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■ Abbreviation / Long Form : PanINs / pancreatic intraepithelial neoplasias

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Total Number of Papers: 98
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Abbreviation:   PanINs  (>> Co-occurring Abbreviation)
Long Form:   pancreatic intraepithelial neoplasias
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No. Year Title Co-occurring Abbreviation
2020 Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse. ADM, Hh, PDAC
2020 Involvement of the Interferon Signaling Pathways in Pancreatic Cancer Cells. IFN, PDAC, TKI, TLR
2020 Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer. KPC, OXPHOS, PDAC
2020 Survival Outcomes of Pancreatic Intraepithelial Neoplasm (PanIN) versus Intraductal Papillary Mucinous Neoplasm (IPMN) Associated Pancreatic Adenocarcinoma. IPMN, IPMNs, OS, PanIN, PFS
2019 Circumventing senescence is associated with stem cell properties and metformin sensitivity. PDAC
2019 High-grade precursor lesions can be used as surrogate markers to identify the epicenter of periampullary carcinomas. BilINs
2019 Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice. KPNA2, PDGs, Tg mice
2019 MSP-RON Signaling Is Activated in the Transition From Pancreatic Intraepithelial Neoplasia (PanIN) to Pancreatic Ductal Adenocarcinoma (PDAC). IHC, MSP, PanIN, PDAC, PSCs, RON
2019 Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet. HFD, PDAC, rhFGF21
10  2019 Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism. ---
11  2019 PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer. ---
12  2019 Spheroid Culture of Human Pancreatic Ductal Cells to Reconstitute Development of Pancreatic Intraepithelial Neoplasia. PDA
13  2018 ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma inMice. ATP, IPMNs, PDACs, PDCs
14  2018 c-Met affects gemcitabine resistance during carcinogenesis in a mouse model of pancreatic cancer. CSCs, PDAC
15  2018 Cells of origin of pancreatic neoplasms. IPMNs, MCNs, PDAC
16  2018 Genetic and pharmacologic abrogation of Snail1 inhibits acinar-to-ductal metaplasia in precursor lesions of pancreatic ductal adenocarcinoma and pancreatic injury. KP, KPS, TMA
17  2018 Kruppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice. ADM, KLF5, PDACs
18  2018 Precursor Lesions of Pancreatic Cancer. IOPNs, IPMNs, ITPNs, MCNs, PDAC
19  2018 Relationship between pancreatic intraepithelial neoplasias, pancreatic ductal adenocarcinomas, and single nucleotide polymorphisms in autopsied elderly patients. PDACs, SNPs
20  2018 SALL4 suppresses reactive oxygen species in pancreatic ductal adenocarcinoma phenotype via FoxM1/Prx III axis. EMT, PDAC, ROS, SALL4
21  2018 SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer. ADM, HPNE, MCMs, MDC1, PDAC
22  2018 The advanced glycation end-product Nϵ -carboxymethyllysine promotes progression of pancreatic cancer: implications for diabetes-associated risk and its prevention. AGEs, CTR, PaC, PDA, RAGE, RAP
23  2017 Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression. PDAC
24  2017 ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation. AGR2, CP, CSC, ER, KC, PDAC, PDX, TC
25  2017 hsa-miR-96 and hsa-miR-217 Expression Down-Regulates with Increasing Dysplasia in Pancreatic Intraepithelial Neoplasias and Intraductal Papillary Mucinous Neoplasms. IPMNs, LNA-ISH, PDAs
26  2017 Increased Bcl-xL Expression in Pancreatic Neoplasia Promotes Carcinogenesis by Inhibiting Senescence and Apoptosis. P-KrasG12D, PDAC
27  2017 Lack of chemopreventive effects of P2X7R inhibitors against pancreatic cancer. PC
28  2017 MicroRNAs of the mir-17~92 cluster regulate multiple aspects of pancreatic tumor development and progression. miRNAs, PDAC
29  2017 Neat1 is a p53-inducible lincRNA essential for transformation suppression. ChIP, lincRNA, ncRNA
30  2017 Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells. ---
31  2017 The TALE homeodomain transcription factor MEIS1 activates the pro-metastatic melanoma cell adhesion molecule Mcam to promote migration of pancreatic cancer cells. ChIP, MCAM, PDAC
32  2016 A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns. ---
33  2016 Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers. MADM
34  2016 The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-beta1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-beta1. Nrf2, PDAC, TGF-beta1
35  2016 The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma. IHC, KD, PC
36  2016 The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes Kras(G12D)-mediated pancreatic cancer initiation. PDAC, VMP1
37  2015 Acinar cell reprogramming: a clinically important target in pancreatic disease. PDAC
38  2015 Clinicopathological Significance of CDKN2A Promoter Hypermethylation Frequency with Pancreatic Cancer. CP
39  2015 Constitutively active Akt1 cooperates with KRas(G12D) to accelerate in vivo pancreatic tumor onset and progression. ---
40  2015 Elevated miR-483-3p expression is an early event and indicates poor prognosis in pancreatic ductal adenocarcinoma. CP, LNA-ISH, PDAC
41  2015 GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated adenocarcinomas. IPMNs, MCNs, PDAs
42  2015 Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and without cancer in the pancreas. ---
43  2015 Metachronous pancreatic cancer originating from disseminated founder pancreatic intraductal neoplasias (PanINs). PDA
44  2015 Pancreatic cancer stromal biology and therapy. ---
45  2015 PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors. mTOR, PI3K
46  2015 Simultaneous targeting of 5-LOX-COX and EGFR blocks progression of pancreatic ductal adenocarcinoma. 5-LOX, COX-2, EGRF, NGS, PDAC
47  2014 Investigation of Schwann cells at neoplastic cell sites before the onset of cancer invasion. GFAP, NGF, NI
48  2014 Loss of HNF6 expression correlates with human pancreatic cancer progression. HNF6, PDAC
49  2014 MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in mice. MAPK
50  2014 Polarization of the vacuolar adenosine triphosphatase delineates a transition to high-grade pancreatic intraepithelial neoplasm lesions. EGF, LRP6, V-ATPase
51  2013 Bmi1 enhances tumorigenicity and cancer stem cell function in pancreatic adenocarcinoma. PRC1
52  2013 Differential ezrin and phosphorylated ezrin expression profiles between pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and invasive ductal carcinoma of the pancreas. IPMNs, p-ezrin
53  2013 Intraductal papillary mucinous neoplasms of the pancreas (IPMNs): epidemiology, diagnosis and future aspects. IPMNs
54  2013 Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia. IPMNs
55  2013 Simvastatin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer. ---
56  2012 Atorvastatin delays progression of pancreatic lesions to carcinoma by regulating PI3/AKT signaling in p48Cre/+ LSL-KrasG12D/+ mice. PDAC
57  2012 Chemoprevention of pancreatic cancer-one step closer. ---
58  2012 Early detection and prevention of pancreatic cancer: use of genetically engineered mouse models and advanced imaging technologies. CT, GEM, MRI, PDAC, PET, SPECT, US
59  2012 Endogenous n-3 polyunsaturated fatty acids delay progression of pancreatic ductal adenocarcinoma in Fat-1-p48(Cre/+)-LSL-Kras(G12D/+) mice. 5-LOX, PDAC
60  2012 Expression of cancer stem cell markers in pancreatic intraepithelial neoplasias and pancreatic ductal adenocarcinomas. CSCs, PDAC
61  2012 Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis. IER3, NUPR1, PDAC
62  2011 Claudin-18 is an early-stage marker of pancreatic carcinogenesis. CLDN18, IPMNs, MCNs, PDACs, PMA
63  2011 Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model. ---
64  2011 GLUT-1 expression in pancreatic neoplasia: implications in pathogenesis, diagnosis, and prognosis. DAs, IPMNs
65  2011 Loss of heterozygosity status of D9S105 marker is associated with downregulation of Kruppel-like factor 4 expression in pancreatic ductal adenocarcinoma and pancreatic intraepithelial lesions. KLF4, LOH, OS, PDAC
66  2011 Pancreatic Intraepithelial Neoplasia. ---
67  2011 Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. PDAC
68  2011 Tissue Transglutaminase (TG2)-Induced Inflammation in Initiation, Progression, and Pathogenesis of Pancreatic Cancer. PC
69  2010 Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia. AGR2, IPMNs
70  2010 Genomic instability at both the base pair level and the chromosomal level is detectable in earliest PanIN lesions in tissues of chronic pancreatitis. ADM, CP, LOH, PC
71  2010 The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer. ---
72  2008 BLT2 is expressed in PanINs, IPMNs, pancreatic cancer and stimulates tumour cell proliferation. IPMNs
73  2008 Expression of COX-2 is associated with accumulation of p53 in pancreatic cancer: analysis of COX-2 and p53 expression in premalignant and malignant ductal pancreatic lesions. COX-2
74  2008 Morphogenesis of pancreatic cancer: role of pancreatic intraepithelial neoplasia (PanINs). PanIN
75  2008 Multicentric pancreatic intraepithelial neoplasias (PanINs) presenting with the clinical features of chronic pancreatitis. PanIN
76  2008 Pancreatic intraepithelial neoplasms in the normal appearing pancreas: on their precise relationship with age. ---
77  2007 15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth. 5-LOX, RT-PCR
78  2007 Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. PDA
79  2007 Different patterns of p16INK4A and p53 protein expressions in intraductal papillary-mucinous neoplasms and pancreatic intraepithelial neoplasia. IPMNs
80  2007 Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases. ---
81  2007 Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells. PDAC, SPAG-1
82  2007 The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia. PDAC
83  2006 Current topics on precursors to pancreatic cancer. IPMNs, MCNs
84  2006 Cyclooxygenase-2 expression in hamster and human pancreatic neoplasia. COX-2
85  2005 Application of fluorescence difference gel electrophoresis saturation labelling for the analysis of microdissected precursor lesions of pancreatic ductal adenocarcinoma. ---
86  2005 Early diagnosis of pancreatobiliary duct malignancies by brush cytology and biopsy. ---
87  2004 An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. IPMNs
88  2004 Chronic exposure of transforming growth factor beta 1 confers a more aggressive tumor phenotype through downregulation of p21(WAF1/CIP1) in conditionally immortalized pancreatic epithelial cells. IMPE, TGF-beta1
89  2004 Proliferative activity in pancreatic intraepithelial neoplasias of chronic pancreatitis resection specimens: detection of a high-risk lesion. ---
90  2003 Aberrant expression of MUC3 and MUC4 membrane-associated mucins and sialyl Le(x) antigen in pancreatic intraepithelial neoplasia. ---
91  2003 Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms. IPMNs, JAK/STAT, SOCS-1
92  2003 Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. ---
93  2003 p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis. ---
94  2003 Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. ---
95  2003 Surveillance for familial pancreatic cancer. PC
96  2003 The MUC gene family: their role in diagnosis and early detection of pancreatic cancer. IPMNs, MUCs
97  2002 MUC4 expression increases progressively in pancreatic intraepithelial neoplasia. ---
98  2000 Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression. ---