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■ Abbreviation / Long Form : PH / pleckstrin homology

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Total Number of Papers: 1120
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Abbreviation:   PH  (>> Co-occurring Abbreviation)
Long Form:   pleckstrin homology
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No. Year Title Co-occurring Abbreviation
2019 A novel overlapping NLS/NES region within the PH domain of Rho Guanine Nucleotide Exchange Factor (RGNEF) regulates its nuclear-cytoplasmic localization. ALS, NES, NLS, RGNEF
2019 A Pathogenic Homozygous Mutation in The Pleckstrin Homology Domain of RASA1 Is Responsible for Familial Tricuspid Atresia in An Iranian Consanguineous Family. CHD, CM/AVM, TA, WES
2019 An inhibitor of the pleckstrin homology domain of CNK1 selectively blocks the growth of mutant KRAS cells and tumors. mut-KRAS, WT
2019 Analysis of the roles of phosphatidylinositol-4,5- bisphosphate and individual subunits in assembly, localization and function of Saccharomyces cerevisiae Target of Rapamycin Complex 2. PM, PtdIns-4,5-P2, TOR
2019 DOK7V1 influences the malignant phenotype of lung cancer cells through PI3K/AKT/mTOR and FAK/paxillin signaling pathways. DOK7V1, FAK, mTOR, PI3K, PTB
2019 Monitoring Non-vesicular Transport of Phosphatidylserine and Phosphatidylinositol 4-Phosphate in Intact Cells by BRET Analysis. BRET, LTPs, MCSs, ORP, PI4P, PM, PS
2019 Mutation p.R356Q in the Collybistin Phosphoinositide Binding Site Is Associated With Mild Intellectual Disability. CB, XLID
2019 REC114 Partner ANKRD31 Controls Number, Timing, and Location of Meiotic DNA Breaks. DSBs, PARs
2019 Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. ---
10  2019 Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential. DH, GEF, GPCRs, GTPase
11  2018 Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. ---
12  2018 alpha5beta1 integrin trafficking and Rac activation are regulated by APPL1 in a Rab5-dependent manner to inhibit cell migration. PTB
13  2018 Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis. Arg-II, mTORC1, Myo1b, S6K1, TSC
14  2018 ARHGEF19 interacts with BRAF to activate MAPK signaling during the tumorigenesis of non-small cell lung cancer. DH, MAPK, NSCLC, OS, PFS, RhoGEFs
15  2018 Both the N- and C- terminal regions of the Chlamydial inclusion protein D (IncD) are required for interaction with the pleckstrin homology domain of the ceramide transport protein CERT. CERT, IncD
16  2018 Chlorogenic Acid Targeting of the AKT PH Domain Activates AKT/GSK3beta/FOXO1 Signaling and Improves Glucose Metabolism. CGA, FOXO1, GSK3beta
17  2018 Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase. ---
18  2018 Dandelion Root Extract Induces Intracellular Ca2+ Increases in HEK293 Cells. DRE, ER, FRET, GFP, HEK, PLC
19  2018 Deletion analysis of AGD1 reveals domains crucial for plasma membrane recruitment and function in root hair polarity. ARF-GAP, GFP, PM
20  2018 Direct regulation of p190RhoGEF by activated Rho and Rac GTPases. DH, RhoGEFs
21  2018 Functions of Rhotekin, an Effector of Rho GTPase, and Its Binding Partners in Mammals. RBD
22  2018 LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein. ESCs, LIF
23  2018 Modeling of PH Domains and Phosphoinositides Interactions and Beyond. PIs
24  2018 Modes of Interaction of Pleckstrin Homology Domains with Membranes: Toward a Computational Biochemistry of Membrane Recognition. PIP
25  2018 Molecular characterization and function analysis of grouper (Epinephelus coioides) Bruton's tyrosine kinase BTK. BCR, BTK, PKc, SH2, SH3, TH, XLA, XLD
26  2018 NBEAL2 mutations and bleeding in patients with gray platelet syndrome. BEACH, GPS, NBEAL2
27  2018 Numerical Simulation and FRAP Experiments Show That the Plasma Membrane Binding Protein PH-EFA6 Does Not Exhibit Anomalous Subdiffusion in Cells. BHK, CTRW, FRAP
28  2018 Oxysterol-binding protein-related protein (ORP) 6 localizes to the ER and ER-plasma membrane contact sites and is involved in the turnover of PI4P in cerebellar granule neurons. E-Syt2, ER, ORD, ORP, OSBP, PI4P, PM
29  2018 PHLPP1 mediates melanoma metastasis suppression through repressing AKT2 activation. ---
30  2018 Phosphoinositide binding by the PH domain in ceramide transfer protein (CERT) is inhibited by hyperphosphorylation of an adjacent serine-repeat motif. CERT, PI4P, SRM
31  2018 Phosphorylation-Dependent Inhibition of Akt1. ---
32  2018 Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy. CCCP, CL, CML
33  2018 Regulation of AKT Activity by Inhibition of the Pleckstrin Homology Domain-PtdIns(3,4,5)P3 Interaction Using Flavonoids. PIP3
34  2018 Resistance training recovers attenuated APPL1 expression and improves insulin-induced Akt signal activation in skeletal muscle of type 2 diabetic rats. PTB, RT, T2D
35  2018 Silencing of PHLPP1 promotes neuronal apoptosis and inhibits functional recovery after spinal cord injury in mice. Nrf2, SCI, siRNA, WT
36  2018 Steric interference from intrinsically disordered regions controls dynamin-related protein 1 self-assembly during mitochondrial fission. Drp1, IDRs, PRD, VD
37  2018 Structural basis of sterol recognition and nonvesicular transport by lipid transfer proteins anchored at membrane contact sites. ER, LAMs, MCSs, SD
38  2018 Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors. GEFs, GTPase
39  2018 Structure and function of the Fgd family of divergent FYVE domain proteins. DH, Fgd, MODA, PI, PI3P, PX
40  2018 Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae. ---
41  2018 The ABD on the nascent polypeptide and PH domain are required for the precise Anillin localization in Drosophila syncytial blastoderm. ABD
42  2018 The ARF guanine nucleotide exchange factor GBF1 is targeted to Golgi membranes through a PIP-binding domain. ARF, GEFs, HDS1, PIP, Sec7d
43  2018 The flavonoid baicalin improves glucose metabolism by targeting the PH domain of AKT and activating AKT/GSK3beta phosphorylation. GSK3beta
44  2017 A New Electron Microscopic Method to Observe the Distribution of Phosphatidylinositol 3,4-bisphosphate. ---
45  2017 A pleckstrin homology-like domain is critical for F-actin binding and cofilin-phosphatase activity of Slingshot-1. SSH1
46  2017 Abrus Agglutinin, a type II ribosome inactivating protein inhibits Akt/PH domain to induce endoplasmic reticulum stress mediated autophagy-dependent cell death. 3-MA, AGG, Bax-KD, NAC
47  2017 alpha-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation. AMPK, MPTP, PIKE-L
48  2017 An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition. ITK, PIP3
49  2017 APPL1 is a multifunctional endosomal signaling adaptor protein. PTB
50  2017 CAPS-1 requires its C2, PH, MHD1 and DCV domains for dense core vesicle exocytosis in mammalian CNS neurons. CAPS, DCVs, SVs
51  2017 Common TFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways. GGR, TCR
52  2017 Computational and theoretical approaches for studies of a lipid recognition protein on biological membranes. PIP, PMPs
53  2017 D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes. APCs, LFA-1, SKAP55, TCR
54  2017 Dynamic interactions between a membrane binding protein and lipids induce fluctuating diffusivity. PIP
55  2017 Enhanced Binding Affinity via Destabilization of the Unbound State: A Millisecond Hydrogen-Deuterium Exchange Study of the Interaction between p53 and a Pleckstrin Homology Domain. TAD
56  2017 Identification and insilico structural analysis of Gallus gallus protein arginine methyltransferase 4 (PRMT4). ggPRMT4, H3-R17, PRMT4
57  2017 Increased intracellular Ca2+ concentrations prevent membrane localization of PH domains through the formation of Ca2+-phosphoinositides. Akt, PIPs
58  2017 Inhibitory potential of flavonoids on PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 pleckstrin homology domain. EGFP, PDK1, PI3K, QSAR
59  2017 Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain. CERT, START
60  2017 IRS1 and IRS2: molecular characterization, tissue expression and transcriptional regulation by insulin in yellow catfish Pelteobagrus fulvidraco. IRS, mRNA, PTB
61  2017 Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells. GSK3beta, HDAC6, mTOR, NPCs, PI3K
62  2017 Molecular characterization and expression analysis of olive flounder (Paralichthys olivaceus) phospholipase C gamma 1 and gamma 2. PLCG1, PLCG2, RACE, SH2, SH3
63  2017 Novel functions of CCM1 delimit the relationship of PTB/PH domains. CSC, PTB
64  2017 Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway. ---
65  2017 Phosphatidylinositol 3-phosphate-binding protein AtPH1 controls the localization of the metal transporter NRAMP1 in Arabidopsis. PI3P
66  2017 Prediction of a highly deleterious mutation E17K in AKT-1 gene: An in silico approach. ---
67  2017 Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain. CME
68  2017 Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases. AML, PI3K, PIPP, PtdIns3P, PTEN
69  2017 Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. DH
70  2017 Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain. PtdInsP, SPR
71  2017 The carboxyl-terminal region of Dok-7 plays a key, but not essential, role in activation of muscle-specific receptor kinase MuSK and neuromuscular synapse formation. NMJ, PTB
72  2017 The Effect of SIN1 and Microtubules on Insulin Induced PKC zeta Activation. Co-IP, IR, PKCzeta, siRNA
73  2017 The possible roles of B-cell novel protein-1 (BCNP1) in cellular signalling pathways and in cancer. BCNP1, FAM129C, LZ, PR, TP53
74  2017 The VPS34 PI3K negatively regulates RAB-5 during endosome maturation. PI3K
75  2016 A 2D-QSAR and Grid-Independent Molecular Descriptor (GRIND) Analysis of Quinoline-Type Inhibitors of Akt2: Exploration of the Binding Mode in the Pleckstrin Homology (PH) Domain. GRIND
76  2016 A novel FGD1 mutation in a family with Aarskog-Scott syndrome and predominant features of congenital joint contractures. AAS
77  2016 Allosteric properties of PH domains in Arf regulatory proteins. ARFs, GAPs, GEFs
78  2016 An Apicomplexan Actin-Binding Protein Serves as a Connector and Lipid Sensor to Coordinate Motility and Invasion. GAC
79  2016 Association of Peripheral Membrane Proteins with Membranes: Free Energy of Binding of GRP1 PH Domain with Phosphatidylinositol Phosphate-Containing Model Bilayers. MD, PIPs
80  2016 Characterization of a Plasmodium berghei sexual stage antigen PbPH as a new candidate for malaria transmission-blocking vaccine. IFA, TBVs
81  2016 Computational studies of the binding profile of phosphoinositide PtdIns (3,4,5) P₃ with the pleckstrin homology domain of an oomycete cellulose synthase. ---
82  2016 Crystal structure of hGEF-H1 PH domain provides insight into incapability in phosphoinositide binding. DH, ITC, TSA
83  2016 Crystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate Specificity. PTP
84  2016 Dataset for the NMR structure of the intrinsically disordered acidic region of XPC bound to the PH domain of TFIIH p62. NMR, NOE
85  2016 Direct Functional Interaction of the Kinesin-13 Family Member Kinesin-like Protein 2A (Kif2A) and Arf GAP with GTP-binding Protein-like, Ankyrin Repeats and PH Domains1 (AGAP1). AGAP1, KD, Kif2A
86  2016 Effect of Lipid Composition on the Membrane Orientation of the G Protein-Coupled Receptor Kinase 2-Gbeta1gamma2 Complex. GPCR
87  2016 Effects of Glycerophospholipids on Ceramide Kinase Activity: Cardiolipin-Affected Cellular Formation of Ceramide-1-phosphate. C1P, CERK, PI
88  2016 Genome-Wide Comparative Analysis of the Phospholipase D Gene Families among Allotetraploid Cotton and Its Diploid Progenitors. PLD, PX
89  2016 Helix-Grafted Pleckstrin Homology Domains Suppress HIV-1 Infection of CD4-Positive Cells. ---
90  2016 Ibrutinib inhibition of Bruton protein-tyrosine kinase (BTK) in the treatment of B cell neoplasms. BTK, BTK
91  2016 Identification of Toxoplasma TgPH1, a pleckstrin homology domain-containing protein that binds to the phosphoinositide PI(3,5)P2. ---
92  2016 Interactions of Pleckstrin Homology Domains with Membranes: Adding Back the Bilayer via High-Throughput Molecular Dynamics. PIP
93  2016 Intrinsic Pleckstrin Homology (PH) Domain Motion in Phospholipase C-beta Exposes a Gbetagamma Protein Binding Site. PLCbeta
94  2016 Mechanistic insights into the phosphatidylinositol binding properties of the pleckstrin homology domain of lamellipodin. FRET, Lpd, PDGF, PIP, SPR
95  2016 Molecular characterization of the Haemonchus contortus phosphoinositide-dependent protein kinase-1 gene (Hc-pdk-1). GFP, Hc-pdk-1, Hc-pdk-1
96  2016 Multiscale Simulations Suggest a Mechanism for the Association of the Dok7 PH Domain with PIP-Containing Membranes. PIPs, PTB
97  2016 Phosphatidic Acid-Mediated Signaling Regulates Microneme Secretion in Toxoplasma. DAG, PA, PLC
98  2016 Phosphatidylinositol-3,4-Bisphosphate and Its Binding Protein Lamellipodin Regulate Chemotaxis of Malignant B Lymphocytes. Lpd
99  2016 Phospholipase Cbeta1 induces membrane tubulation and is involved in caveolae formation. BAR, PLCbeta1
100  2016 Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity. CREB, GPCR, NF1, Ras-GAP