiac Metabolomes and Antioxidants in Diabetic Rats. beta-OHB, DM, LETO, MI
64  2018 Long-term insulin treatment leads to a change in myosin heavy chain fiber distribution in OLETF rat skeletal muscle. LETO
65  2018 Metabolomic and lipidomic analysis of the effect of pioglitazone on hepatic steatosis in a rat model of obese Type 2 diabetes. ---
66  2018 Mild hyperbaric oxygen inhibits the growth-related decline in skeletal muscle oxidative capacity and prevents hyperglycemia in rats with type 2 diabetes mellitus. LETO, Myf5, MyoG, PGC-1alpha, T2DM
67  2018 Mineralocorticoid receptor antagonism reverses diabetes-related coronary vasodilator dysfunction: A unique vascular transcriptomic signature. MR, SP
68  2018 miR-192 prevents renal tubulointerstitial fibrosis in diabetic nephropathy by targeting Egr1. DN, Egr-1, ESRD, FN, LETO, qRT-PCR, TGF-beta1
69  2018 Repression of Transcriptional Activity of Forkhead Box O1 by Histone Deacetylase Inhibitors Ameliorates Hyperglycemia in Type 2 Diabetic Rats. EMSA, FOXO1, HDACi, LETO, T2DM
70  2018 Rosiglitazone Elicits an Adiponectin-Mediated Insulin-Sensitizing Action at the Adipose Tissue-Liver Axis in Otsuka Long-Evans Tokushima Fatty Rats. IRS-1
71  2018 Simultaneous GLP-1 receptor activation and angiotensin receptor blockade increase natriuresis independent of altered arterial pressure in obese OLETF rats. AT1, GLP-1, LETO, MAP
72  2018 Soy Protein Isolate Suppresses Bone Resorption and Improves Trabecular Microarchitecture in Spontaneously Hyperphagic, Rapidly Growing Male OLETF Rats. MPI, SPI
73  2017 A role of pancreatic stellate cells in islet fibrosis and beta-cell dysfunction in type 2 diabetes mellitus. PSCs, T2DM
74  2017 Alteration of Vascular Responsiveness to Uridine Adenosine Tetraphosphate in Aortas Isolated from Male Diabetic Otsuka Long-Evans Tokushima Fatty Rats: The Involvement of Prostanoids. LETO, NOS, PG, TX
75  2017 Angiotensin receptor blockade improves cardiac mitochondrial activity in response to an acute glucose load in obese insulin resistant rats. ARB, AT1, CAT, LETO, Nrf2, RAS, SOD
76  2017 Augmented Contractility to Noradrenaline in Femoral Arteries from the Otsuka Long-Evans Tokushima Fatty Rat, a Model of Type 2 Diabetes. COX, L-NNA, LETO, NOS
77  2017 Chronic saponin treatment attenuates damage to the pancreas in chronic alcohol-treated diabetic rats. LC, LE, LES, LETO, O-E, OC, OES
78  2017 Combined long-term caffeine intake and exercise inhibits the development of diabetic nephropathy in OLETF rats. BP, BW, Ccr, DN, UV
79  2017 Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent pathways in type 2 diabetic OLETF rats. AMPK, CK, HFD
80  2017 Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal Toll-like receptors in rats. AKI, DM, KIM-1, LETO, MI, MyD88, NGAL, TLRs
81  2017 Effects of early postnatal environment on hypothalamic gene expression in OLETF rats. DMH, LETO, NPY, PND 23
82  2017 Endurance training lowers ribosome density despite increasing ribosome biogenesis markers in rodent skeletal muscle. WD
83  2017 Exercise improves femoral whole-bone and tissue-level biomechanical properties in hyperphagic OLETF rats. EX, L-SED, O-CR, T2D
84  2017 Exercise initiated after the onset of insulin resistance improves trabecular microarchitecture and cortical bone biomechanics of the tibia in hyperphagic Otsuka Long Evans Tokushima Fatty rats. BMC, BMD, CCK-1 receptor, IGF-I, L-SED, SMI, T2D, Tb.N, Tb.Sp, TRAP5b
85  2017 Flos Lonicera Combined with Metformin Ameliorates Hepatosteatosis and Glucose Intolerance in Association with Gut Microbiota Modulation. FL, MET, NAFLD, T2D
86  2017 Houttuynia cordata Facilitates Metformin on Ameliorating Insulin Resistance Associated with Gut Microbiota Alteration in OLETF Rats. AMPK, DGGE, HCE, IL-6, ITT, OGTT, TNF-alpha
87  2017 Impaired endothelium-derived hyperpolarization-type relaxation in superior mesenteric arteries isolated from female Otsuka Long-Evans Tokushima Fatty rats. EDH, LETO
88  2017 Insulin-Stimulated Bone Blood Flow and Bone Biomechanical Properties Are Compromised in Obese, Type 2 Diabetic OLETF Rats. BW, Ct.Ar, muCT, O-T2D, T2D, Tt.Ar
89  2017 Long-term wheel-running can prevent deterioration of bone properties in diabetes mellitus model rats. LETO
90  2017 Obesity and type 2 diabetes, not a diet high in fat, sucrose, and cholesterol, negatively impacts bone outcomes in the hyperphagic Otsuka Long Evans Tokushima Fatty rat. BMC, HFSC, LETO, T2D
91  2017 Role of Glyceraldehyde-Derived AGEs and Mitochondria in Superoxide Production in Femoral Artery of OLETF Rat and Effects of Pravastatin. AGEs, ELISA, Glycer-AGEs, LETO, PAD, TTFA
92  2017 Soy compared with milk protein in a Western diet changes fecal microbiota and decreases hepatic steatosis in obese OLETF rats. MPI, MS, SPI
93  2017 UDP-induced relaxation is enhanced in aorta from female obese Otsuka Long-Evans Tokushima Fatty rats. ACh, LETO, NO, PE, UDP
94  2016 A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats. AL, CR, NAFLD, pACC
95  2016 A sodium-glucose co-transporter 2 inhibitor empagliflozin prevents abnormality of circadian rhythm of blood pressure in salt-treated obese rats. SGLT2
96  2016 Acupuncture Alters Expression of Insulin Signaling Related Molecules and Improves Insulin Resistance in OLETF Rats. CP, EA, FINS, HOMA-IR, SD
97  2016 Aerobic exercise training in the treatment of non-alcoholic fatty liver disease related fibrosis. FR, NASH, O-SED, WD
98  2016 Alterations of voltage-dependent K(+) channels in the mesenteric artery during the early and chronic phases of diabetes. 4-AP, Kv, LETO
99  2016 Anti-Proliferative Effects of Rutin on OLETF Rat Vascular Smooth Muscle Cells Stimulated by Glucose Variability. Bcl, JNK, MAPK, NF-kappaB, PI3K, ROS, VSMCs
100  2016 Dioscorea esculenta-induced increase in muscle sex steroid hormones is associated with enhanced insulin sensitivity in a type 2 diabetes rat model. DHT