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■ Abbreviation / Long Form : PKB / protein kinase B

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Total Number of Papers: 1200
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Abbreviation:   PKB  (>> Co-occurring Abbreviation)
Long Form:   protein kinase B
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No. Year Title Co-occurring Abbreviation
2020 A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis. SERCA2a
2020 AMPK activation suppresses mTOR/S6K1 phosphorylation and induces leucine resistance in rats with sepsis. AICAR, CLP, TPN
2020 Capillarisin protects SH-SY5Y cells against bupivacaine-induced apoptosis via ROS-mediated PI3K/PKB pathway. ATP, CAT, CHOP, GRP78, GSH-Px, LDH, MDA, PARP, PI3K, ROS, SOD
2020 Circular RNA circ‑ACACA regulates proliferation, migration and glycolysis in non‑small‑cell lungcarcinoma via miR‑1183 and PI3K/PKB pathway. circRNAs, miR, NSCLC, PI3K
2020 Disrupting insulin signaling in Schwann cells impairs myelination and induces a sensory neuropathy. DN, IGF1R, INSR, SCs
2020 Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue. ACC, ACL, PDH
2020 Emergence of allosteric drug-resistance mutations: new challenges for allosteric drug discovery. Bcr-Abl, IDH, MEK, SHP2
2020 FCHO1560-571 peptide, a PKB kinase motif, inhibits tumor progression. FCHO1
2020 Metabolic Heterogeneity of Cancer Cells: An Interplay between HIF-1, GLUTs, and AMPK. AMPK, GLUTs, HIF-1, LKB1, OXPHOS, PI3K, ROS
10  2020 MicroRNA-143 Increases Oxidative Stress and Myocardial Cell Apoptosis in a Mouse Model of Doxorubicin-Induced Cardiac Toxicity. miR, miR-143, qRT-PCR
11  2020 Molecular insights into kinase mediated signaling pathways of chemokines and their cognate G protein coupled receptors. GPCRs, GRKs, JAKs, MAPK/ERK, PI3K, PKA, PKC
12  2020 Nitroglycerin Enhances Cisplatin-Induced Cytotoxicity via AKT Inactivation and Thymidylate Synthase Downregulation in Human Lung Cancer Cells. NSCLC, NTG, TS
13  2020 Parthenolide inhibits human lung cancer cell growth by modulating the IGF‑1R/PI3K/Akt signaling pathway. FoxO3alpha, PTL
14  2020 Phosphorylation and dephosphorylation of Ca2+/calmodulin-dependent protein kinase kinase beta at Thr144 in HeLa cells. AMPK, CaMKKbeta, OA, PKA
15  2020 Polyploid Adipose Stem Cells Shift the Balance of IGF1/IGFBP2 to Promote the Growth of Breast Cancer. ASCs, vASC
16  2020 Protein kinase Akt2/PKBbeta is involved in blastomere proliferation of preimplantation mouse embryos. PI3K
17  2020 Role of aldo-keto reductase family 1 member B1 (AKR1B1) in the cancer process and its therapeutic potential. AKR1B1, CDKs, mTOR, NF-kappaB, ROS
18  2020 Salvianolic acid A increases the accumulation of doxorubicin in brain tumors through Caveolae endocytosis. BTB, CNS, DOX, FITC-BSA, GECs, MbetaCD, pCaveolin-1, Sal A, Src, TEER, TJs
19  2020 Serum proteomic profiling of patients with amphetamine use disorder. IPA
20  2020 Synthesis, characterization, antidiabetic and antioxidative evaluation of a novel Zn(II)-gallic acid complex with multi-facet activity. FTIR, GLUT-4
21  2020 Targeting AKT/PKB to improve treatment outcomes for solid tumors. PI3K, RTKs
22  2020 Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. AD, APP, CREB, DS, FL-APP, i.p, p-tau
23  2020 The physiological modulation by intracellular kinases of hippocampal gamma-oscillation in vitro. AMPK, ERK, PKA, PKC, sEPSC, sIPSC
24  2020 Tris(1,3-dichloro-2-propyl)phosphate Reduces the Lifespan via Activation of an Unconventional Insulin/Insulin-Like Growth Factor-1 Signaling Pathway. IIS, PIP3, TDCPP
25  2020 Withanolide Metabolites Inhibit PI3K/AKT and MAPK Pro-Survival Pathways and Induce Apoptosis in Acute Myeloid Leukemia Cells. AML, CoA, mTOR, PI3K, WTH
26  2019 1,2-Dichloropropane (1,2-DCP)-Induced Angiogenesis in Dermatitis. 1,2-DCP, mTOR
27  2019 AKT and ERK dual inhibitors: The way forward? ERK, MAPK, MEK, PI3K
28  2019 Characterization and Hypoglycemic Activity of a Rhamnan-Type Sulfated Polysaccharide Derivative. GSK-3beta, IR, IRS2, PI3K, SPE, SPED
29  2019 Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer. ER, PI3K
30  2019 Effect of insulin on thyroid cell proliferation, tumor cell migration, and potentially related mechanisms. HI, IG, pre
31  2019 Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway. PT, TII
32  2019 Lysyl oxidase-like 2 is a regulator of angiogenesis through modulation of endothelial-to-mesenchymal transition. ECs, EMT, EndMT, FAK, LOXL2, TGF-beta
33  2019 MicroRNA‑4712‑5p promotes proliferation of the vulvar squamous cell carcinoma cell line A431 by targeting PTEN through the AKT/cyclin D1 signaling pathways. GSK, PTEN, VSCC
34  2019 Neuroprotective and neuroregenerative effects of CRMP-5 on retinal ganglion cells in an experimental in vivo and in vitro model of glaucoma. CRMP-5, IOP, ONC, RGCs, SD
35  2019 Phosphoinositide spatially free AKT/PKB activation to all membrane compartments. ---
36  2019 PI3K-PKB-mTOR hyperactivation in relation to nasopharyngeal carcinoma progression and prognosis. mTOR, NPC, PI3K
37  2019 Preparation of a Novel One-Armed Anti-c-Met Antibody with Antitumor Activity Against Hepatocellular Carcinoma. c-Met, Gab-1, HCC, HGF, HUVECs
38  2019 Regulation of PKB/Akt-pathway in the chemopreventive effect of lactoferrin against diethylnitrosamine-induced hepatocarcinogenesis in rats. DENA, HCC, LF
39  2019 Regulation of PKB/Akt-pathway in the chemopreventive effect of lactoferrin against diethylnitrosamine-induced hepatocarcinogenesis in rats. DENA, HCC, LF
40  2019 Role of the Balance of Akt and MAPK Pathways in the Exercise-Regulated Phenotype Switching in Spontaneously Hypertensive Rats. MAPK, OPN, SHRs, VSMC
41  2019 Sodium Butyrate Improves Liver Glycogen Metabolism in Type 2 Diabetes Mellitus. GLUT2, GPR43, GSK-3, SGLT1, T2DM
42  2019 Targeting AKT for cancer therapy. PI3K
43  2019 Targeting allosteric site of AKT by 5,7-dimethoxy-1,4-phenanthrenequinone suppresses neutrophilic inflammation. ALI, dHL-60, LPS
44  2019 The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion. Bax, Bcl-xL, JNK, p38 MAPK, ROS
45  2019 The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner. HDAC6, mTOR, Nrf2, PI3K, SFN
46  2019 Virtual Screening of 1,4-Naphthoquinone Derivatives for Inhibition of a Key Cancer Signaling Protein, AKT1 Kinase. ---
47  2018 A systematic review of p53 regulation of oxidative stress in skeletal muscle. NO, PMAIP1, PTIO
48  2018 Activation of transglutaminase 2 by nerve growth factor in differentiating neuroblastoma cells: A role in cell survival and neurite outgrowth. NGF, PKC
49  2018 Amyloid formation reduces protein kinase B phosphorylation in primary islet beta-cells which is improved by blocking IL-1beta signaling. hIAPP, IL-1beta, T2D
50  2018 Cell-geometry-dependent changes in plasma membrane order direct stem cell signalling and fate. ---
51  2018 Coptisine Suppresses Mast Cell Degranulation and Ovalbumin-Induced Allergic Rhinitis. AR, F-actin, Ig, IL, OVA, PI3K, TNF
52  2018 Delayed treatment of propofol inhibits lipopolysaccharide-induced inflammation in microglia through the PI3K/PKB pathway. COX-2, IL-1beta, IL-6, iNOS, LPS, PI3K, RT-PCR, TNF-alpha
53  2018 Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action. CDK, IRS, IRS, MS, PKC, SILAC
54  2018 Downregulation of Akt2 attenuates ER stress-induced cytotoxicity through JNK-Wnt pathway in cardiomyocytes. LDH, ROS, TM, UPR
55  2018 Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity. ---
56  2018 Impact of PI3Kalpha (Phosphoinositide 3-Kinase Alpha) Inhibition on Hemostasis and Thrombosis. ---
57  2018 Impact of weight cycling on CTRP3 expression, adipose tissue inflammation and insulin sensitivity in C57BL/6J mice. GLUT, IL, PI3K, TNF
58  2018 Insulin suppresses the production of fibroblast growth factor 23 (FGF23). FGF23, FOXO1, IGF1, PI3K, PTH
59  2018 Intact glucose uptake despite deteriorating signaling in adipocytes with high-fat feeding. AS160, HFD, IRS-1
60  2018 Intermittent bolus feeding promotes greater lean growth than continuous feeding in a neonatal piglet model. CON, eIF
61  2018 Investigation of Novel Regulation of N-myristoyltransferase by Mammalian Target of Rapamycin in Breast Cancer Cells. ER, mTOR, NMT1
62  2018 Quercetin Prevents In Vivo and In Vitro Myocardial Hypertrophy Through the Proteasome-GSK-3 Pathway. ANF, Ang II, ERK, GATA4, GSK-3, PSMB, Rpt
63  2018 Role of PKB/SGK-dependent phosphorylation of GSK-3alpha/beta in vascular calcification during cholecalciferol overload in mice. ALPL, GSK-3, gsk-3KI, PAI-1, SGK1
64  2018 [Effects of deoxygedunin on Alzheimer-like pathologic dysfunction induced by D-galactose combined with AlCl3]. ELISA, ERK1, MDA, SOD, TrkB
65  2017 A systems biology analysis connects insulin receptor signaling with glucose transporter translocation in rat adipocytes. AS160, GLUT4, IR
66  2017 AKT/PKB Signaling: Navigating the Network. ---
67  2017 Baicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2A receptor-induced SDF-1/CXCR4/PI3K/AKT signaling. A2AR, CXCR4, HPH, mCAP, PAH, PI3K, RVSP, SDF-1, WT
68  2017 Clove and Its Active Compound Attenuate Free Fatty Acid-Mediated Insulin Resistance in Skeletal Muscle Cells and in Mice. GSK-3 beta, IRS-1, NGC, SAM
69  2017 Cross-talks via mTORC2 can explain enhanced activation in response to insulin in diabetic patients. mTOR, mTORC2, S6K
70  2017 Effect of L-arginine supplementation on the hepatic phosphatidylinositol 3-kinase signaling pathway and gluconeogenic enzymes in early intrauterine growth-restricted rats. CON, G6Pase, HOMA-IR, IUGR, L-Arg, LA, PEPCK, PI3K
71  2017 Fascaplysin Sensitizes Anti-Cancer Effects of Drugs Targeting AKT and AMPK. AMPK, MTX
72  2017 Human hair follicle transcriptome profiling: a minimally invasive tool to assess molecular adaptations upon low-volume, high-intensity interval training. DE, GO, GS, HIIT, JAK, miRNAs, PI3K, STAT
73  2017 Identification of a RAC/AKT-like gene in Leishmania parasites as a putative therapeutic target in leishmaniasis. RAC
74  2017 Kolaviron, a biflavonoid of Garcinia kola seed mitigates ischemic/reperfusion injury by modulation of pro-survival and apoptotic signaling pathways. KV
75  2017 Leptolide Improves Insulin Resistance in Diet-Induced Obese Mice. ---
76  2017 Modified lingguizhugan decoction incorporated with dietary restriction and exercise ameliorates hyperglycemia, hyperlipidemia and hypertension in a rat model of the metabolic syndrome. ELISA, HFD, HFD-DR, MLD, MS, TNF-alpha
77  2017 Protein kinase B: emerging mechanisms of isoform-specific regulation of cellular signaling in cancer. PI3K
78  2017 Restoration of Circulating MFGE8 (Milk Fat Globule-EGF Factor 8) Attenuates Cardiac Hypertrophy Through Inhibition of Akt Pathway. MAPK, MFGE8
79  2017 Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes. Con A, Fru-2,6-P2, PFK-1, PFK-2, rpS6
80  2017 Salidroside Modulates Insulin Signaling in a Rat Model of Nonalcoholic Steatohepatitis. IRS-1, NASH, PI3K
81  2017 Signal-Regulated Protein Kinases/Protein Kinase B-p53-BH3-Interacting Domain Death Agonist Pathway Regulates Gingipain-Induced Apoptosis in Osteoblasts. Bid, ERK, si
82  2017 SodC modulates ras and PKB signaling in Dictyostelium. PIP3, SodC
83  2017 Stress-Kinase Regulation of TASK-1 and TASK-3. AFib, BAT, SGKs
84  2017 Sulforaphane inhibits the interferon-gamma-induced expression of MIG, IP-10 and I-TAC in INS‑1 pancreatic beta-cells through the downregulation of IRF-1, STAT-1 and PKB. EGCG, I-TAC, IFN-gamma, IP-10, IRF-1, MIG, SFN, STAT-1
85  2017 Synthesis and anti-diabetic activity of new N,N-dimethylphenylenediamine-derivatized nitrilotriacetic acid vanadyl complexes. DMPD, JNK
86  2017 The PI3K/Akt/mTOR pathway is involved in CVB3-induced autophagy of HeLa cells. CVB3, LC3, mTOR, PI3K, VMC
87  2016 1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in db/db Mice. AST, DNJ, G6Pase, GP, GS, GSK-3beta, HK, IL-1, IL-6, LDL-C, PEPCK, PI3K, PK, TC, TG, TNF-alpha
88  2016 A new glycotoxins inhibitor attenuates insulin resistance in liver and fat cells. AGEs, GSK-3-beta, MGO, RAGE
89  2016 Akt attenuates apoptotic death through phosphorylation of H2A under hydrogen peroxide-induced oxidative stress in PC12 cells and hippocampal neurons. H2A, SIRT2
90  2016 Application of citrate as a tricarboxylic acid (TCA) cycle intermediate, prevents diabetic-induced heart damages in mice. EC, HE, p-AKT, PAI-1, ROS, SCOT, TCA
91  2016 Autocrine VEGFR1 and VEGFR2 signaling promotes survival in human glioblastoma models in vitro and in vivo. MAPK/ERK, MMP9, PlGF, VEGF, VEGFR
92  2016 BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling. 5-ASA, Bcl3, mTOR, NF-kappaB
93  2016 Cadmium-induced heme-oxygenase-1 expression plays dual roles in autophagy and apoptosis and is regulated by both PKC-delta and PKB/Akt activation in NRK52E kidney cells. Cd, eIF, GSK, HO-1, PKC, pSer
94  2016 Deregulation of vital mitotic kinase-phosphatase signaling in hematopoietic stem/progenitor compartment leads to cellular catastrophe in experimental aplastic anemia. HSPC
95  2016 Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion. AMPK, IGF1, KI
96  2016 Effects of Per2 overexpression on growth inhibition and metastasis, and on MTA1, nm23-H1 and the autophagy-associated PI3K/PKB signaling pathway in nude mice xenograft models of ovarian cancer. PBS, Per2, PI3K
97  2016 Emerging therapeutics for targeting Akt in cancer. ---
98  2016 Exogenous Secreted Frizzled-Related Protein-4 Modulates Steroidogenesis of Rat Granulosa Cells through Wnt/beta-catenin and PI3K/AKT Signaling Pathways. FSH, GCs, LH, rhSFRP-4
99  2016 FOXO3a orchestrates glioma cell responses to starvation conditions and promotes hypoxia-induced cell death. FOXO, GLUT1, HIF-1alpha, TRAIL
100  2016 Fucoidan from sea cucumber Cucumaria frondosa exhibits anti-hyperglycemic effects in insulin resistant mice via activating the PI3K/PKB pathway and GLUT4. GLUT4, IR, IRS-1, PI3K