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■ Abbreviation / Long Form : ROC / Ras of complex proteins

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Total Number of Papers: 30
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Abbreviation:   ROC  (>> Co-occurring Abbreviation)
Long Form:   Ras of complex proteins
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No. Year Title Co-occurring Abbreviation
2019 Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics. LRRK2, PD
2019 The emerging interrelation between ROCO and related kinases, intracellular Ca2+ signaling, and autophagy. COR, DAPK, LRRK
2019 The Parkinson's disease-associated mutation N1437H impairs conformational dynamics in the G domain of LRRK2. LRRK2, PD
2017 The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2. CHIP, LRRK2, PD
2016 Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2. LRRK2, PD, PP2A
2016 Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts. LRRK2, PD
2015 Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations. COR, LRR, nt, PD
2015 LRRK2 and ubiquitination: implications for kinase inhibitor therapy. LRRK2, PD
2015 The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. Dl, Dll1, LRRK2, PD
10  2014 Genetic, structural, and molecular insights into the function of ras of complex proteins domains. DAPK1, LRRK2
11  2014 GTP binding controls complex formation by the human ROCO protein MASL1. DAPK1, LRRK1, LRRK2, MASL1
12  2014 Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications. COR, LRRK2, PD
13  2014 Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain. LRRK2, PD, RocR1441H
14  2014 Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3. LRRK2, PD, PKA
15  2012 Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations. COR, LRRK2
16  2012 Biochemical and functional characterization of the ROC domain of DAPK establishes a new paradigm of GTP regulation in ROCO proteins. COR, DAPK, LRRK2
17  2012 GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1. DAPK1, LRRK2
18  2012 LRRK2 haplotype-sharing analysis in Parkinson's disease reveals a novel p.S1761R mutation. LRRK2
19  2012 MASL1: a neglected ROCO protein. COR
20  2012 The GTPase function of LRRK2. COR, LRRK2, PD
21  2011 GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling. DAPk
22  2011 Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant. COR, LRRK2
23  2011 LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding. LRRK2, PD
24  2010 14-3-3 proteins are promising LRRK2 interactors. LRRK2, PD
25  2009 Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment. LRRK2, PD
26  2009 Sequence conservation between porcine and human LRRK2. LRRK2
27  2008 ROCO kinase activity is controlled by internal GTPase function. GTP, GTPases, LRRK2, PD
28  2008 Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. COR, LRRK2, PD
29  2008 Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. COR
30  2006 Leucine-rich repeat kinase 2: relevance to Parkinson's disease. LRRK2, MAPKKK