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■ Abbreviation / Long Form : RTA / replication and transcription activator

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Total Number of Papers: 110
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Abbreviation:   RTA  (>> Co-occurring Abbreviation)
Long Form:   replication and transcription activator
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No. Year Title Co-occurring Abbreviation
2020 Epigenetic factor siRNA screen during primary KSHV infection identifies novel host restriction factors for the lytic cycle of KSHV. KSHV, LANA, NuRD
2019 Genome-Wide Identification of Direct RTA Targets Reveals Key Host Factors for Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation. core RIGs, KSHV
2019 Induction of Kaposi Sarcoma Associated Herpesvirus-encoded Thymidine Kinase (ORF21) by X-Box Binding Protein-1. KS, KSHV, MCD, PEL, TK, vIL-6, XRE
2019 Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis. eIF4F, KSHV, mTORC1
2019 NCOA2 promotes lytic reactivation of Kaposi's sarcoma-associated herpesvirus by enhancing the expression of the master switch protein RTA. KSHV, NCOA2, PARS
2018 Inhibition of murine herpesvirus-68 replication by IFN-gamma in macrophages is counteracted by the induction of SOCS1 expression. BMMs, SOCS1, TLR3
2018 Structure-based mechanism of action of a viral poly(ADP-ribose) polymerase 1-interacting protein facilitating virus replication. MHV-68, PARP-1, vPIP
2017 Alterations in Acetylation of Histone H4 Lysine 8 and Trimethylation of Lysine 20 Associated with Lytic Gene Promoters during Kaposi's Sarcoma-Associated Herpesvirus Reactivation. KSHV
2017 Epigenetic Landscape of Kaposi's Sarcoma-Associated Herpesvirus Genome in Classic Kaposi's Sarcoma Tissues. KS, KSHV, LANA, MCD, PEL, TR
10  2017 Expression and Subcellular Localization of the Kaposi's Sarcoma-Associated Herpesvirus K15P Protein during Latency and Lytic Reactivation in Primary Effusion Lymphoma Cells. BCR, KSHV, PEL, TGN
11  2017 Guanylate-Binding Protein 1 Inhibits Nuclear Delivery of Kaposi's Sarcoma-Associated Herpesvirus Virions by Disrupting Formation of Actin Filament. GBP1, KSHV
12  2017 Identification of Novel Kaposi's Sarcoma-Associated Herpesvirus Orf50 Transcripts: Discovery of New RTA Isoforms with Variable Transactivation Potential. KSHV
13  2017 Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N6-Adenosine Methylation To Promote Lytic Replication. KSHV, SRSF3, YTHDC1
14  2017 KSHV and the Role of Notch Receptor Dysregulation in Disease Progression. KS, KSHV, MCD, PEL, RBP-Jk
15  2017 KSHV and the Role of Notch Receptor Dysregulation in Disease Progression. KS, KSHV, MCD, PEL, RBP-Jk
16  2017 Modulation of global SUMOylation by Kaposi's sarcoma-associated herpesvirus and its effects on viral gene expression. KSHV
17  2017 Nuclear Localization and Cleavage of STAT6 Is Induced by Kaposi's Sarcoma-Associated Herpesvirus for Viral Latency. KS, KSHV, PELs
18  2017 Regulation of the viral life cycle by murine gammaherpesvirus 68 microRNAs. AP-1, gammaHV, miRNAs
19  2017 Structure of the Open Reading Frame 49 Protein Encoded by Kaposi's Sarcoma-Associated Herpesvirus. KSHV, ORF49KSHV, ORF49KSHV
20  2017 The replication and transcription activator of murine gammaherpesvirus 68 cooperatively enhances cytokine-activated, STAT3-mediated gene expression. gammaHVs
21  2016 ARID3B: a Novel Regulator of the Kaposi's Sarcoma-Associated Herpesvirus Lytic Cycle. ARID3B, KS, KSHV, oriLyt, PEL, SILAC, siRNA
22  2016 Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway. Hes1, KS, LEF1
23  2016 Induction of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interleukin-6 by X-Box Binding Protein 1. ER, KS, KSHV, MCD, PEL, vIL-6, XREs
24  2016 Kaposi's Sarcoma-Associated Herpesvirus Reduces Cellular Myeloid Differentiation Primary-Response Gene 88 (MyD88) Expression via Modulation of Its RNA. IL-1, KS, MyD88, TLR
25  2016 Major Histocompatibility Complex Class II HLA-DRalpha Is Downregulated by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Lytic Transactivator RTA and MARCH8. KSHV, MARCH, MHC-II
26  2016 Nuclear Innate Immune DNA Sensor IFI16 Is Degraded during Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV): Role of IFI16 in Maintenance of KSHV Latency. EBV, HCMV, HPV, HSV-1, KSHV, TPA
27  2016 The Role of Gammaherpesviruses in Cancer Pathogenesis. ---
28  2016 TRIM5alpha Promotes Ubiquitination of Rta from Epstein-Barr Virus to Attenuate Lytic Progression. EBV
29  2015 Activation and degradation of open reading frame 45 by the replication and transcription activator of Kaposi's sarcoma-associated herpesvirus. KSHV, ORF45
30  2015 Celecoxib Inhibits the Lytic Activation of Kaposi's Sarcoma-Associated Herpesvirus through Down-Regulation of RTA Expression by Inhibiting the Activation of p38 MAPK. KS, KSHV, MCD, PEL
31  2015 Downregulation of Poly(ADP-Ribose) Polymerase 1 by a Viral Processivity Factor Facilitates Lytic Replication of Gammaherpesvirus. KSHV, PARP-1, PARylated
32  2015 Epigenetic modification of Rta (ORF50) promoter is not responsible for distinct reactivation patterns of murine gammaherpesviruses. MHV-68, TSA
33  2015 Fumagillin, a potent angiogenesis inhibitor, induces Kaposi sarcoma-associated herpesvirus replication in primary effusion lymphoma cells. KSHV, TPA
34  2015 Kaposi's sarcoma-associated herpesvirus-encoded replication and transcription activator impairs innate immunity via ubiquitin-mediated degradation of myeloid differentiation factor 88. IFNs, KSHV, LPS, MyD88, TLRs, Ub
35  2015 Molecular biology of KSHV lytic reactivation. KSHV
36  2015 Murine Gammaherpesvirus 68 ORF48 Is an RTA-Responsive Gene Product and Functions in both Viral Lytic Replication and Latency during In Vivo Infection. MHV-68
37  2015 Preparation and characterization of polyclonal antibody against Kaposi's sarcoma-associated herpesvirus lytic gene encoding RTA. KSHV
38  2014 A novel role of SIRT1 in gammaherpesvirus latency and replication. ---
39  2014 Acetylation changes at lysine 5 of histone H4 associated with lytic gene promoters during reactivation of Kaposi's sarcoma-associated herpesvirus. EBV, HVS, KSHV
40  2014 Inhibition of KAP1 enhances hypoxia-induced Kaposi's sarcoma-associated herpesvirus reactivation through RBP-Jkappa. HIF-1alpha, KS, KSHV, LANA, PEL, TPA
41  2014 Repression of interferon regulatory factor 3 by the Epstein-Barr virus immediate-early protein Rta is mediated through E2F1 in HeLa cells. ChIP, EBV, IFN, IRF3, siRNA
42  2014 The gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus 68 modulate the Toll-like receptor-induced proinflammatory cytokine response. BMDMs, KSHV, MHV-68, NF-kappaB, ORF, TLRs, YFP
43  2013 A virally encoded small peptide regulates RTA stability and facilitates Kaposi's sarcoma-associated herpesvirus lytic replication. KSHV, ORF50, PARS, vSP-1
44  2013 Activation of human herpesvirus replication by apoptosis. HHV-8
45  2013 Cellular microRNAs 498 and 320d regulate herpes simplex virus 1 induction of Kaposi's sarcoma-associated herpesvirus lytic replication by targeting RTA. GO, HSV, KSHV, miRNAs, TGF, UTR
46  2013 Phosphorylation of Kaposi's sarcoma-associated herpesvirus processivity factor ORF59 by a viral kinase modulates its ability to associate with RTA and oriLyt. KSHV
47  2013 TLR-TRIF pathway enhances the expression of KSHV replication and transcription activator. IFN, KSHV, RIP1, TLRs, TRIF
48  2012 Carboxyl-terminal amino acids 1052 to 1082 of the latency-associated nuclear antigen (LANA) interact with RBP-Jkappa and are responsible for LANA-mediated RTA repression. KSHV, LANA, RAM
49  2012 Importance of antibody in virus infection and vaccine-mediated protection by a latency-deficient recombinant murine gamma-herpesvirus-68. gammaHV68
50  2012 Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors. ChIP, EMSA, HIFs, HRE, KSHV, LANA, LTc, PEL
51  2012 Resveratrol inhibits KSHV reactivation by lowering the levels of cellular EGR-1. ChIP, Egr-1, EMSA, KSHV, ORF50p
52  2012 Ser-634 and Ser-636 of Kaposi's Sarcoma-Associated Herpesvirus RTA are Involved in Transactivation and are Potential Cdk9 Phosphorylation Sites. KSHV
53  2012 Suppressive regulation of KSHV RTA with O-GlcNAcylation. K-RTA, KSHV, OGT
54  2012 The virion-associated open reading frame 49 of murine gammaherpesvirus 68 promotes viral replication both in vitro and in vivo as a derepressor of RTA. ORF49, PARP-1
55  2011 Activation of T-cell-factor-dependent transcription by Kaposi's sarcoma-associated herpesvirus replication transactivation activator. KSHV, TCF
56  2011 Construction of a lytically replicating Kaposi's sarcoma-associated herpesvirus. BAC36, KSHV, LANA, ORF50
57  2011 Effect of Rta protein of Epstein-Barr virus on the cell cycle in HeLa cells. EBV
58  2011 Functional characterization of Kaposi's sarcoma-associated herpesvirus open reading frame K8 by bacterial artificial chromosome-based mutagenesis. BAC, bZIP, KSHV, TPA
59  2011 Kaposi sarcoma-associated herpesvirus degrades cellular Toll-interleukin-1 receptor domain-containing adaptor-inducing beta-interferon (TRIF). IFN, IRF7, KSHV, TICAM-1, TIR, TLR3, TRIF
60  2011 Lysine residues of interferon regulatory factor 7 affect the replication and transcription activator-mediated lytic replication of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. IFN, IRF7, KSHV
61  2011 miR-K12-7-5p encoded by Kaposi's sarcoma-associated herpesvirus stabilizes the latent state by targeting viral ORF50/RTA. KSHV, RTA3'UTR
62  2011 Rapamycin blocks production of KSHV/HHV8: insights into the anti-tumor activity of an immunosuppressant drug. KS
63  2011 Replication and transcription activator (RTA) of murine gammaherpesvirus 68 binds to an RTA-responsive element and activates the expression of ORF18. ChIP, EBV, EMSA, KSHV, MHV-68, RRE
64  2011 The single RBP-Jkappa site within the LANA promoter is crucial for establishing Kaposi's sarcoma-associated herpesvirus latency during primary infection. BAC, HHV-8, KS, KSHV, LANA, MCD, PBMCs, PEL
65  2011 Upregulation of cellular Bcl-2 by the KSHV encoded RTA promotes virion production. shRNA
66  2011 X-box binding protein 1 induces the expression of the lytic cycle transactivator of Kaposi's sarcoma-associated herpesvirus but not Epstein-Barr virus in co-infected primary effusion lymphoma. EBV, HDACs, KSHV, PEL, XBP1
67  2010 Autoexcision of bacterial artificial chromosome facilitated by terminal repeat-mediated homologous recombination: a novel approach for generating traceless genetic mutants of herpesviruses. BACs, RRV, TR
68  2010 Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. GST, KSHV, ORF50, SP, TLE2
69  2010 Gene expression and transcription factor profiling reveal inhibition of transcription factor cAMP-response element-binding protein by gamma-herpesvirus replication and transcription activator. CREB
70  2010 Generation and application of polyclonal antibody against replication and transcription activator of Kaposi's sarcoma-associated herpesvirus. KSHV
71  2010 MicroRNAs encoded by Kaposi's sarcoma-associated herpesvirus regulate viral life cycle. KSHV, miRNAs
72  2010 Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication. gammaHV68, MAVS
73  2010 Number of and distance between response elements in Kaposi's sarcoma-associated herpesvirus ORF57 promoter influence its activation by replication and transcription activator and its repression by interferon regulatory factor 7. IRF7, RBP-Jkappa, RREs
74  2010 The de novo methyltransferases DNMT3a and DNMT3b target the murine gammaherpesvirus immediate-early gene 50 promoter during establishment of latency. DNMTs
75  2009 Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus replication. KSHV, MCD, PEL
76  2009 Genome-wide identification of binding sites for Kaposi's sarcoma-associated herpesvirus lytic switch protein, RTA. KSHV
77  2009 Identification and characterization of a new Kaposi's sarcoma-associated herpesvirus replication and transcription activator (RTA)-responsive element involved in RTA-mediated transactivation. KSHV, RRE
78  2009 Kaposi's sarcoma-associated herpesvirus K-bZIP protein is necessary for lytic viral gene expression, DNA replication, and virion production in primary effusion lymphoma cell lines. KSHV, PEL, shRNA, Tet
79  2009 Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathway. KSHV
80  2009 RTA promoter demethylation and histone acetylation regulation of murine gammaherpesvirus 68 reactivation. 5-azaC, DNMTs, HDAC, MHV-68, TSA
81  2008 Regulation of Kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways. EGFP, KSHV
82  2008 The interaction between KSHV RTA and cellular RBP-Jkappa and their subsequent DNA binding are not sufficient for activation of RBP-Jkappa. KSHV, RBP-Jkappa
83  2008 Transcriptional regulation of the open reading frame 35 encoded by Kaposi's sarcoma-associated herpesvirus. KSHV
84  2007 B cell terminal differentiation factor XBP-1 induces reactivation of Kaposi's sarcoma-associated herpesvirus. KSHV, XBP1
85  2007 Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression. IFN, IFN, NF-kappaB, TBK1
86  2007 Control of Rta expression critically determines transcription of viral and cellular genes following gammaherpesvirus infection. MHV
87  2007 In primary effusion lymphoma cells, MYB transcriptional repression is associated with v-FLIP expression during latent KSHV infection while both v-FLIP and v-GPCR become involved during the lytic cycle. KSHV, NF, PEL, v-GPCR, vFLIP
88  2007 Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers. KSHV, LANA, PEL, PMO, PPMO
89  2007 Regulation of KSHV lytic gene expression. ---
90  2007 The transcriptional repressor K-RBP modulates RTA-mediated transactivation and lytic replication of Kaposi's sarcoma-associated herpesvirus. K-RBP, KRAB, KS
91  2006 Asynchronous progression through the lytic cascade and variations in intracellular viral loads revealed by high-throughput single-cell analysis of Kaposi's sarcoma-associated herpesvirus infection. LANA
92  2006 Identification and characterization of the Orf49 protein of Kaposi's sarcoma-associated herpesvirus. JNK, KSHV
93  2006 Intracellular-activated Notch1 can reactivate Kaposi's sarcoma-associated herpesvirus from latency. KSHV, LANA, PEL
94  2006 Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: dual role of replication and transcription activator. KSHV
95  2005 Activation of CD21 and CD23 gene expression by Kaposi's sarcoma-associated herpesvirus RTA. EBV, Igmu, KSHV, sCD23
96  2005 Activation of the Kaposi's sarcoma-associated herpesvirus major latency locus by the lytic switch protein RTA (ORF50). KSHV, LT, ORF71
97  2005 Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 replication and transcription activator regulates viral and cellular genes via interferon-stimulated response elements. HHV-8, IRF, ISGs, ISRE, ORF
98  2005 Modulation of human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus replication and transcription activator transactivation by interferon regulatory factor 7. HHV-8, IRF7, ORF57
99  2005 The Herpesvirus saimiri replication and transcription activator acts synergistically with CCAAT enhancer binding protein alpha to activate the DNA polymerase promoter. DE, HVS, ORF, RE
100  2004 A posttranscriptional regulator of Kaposi's sarcoma-associated herpesvirus interacts with RNA-binding protein PCBP1 and controls gene expression through the IRES. IRES, KSHV, mAbs, PCBP1, XIAP