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■ Abbreviation / Long Form : S1P / site-1 protease

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Total Number of Papers: 79
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Abbreviation:   S1P  (>> Co-occurring Abbreviation)
Long Form:   site-1 protease
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No. Year Title Co-occurring Abbreviation
2020 Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome. LDLR, S2P, SRE, SREBP1
2020 POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation. POST1, SREBPs
2020 Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis. BSP, ER, RIP, S2P
2020 Site-1 protease ablation in the osterix-lineage in mice results in bone marrow neutrophilia and hematopoietic stem cell alterations. Stfa
2020 Soluble (pro)renin receptor promotes fibrotic response in renal proximal tubule epithelial cells in vitro via Akt/beta-catenin/Snail signaling pathway. CKD, FN, HK-2, sPRR
2020 Spondyloepimetaphyseal dysplasia with elevated plasma lysosomal enzymes caused by homozygous variant in MBTPS1. ---
2020 Transcription factors activated through RIP (regulated intramembrane proteolysis) and RAT (regulated alternative translocation). CREB3L1, ER, RAT, RIP, S2P, TM4SF20
2019 A mutation in Site-1 Protease is associated with a complex phenotype that includes episodic hyperCKemia and focal myoedema. UPR
2019 Membrane-Bound Transcription Factor Site-1 Protease in PF429242 Bound State: Computational Kinetics and Dynamics of Reversible Binding. ---
10  2019 p38alpha/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma. EZH2, HCC, SAM, SREBP2
11  2018 Assays to Assess Arenaviral Glycoprotein Function. GPC, LASV, NP, PICV, SKI-1, SSP, VLP
12  2018 Enzymatic sources and physio-pathological functions of soluble (pro)renin receptor. sPRR
13  2018 ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. ER, NAFLD, NASH, SREBP
14  2018 Pharmacologic inhibition of S1P attenuates ATF6 expression, causes ER stress and contributes to apoptotic cell death. ATF6, ER, IRE1alpha, PERK, PF, SREBPs, UPR
15  2018 Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking. ER
16  2018 Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice. ---
17  2018 The cholesterol, fatty acid and triglyceride synthesis pathways regulated by site 1 protease (S1P) are required for efficient replication of severe fever with thrombocytopenia syndrome virus. SFTS, SFTSV
18  2017 (Pro)renin receptor mediates albumin-induced cellular responses: role of site-1 protease-derived soluble (pro)renin receptor in renal epithelial cells. BSA, HK-2, pro, RAS, sPRR
19  2017 Activation of the Arabidopsis membrane-bound transcription factor bZIP28 is mediated by site-2 protease, but not site-1 protease. ER, S2P, UPR
20  2017 Human Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P) regulates cytoplasmic lipid droplet abundance: A potential target for indirect-acting anti-dengue virus agents. DENV, LDs, SI, SKI-1
21  2017 Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiation invitro. SREBP
22  2017 Regulation of SREBP-2 intracellular trafficking improves impaired autophagic flux and alleviates endoplasmic reticulum stress in NAFLD. ERS, NAFLD, S2P, SREBP-2
23  2017 Role of spacer-1 in the maturation and function of GlcNAc-1-phosphotransferase. GlcNAc-1-PT
24  2017 Site-1 protease and lysosomal homeostasis. ATF6, SREPBs
25  2017 Site-1 protease is required for the generation of soluble (pro)renin receptor. BFA, CHO, pro
26  2017 Site-1 protease, a novel metabolic target for glioblastoma. SREBPs
27  2017 The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling. BAK1, EFR, FER, FLS2, RALF
28  2016 A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease. GPC, SKI-1
29  2016 Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P). SKI-1
30  2016 Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation. DENV, SREBPs
31  2015 Analyses of disease-related GNPTAB mutations define a novel GlcNAc-1-phosphotransferase interaction domain and an alternative site-1 protease cleavage site. ER, MLII
32  2015 Analysis of Assembly and Budding of Lujo Virus. LUJV
33  2015 Hepatic S1P deficiency lowers plasma cholesterol levels in apoB-containing lipoproteins when LDLR function is compromised. Blp, Blp-c, KD, LDL-C, LDLR, PCSK9, SREBPs
34  2015 Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin. CCHFV, PCs
35  2015 Site-1 protease cleavage site is important for the ER stress-induced activation of membrane-associated transcription factor bZIP28 in Arabidopsis. ER, UPR
36  2015 Site-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription control. ER, M6P, SREBPs
37  2015 The membrane protein PrsS mimics sigmaS in protecting Staphylococcus aureus against cell wall-targeting antibiotics and DNA-damaging agents. ECF, MMS
38  2015 Tropism of CPMV to Professional Antigen Presenting Cells Enables a Platform to Eliminate Chronic Infections. CPMV, DCs, LCMV
39  2014 Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis. COMP, SCD1, UPR
40  2014 Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease. SKI-1
41  2013 Differential recognition of Old World and New World arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P). GPC, SKI-1
42  2013 The role of proteolytic processing and the stable signal peptide in expression of the Old World arenavirus envelope glycoprotein ectodomain. GPC, LASV, LCMV, SKI-1, SSP
43  2012 Envelope glycoprotein of arenaviruses. GPC, SKI-1, SSP
44  2012 Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242. GPC, SKI-1
45  2012 Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents. ADRP, HCV, LDs, SKI-1, SREBPs
46  2012 Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease. ER, GP, GPC, LASV, LCMV, PC, SKI-1
47  2012 Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer. ATF6, S2P, siRNAs, SREBP-1
48  2011 A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism. ---
49  2011 Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. GP, LASV, LCMV
50  2011 Arenavirus envelope glycoproteins mimic autoprocessing sites of the cellular proprotein convertase subtilisin kexin isozyme-1/site-1 protease. GPC, PC, SKI-1
51  2011 Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6. ATF6, ER, NFV, S2P, SREBP-1
52  2011 Site-1 protease is essential to growth plate maintenance and is a critical regulator of chondrocyte hypertrophic differentiation in postnatal mice. ---
53  2010 Targeting the proteolytic processing of the viral glycoprotein precursor is a promising novel antiviral strategy against arenaviruses. CMK, dec, GP, GPC, LCMV, SKI-1
54  2009 Activation of sterol regulatory element-binding protein by the caspase Drice in Drosophila larvae. S2P
55  2009 Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster. dSREBP, S2P, SREBP
56  2009 Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage. RIP, S2P
57  2009 Inhibition of Lassa virus glycoprotein cleavage and multicycle replication by site 1 protease-adapted alpha(1)-antitrypsin variants. ---
58  2008 Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals. SREBPs
59  2008 Site 1 protease is required for proteolytic processing of the glycoproteins of the South American hemorrhagic fever viruses Junin, Machupo, and Guanarito. GPs
60  2008 Spatial separation of Golgi and ER during mitosis protects SREBP from unregulated activation. ER, SREBPs
61  2007 Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation. ATF6, ER, NUCB1, UPR
62  2007 Site-1 protease is essential for endochondral bone formation in mice. ER
63  2007 The proprotein convertases are potential targets in the treatment of dyslipidemia. aa, LDLR, PCs, PCSK9, SKI-1
64  2007 Transcriptional activation of ATF6 by endoplasmic reticulum stressors. ATF6, ER, S2P
65  2005 Inhibitors of proprotein convertases. NARC-1, PCs, SKI-1, SPCs
66  2003 Site-1 protease is required for cartilage development in zebrafish. goz, SREBPs
67  2002 A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus. GP-C, IQF, SKI-1
68  2002 Genetic mapping of the gene for SKI-1/S1P protease (locus symbol Mbtps1) to mouse chromosome 8. SKI-1, SREBPs
69  2002 Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis. ER, RIP, SREBPs
70  2001 Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene. LDL, SREBPs
71  2001 Proteolytic activation of SREBPs during adipocyte differentiation. S2P, SCAP, SREBP
72  2000 ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. ER, S2P
73  2000 Genomic structure and chromosomal mapping of the human site-1 protease (S1P) gene. SREBPs
74  1999 A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. SCAP, SREBPs
75  1999 Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins. SREBPs
76  1999 Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins. SREBPs
77  1999 Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. ---
78  1998 Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1. S2P, SREBPs
79  1998 Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. PLAP