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■ Abbreviation / Long Form : PDBu / phorbol 12,13-dibutyrate

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Abbreviation:   PDBu  (>> Co-occurring Abbreviation)
Long Form:   phorbol 12,13-dibutyrate
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No. Year Title Co-occurring Abbreviation
2019 Embelin as a Novel Inhibitor of PKC in the Prevention of Platelet Activation and Thrombus Formation. PKC
2019 Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2. 8,9,11-EHET, COX-2, EET, EETs, EHETs, HAECs, VEGF
2019 PKCalpha-Mediated Downregulation of RhoA Activity in Depolarized Vascular Smooth Muscle: Synergistic Vasorelaxant Effect of PKCalpha and ROCK Inhibition. PKC, ROCK, VSMCs
2019 Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling. KO, PKC, ROCK, SMTNL1, WT
2018 Involvement of LPA receptor-5 in the enhancement of cell motile activity by phorbol ester and anticancer drug treatments in melanoma A375 cells. LPA, TPA
2018 miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene. ECM, HGF, NSCLC
2018 Modulation of store-operated calcium entry and nascent adhesion by p21-activated kinase 1. PAKs, SOCE, STIM1, TG
2018 Single Ethanol Withdrawal Regulates Extrasynaptic delta-GABAA Receptors Via PKCdelta Activation. GABAARs, OA, PKC
2017 Decreased homodimerization and increased TIMP-1 complexation of uteroplacental and uterine arterial matrix metalloproteinase-9 during hypertension-in-pregnancy. BP, EGF, HTN-Preg, IUGR, MMPs, PKC, PREG, RUPP
10  2017 Matrix Metalloproteinases -14, -9 and -2 are Localized to the Podosome and Involved in Podosome Development in the A7r5 Smooth Muscle Cell. MMP, TIMPs
11  2017 Nestin Expressed by Pre-Existing Cardiomyocytes Recapitulated in Part an Embryonic Phenotype; Suppressive Role of p38 MAPK. EGFP, NNVM
12  2017 Paclitaxel inhibits the activity and membrane localization of PKCalpha and PKCbetaI/II to elicit a decrease in stimulated calcitonin gene-related peptide release from cultured sensory neurons. CGRP, cPKC
13  2017 Phorbol 12,13-dibutyrate-induced protein kinase C activation triggers sustained contracture in human myometrium invitro. PKC
14  2017 Role of Transient Receptor Potential Channels Trpv1 and Trpm8 in Diabetic Peripheral Neuropathy. DPN, DRG
15  2016 A Comparison Between Phorbol 12 Myristate 13 Acetate and Phorbol 12, 13 Dibutyrate in Human Melanocyte Culture. MTT, PMA
16  2016 Experimental and bioinformatic analysis of cultured Bovine Endometrial Cells (BEND) responding to interferon tau (IFNT). BEND, ESR1, IFNT, IRFs, miRNAs, PLA2G4A, PR, PTGS2
17  2016 Lipid emulsion inhibits vasodilation induced by a toxic dose of bupivacaine by suppressing bupivacaine-induced PKC and CPI-17 dephosphorylation but has no effect on vasodilation induced by a toxic dose of mepivacaine. PKC, VSMCs
18  2016 Mepivacaine attenuates vasodilation induced by ATP-sensitive potassium channels in rat aorta. PKC
19  2016 Regulation of Extrasynaptic GABAA alpha4 Receptors by Ethanol-Induced Protein Kinase A, but Not Protein Kinase C Activation in Cultured Rat Cerebral Cortical Neurons. GABAAR, PKA, PKC, THIP
20  2015 Biophysical induction of vascular smooth muscle cell podosomes. MMP, VSMC
21  2015 Effects of alpha1-adrenoceptor agonist phenylephrine on swelling-activated chloride currents in human atrial myocytes. BIM, PKC
22  2015 Lipid Emulsion Inhibits Vasodilation Induced by a Toxic Dose of Bupivacaine via Attenuated Dephosphorylation of Myosin Phosphatase Target Subunit 1 in Isolated Rat Aorta. MYPT1
23  2015 Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms. BIM1, BMS, EFS, NVC, PKC, PMA
24  2015 TAT cell-penetrating peptide modulates inflammatory response and apoptosis in human lung epithelial cells. Bcl-2, CPPs, PKC, Tat
25  2014 Dexmedetomidine-induced contraction involves phosphorylation of caldesmon by JNK in endothelium-denuded rat aortas. DMT, JNK, PKC, VSMCs
26  2014 Effect of Antrodia camphorata on inflammatory arterial thrombosis-mediated platelet activation: the pivotal role of protein kinase C. PKC
27  2014 Gestational hypoxia up-regulates protein kinase C and inhibits calcium-activated potassium channels in ovine uterine arteries. PKC, SK
28  2014 Ionomycin inhibits Jurkat T cell behaviors in the presence of phorbol-12,13-dibutyrate. TGF-beta
29  2014 Protein kinase Cdelta-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation. Cx43
30  2014 Protein kinase D activity controls endothelial nitric oxide synthesis. eNOS, PKD, VEGF
31  2013 Altered pharmacology of native rodent spinal cord TRPV1 after phosphorylation. ---
32  2013 COX-2 Gene Promoter Methylation in Patients Infected with Helicobacter Pylori. COX, HP
33  2013 MEK/ERK pathway mediates PKC activation-induced recruitment of PKCzeta and MMP-9 to podosomes. NHBE, PKC, PS
34  2013 PKC activation induces inflammatory response and cell death in human bronchial epithelial cells. PKC
35  2013 Role of endothelium in vasomotor responses to endothelin system and protein kinase C activation in porcine retinal arterioles. ECE-1, ET-1, L-VOCC, NO, PKC
36  2013 Spontaneous and evoked contractions are regulated by PKC-mediated signaling in detrusor smooth muscle: involvement of BK channels. BIM1, DSM, PBOO, PKC
37  2013 Tonic and phasic smooth muscle contraction is not regulated by the PKCalpha - CPI-17 pathway in swine stomach antrum and fundus. CCh, MLCP, PKC, SM
38  2012 Chronic hypoxia differentially up-regulates protein kinase C-mediated ovine uterine arterial contraction via actin polymerization signaling in pregnancy. CH, cyto B, NE, PKC
39  2012 Effects of magnolol on vascular contraction in rat aortic rings. GTP, MYPT1
40  2012 MARCKS dephosphorylation is involved in bradykinin-induced neurite outgrowth in neuroblastoma SH-SY5Y cells. BK, CNS, GST, MARCKS, PKC, PLC, PP, ROCK
41  2012 Modulation of Kv3.4 channel N-type inactivation by protein kinase C shapes the action potential in dorsal root ganglion neurons. AP, GPCR, PKC
42  2012 Phorbol 12,13-dibutyrate-induced, protein kinase C-mediated contraction of rabbit bladder smooth muscle. BIS, DOG, PKC
43  2012 TRPC1 proteins confer PKC and phosphoinositol activation on native heteromeric TRPC1/C5 channels in vascular smooth muscle: comparative study of wild-type and TRPC1-/- mice. BAPTA-AM, CPA, PKC, TRPC1, VSMCs, WT
44  2011 Effects of gomisin A on vascular contraction in rat aortic rings. GA, MYPT1
45  2011 HMC05 attenuates vascular contraction through inhibition of RhoA/Rho-kinase signaling pathway. MYPT1, PKC
46  2011 Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. IAS, SMCs
47  2011 Myosin light chain kinase/actin interaction in phorbol dibutyrate-stimulated smooth muscle cells. MLCK
48  2010 Activation of L-type Ca2+ channels by protein kinase C is reduced in smooth muscle-specific Na+/Ca2+ exchanger knockout mice. PKC, SM, WT
49  2010 Augmented PDBu-mediated contraction of bronchial smooth muscle of mice with antigen-induced airway hyperresponsiveness. AHR, BSM, PKC
50  2010 CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway. EGF, PKD
51  2010 Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL-60 cells. PKC
52  2010 h3/Acidic calponin: an actin-binding protein that controls extracellular signal-regulated kinase 1/2 activity in nonmuscle cells. ERK, PKC
53  2010 Maturation and long-term hypoxia-induced acclimatization responses in PKC-mediated signaling pathways in ovine cerebral arterial contractility. AH, AN, CA, FH, FN, LTH
54  2010 Phorbol 12,13-dibutyrate-mediated contraction of the stimulated bronchial smooth muscles of mice. BSM, MLC, PKC
55  2010 Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells. GIT1, PKC, PLCgamma, VSMC
56  2010 PKC regulates alpha(1)-adrenoceptor-mediated contractions and baseline Ca(2+) sensitivity in the uterine arteries of nonpregnant and pregnant sheep acclimatized to high altitude hypoxia. PKC
57  2010 Rac/ROS-related protein kinase C and phosphatidylinositol-3-kinase signaling are involved in a negative regulating cascade in B cell activation by antibody-mediated cross-linking of MHC class II molecules. PI3K
58  2010 Raf-1 kinase regulates smooth muscle contraction in the rat mesenteric arteries. PE, VSMCs
59  2010 Rapid activation of dormant presynaptic terminals by phorbol esters. NMDAR
60  2010 Synapsin-dependent vesicle recruitment modulated by forskolin, phorbol ester and ca in mouse excitatory hippocampal synapses. DRE
61  2010 The protein kinase C cascade regulates recruitment of matrix metalloprotease 9 to podosomes and its release and activation. MMP-9, PKC, siRNA
62  2010 The role of ERK-1/2 in the N/OFQ-induced inhibition of delayed rectifier potassium currents. ELK1, IDB, N/OFQ, PKC
63  2009 A role for Rho-kinase in Ca-independent contractions induced by phorbol-12,13-dibutyrate. MLCP, MYPT1, PKC
64  2009 Alteration of the PKC-mediated signaling pathway for smooth muscle contraction in obstruction-induced hypertrophy of the urinary bladder. BIS, DSM, PBOO, PKC
65  2009 Chronic hypoxia increases pressure-dependent myogenic tone of the uterine artery in pregnant sheep: role of ERK/PKC pathway. UA
66  2009 Hindlimb unweighting induces changes in the p38MAPK contractile pathway of the rat abdominal aorta. HLU
67  2009 Maturation and the role of PKC-mediated contractility in ovine cerebral arteries. CPI-17, PKC
68  2009 Modulation of transient receptor potential Vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C. 4 alpha-PDD, BIM, DH, DRG, mEPSCs, TRPV
69  2009 Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes. CPA, PKC, SOC
70  2009 Peroxide generation by p47phox-Src activation of Nox2 has a key role in protein kinase C-induced arterial smooth muscle contraction. NOX, PKC
71  2009 Phorbol ester-induced PKCepsilon down-modulation sensitizes AML cells to TRAIL-induced apoptosis and cell differentiation. AML, TRAIL
72  2009 Phorbol ester-induced podosomes in normal human bronchial epithelial cells. ---
73  2009 Regulation of protein kinase C delta downregulation by protein kinase C epsilon and mammalian target of rapamycin complex 2. mTORC2
74  2009 Role of protein kinase C in regulation of Na+- and K +-dependent ATPase activity and pump function in corneal endothelial cells. Na,K-ATPase, PKC
75  2009 Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway. ---
76  2008 17beta-estradiol inhibits calcium-dependent and -independent contractions in isolated human saphenous vein. CPA, HSVs, NIF, PKC
77  2008 Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes. CPA, OAG, PKC, SOCs
78  2008 Impact of protein kinase C activation on epileptiform activity in the hippocampal slice. mGluR, PKC
79  2008 Implication of endogenous beta-endorphin in the inhibition of the morphine-induced rewarding effect by the direct activation of spinal protein kinase C in mice. i.t, PKC
80  2008 Implication of spinal protein kinase Cgamma isoform in activation of the mouse brain by intrathecal injection of the protein kinase C activator phorbol 12,13-dibutyrate using functional magnetic resonance imaging analysis. fMRI, i.t, PKC
81  2008 Mechanisms of hyperthermia-induced depression of GABAergic synaptic transmission in the immature rat hippocampus. evIPSCs, mIPSCs, sIPSCs
82  2008 Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats. CAPS, NAcPh, NK, PKC, SP, TRPV1
83  2008 Pertussis toxin B-oligomer suppresses human immunodeficiency virus-1 Tat-induced neuronal apoptosis through feedback inhibition of phospholipase C-beta by protein kinase C. BIM, HIV, PKC, PLCbeta, PTX, PTX-B
84  2008 Phosphorylation of AFAP-110 affects podosome lifespan in A7r5 cells. PE
85  2008 Presenilin regulates extracellular regulated kinase (Erk) activity by a protein kinase C alpha dependent mechanism. AD, APP, ERK, MEFs, PKC, PLC
86  2008 Role of protein kinase C isozymes in the regulation of alpha1-adrenergic receptor-mediated contractions in ovine uterine arteries. PRKC
87  2008 Short-term regulation of the Cl-/HCO3(-) exchanger in immortalized SHR proximal tubular epithelial cells. db-cAMP, PTE, SHR, WKY
88  2007 (+/-)3,4-Methylenedioxyamphetamine elicits action potential bursts in a central snail neuron. OAG, PKA, PKC, PLC
89  2007 Characterization and phospholipase D mediation of the angiotensin II priming response in adrenal glomerulosa cells. Ang II, DAG, PLD
90  2007 Cross-linking of MHC class II molecules interferes with phorbol 12,13-dibutyrate-induced differentiation of resting B cells by inhibiting Rac-associated ROS-dependent ERK/p38 MAP kinase pathways leading to NF-kappaB activation. MHC
91  2007 Down-regulation of calponin destabilizes actin cytoskeletal structure in A7r5 cells. CaP, FRET, LSCM, PDGF, TGF
92  2007 Effects of phorbol-12,13-dibuterate on sodium currents and potassium currents in rat trigeminal ganglion neurons. TG
93  2007 Potentiation of glutamatergic synaptic transmission by protein kinase C-mediated sensitization of TRPV1 at the first sensory synapse. BIM, BK, DH, DRG, mEPSCs, PKC, TRPV1
94  2007 Protein kinase C activation increases endothelial nitric oxide release in mesenteric arteries from orchidectomized rats. ACh, eNOS, NO, PKC, PKC-zeta-PI, SNP, SOD
95  2007 Regulation of alpha1-adrenoceptor-mediated contractions of the uterine artery by protein kinase C: role of the thick- and thin-filament regulatory pathways. NPUA, PKC, PUA
96  2006 Activation of P2Y1 receptor triggers two calcium signaling pathways in bone marrow erythroblasts. 2-APB, CaMKII, PKC, RT-PCR
97  2006 Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators. APP
98  2006 Chronic propranolol treatment causes desensitization of the steroidogenic response in testicular interstitial cells but does not alter protein kinase C. dbcAMP, PKA, PKC
99  2006 Conjugated linoleic acid reduces phorbol ester-induced prostaglandin F2alpha production by bovine endometrial cells. BEND, CLA, PGHS-2, PPARdelta
100  2006 Differential actin isoform reorganization in the contracting A7r5 cell. ---