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■ Abbreviation / Long Form : PS / phosphorothioate

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Total Number of Papers: 232
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Abbreviation:   PS  (>> Co-occurring Abbreviation)
Long Form:   phosphorothioate
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No. Year Title Co-occurring Abbreviation
2020 In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3' and 5' thiophosphate linkages. ---
2019 4'-C-Trifluoromethyl modified oligodeoxynucleotides: synthesis, biochemical studies, and cellular uptake properties. ODNs
2019 A Camptothecin-Grafted DNA Tetrahedron as a Precise Nanomedicine to Inhibit Tumor Growth. CPT, DDCs
2019 Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay. ASOs, FP, HRG
2019 Development of gapmer antisense oligonucleotide with deoxyribonucleic guanidine (DNG) modifications. ASO, DNG
2019 Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines. ASOs, cEt
2019 Efficient Conjugation to Phosphorothioate Oligonucleotides by Cu-Catalyzed Huisgen 1,3-Dipolar Cycloaddition. ON
2019 Evaluating the Impact of Variable Phosphorothioate Content in Tricyclo-DNA Antisense Oligonucleotides in a Duchenne Muscular Dystrophy Mouse Model. ASOs, DMD, tcDNA
2019 Identification of Novel Tricyclic P(III) Chiral Auxiliary for Solid Supported Synthesis of Stereopure Phosphorothioate Containing Oligonucleotides. ---
10  2019 Identifying and Avoiding tcDNA-ASO Sequence-Specific Toxicity for the Development of DMD Exon 51 Skipping Therapy. ASOs, DMD, tcDNA
11  2019 Impact of chemistry and nanoformulation parameters on cellular uptake and airway distribution of RNA oligonucleotides. NP, ON
12  2019 Impact of Phosphorothioate Chirality on Double-stranded siRNAs: A Systematic Evaluation of Stereopure siRNA Designs. ASOs
13  2019 Instantaneous Iodine-Assisted DNAzyme Cleavage of Phosphorothioate RNA. ---
14  2019 Integrated Assessment of the Clinical Performance of GalNAc3-Conjugated 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience. 2'-MOE, 2'MOE, ASOs
15  2019 Investigation of PLGA nanoparticles in conjunction with nuclear localization sequence for enhanced delivery of antimiR phosphorothioates in cancer cells in vitro. PLGA
16  2019 Molecular Dynamics Study of the Hybridization between RNA and Modified Oligonucleotides. LNA, MD, miR-22-3p, miRNAs, NAFLD, PNA
17  2019 Phosphorothioate DNA Mediated Sequence-Insensitive Etching and Ripening of Silver Nanoparticles. ---
18  2019 Structural insight into antisense gapmer-RNA oligomer duplexes through molecular dynamics simulations. LNA, MD, MOE, SASA
19  2019 Structural optimization and additional targets identification of antisense oligonucleotide G3139 encapsulated in a neutral cytidinyl-lipid combined with a cationic lipid in vitro and in vivo. ASOs, LNA
20  2019 Sulfur-centered hemi-bond radicals as active intermediates in S-DNA phosphorothioate oxidation. S-DNA
21  2019 Systematic evaluation of 2'-Fluoro modified chimeric antisense oligonucleotide-mediated exon skipping in vitro. 2'-OMe, AMD, AO, DMD, FDA, LNA, PMO
22  2018 5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes. 5'-PSL, gamma-PSL, m7G, mRNA
23  2018 A signal-on, colorimetric determination of deoxyribonuclease I activity utilizing the photoinduced synthesis of gold nanoparticles. DNase I, Thr
24  2018 Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins. 2'-MOE, ASOs, cEt, DBHS
25  2018 Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides. ASOs, EGFR
26  2018 Chromatographic approaches for the characterization and quality control of therapeutic oligonucleotide impurities. ---
27  2018 Detection of phosphorothioated (PS) oligonucleotides in horse plasma using a product ion (m/z 94.9362) derived from the PS moiety for doping control. PSOs
28  2018 Electrochemical Biosensor Using DNA Embedded Phosphorothioate Modified RNA for Mercury Ion Determination. ---
29  2018 Endosomal Escape of Antisense Oligonucleotides Internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 During Endosomal Maturation. ASOs
30  2018 Optimizing Molecular Beacons for Intracellular Analysis of RNA. 2Me, MBs
31  2018 Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity. PO
32  2018 Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver. ASOs
33  2018 Solid-Phase Synthesis of Phosphorothioate Oligonucleotides Using Sulfurization Byproducts for in Situ Capping. ---
34  2018 Structural Determinants for the Interactions of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor. ASOs
35  2018 Synthetic Oligonucleotides Inhibit CRISPR-Cpf1-Mediated Genome Editing. ---
36  2017 An Exceptionally Selective DNA Cooperatively Binding Two Ca2+ Ions. ---
37  2017 Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia. GPVI, LNA, ON, PF4
38  2017 Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice. ODNs
39  2017 Cellular uptake and trafficking of antisense oligonucleotides. ASOs
40  2017 Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver. ASOs, EON, NPCs
41  2017 Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides. ASO
42  2017 Electronic Structures of LNA Phosphorothioate Oligonucleotides. LNA, QM
43  2017 Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation. ASOs, HSA, PO
44  2017 Impact of Oligonucleotide Structure, Chemistry, and Delivery Method on In Vitro Cytotoxicity. ds, DSBs, ONs, ss
45  2017 Intra-endosomal trafficking mediated by lysobisphosphatidic acid contributes to intracellular release of phosphorothioate-modified antisense oligonucleotides. ASOs, EEs, ILVs, LBPA, LEs
46  2017 Rational Design of Short Locked Nucleic Acid-Modified 2'-O-Methyl Antisense Oligonucleotides for Efficient Exon-Skipping InVitro. AO
47  2017 Reconstruction of Toll-like receptor 9-mediated responses in HEK-Blue hTLR9 cells by transfection of human macrophage scavenger receptor 1 gene. hMSR1, hTLR9, PO, SEAP, ssCpG
48  2017 Two Completely Different Mechanisms for Highly Specific Na+ Recognition by DNAzymes. ---
49  2016 A primerless molecular diagnostic: phosphorothioated-terminal hairpin formation and self-priming extension (PS-THSP). PS-THSP
50  2016 An Ultrasensitive Light-up Cu(2+) Biosensor Using a New DNAzyme Cleaving a Phosphorothioate-Modified Substrate. ---
51  2016 Annexin A2 facilitates endocytic trafficking of antisense oligonucleotides. ANXA2, ASOs, EEs, LEs
52  2016 Chemical modifications in the seed region of miRNAs 221/222 increase the silencing performances in gastrointestinal stromal tumor cells. 2'-OMe, GISTs
53  2016 Evaluation of anhydrohexitol nucleic acid, cyclohexenyl nucleic acid and d-altritol nucleic acid-modified 2'-O-methyl RNA mixmer antisense oligonucleotides for exon skipping in vitro. 2'-OMe, ANA, AO, CeNA, DMD, HNA
54  2016 Hg(2+) detection using a phosphorothioate RNA probe adsorbed on graphene oxide and a comparison with thymine-rich DNA. NGO
55  2016 Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2'-modifications and enhances antisense activity. ASOs, LNA, MOE
56  2016 In Vitro Selection of a DNAzyme Cooperatively Binding Two Lanthanide Ions for RNA Cleavage. ---
57  2016 In vivo knockdown of basal forebrain p75 neurotrophin receptor stimulates choline acetyltransferase activity in the mature hippocampus. AS, ChAT, MO
58  2016 Noninvasive visualization of microRNA-155 in multiple kinds of tumors using a radiolabeled anti-miRNA oligonucleotide. 2'-OMe, AMO-155, HPLC
59  2016 Single-molecule detection and tracking of RNA transcripts in living cells using phosphorothioate-optimized 2'-O-methyl RNA molecular beacons. 2Me, MBs
60  2016 Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver. ASOs
61  2016 Synergistic effect of phosphorothioate, 5'-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA. ---
62  2015 Biochemical Characterization of a Lanthanide-Dependent DNAzyme with Normal and Phosphorothioate-Modified Substrates. ---
63  2015 Cleavable Molecular Beacon for Hg(2+) Detection Based on Phosphorothioate RNA Modifications. ---
64  2015 Desulfurization Activated Phosphorothioate DNAzyme for the Detection of Thallium. Tl
65  2015 In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization. ASOs, MM, OTEs
66  2015 Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators. anti, GPVI
67  2015 Phosphorothioate DNA Stabilized Fluorescent Gold and Silver Nanoclusters. NCs
68  2015 Phosphorothioate modification of chimeric 2-O-methyl RNA/ethylene-bridged nucleic acid oligonucleotides increases dystrophin exon 45 skipping capability and reduces cytotoxicity. AO, DMD, ENA
69  2015 Synthesis of a stabilized 177Lu-siRNA complex and evaluation of its stability and RNAi activity. 2'-OMe, siRNA
70  2014 Correlating In Vitro Splice Switching Activity With Systemic In Vivo Delivery Using Novel ZEN-modified Oligonucleotides. 2'-OMe, SSOs
71  2014 Exploring directional invasion of serum nuclease into siRNA duplexes by asymmetrical terminal modifications. ---
72  2014 Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with (18)F-incorporated oligodeoxynucleotides. BNA, DDSs, PCSK9, PET, PO
73  2014 Sensing parts-per-trillion Cd(2+), Hg(2+), and Pb(2+) collectively and individually using phosphorothioate DNAzymes. ---
74  2014 Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages. ASOs
75  2014 Tandem phosphorothioate modifications for DNA adsorption strength and polarity control on gold nanoparticles. ---
76  2014 TCP1 complex proteins interact with phosphorothioate oligonucleotides and can co-localize in oligonucleotide-induced nuclear bodies in mammalian cells. ASOs, Ran, TCP-1
77  2013 Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery. AONs, ONs, siRNAs
78  2013 Effective exon skipping and dystrophin restoration by 2'-o-methoxyethyl antisense oligonucleotide in dystrophin-deficient mice. 2'OmePS, AO, DMD, MOE
79  2013 Electron transfer followed by collision-induced dissociation (NET-CID) for generating sequence information from backbone-modified oligonucleotide anions. CID, MBOs, PO
80  2013 Enzymatic cleavage of type II restriction endonucleases on the 2'-O-methyl nucleotide and phosphorothioate substituted DNA. 2'-OMeN
81  2013 Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier. 2'OMe, AMOs, LNA, miRNA
82  2013 SNP detection in mRNA in living cells using allele specific FRET probes. FRET, SNP
83  2012 Development of a 2',4'-BNA/LNA-based siRNA for Dyslipidemia and Assessment of the Effects of Its Chemical Modifications In Vivo. apoB, BNA, IFN-alpha, isRNA, LNA, RNAi, siRNAs, TC
84  2012 DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature. TLR9
85  2012 Efficient stabilization of phosphodiester (PO), phosphorothioate (PS), and 2'-O-methoxy (2'-OMe) DNARNA hybrid duplexes by amino sugars. 2'-OMe, PO
86  2012 Gene silencing activity of siRNA molecules containing phosphorodithioate substitutions. siRNAs
87  2012 Nitroxide sensing of a DNA microenvironment: mechanistic insights from EPR spectroscopy and molecular dynamics simulations. EPR, MD
88  2012 TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry. ASOs, cEt, MOE, tcDNA
89  2011 Cell stress is related to re-localization of Argonaute 2 and to decreased RNA interference in human cells. CHX, hAgo2, ON, PBs, RISC, RNAi, SGs
90  2011 Conformational variability of organophosphorus hydrolase upon soman and paraoxon binding. MD, OPH, P-F, PO
91  2011 New vistas on TLR9 activation. IN-ODNs, ODNs, PD, TLR9ecto
92  2011 Optimal oligonucleotide sequences for TLR9 inhibitory activity in human cells: lack of correlation with TLR9 binding. HEK, INH-ODN, PO, TLR
93  2011 Potent and sustained cellular inhibition of miR-122 by lysine-derivatized peptide nucleic acids (PNA) and phosphorothioate locked nucleic acid (LNA)/2'-O-methyl (OMe) mixmer anti-miRs in the absence of transfection agents. LNA, miR-122, OMe, ONs, PNA, PO
94  2011 The immunostimulatory activity of phosphorothioate CpG oligonucleotides is affected by distal sequence changes. ODN, PO, TLR9
95  2011 Uptake, efficacy, and systemic distribution of naked, inhaled short interfering RNA (siRNA) and locked nucleic acid (LNA) antisense. ASOs, i.t, LNA, siRNA
96  2010 beta-1,3-Glucan/antisense oligonucleotide complex stabilized with phosphorothioation and its gene suppression. ASOs
97  2010 Efficient delivery of intact phosphodiester oligonucleotides by poly-beta-amino esters. FRET, PO-ODNs, siRNA
98  2010 Phosphothioate oligodeoxynucleotides inhibit Plasmodium sporozoite gliding motility. ODNs, TLR9
99  2010 Structural and immunostimulatory properties of Y-shaped DNA consisting of phosphodiester and phosphorothioate oligodeoxynucleotides. ODNs, PO, Y-DNA
100  2009 A convenient thiazole orange fluorescence assay for the evaluation of DNA duplex hybridization stability. mRNA, PO, TO