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■ Abbreviation / Long Form : ROK / Rho kinase

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Total Number of Papers: 121
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Abbreviation:   ROK  (>> Co-occurring Abbreviation)
Long Form:   Rho kinase
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No. Year Title Co-occurring Abbreviation
2020 Detecting New Allies: Modifier Screen Identifies a Genetic Interaction Between Imaginal disc growth factor 3 and combover, a Rho-kinase Substrate, During Dorsal Appendage Tube Formation in Drosophila. CLPs, cmb, Idgf, PCP
2020 Rho-Kinase Planar Polarization at Tissue Boundaries Depends on Phospho-regulation of Membrane Residence Time. PH
2019 Dietary macronutrients modulate hypertrophy and contractility of the detrusor in an experimental model of bladder obstruction. BOO, HCD, MLCK
2018 Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1). CFL1, FP, KO, LIMKs, pCFL1, TESK1
2017 Cell Polarity Regulates Biased Myosin Activity and Dynamics during Asymmetric Cell Division via Drosophila Rho Kinase and Protein Kinase N. NEB, Pins, Pkn
2016 Actions of cAMP on calcium sensitization in human detrusor smooth muscle contraction. CCh, Epac, PKA, PKC
2015 Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase. APACHE, MLCK, MLCP, SOFA, TRAP
2015 Calcium desensitisation in late polymicrobial sepsis is associated with loss of vasopressor sensitivity in a murine model. CLP, MLCP, PDBu, SR
2015 Pelvic organ prolapse is associated with alteration of sphingosine-1-phosphate/Rho-kinase signalling pathway in human vaginal wall. POP, S1P, S1P1-S1P3
10  2014 Combover/CG10732, a novel PCP effector for Drosophila wing hair formation. Cmb, MHC, Mwh, PCP
11  2014 Myogenic properties of brain and cardiac vessels and their relation to disease. PKC
12  2013 Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton. MRTF
13  2013 In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling. ACT, ACT, ACT, F-actin, JNK, TNF
14  2013 Involvement of stretch-induced Rho-kinase activation in the generation of bladder tone. ---
15  2012 Assessing the critical period for Rho kinase activity during Drosophila ventral furrow formation. VFF
16  2012 Effect of fasudil, a selective inhibitor of Rho kinase activity, in the secondary injury associated with the experimental model of spinal cord trauma. IL-1beta, NF-kappaB
17  2012 Functional role of muscarinic receptor subtypes in calcium sensitization and their contribution to rho-kinase and protein kinase C pathways in contraction of human detrusor smooth muscle. CCh, DSM, PKC
18  2012 HLA class I-mediated stress fiber formation requires ERK1/2 activation in the absence of an increase in intracellular Ca2+ in human aortic endothelial cells. ECs, HAECs, MLC, MLCK, mTORC2
19  2012 Obstruction enhances rho-kinase pathway and diminishes protein kinase C pathway in carbachol-induced calcium sensitization in contraction of alpha-toxin permeabilized guinea pig detrusor smooth muscle. BOO, CCh, DSM, PKC
20  2012 Pennogenin tetraglycoside induces rat myometrial contraction and MLC20 phosphorylation via PLC-IP(3) and RhoA/Rho kinase signaling pathways. MLCK, PLC
21  2012 Rho kinase (ROK)-related proteins in human cavernous arteries: an immunohistochemical and functional approach. ROKs
22  2012 RhoA and Rho kinase mediate cyclosporine A and sirolimus-induced barrier tightening in renal proximal tubular cells. CsA, SRL, TER
23  2012 TGF-beta1-induced LPP expression dependant on Rho kinase during differentiation and migration of bone marrow-derived smooth muscle progenitor cells. LPP, MAoSMCs, SMMHC, SMPCs
24  2011 Endothelin-1 contributes to increased NFATc3 activation by chronic hypoxia in pulmonary arteries. CH, ET-1, NFATc3, PASMC
25  2011 Inhibition of Rho-kinase abrogates migration of human transitional cell carcinoma cells: results of an in vitro study. ---
26  2011 Key role of the RhoA/Rho kinase system in pulmonary hypertension. CH, COPD, HPV, mPAP, PAH, PH, PVR
27  2011 Mechanisms of myogenic response: Ca(2+)-dependent and -independent signaling. MR, PKC, SACs
28  2011 Phos-tag-based analysis of myosin regulatory light chain phosphorylation in human uterine myocytes. Ab, Calp, OT, RLC
29  2011 Regulation of basal LC20 phosphorylation by MYPT1 and CPI-17 in murine gastric antrum, gastric fundus, and proximal colon smooth muscles. M-RIP, MLCK, MLCP, MYPT1
30  2011 Rho-kinase, a common final path of various contractile bladder and ureter stimuli. SM, smMLCK, SMMLCP
31  2011 Rho-mediated activation of PI(4)P5K and lipid second messengers is necessary for promotion of angiogenesis by Semaphorin 4D. HUVEC, Sema4D
32  2011 The effect of L-arginine on bladder dysfunction following ovariectomy in a rabbit model. CaD, CaP
33  2011 Update on corpus cavernosum smooth muscle contractile pathways in erectile function: a role for testosterone? CCSM, ED, EF, SMM
34  2010 Androgens induce nongenomic stimulation of colonic contractile activity through induction of calcium sensitization and phosphorylation of LC20 and CPI-17. DHT, MLC, PKC
35  2010 Differential modulation of intracellular Ca2+ responses associated with calcium-sensing receptor activation in renal collecting duct cells. CaR
36  2010 Distinct effects of voltage- and store-dependent calcium influx on stretch-induced differentiation and growth in vascular smooth muscle. MEF
37  2010 Extracellular signal-regulated kinase and GEF-H1 mediate depolarization-induced Rho activation and paracellular permeability increase. MDCK, MLC
38  2010 Fasudil hydrochloride induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression. BMP-2
39  2010 Hyaluronan-CD44 interaction promotes c-Src-mediated twist signaling, microRNA-10b expression, and RhoA/RhoC up-regulation, leading to Rho-kinase-associated cytoskeleton activation and breast tumor cell invasion. HA
40  2010 The sphingosine-1-phosphate pathway is upregulated in response to partial urethral obstruction in male rats and activates RhoA/Rho-kinase signalling. PUO
41  2009 Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression. AICAR, AMPK, BMP-2, eNOS, ERK, HMG
42  2009 Ca2+ sensitization via phosphorylation of myosin phosphatase targeting subunit at threonine-855 by Rho kinase contributes to the arterial myogenic response. MLCP, PKC
43  2009 Extracellular matrix controls insulin signaling in mammary epithelial cells through the RhoA/Rok pathway. BM, ECM, IRS-1, MECs
44  2009 Mineralocorticoid receptor antagonism attenuates glomerular filtration barrier remodeling in the transgenic Ren2 rat. Ang II, IRS-1, MR, NADPH, RAAS, ROS, SD
45  2009 Obstruction alters muscarinic receptor-coupled RhoA/Rho-kinase pathway in the urinary bladder of the rat. BOO, CCh, EFS, MR
46  2009 Role of rho-kinase in the regulation of vascular tone in hypertensive renal transplant recipients. CTL, FBF, NO, VSMC
47  2009 The effect of 2- and 4-week ovariectomy on female rabbit urinary bladder function. ---
48  2009 The effect of ischemia/reperfusion on rabbit bladder--role of Rho-kinase and smooth muscle regulatory proteins. CaD, CaP, I/R
49  2008 Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis. CIA, IL-1beta, RA, TNF-alpha
50  2008 Brazilein-induced contraction of rat arterial smooth muscle involves activation of Ca2+ entry and ROK, ERK pathways. ERK, L-NAME, MLCK, NOS, PKC
51  2008 Changes in the smooth muscle of the corpora cavernosum related to reversal of partial bladder outlet obstruction in rabbits. CCSM, EFS, PBOO, SNP
52  2008 Characterisation of the signal transduction cascade caused by propofol in rat neurons: from the GABA(A) receptor to the cytoskeleton. ---
53  2008 Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries. atm, CH, ID, VSM
54  2008 Effect of age on the role of Rho-kinase in short-term partial bladder outlet obstruction. SM
55  2008 Inhibitory effects of eicosapentaenoic acid on chronic cerebral vasospasm after subarachnoid hemorrhage: possible involvement of a sphingosylphosphorylcholine-rho-kinase pathway. CV, EPA, SAH, SPC, SrcPTKs, VSM
56  2008 Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia. CH, ET, MLCK, MLCP, ROS, TK, VSM
57  2008 Rho GTPase controls invagination and cohesive migration of the Drosophila salivary gland through Crumbs and Rho-kinase. Crb
58  2008 Rho Kinase-Mediated Reduction in Cardiac Capillary Endothelial Cell Dimensions, In Situ, Against Flow. ---
59  2007 Ca2+ signaling in hypoxic pulmonary vasoconstriction: effects of myosin light chain and Rho kinase antagonists. HPV, MLC, PASMC
60  2007 Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway. DN-MLC, EMT, MLC, MRTF, SMA, SRF, TGF-beta1
61  2007 Long term partial bladder outlet obstruction induced contractile dysfunction in male rabbits: a role for Rho-kinase. FS, SM
62  2007 Plexin-B1 utilizes RhoA and Rho kinase to promote the integrin-dependent activation of Akt and ERK and endothelial cell motility. PI3K
63  2006 Androgens differentially potentiate mouse intestinal smooth muscle by nongenomic activation of polyamine synthesis and Rho kinase activation. anti-AR
64  2006 Convergence of Ca2+-desensitizing mechanisms activated by forskolin and phenylephrine pretreatment, but not 8-bromo-cGMP. FSK, MLCP, PE
65  2006 Differential regulation of Pyk2 phosphorylation at Tyr-402 and Tyr-580 in intestinal epithelial cells: roles of calcium, Src, Rho kinase, and the cytoskeleton. FAK
66  2006 Enhanced role for RhoA-associated kinase in adrenergic-mediated vasoconstriction in gracilis arteries from obese Zucker rats. OZ, PE
67  2006 Experimental therapies for hypoxia-induced pulmonary hypertension during acute lung injury. HPV, NO, PDE5
68  2006 Gem protein signaling and regulation. ---
69  2006 Involvement of Rho kinase and protein kinase C in carbachol-induced calcium sensitization in beta-escin skinned rat and guinea-pig bladders. CCh, CPA, PKC
70  2006 LPP expression during in vitro smooth muscle differentiation and stent-induced vascular injury. FAK, LPP, SM, SMC
71  2006 Protein kinase D protects against oxidative stress-induced intestinal epithelial cell injury via Rho/ROK/PKC-delta pathway activation. PKD, siRNA
72  2006 Rho GTPases: promising cellular targets for novel anticancer drugs. ECM, GEFs, IR, Rho
73  2006 Rho kinase as a novel molecular therapeutic target for hypertensive internal anal sphincter. IAS, SMCs
74  2006 Rho-kinase controls cell shape changes during cytokinesis. Mbs
75  2006 Spontaneously tonic smooth muscle has characteristically higher levels of RhoA/ROK compared with the phasic smooth muscle. ASM, IAS, MLC20, RSM
76  2006 The response to brain tumor-derived growth factors is altered in radioresistant human brain endothelial cells. HBMEC, IR, S1P, VEGF
77  2006 Therapeutic concepts for hypoxic pulmonary vasoconstriction involving ion regulation and the smooth muscle contractile apparatus. HPV
78  2005 Ca2+ sensitization and the regulation of contractility in rat anococcygeus and retractor penis muscle. ---
79  2005 Cellular mechanisms of thromboxane A2-mediated contraction in pulmonary veins. PV, PVSM, TK
80  2005 Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment. PKG, SPARC
81  2005 Expression and functional role of the RhoA/Rho-kinase pathway in rat coeliac artery. LARG, NO, PE, RhoGEF, SNP
82  2005 Inhibition of the RhoA/Rho kinase system attenuates catecholamine biosynthesis in PC 12 rat pheochromocytoma cells. TH
83  2005 Myristoylated alanine-rich C kinase substrate-mediated neurotensin release via protein kinase C-delta downstream of the Rho/ROK pathway. BBS, MARCKS, NT, PKC, PMA, siRNA
84  2005 PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation. CRIK, MLK, PKN
85  2005 Probing the infiltrating character of brain tumors: inhibition of RhoA/ROK-mediated CD44 cell surface shedding from glioma cells by the green tea catechin EGCg. ECM, HA, MT1-MMP
86  2005 Reduced mRNA and protein content of rho guanine nucleotide exchange factor (RhoGEF) in Bartter's and Gitelman's syndromes: relevance for the pathophysiology of hypertension. Ang II, BS/GS, RhoGDI, RhoGEF, RT-PCR
87  2005 ROK-induced cross-link formation stiffens passive muscle: reversible strain-induced stress softening in rabbit detrusor. CCh
88  2005 Role of Rho-kinase in regulation of insulin action and glucose homeostasis. ---
89  2005 The involvement of Rho-associated kinases in agonist-dependent contractions of human maternal and placental arteries at term gestation. ---
90  2004 CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. HA, Hyal-2
91  2004 Chronic hypoxia augments protein kinase G-mediated Ca2+ desensitization in pulmonary vascular smooth muscle through inhibition of RhoA/Rho kinase signaling. CH, NO, PKC, VSM
92  2004 HLA class I signal transduction is dependent on Rho GTPase and ROK. Ab, EC, SMC
93  2004 L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism. ChIP, siRNA, SMC, SMMHC
94  2004 Regulation of myosin light chain phosphorylation by RhoB in neuronal cells. MLC
95  2004 Rho kinase and PAI-1 in Bartter's/Gitelman's syndromes: relationship to angiotensin II signaling. Ang II, BS/GS, DU, PAI-1, RT-PCR
96  2004 The role of protein kinase D in neurotensin secretion mediated by protein kinase C-alpha/-delta and Rho/Rho kinase. GI, NT, PKC, PKD, siRNA
97  2004 Uncoupling of GPCR and RhoA-induced Ca2+-sensitization of chicken amnion smooth muscle lacking CPI-17. MLCP
98  2003 Activation of phospholipase D1 by ADP-ribosylated RhoA. PLD1
99  2003 Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. GEFs, MLCK, MLCP
100  2003 Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition. A/T, DN, EMT, SMA