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■ Abbreviation / Long Form : PPARalpha / peroxisome proliferator-activated receptor alpha

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Abbreviation:   PPARalpha  (>> Co-occurring Abbreviation)
Long Form:   peroxisome proliferator-activated receptor alpha
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No. Year Title Co-occurring Abbreviation
2022 Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages. SCFAs
2022 Target Deconvolution of Fenofibrate in Nonalcoholic Fatty Liver Disease Using Bioinformatics Analysis. GO, NAFLD, NASH
2021 A Novel Identified Peptide Hormone "Metabolitin" Attenuates Lipid Absorption in the Small Intestine of Diabetic Mice with Nonalcoholic Fatty Liver Disease by Regulating Neurotensin and AMPK Signaling Pathway. ACC, AMPK, CPT1, FAS, GTT, ITT, NAFLD, NT, SCD-1, SREBP1, T2DM, TC, TG
2021 A Palmitoylethanolamide Producing Lactobacillus paracasei Improves Clostridium difficile Toxin A-Induced Colitis. CDI, NAPE-PLD
2021 Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy. AMPK, CHREBP, DGAT1, DKO, FAS, FOXO1, G6Pase, LC3B, PEPCK, PGC-1alpha, RER, RNA-Seq, SCD-1, SREBP1, WT
2021 ACOX2 is a prognostic marker and impedes the progression of hepatocellular carcinoma via PPARalpha pathway. Acox2, DEGs, DEPs, DIA, HCC, PRGs
2021 Activation of PPARα by Fenofibrate Attenuates the Effect of Local Heart High Dose Irradiation on the Mouse Cardiac Proteome. ---
2021 Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver. A-PHLPP2, HFD, T2D
2021 Adjunct Fenofibrate Up-regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis. ALP, BAs, CDCA, DCA, LCA
10  2021 Anti-Obesity Effect of T. Chebula Fruit Extract on High Fat Diet Induced Obese Mice: A Possible Alternative Therapy. CPT-1, EETC, FAS, FTIR, GC-MS, IL-6, LC-MS, TNF-alpha
11  2021 Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARalpha Agonists. 1-PG, 2-PG, eCBome
12  2021 BHBA regulates the expressions of lipid synthesis and oxidation genes in sheep hepatocytes through the AMPK pathway. AMPK, ATGL, BHBA, HSL, PT, SREBP-1c, TG, VLDL
13  2021 Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance. BVRA
14  2021 Biomarkers and key pathways in atrial fibrillation associated with mitral valve disease identified by multi-omics study. AF, apoA-I, apoA-II, DMs, DPs, ELISA, iTRAQ, LMO7, MVD, RAAS, SR, VN
15  2021 Cardiomyocyte peroxisome proliferator-activated receptor alpha is essential for energy metabolism and extracellular matrix homeostasis during pressure overload-induced cardiac remodeling. ECAR, ECM, TAC
16  2021 Carnitine palmitoyltransferase 1 (CPT1) alleviates oxidative stress and apoptosis of hippocampal neuron in response to beta-Amyloid peptide fragment Aβ25-35. Abeta25-35, AD, APP, Bace-1, CCK-8, CPT1, LDH, MDA, ROS, SOD
17  2021 Clofibrate, a Peroxisome Proliferator-Activated Receptor-Alpha (PPARalpha) Agonist, and Its Molecular Mechanisms of Action against Sodium Fluoride-Induced Toxicity. NF-kappaB
18  2021 Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). CAR, MOA, PB
19  2021 Critical role of peroxisome proliferator-activated receptor alpha in promoting platelet hyperreactivity and thrombosis under hyperlipidemia. HFD, NOX, ox-LDL, ROS, WT
20  2021 Curcumin Conjugated Gold Nanoclusters as Perspective Therapeutics for Diabetic Cardiomyopathy. AuCur, CUR, DCM, ROS
21  2021 Delphinidin-3-sambubioside from Hibiscus sabdariffa. L attenuates hyperlipidemia in high fat diet-induced obese rats and oleic acid-induced steatosis in HepG2 cells. ACC, ACOX, CPT1, CYP7A1, Dp3-Sam, FASN, HMGCR, p-AMPK, SREBP-1C
22  2021 Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARalpha pathway. ALD, DEPDC5, Depdc5-LKO, GATOR1, mTORC1
23  2021 Design and synthesis of novel quinazolinone-based fibrates as PPARα agonists with antihyperlipidemic activity. ---
24  2021 Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARalpha Agonist in PPARA-Humanized Mice. ---
25  2021 Dissecting the Balance Between Metabolic and Oncogenic Functions of Astrocyte-Elevated Gene-1/Metadherin. AEG-1, CRISPR, FAO, HCC, NASH
26  2021 DNMT1-mediated PPARalpha methylation aggravates damage of retinal tissues in diabetic retinopathy mice. DAC, DNMT1, DR, HG, HRCPs, ROS
27  2021 Effect of regioisomers of hydroxystearic acids as peroxisomal proliferator-activated receptor agonists to boost the anti-ageing potential of retinoids. 10-HSA, SA
28  2021 Effects of Danhong injection on dyslipidemia and cholesterol metabolism in high-fat diets fed rats. ALT, AST, CYP7A1, DHI, FFA, GSH-Px, HDL-C, LDL-C, LDLR, LXRalpha, MDA, RT-PCR, SD, SOD, SREBP-2, TC, TG
29  2021 Efficacy and Safety of Low-Dose Pemafibrate Therapy for Hypertriglyceridemia in Patients with Type 2 Diabetes. apo, HDL-C, LDL-C, RLP-C, TG
30  2021 Elucidation of the mechanism of NEFA-induced PERK-eIF2alpha signaling pathway regulation of lipid metabolism in bovine hepatocytes. apoB, CHOP, CPT1A, eIF2alpha, ERS, FASN, GRP78, LDLR, NEB, NEFA, PERK, SREBP-1c, TG, VLDL
31  2021 Emodin Improves Glucose and Lipid Metabolism Disorders in Obese Mice via Activating Brown Adipose Tissue and Inducing Browning of White Adipose Tissue. BAT, Cers, FATP4, LPCs, LPCs-O, PEs-O, scWAT, TMEM26, UCP1, WAT
32  2021 Engineered Bacteria of MG1363-pMG36e-GLP-1 Attenuated Obesity-Induced by High Fat Diet in Mice. GLP-1, HFD, M-GLP-1, TG
33  2021 Estrogen-Wnt signaling cascade regulates expression of hepatic fibroblast growth factor 21. FGF21, MPH, RNA, TCFBs, TG
34  2021 Euphausia pacifica (North Pacific Krill): Review of Chemical Features and Potential Benefits of 8-HEPE against Metabolic Syndrome, Dyslipidemia, NAFLD, and Atherosclerosis. 8-HEPE, E. pacifica
35  2021 Exposure of male mice to perfluorooctanoic acid induces anxiety-like behaviors by increasing corticotropin-releasing factor in the basolateral amygdala complex. BLA, CRF, CRF-R1, FGF21, FGFR1, LTD, LTP, NMDAR, PFOA, PVN
36  2021 Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPARα-FGF21 Axis. D5D, FADS1, LC-PUFAs, PUFAs
37  2021 Feedback repression of PPARalpha signaling by Let-7 microRNA. miRNA, Rnf8, RXRalpha
38  2021 Fenofibrate (a PPAR-alpha Agonist) Administered During Ethanol Withdrawal Reverts Ethanol-Induced Astrogliosis and Restores the Levels of Glutamate Transporter in Ethanol-Administered Adolescent Rats. GFAP
39  2021 Fenofibrate inhibits hypoxia-inducible factor-1 alpha and carbonic anhydrase expression through activation of AMP-activated protein kinase/HO-1/Sirt1 pathway in glioblastoma cells. AMPK, GBM, HIF-1alpha
40  2021 Fenofibrate Protects against Retinal Dysfunction in a Murine Model of Common Carotid Artery Occlusion-Induced Ocular Ischemia. FGF21, UCCAO
41  2021 Fenofibrate Protects Cardiomyocytes from Hypoxia/Reperfusion- and High Glucose-Induced Detrimental Effects. CT, HG, NADPH, Nrf2, ROS
42  2021 Fenofibrate protects the neurovascular unit and ameliorates plasma corticosterone levels in pentylenetetrazole-induced kindling seizure in mice. BBB, BDNF, MDA, PTZ
43  2021 Fenofibrate Reduces the Severity of Neuroretinopathy in a Type 2 Model of Diabetes without Inducing Peroxisome Proliferator-Activated Receptor Alpha-Dependent Retinal Gene Expression. DR, ERG, PPRE
44  2021 Fenofibrate Regulates Visceral Obesity and Nonalcoholic Steatohepatitis in Obese Female Ovariectomized C57BL/6J Mice. HFD
45  2021 Fenofibrate reverses liver fibrosis in cholestatic mice induced by alpha-naphthylisothiocyanate. alpha-SMA, ANIT, Collagen I, MCP-1, TIMP-1, WT
46  2021 Fetal Cardiac Lipid Sensing Triggers an Early and Sex-related Metabolic Energy Switch in Intrauterine Growth Restriction. IUGR, LCFAs
47  2021 Formononetin protects against cisplatin‑induced acute kidney injury through activation of thePPARalpha/Nrf2/HO‑1/NQO1 pathway. AKI, CIS, FOR, NQO1, Nrf2
48  2021 Gastric Bypass Increases Circulating Bile Acids and Activates Hepatic Farnesoid X Receptor (FXR) but Requires Intact Peroxisome Proliferator Activator Receptor Alpha (PPARalpha) Signaling to Significantly Reduce Liver Fat Content. BA, FXR, NAFLD
49  2021 Gemfibrozil Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease via PPARalpha-Dependent Astrocytic GDNF Pathway. GDNF, MPTP, PD, TH
50  2021 Genistein Regulates Lipid Metabolism via Estrogen Receptor β and Its Downstream Signal Akt/mTOR in HepG2 Cells. CPT-1alpha, ERbeta, FASN, GEN, mTOR, SCD1, SREBP-1c
51  2021 Genome-wide DNA methylation profiling of high-fat emulsion-induced hyperlipidemia mice intervened by a polysaccharide from Cyclocarya paliurus (Batal) Iljinskaja. AMPK, FAS, GO, HFE, KEGG
52  2021 Hepatic Ago2 Regulates PPARα for Oxidative Metabolism Linked to Glycemic Control in Obesity and Post Bariatric Surgery. Ago2, KO, miRNAs, VSG
53  2021 Hepatic CPT1A Facilitates Liver-Adipose Cross-Talk via Induction of FGF21 in Mice. CPT1A, FGF21, HFD, WT
54  2021 Hepatic CPT1A Facilitates Liver-Adipose Cross-Talk via Induction of FGF21 in Mice. CPT1A, FGF21, HFD, WT
55  2021 Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk. SUMO
56  2021 Hesperidin and Naringin Improve Broiler Meat Fatty Acid Profile and Modulate the Expression of Genes Involved in Fatty Acid beta-oxidation and Antioxidant Defense in a Dose Dependent Manner. ACOX1, FA, FASN, GSR, PUFA, SFA, VE
57  2021 Hexafluoropropylene oxide dimer acid (HFPO-DA) induced developmental cardiotoxicity and hepatotoxicity in hatchling chickens: Roles of peroxisome proliferator activated receptor alpha. CD36, EHHADH, HFPO-DA, L-FABP, PFOA
58  2021 HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARalpha axis. ChIP, Co-IP, EZH2, HDL-C, HFD, LDL-C, miR-429, OA/PA, TC, TNF
59  2021 Hippocampal PPARalpha Plays a Role in the Pharmacological Mechanism of Vortioxetine, a Multimodal-Acting Antidepressant. AAV, CSDS, CUMS
60  2021 Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling. AMPK, AST, CDAA, CSAA, HO-1, HRW, IL-10, NASH, PPARgamma, SIRT1
61  2021 Hydroxychloroquine Potentiates Apoptosis Induced by PPARalpha Antagonist in 786-O Clear Cell Renal Cell Carcinoma Cells Associated with Inhibiting Autophagy. ccRCC
62  2021 Icaritin ameliorates hepatic steatosis via promoting fatty acid beta-oxidation and insulin sensitivity. HFD, ICT, PA
63  2021 Identification of Binding Regions of Bilirubin in the Ligand-Binding Pocket of the Peroxisome Proliferator-Activated Receptor-A (PPARalpha). LBD
64  2021 Impact of Dietary Crude Protein Level on Hepatic Lipid Metabolism in Weaned Female Piglets. ACACalpha, CP, FASN, G6PC, HDL-C, HSL, LPL, PGC-1alpha, PKC1, SCD, SREBPF1
65  2021 Impact of peroxisome proliferator-activated receptor-alpha on diabetic cardiomyopathy. DCM
66  2021 In vivo brain levels of acetylcholine and 5-hydroxytryptamine after oleoylethanolamide or palmitoylethanolamide administrations are mediated by PPARalpha engagement. 5-HT, ACh, OEA, PEA
67  2021 Inhalation exposure to 2-ethyl-1-hexanol causes hepatomegaly and transient lipid accumulation without induction of peroxisome proliferator-activated receptor alpha in mice. 2EH
68  2021 Integrating metabolomics and network pharmacology to explore Rhizoma Coptidis extracts against sepsis-associated acute kidney injury. AKI, HO-1, NOS2, Nrf2, RC, RCE, ROS, SA-AKI
69  2021 Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease. NAFLD, RB, SSa, SSd, SSs
70  2021 Integrative study of diet-induced mouse models of NAFLD identifies PPARalpha as a sexually dimorphic drug target. NAFLD
71  2021 Liraglutide Alleviates Hepatic Steatosis and Liver Injury in T2MD Rats via a GLP-1R Dependent AMPK Pathway. GLP-1, NAFLD, T2DM, ZDF
72  2021 Liver X Receptor Expression and Pentraxin 3 Production in Chronic Rhinosinusitis and Sinonasal Mucosal Fibroblast Cells. CRS, CRSsNP, LXRs, NRs, PTX3
73  2021 Liver-specific Nrf2 deficiency accelerates ethanol-induced lethality and hepatic injury in vivo. ALD, Nrf2
74  2021 Localisation of Cannabinoid and Cannabinoid-Related Receptors in the Horse Ileum. 5-HT1aR, CB1R
75  2021 Low-dose mono(2-ethylhexyl) phthalate promotes ovarian cancer development through PPARalpha-dependent PI3K/Akt/NF-kappaB pathway. DEHP, EMT, GO, KEGG, MEHP
76  2021 LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia. AQP7, ATP, GPD2, LPL, MI
77  2021 Maternal DHA supplementation influences sex-specific disruption of placental gene expression following early prenatal stress. DHA, EPS, HIF3alpha
78  2021 Mechanisms Mediating the Regulation of Peroxisomal Fatty Acid Beta-Oxidation by PPARalpha. PPRE
79  2021 Metabolic maturation of differentiating cardiosphere-derived cells. CDCs
80  2021 Mitochondria damage in ambient particulate matter induced cardiotoxicity: Roles of PPAR alpha/PGC-1 alpha signaling. PGC1A, PM
81  2021 mTORC1 activation is not sufficient to suppress hepatic PPARalpha signaling or ketogenesis. mTOR, TSC
82  2021 Mulberry leaf activates brown adipose tissue and induces browning of inguinal white adipose tissue in type 2 diabetic rats through regulating AMP-activated protein kinase signalling pathway. AMPK, BAT, CPT-1, iWAT, NRF1, PGC-1alpha, PRDM16, T2DM, TMEM26, UCP1
83  2021 NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding. BMAL1, SIRT1, TRF-CR
84  2021 Nanoparticle conjugation of ginsenoside Rb3 inhibits myocardial fibrosis by regulating PPARalpha pathway. CS, G-Rb3, NpRb3, TPP
85  2021 Nitric oxide synthesis stimulated by arachidonic acid accumulation via PPARalpha in acetylcholine-stimulated gastric mucous cells. AA, F-HPLC
86  2021 Oleamide, a Sleep-Inducing Supplement, Upregulates Doublecortin in Hippocampal Progenitor Cells via PPARα. HPCs, OCT
87  2021 Oleuropein-Induced Acceleration of Cytochrome P450-Catalyzed Drug Metabolism: Central Role for Nuclear Receptor Peroxisome Proliferator-Activated Receptor alpha. AKT, OLE
88  2021 Overcompensation of CoA Trapping by Di(2-ethylhexyl) Phthalate (DEHP) Metabolites in Livers of Wistar Rats. DEHP
89  2021 Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity. HFD, NAEs, OA, OEA, POA, POEA
90  2021 Palmitoylethanolamide (PEA) reduces postoperative adhesions after experimental strabismus surgery in rabbits by suppressing canonical and non-canonical TGFbeta signaling through PPARalpha. NAAA, PEA, TAK1
91  2021 Pemafibrate Protects against Fatty Acid-Induced Nephropathy by Maintaining Renal Fatty Acid Metabolism. FAM, FAON, FFA, PEM
92  2021 Pemafibrate suppresses oxidative stress and apoptosis under cardiomyocyte ischemia-reperfusion injury in type 1 diabetes mellitus. D-IRI, IR, NF-kappaB, T1DM
93  2021 Perilipin 2 Impacts Acute Kidney Injury via Regulation of PPARalpha. AKI, I/R, Plin2, ROS
94  2021 Physiological and pharmacological stimulation for in vitro maturation of substrate metabolism in human induced pluripotent stem cell-derived cardiomyocytes. EHT, FAO, hiPSC-CMs
95  2021 Pomegranate peel as a phytogenic in broiler chickens: Influence upon antioxidant, lipogenesis and hypotensive response. MDA, PP, SOD1
96  2021 PPAR control of metabolism and cardiovascular functions. ---
97  2021 PPARalpha agonist exerts protective effects in podocyte injury via inhibition of the ANGPTL3 pathway. ANGPTL3, PAN
98  2021 PPARalpha agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and beta-catenin signaling. alpha-SMA, HK, IRI, Sirt3
99  2021 PPARalpha agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase. ADH, AFL, CYP2E1
100  2021 PPARalpha agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1. ALD, FGF21, FGFR1, TG