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■ Abbreviation / Long Form : PC / pyruvate carboxylase

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Total Number of Papers: 273
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Abbreviation:   PC  (>> Co-occurring Abbreviation)
Long Form:   pyruvate carboxylase
 Abbreviation Variation
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No. Year Title Co-occurring Abbreviation
2019 Astrocytic pyruvate carboxylation: Status after 35 years. ---
2019 Effects of sodium salicylate on glucose kinetics and insulin signaling in postpartum dairy cows. G6PC, GLUT4, SS
2019 Generation of Human Pyruvate Carboxylase Knockout Cell Lines Using Retrovirus Expressing Short Hairpin RNA and CRISPR-Cas9 as Models to Study Its Metabolic Role in Cancer Research. gRNA, shRNA
2019 Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver. LPCKO
2019 Tankyrase Promotes Aerobic Glycolysis and Proliferation of Ovarian Cancer through Activation of Wnt/beta-Catenin Signaling. TNKS
2018 A high-throughput screening assay for pyruvate carboxylase. FVB, OAA
2018 Allosteric regulation alters carrier domain translocation in pyruvate carboxylase. ---
2018 Berberine Reduces Pyruvate-driven Hepatic Glucose Production by Limiting Mitochondrial Import of Pyruvate through Mitochondrial Pyruvate Carrier 1. acetyl-CoA, HFD, HGP, MPC, MPC1, PDH, Sirt3
2018 Buffering agent-induced lactose content increases via growth hormone-mediated activation of gluconeogenesis in lactating goats. G6PC, HC, LPS, PEPCK
10  2018 Curcumin restrains hepatic glucose production by blocking cAMP/PKA signaling and reducing acetyl CoA accumulation in high-fat diet (HFD)-fed mice. HFD, HGP, PA, PDH
11  2018 Effect of high dietary starch levels on growth, hepatic glucose metabolism, oxidative status and immune response of juvenile largemouth bass, Micropterus salmoides. ALP, AST, CAT, FBPase, FCR, GK, iNOS, MDA, NO, PER, PFK, PK, SGR, SOD
12  2018 Effects of chronic dexamethasone administration on hyperglycemia and insulin release in goats. DEX, G6PC, GLUT2, MuRF1, SGLT1
13  2018 First evidence for a multienzyme complex of lipid biosynthesis pathway enzymes in Cunninghamella bainieri. ACC, ACL, BN, FAS, MDH, ME
14  2018 In ovo feeding of creatine pyruvate modulates growth performance, energy reserves and mRNA expression levels of gluconeogenesis and glycogenesis enzymes in liver of embryos and neonatal broilers. BW, CrPyr, GYS2, PEPCK
15  2018 In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia. MCPA, MCPG
16  2018 Kaempferol ameliorates hyperglycemia through suppressing hepatic gluconeogenesis and enhancing hepatic insulin sensitivity in diet-induced obese mice. IR
17  2018 Pyruvate Carboxylase Deficiency Type C: A Rare Cause of Acute Transient Flaccid Paralysis with Ketoacidosis. ---
18  2018 Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer. ---
19  2018 Roles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection. ---
20  2018 Taurine supplementation induces long-term beneficial effects on glucose homeostasis in ob/ob mice. AMPK, Tau
21  2017 1alpha,25-dihydroxyvitamin D inhibits de novo fatty acid synthesis and lipid accumulation in metastatic breast cancer cells through down-regulation of pyruvate carboxylase. ---
22  2017 An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice. CAPE, FXR
23  2017 Gluconeogenesis, non-essential amino acid synthesis and substrate partitioning in chicken embryos during later development. GNG, NEAA, PDH
24  2017 Inhibition of pyruvate carboxylase by 1alpha,25-dihydroxyvitamin D promotes oxidative stress in early breast cancer progression. ---
25  2017 Kinetic and Thermodynamic Analysis of Acetyl-CoA Activation of Staphylococcus aureus Pyruvate Carboxylase. SaPC
26  2017 Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells. ---
27  2017 Metabolic fate of glucose in rats with traumatic brain injury and pyruvate or glucose treatments: A NMR spectroscopy study. CCI, EP, Glc, NMR, SAL, SP
28  2017 Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein. 2-HG, AKG, CTP, IDH1, MFA, PDH
29  2017 Spirulina platensis prevents hyperglycemia in rats by modulating gluconeogenesis and apoptosis via modification of oxidative stress and MAPK-pathways. CASP3, MAPK, MDA, SP, STZ, TNF-alpha
30  2016 A distinct holoenzyme organization for two-subunit pyruvate carboxylase. BC, BCCP, CT
31  2016 Biotinylation: a novel posttranslational modification linking cell autonomous circadian clocks with metabolism. ACCalpha, CCM, MCC, PCC
32  2016 Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis. TCA
33  2016 Epigenetic regulation of pyruvate carboxylase gene expression in the postpartum liver. NSAID
34  2016 Feeding glycerol-enriched yeast culture improves lactation performance, energy status, and hepatic gluconeogenic enzyme expression of dairy cows during the transition period. BHBA, GK, GY
35  2016 Leptin regulates energy metabolism in MCF-7 breast cancer cells. G6PDH, LDH, PDH
36  2016 Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells. BaP, PDH, SDH
37  2016 Metabolic networks to generate pyruvate, PEP and ATP from glycerol in Pseudomonas fluorescens. ACK, AK, ATP, GDH, PEP, PEPC, PEPS, PK, PPDK, SLP
38  2016 Propionate induces mRNA expression of gluconeogenic genes in bovine calf hepatocytes. cAMP, G6PC
39  2016 Pyruvate Carboxylase Activates the RIG-I-like Receptor-Mediated Antiviral Immune Response by Targeting the MAVS signalosome. EV71, IAV, IFNs, IKK, ISGs, MAVS, MDA5, Mx1, NF-kappaB, PKR, VSV
40  2016 Pyruvate Occupancy in the Carboxyl Transferase Domain of Pyruvate Carboxylase Facilitates Product Release from the Biotin Carboxylase Domain through an Intermolecular Mechanism. BC, CT
41  2016 Short communication: Regulation of hepatic gluconeogenic enzymes by dietary glycerol in transition dairy cows. DRTC
42  2016 The effect of increasing concentrations of dl-methionine and 2-hydroxy-4-(methylthio) butanoic acid on hepatic genes controlling methionine regeneration and gluconeogenesis. BHMT, CPT1a, G6PC, HMB, HMBi, MAT1A, Met, MTHFR, MTR, SAHH, SAM
43  2016 The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic beta-cells. GSIS
44  2016 Toward understanding the impacts of sediment contamination on a native fish species: transcriptional effects, EROD activity, and biliary PAH metabolites. abcc9, AhR, CYP 1A, DLCs, PAHs, pkcd, SOD, tfd
45  2015 C4-dicarboxylic acid production by overexpressing the reductive TCA pathway. TCA
46  2015 Effect of propionate on mRNA expression of key genes for gluconeogenesis in liver of dairy cattle. BW, G6PC
47  2015 Effect of sorghum grain supplementation on glucose metabolism in cattle and sheep fed temperate pasture. BW, INSR, VFA
48  2015 Effects of dry period length on milk production, body condition, metabolites, and hepatic glucose metabolism in dairy cows. BCS, BFT, BW, DP, LFC, PP
49  2015 H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells. CSE
50  2015 Hepatic metabolic response of Holstein cows in early and mid lactation is altered by nutrient supply and lipopolysaccharide in vitro. LPS, PDH, PEPCK, Pyr, TNF-alpha
51  2015 Metabolic control analysis of L-lactate synthesis pathway in Rhizopus oryzae As 3.2686. ADH, LDH, PDC, PDH
52  2015 Pyruvate carboxylase deficiency: An underestimated cause of lactic acidosis. C IV, TCA
53  2015 Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. GLS1, NSCLC
54  2015 Pyruvate Carboxylase Is Up-Regulated in Breast Cancer and Essential to Support Growth and Invasion of MDA-MB-231 Cells. ---
55  2014 Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets. FBP1
56  2014 Functional conformations for pyruvate carboxylase during catalysis explored by cryoelectron microscopy. cryo-EM
57  2014 Glial dysfunction causes age-related memory impairment in Drosophila. AMI, PKA
58  2014 Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase. IDH1, PDH, TCA
59  2014 Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive element. ChREBP, GRE, Sp1
60  2014 Nearly 50 years in the making: defining the catalytic mechanism of the multifunctional enzyme, pyruvate carboxylase. ---
61  2014 Pyruvate carboxylase and pentose phosphate fluxes are reduced in AbetaPP-PS1 mouse model of Alzheimer's disease: a C NMR study. AD, PDH, PPP
62  2014 Pyruvate carboxylase as a sensitive protein biomarker for exogenous steroid chemicals. MT
63  2014 QM/MM study of the reaction mechanism of the carboxyl transferase domain of pyruvate carboxylase from Staphylococcus aureus. ---
64  2014 The pentose phosphate pathway and pyruvate carboxylation after neonatal hypoxic-ischemic brain injury. HI, HPLC, PPP
65  2014 The role of biotin and oxamate in the carboxyltransferase reaction of pyruvate carboxylase. ---
66  2014 Toxicity generated through inhibition of pyruvate carboxylase and carnitine palmitoyl transferase-1 is similar to high glucose/palmitate-induced glucolipotoxicity in INS-1 beta cells. CPT-1, Eto, HG/PA, PAA, TCA
67  2014 TR4 promotes fatty acid synthesis in 3T3-L1 adipocytes by activation of pyruvate carboxylase expression. OAA, PAA, siRNA, TR4
68  2014 Unsuccessful treatment of severe pyruvate carboxylase deficiency with triheptanoin. ---
69  2013 A substrate-induced biotin binding pocket in the carboxyltransferase domain of pyruvate carboxylase. ---
70  2013 Characterization of the distal promoter of the human pyruvate carboxylase gene in pancreatic beta cells. NF-Y
71  2013 Characterizing the importance of the biotin carboxylase domain dimer for Staphylococcus aureus pyruvate carboxylase catalysis. BC, SaPC
72  2013 Differences of glycolysis in skeletal muscle and lactate metabolism in liver between plateau zokor (Myospalax baileyi) and plateau pika (Ochotona curzoniae). LD, PAGE
73  2013 Expression of key lipid metabolism genes in adipose tissue is not altered by once-daily milking during a feed restriction of grazing dairy cows. ACSL1, AF, CPT2, DGAT2, FA, FASN, GPD1, SCD, UF
74  2013 Hepatic gene expression involved in glucose and lipid metabolism in transition cows: effects of fat mobilization during early lactation in relation to milk performance and metabolic changes. ASCL1, CoA, CPT1A, DM, LFC
75  2013 Hepatocyte nuclear factor 4alpha regulates the expression of the murine pyruvate carboxylase gene through the HNF4-specific binding motif in its proximal promoter. DR1, H4-SBM, HNF4alpha
76  2013 In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model. HFD, HGP, MRS
77  2013 Insights into the carboxyltransferase reaction of pyruvate carboxylase from the structures of bound product and intermediate analogs. CT
78  2013 Metabolic engineering of Lactobacillus plantarum for succinic acid production through activation of the reductive branch of the tricarboxylic acid cycle. LAB, PEPCK, TCA
79  2013 Nonstructural 5A protein of hepatitis C virus interacts with pyruvate carboxylase and modulates viral propagation. FAS, HCV, HCV
80  2013 Novel Mutations in the PC Gene in Patients with Type B Pyruvate Carboxylase Deficiency. ---
81  2013 Oxamate is an alternative substrate for pyruvate carboxylase from Rhizobium etli. NMR
82  2013 Rosmarinus officinalis polyphenols produce anti-depressant like effect through monoaminergic and cholinergic functions modulation. CA, LUT, MAPK, R. officinalis, RA, ROP, TH, TST
83  2013 Structure and function of biotin-dependent carboxylases. ACC, BC, CT, MCC, PCC, UC
84  2013 [Expression and clinical significance of pyruvate carboxylase in gastric adenocarcinoma]. GC, GES
85  2012 Assays of pyruvate dehydrogenase complex and pyruvate carboxylase activity. CS, PDC
86  2012 Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation. ---
87  2012 Effect of insulin-like growth factor-1 (IGF-1) on the gluconeogenesis in calf hepatocytes cultured in vitro. IGF-1, PEPCK
88  2012 Effects of cecal oxytetracycline infusion, and dietary avidin and biotin supplementation on the biotin status of nongravid gilts. CS, OTC, PUN, SP
89  2012 Effects of non-esterified fatty acids on the gluconeogenesis in bovine hepatocytes. NEFAs
90  2012 Gluconeogenic enzymes are differentially regulated by fatty acid cocktails in Madin-Darby bovine kidney cells. CALV, G6Pase, IFL, MDBK, UTR
91  2012 Hepatocellular apoptosis in mice is associated with early upregulation of mitochondrial glucose metabolism. EGF, PDH
92  2012 Localization of inhibitory antibodies to the biotin domain of human pyruvate carboxylase. mAbs
93  2012 Rational design of C-labeling experiments for metabolic flux analysis in mammalian cells. C-MFA, EMU, oxPPP
94  2012 Regulation of bovine pyruvate carboxylase mRNA and promoter expression by thermal stress. MDBK, UTR
95  2012 Short communication: Genetic differences between New Zealand and North American dairy cows alter milk production and gluconeogenic enzyme expression. NA, NZ, WRTC
96  2012 Wnt/Snail signaling regulates cytochrome C oxidase and glucose metabolism. COX, EMT
97  2011 A comprehensive metabolic profile of cultured astrocytes using isotopic transient metabolic flux analysis and C-labeled glucose. MFA, PDH
98  2011 Activation and inhibition of pyruvate carboxylase from Rhizobium etli. BC, CT
99  2011 Bovine pyruvate carboxylase 5' untranslated region variant expression during transition to lactation and feed restriction in dairy cows. DRTC, TCA, UTR
100  2011 Catabolite repression of phosphoenolpyruvate carboxykinase by a zinc finger protein under biotin- and pyruvate carboxylase-deficient conditions in Pichia pastoris. DeltaROP, PEPCK