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■ Abbreviation / Long Form : ROCK / Rho-associated kinase

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Total Number of Papers: 942
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Abbreviation:   ROCK  (>> Co-occurring Abbreviation)
Long Form:   Rho-associated kinase
 Abbreviation Variation
 Long Form Variation
 Pair(Abbreviation/Long Form) Variation
No. Year Title Co-occurring Abbreviation
2020 Advanced glycation end products induce immature angiogenesis in in vivo and ex vivo mouse models. AGE, AGEs, PDR, RAGE
2020 Airway smooth muscle tone increases actin filamentogenesis and contractile capacity. ASM, MLCK, PKC, RLC
2020 Enhanced Vascular Smooth Muscle Calcium Sensitivity and Loss of Endothelial Vasodilator Influence Contribute to Myogenic Tone Development in Rat Radial Uterine Arteries during Gestation. LP, MT, NO, NOS, VSM
2020 Generation and evaluation of a transgenic zebrafish for tissue-specific expression of a dominant-negative Rho-associated protein kinase-2. dnROCK-2, dpf, Rho, UAS
2020 Impact of RhoA overexpression on clinical outcomes in cervical squamous cell carcinoma treated with concurrent chemoradiotherapy. CCRT
2020 Inhibition of Rho-associated protein kinase improves the survival of human induced pluripotent stem cell-derived cardiomyocytes after dissociation. CMs, iPSCs
2020 MLCK and ROCK mutualism in endothelial barrier dysfunction. EC, MLCK, MLCP, RLC
2020 Murine neuroblastoma cell lines developed by conditional reprogramming preserve heterogeneous phenotypes observed in vivo. CR, NB
2020 Optimal concentration of Rho-associated coiled-coil kinase (ROCK) inhibitor improved sperm membrane functionality and fertilizing ability of cryopreserved-thawed feline sperm. ---
10  2020 P-Tyr42 RhoA GTPase amplifies superoxide formation through p47phox, phosphorylated by ROCK. p-Ser345 p47phox, PMA, ROS
11  2020 Regulation of RhoA GTPase and novel target proteins for ROCK. GAPs, GDF, GEFs, GSK, NEMO
12  2020 Remote ischemic post-conditioning protects against myocardial ischemia/reperfusion injury by inhibiting the Rho-kinase signaling pathway. Bax, Bcl-2, CK, cTnI, I/R, LDH, MDA, p-MLC, RIPostC, SOD
13  2020 Rho-Associated Kinase Inhibitor Decreases Human Corneal Endothelial Cell Apoptosis: Ex-Vivo Study of Corneal-Scleral Rims in Optisol-GS Storage Medium. CEC, PI
14  2020 Rho-associated protein kinase and cyclophilin a are involved in inorganic phosphate-induced calcification signaling in vascular smooth muscle cells. CypA, ERK, Pi, RASMCs, VSMCs
15  2020 RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin. DRG, RhoA
16  2020 RhoA/ROCK Regulates Prion Pathogenesis by Controlling Connexin 43 Activity. Cx43
17  2020 ROCK-TAZ signaling axis regulates mechanical tension-induced osteogenic differentiation of rat cranial sagittal suture mesenchymal stem cells. rSAGs, TAZ
18  2020 ROCK/PKA inhibition rescues hippocampal hyperexcitability and GABAergic neuron alterations in Oligophrenin-1 Knock-out mouse model of X-linked intellectual disability. KO, Ophn1, PKA, XLID
19  2020 Substance P enhances cellular migration and inhibits senescence in human dermal fibroblasts under hyperglycemic conditions. SP
20  2020 Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening. ---
21  2020 Targeting ROCK signaling in health, malignant and non-malignant diseases. ---
22  2020 TAZ contributes to osteogenic differentiation of periodontal ligament cells under tensile stress. ALP, Cbfalpha1, CTS, PDLCs, TAZ, TAZ
23  2020 TGR5 receptor activation attenuates diabetic retinopathy through suppression of RhoA/ROCK signaling. BA, DR, RMECs, STZ
24  2020 The Effects of ROCK Inhibition on Mesenchymal Stem Cell Chondrogenesis Are Culture Model Dependent. 3D-HGs, MSC, MSCs
25  2020 The ROCK isoforms differentially regulate the morphological characteristics of carcinoma cells. ---
26  2019 A Case Report Illustrating the Postoperative Course of Descemetorhexis without Endothelial Keratoplasty with Topical Netarsudil Therapy. DSO, DWEK, FECD
27  2019 A Highly Selective Rho-Kinase Inhibitor (ITRI-E-212) Potentially Treats Glaucoma Upon Topical Administration With Low Incidence of Ocular Hyperemia. AH
28  2019 A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition. MYPT, NO, TXA2
29  2019 A steroid alkaloid derivative 02F04 upregulates thymic stromal lymphopoietin expression slowly and continuously through a novel Gq/11-ROCK-ERK1/2 signaling pathway in mouse keratinocytes. TSLP
30  2019 Additive intraocular pressure-lowering effects of the Rho kinase inhibitor ripasudil in Japanese patients with various subtypes of glaucoma. IOP, POAG, SG
31  2019 Alkaloids from Nelumbinis Plumula (AFNP) ameliorate aortic remodeling via RhoA/ROCK pathway. AFNP, Ang II
32  2019 An in vitro study of scarring formation mediated by human Tenon fibroblasts: Effect of Y-27632, a Rho kinase inhibitor. HTFs, TGF
33  2019 Azithromycin inhibits muscarinic 2 receptor-activated and voltage-activated Ca2+ permeant ion channels and Ca2+ sensitization, relaxing airway smooth muscle contraction. ACH, ASMs, AZM, COPD, NSCCs
34  2019 Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility. HPKs, MLC, MLCK
35  2019 Brain Endothelial Cells Release Apical and Basolateral Microparticles in Response to Inflammatory Cytokine Stimulation: Relevance to Neuroinflammatory Stress? BMP, MP
36  2019 Causative glaucoma treatment: promising targets and delivery systems. CTGF, IOP, NO, TGF-beta2
37  2019 Ciliated Epithelial Cell Differentiation at Air-Liquid Interface Using Commercially Available Culture Media. COPD, PCD, TEER
38  2019 Compression Generated by a 3D Supracellular Actomyosin Cortex Promotes Embryonic Stem Cell Colony Growth and Expression of Nanog and Oct4. mESCs
39  2019 Connexin 40 regulates lung endothelial permeability in acute lung injury via the ROCK1-MYPT1- MLC20 pathway. ALI, Cx40, MLC, PMVECs
40  2019 Constraint-induced movement therapy enhances angiogenesis and neurogenesis after cerebral ischemia/reperfusion. ---
41  2019 Derivation of Mouse Haploid Trophoblast Stem Cells. haTSCs, TS
42  2019 Diabetes abolish cardioprotective effects of remote ischemic conditioning: evidences and possible mechanisms. ERK, mTOR, NO, O-GlcNAc, PI3K, ROS
43  2019 Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging. AKT, FAK, MCM, MLC, mTOR
44  2019 Effect of miR-133 on apoptosis of trophoblasts in human placenta tissues via Rho/ROCK signaling pathway. IL-6, miR, PE, Rho, RT-PCR, TNF-alpha
45  2019 Effect of ripasudil on diabetic macular edema. DME, FT, IOP, VA
46  2019 Effects of RhoC downregulation on the angiogenesis characteristics of myeloma vascular endothelial cells. HUVECs, MVECs, pMAPK, qRT-PCR, VECs
47  2019 Efficient primary culture model of patient‑derived tumor cells from colorectal cancer using a Rho‑associated protein kinase inhibitor and feeder cells. ---
48  2019 Elevated Platelet Galectin-3 and Rho-Associated Protein Kinase Activity Are Associated with Hemodialysis Arteriovenous Shunt Dysfunction among Subjects with Diabetes Mellitus. ELISA, MYPT
49  2019 Endocytosis of CF in marginal cells of stria vascularis regulated by ROCK and MLCK signaling cascade, but not G-proteins. CF, GPCR, MLCK, MPO, MT, PTX
50  2019 Epithelial polarization in 3D matrix requires DDR1 signaling to regulate actomyosin contractility. DDR1, MT1-MMP
51  2019 Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study. baPWV, FMD, IHA, IMT, NID, RHI
52  2019 Establishing a cryopreservation protocol for patient-derived xenografts of prostate cancer. DMSO, FCS, PDXs
53  2019 Establishment of Primary Transgenic Human Airway Epithelial Cell Cultures to Study Respiratory Virus-Host Interactions. FACS, HAEC, HCoV-229E, HRSV, sh
54  2019 Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors. ---
55  2019 Fetal bovine serum promotes the development of in vitro porcine blastocysts by activating the Rho-associated kinase signalling pathway. FBS
56  2019 G-protein coupled receptor 55 agonists increase insulin secretion through inositol trisphosphate-mediated calcium release in pancreatic beta-cells. 2-APB, Abn-CBD, GPR55, T2DM
57  2019 Increasing the effectiveness of tyrosine kinase inhibitor (TKI) in combination with a statin in reducing liver fibrosis. alpha-SMA, CTGF, HSCs, PDGF, RhoA, TGF-beta1, TKI
58  2019 Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection. Col I, IL
59  2019 Intraocular pressure-lowering effects of imidazo[1,2-a]- and pyrimido[1,2-a]benzimidazole compounds in rats with dexamethasone-induced ocular hypertension. DEXA, IOP, RGCs
60  2019 Invivo effects of mutant RHOA on tumor formation in an orthotopic inoculation model. DGCs, RHOA, WT
61  2019 Lentiviral Vector-Mediated Expression of Exoenzyme C3 Transferase Lowers Intraocular Pressure in Monkeys. IOP, LV, POAG, Rho, TM
62  2019 Loss of ARHGEF1 causes a human primary antibody deficiency. ---
63  2019 Mechanism of H2S-mediated ROCK inhibition of total flavones of Rhododendra against myocardial ischemia injury. ISO, KO, TFR
64  2019 MicroRNA-92a promotes vascular smooth muscle cell proliferation and migration through the ROCK/MLCK signalling pathway. miR-92a, MLCK, PDGF-BB, STAT3, VSMCs
65  2019 Monocrotaline-induced pulmonary arterial hypertension: Time-course of injury and comparative evaluation of macitentan and Y-27632, a Rho kinase inhibitor. PAH
66  2019 Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma. ED, MARCKS, PI3K, PKC, PTEN
67  2019 Non-muscle myosin II activation: adding a classical touch to ROCK. ---
68  2019 Nonphosphorylatable Src Ser75 Mutation Increases Ethanol Preference and Consumption in Mice. CDK1, SFKs
69  2019 Nuclear position relative to the Golgi body and nuclear orientation are differentially responsive indicators of cell polarized motility. ---
70  2019 Numb Depletion Promotes Drp1-Mediated Mitochondrial Fission and Exacerbates Mitochondrial Fragmentation and Dysfunction in Acute Kidney Injury. AKI, Drp1
71  2019 Overexpression of CDCA8 promotes the malignant progression of cutaneous melanoma and leads to poor prognosis. CDCA8, GEO
72  2019 Overexpression of Na+/H+ exchanger 1 specifically induces cell death in human iPS cells via sustained activation of the Rho kinase ROCK. iPSCs, NHE1
73  2019 Overlapping and unique roles played by ROCK1 and 2 in the modulation of coding and long noncoding RNA expression. DElncRNAs, DEmRNAs, HCC
74  2019 Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness. ECM, MMP, PSCs, SPARC, TGF
75  2019 Pharmacological characterization of a highly selective Rho kinase (ROCK) inhibitor and its therapeutic effects in experimental pulmonary hypertension. MCT, PAH, RVSP
76  2019 PKCalpha-Mediated Downregulation of RhoA Activity in Depolarized Vascular Smooth Muscle: Synergistic Vasorelaxant Effect of PKCalpha and ROCK Inhibition. PDBu, PKC, VSMCs
77  2019 Post-Passage rock inhibition induces cytoskeletal aberrations and apoptosis in Human embryonic stem cells. hESCs
78  2019 Prominin-1 Modulates Rho/ROCK-Mediated Membrane Morphology and Calcium-Dependent Intracellular Chloride Flux. MEF
79  2019 Protective effects of lycium barbarum polysaccharides on blood-retinal barrier via ROCK1 pathway in diabetic rats. BRB, DR, EB, HE, LBP, p-MLC
80  2019 Protein tyrosine phosphatase 11 acts through RhoA/ROCK to regulate eosinophil accumulation in the allergic airway. RhoA, SHP2
81  2019 Rho and Rac, but not ROCK, are required for secretion of human and mouse eosinophil-associated RNases. EARs
82  2019 Rho GTPases in the Physiology and Pathophysiology of Peripheral Sensory Neurons. Cdc42, MLK, PI3K, Rac1, RhoA
83  2019 Rho signaling pathway enhances proliferation of PASMCs by suppressing nuclear translocation of Smad1 in PAH. BMP, MEK, p-Smad, PAH, PASMC, PDGF-BB
84  2019 Rho-Associated Coiled-Coil Kinase 1 Translocates to the Nucleus and Inhibits Human Cytomegalovirus Propagation. HCMV
85  2019 Rho-associated kinase and zipper-interacting protein kinase, but not myosin light chain kinase, are involved in the regulation of myosin phosphorylation in serum-stimulated human arterial smooth muscle cells. MLCK, ZIPK
86  2019 Rho-Associated Protein Kinase (ROCK) Promotes Proliferation and Migration of PC-3 and DU145 Prostate Cancer Cells by Targeting LIM Kinase 1 (LIMK1) and Matrix Metalloproteinase-2 (MMP-2). CCK-8, LIMK1, MMP-2, p-LIMK1, RNAi
87  2019 Rho-kinase ROCK inhibitors reduce oligomeric tau protein. TetOff
88  2019 RHOA activity in expanding blastocysts is essential to regulate HIPPO-YAP signaling and to maintain the trophectoderm-specific gene expression program in a ROCK/actin filament-independent manner. PRKCZ, qRT-PCR, RHOA, SCRIB, TE, TEAD, YAP
89  2019 RhoA/ROCK pathway: implication in osteoarthritis and therapeutic targets. ECM, OA, RhoA
90  2019 RIP3 deficiency alleviates liver fibrosis by inhibiting ROCK1-TLR4-NF-kappaB pathway in macrophages. BDL, RIP
91  2019 ROCK Inhibition Induces Terminal Adipocyte Differentiation and Suppresses Tumorigenesis in Chemoresistant Osteosarcoma Cells. CSC, OSi
92  2019 ROCK inhibitor Y‑27632 protects rats against cerebral ischemia/reperfusion‑induced behavioral deficits and hippocampal damage. AIF1, GFAP, MCAO, RhoA
93  2019 ROCK Inhibitor-Induced Promotion of Retinal Pigment Epithelial Cell Motility during Wound Healing. RPE
94  2019 Rock protein as cardiac hypertrophy modulator in obesity and physical exercise. IRS-1, MAPK
95  2019 Role of Extracellular Calcium and Calcium Sensitization in the Anti-Contractile Effect of Perivascular Adipose Tissue in Pregnant Rat Aorta. 5-HT, PVAT
96  2019 Salidroside prevents diabetes‑induced cognitive impairment via regulating the Rho pathway. NF, SIRT1
97  2019 Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia. BP, CB, CIH, CSN, DPI, NOX, PVN, ROS, RSN
98  2019 Shen'ge powder decreases the cardiomyocyte hypertrophy in chronic heart failure by activating the Rho protein/Rho-associated coiledcoil forming protein kinase signaling pathway. CHF, MLCK, MLCP, MTT
99  2019 Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling. KO, PDBu, PKC, SMTNL1, WT
100  2019 Sphingosine-1-Phosphate Enhances alpha1-Adrenergic Vasoconstriction via S1P2-G12/13-ROCK Mediated Signaling. PE, S1P, WT