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■ Abbreviation / Long Form : OPA1 / optic atrophy 1

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Total Number of Papers: 195
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Abbreviation:   OPA1  (>> Co-occurring Abbreviation)
Long Form:   optic atrophy 1
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2020 Ammonia inhalation impaired immune function and mitochondrial integrity in the broilers bursa of fabricius: Implication of oxidative stress and apoptosis. Bax, Bcl-2, BF, Cyt C, Drp1, Mff, TUNEL
2020 Apolipoprotein E negatively regulates murine allergic airway inflammation via suppressing the activation of NLRP3 inflammasome and oxidative stress. AHR, APOE, BALF, Drp1, Fis1, HDM, Mfn2, OVA, WT
2020 Concurrent OPA1 mutation and chromosome 3q deletion leading to Behr syndrome: a case report. WES
2020 Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding. ---
2020 Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1. EC, NF-kappaB
2020 Down-regulation of the mitochondrial i-AAA protease Yme1L induces muscle atrophy via FoxO3a and myostatin activation. CCCP, Yme1L
2020 Fluoride-induced renal dysfunction via respiratory chain complex abnormal expression and fusion elevation in mice. Mfn1
2020 Harnessing the protective role of OPA1 in diabetic cardiomyopathy. STZ
2020 Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy. ADOA, AMPK, RGC
10  2020 Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction. ---
11  2020 Mitochondrial fusion promoter restores mitochondrial dynamics balance and ameliorates diabetic cardiomyopathy in an optic atrophy 1-dependent way. DCM
12  2020 Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth. CCA, HCC
13  2020 OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion. HCC, mtDNA
14  2020 Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation. NPCs
15  2020 PBMC of Multiple Sclerosis Patients Show Deregulation of OPA1 Processing Associated with Increased ROS and PHB2 Protein Levels. HC, MS, PBMCs, ROS
16  2020 Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function. OGD, tMCAO
17  2020 Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression. I/R, RGCs, SOD
18  2020 Silibinin treatment results in reducing OPA1&MFN1 genes expression in a rat model hepatic ischemia-reperfusion. i.p, IR, Mfn1
19  2020 Silver Nanoparticle Exposure Causes Pulmonary Structural Damage and Mitochondrial Dynamic Imbalance in the Rat: Protective Effects of Sodium Selenite. Drp1, HE, MDA, Mfn2, p-Drp1, SD
20  2020 Testosterone induces up-regulation of mitochondrial gene expression in murine C2C12 skeletal muscle cells accompanied by an increase of nuclear respiratory factor-1 and its downstream effectors. cox1, cyt b, ND1
21  2020 The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress. ---
22  2020 Upregulation of OPA1 by carnosic acid is mediated through induction of IKKgamma ubiquitination by parkin and protects against neurotoxicity. CA, Drp1, IKKgamma, siRNA
23  2020 Vitamin D supplementation rescues simvastatin induced myopathy in mice via improving mitochondrial cristae shape. CK, Drp1, SIM, TEM
24  2020 [Effects of electroacupuncture at "Zusanli"(ST36) on ultrastructure and mitochondrial dynamics of skeletal muscle in rats with spleen qi deficiency syndrome]. Drp1, EA
25  2019 A Missense Mutation in OPA1 Causes Dominant Optic Atrophy in a Chinese Family. DOA
26  2019 Activation of cardiac TrkB receptor by its small molecular agonist 7,8-dihydroxyflavone inhibits doxorubicin-induced cardiotoxicity via enhancing mitochondrial oxidative phosphorylation. 7,8-DHF, AMPK, BDNF, DOX, ERK, STAT3, TrkB
27  2019 Arsenic-induced cardiotoxicity correlates with mitochondrial damage and trace elements imbalance in broiler chickens. Bax, Bcl2, Drp1, Mfn1
28  2019 Augmenter of Liver Regeneration Alleviates Renal Hypoxia-Reoxygenation Injury by Regulating Mitochondrial Dynamics in Renal Tubular Epithelial Cells. AKI, ALR, Drp1, HR, IR, MTFP1
29  2019 Brain-derived neurotrophic factor mimetic, 7,8-dihydroxyflavone, protects against myocardial ischemia by rebalancing optic atrophy 1 processing. 7,8-DHF, BDNF, IHD, MMP, TrkB
30  2019 Ca2+/Calmodulin-Dependent Protein Kinase II Regulation by Inhibitor 1 of Protein Phosphatase 1 Protects Against Myocardial Ischemia-Reperfusion Injury. CaMKIIdelta, CK, Drp1, I/R, I1PP1, LDH, PLB
31  2019 Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle. ADCK1, dADCK1, IMMT, YME1L1
32  2019 Dysregulated Mitochondrial Dynamics and Metabolism in Obesity, Diabetes, and Cancer. Drp1, Mfn1, TCA
33  2019 Effects of Al Exposure on Mitochondrial Dynamics in Rat Hippocampus. Al, CaN, Drp1, Fis1, Mfn1, Mfn2
34  2019 Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement. alpha-SMA, Drp1, HUVECs, MDA, ROS, T-AOC, VEGF
35  2019 Human muscular mitochondrial fusion in athletes during exercise. HIHVT, Mfn, SIT, TEM
36  2019 Indomethacin impairs mitochondrial dynamics by activating the PKCzeta-p38-DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells. Drp1, NSAIDs, PKCzeta
37  2019 Inhibitor 1 of Protein Phosphatase 1 Regulates Ca2+/Calmodulin-Dependent Protein Kinase II to Alleviate Oxidative Stress in Hypoxia-Reoxygenation Injury of Cardiomyocytes. CaMKII, Drp1, I1PP1, LDH, ROS
38  2019 Interval and continuous exercise overcome memory deficits related to beta-Amyloid accumulation through modulating mitochondrial dynamics. CAT, Drp1, Fis1, HIIT, MDA, Mfn1, Mfn2, MICT, ROS, SOD
39  2019 Leptin enhances glycolysis via OPA1-mediated mitochondrial fusion to promote mesenchymal stem cell survival. HPC, MSCs, SGLT1
40  2019 Mdivi-1 Protects CD4+ T Cells against Apoptosis via Balancing Mitochondrial Fusion-Fission and Preventing the Induction of Endoplasmic Reticulum Stress in Sepsis. CLP, Drp1, ERS, LPS, Mfn2, ROS
41  2019 Melatonin attenuates myocardial ischemia-reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK-OPA1 signaling pathways. I/R
42  2019 Meta-analysis of genotype-phenotype analysis of OPA1 mutations in autosomal dominant optic atrophy. ADOA
43  2019 Mitochondrial Dynamics of Proximal Tubular Epithelial Cells in Nephropathic Cystinosis. ---
44  2019 Mitochondrial Morphology, Dynamics, and Function in Human Pressure Overload or Ischemic Heart Disease With Preserved or Reduced Ejection Fraction. HFpEF, HFrEF
45  2019 Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats. EBI, MitoQ, Nrf2, PHB2, SAH, siRNA
46  2019 OPA1 overexpression ameliorates mitochondrial cristae remodeling, mitochondrial dysfunction, and neuronal apoptosis in prion diseases. mtDNA
47  2019 Pioglitazone Improves Mitochondrial Organization and Bioenergetics in Down Syndrome Cells. Drp1, DS, Mfn1, PGZ, ROS
48  2019 Protective effect of hyperoside against renal ischemia-reperfusion injury via modulating mitochondrial fission, oxidative stress, and apoptosis. AKI, IR
49  2019 Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer. SIRT3
50  2019 Sirt3 modulate renal ischemia-reperfusion injury through enhancing mitochondrial fusion and activating the ERK-OPA1 signaling pathway. IR, Sirt3
51  2019 SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo. ChIP, Co-IP, PGC1alpha, SIRT3
52  2019 Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1. Mgm1
53  2019 Targeted next-generation sequencing extends the mutational spectrums for OPA1 mutations in Chinese families with optic atrophy. NGS, OA
54  2019 Triptolide induces toxicity in inner ear stem cells via promoting DNA damage. gammaH2AX
55  2019 [Effects of uncoupling protein 2 overexpression on myocardial mitochondrial dynamics in sepsis rats]. AAV, ATP, CLP, Drp1, Fis1, LVAWd, LVAWs, LVEDd, LVEDs, LVEDV, LVEF, LVESV, LVFS, LVM, LVPWd, LVPWs, SD, Sham group, SV, UCP2, UCP2 group
56  2018 A Plasma Metabolomic Signature Involving Purine Metabolism in Human Optic Atrophy 1 (OPA1)-Related Disorders. DOA, GTP, MIM, OPLS-DA, PCA, UHPLC-HRMS
57  2018 Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases. ---
58  2018 Activation of protein kinase C-alpha/heme oxygenase-1 signaling pathway improves mitochondrial dynamics in lipopolysaccharide-activated NR8383 cells. Drp1, Fis1, HO-1, LPS, Mfn1, Mfn2, PKCalpha, RCR, ROS
59  2018 Depletion of Mitofusin-2 Causes Mitochondrial Damage in Cisplatin-Induced Neuropathy. Drp1, Mfn2
60  2018 Dynamin-related protein 1-mediated mitochondrial fission contributes to IR-783-induced apoptosis in human breast cancer cells. ATP, Cyto C, Drp1, Fis1, Mff, Mfn1, MMP, mPTP
61  2018 Effect of Roux-en-Y gastric bypass on liver mitochondrial dynamics in a rat model of obesity. ROS, RYGB, SD
62  2018 Effects of biphasic and monophasic electrical stimulation on mitochondrial dynamics, cell apoptosis, and cell proliferation. Bax, Bcl-2, Bi Anod, ES, Mfn2, p-DRP1, Total-DRP1
63  2018 Exogenous Hydrogen Sulfide Supplement Attenuates Isoproterenol-Induced Myocardial Hypertrophy in a Sirtuin 3-Dependent Manner. ANP, BNP, Drp1, KO, MDA, SIRT3, SOD, T-AOC
64  2018 Hyperoxia Causes Mitochondrial Fragmentation in Pulmonary Endothelial Cells by Increasing Expression of Pro-Fission Proteins. mtDNA, PEC
65  2018 Iron-induced energy supply deficiency and mitochondrial fragmentation in neurons. ATP
66  2018 Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation. hMSCs, MI, MSCs
67  2018 Mitochondrial dynamics and protective effects of a mitochondrial division inhibitor, Mdivi-1, in lipopolysaccharide-induced brain damage. NSE, p-Drp1, S100B, SAE
68  2018 Mitochondrial dysfunction in iPSC-derived neurons of subjects with chronic mountain sickness. CMS, iPSC, LDH, S-OPA1
69  2018 Mitochondrial Membrane Dynamics-Functional Positioning of OPA1. ---
70  2018 Mitochondrial network structure homeostasis and cell death. Drp1
71  2018 Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission. AKAP121, Drp1, ROS
72  2018 Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production. ATP
73  2018 OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells. PKA
74  2018 Oxidative insults disrupt OPA1-mediated mitochondrial dynamics in cultured mammalian cells. Drp1
75  2018 PGAM5 regulates PINK1/Parkin-mediated mitophagy via DRP1 in CCCP-induced mitochondrial dysfunction. CCCP, Drp1, PGAM5, PINK1
76  2018 Potential Protective Mechanism in the Cardiac Microvascular Injury. CMECs, HF, HG, HG-HF, T2DM, TRPV1
77  2018 Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates. IF1
78  2018 Relationship between OPA1 and cardiolipin in mitochondrial inner-membrane fusion. CL, IM
79  2018 Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1. iPSC
80  2018 Structure, function, and regulation of mitofusin-2 in health and disease. Drp1
81  2018 The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function. ---
82  2018 The Metabolomic Bioenergetic Signature of Opa1-Disrupted Mouse Embryonic Fibroblasts Highlights Aspartate Deficiency. MEFs
83  2018 The relationship between optic atrophy 1 polymorphism and normal tension glaucoma in Taiwan. IVS8, NTG
84  2018 [Effect of Ginkgo biloba extract (EGb50) on mitochondrial function in SH-SY5Y cells after hypoxia/reoxygenation injury]. Drp1, EGb50
85  2018 [Effects of heme oxygenase-1/carbon monoxide pathway on the mitochondrial fusion in rat alveolar epithelial type II cells stimulated by lipopolysaccharide]. AECII, CZL group, ELISA, HZL group, IL-6, LPS, TNF-alpha
86  2017 Advanced glycation end products influence mitochondrial fusion-fission dynamics through RAGE in human aortic endothelial cells. AGE-BSA, AGEs, Drp1, Mfn1, Mfn2, PINK1, PTEN, RAGE
87  2017 Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence. UPR
88  2017 Association between Mitofusin 2 Gene Polymorphisms and Late-Onset Alzheimer's Disease in the Korean Population. AD, Mfn2, SNP
89  2017 Autophagy controls the pathogenicity of OPA1 mutations in dominant optic atrophy. DOA
90  2017 Azidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system. AZT-TP, DRP, HAART, Mff
91  2017 Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division. CoMIC, Drp1, IMM, OMM
92  2017 Control of Mitochondrial Remodeling by the ATPase Inhibitory Factor 1Unveils a Pro-survival Relay via OPA1. IF1, Prx3
93  2017 Effects of trimetazidine on mitochondrial respiratory function, biosynthesis, and fission/fusion in rats with acute myocardial ischemia. Drp1, Mfn1, PPARgamma
94  2017 Inhibition of Drp1-mediated mitochondrial fission improves mitochondrial dynamics and bioenergetics stimulating neurogenesis in hippocampal progenitor cells from a Down syndrome mouse model. Drp1, DS, Mdivi-1, Mnf2, NPCs
95  2017 Intact initiation of autophagy and mitochondrial fission by acute exercise in skeletal muscle of patients with Type2 diabetes. ATG, BNIP3, BNIP3L, Drp1, Fis1, FOXO3a, LC3B, Mfn, Mul1, SQSTM1, T2D, ULK1
96  2017 L-OPA1 regulates mitoflash biogenesis independently from membrane fusion. ---
97  2017 Mitochondrial cAMP prevents apoptosis modulating Sirt3 protein level and OPA1 processing in cardiac myoblast cells. PKA, Sirt3, TBHP
98  2017 Mitochondrial Dynamics as a Therapeutic Target for Treating Cardiac Diseases. Drp1, Fis1, IRI, Mfn1 and 2
99  2017 Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging. BHI, Mfn1, NHFs, OCR
100  2017 Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin. CL, IM