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■ Abbreviation / Long Form : SHIP2 / SH2-containing inositol 5'-phosphatase 2

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Abbreviation:   SHIP2  (>> Co-occurring Abbreviation)
Long Form:   SH2-containing inositol 5'-phosphatase 2
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No. Year Title Co-occurring Abbreviation
2020 IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity. EMT, GC, IQGAP2
2019 Downregulation of SHIP2 by Hepatitis B Virus X Promotes the Metastasis and Chemoresistance of Hepatocellular Carcinoma through SKP2. HBV, HCC, Skp2
2019 Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity. T2D
2019 Upregulation of SHIP2 participates in the development of breast cancer via promoting Wnt/beta-catenin signaling. BC
2019 [Screening of interacting proteins of SHIP2 in human gastric mucosal epithelium by yeast two-hybrid system]. ---
2018 Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease. ---
2018 Protein phosphatases and podocyte function. PTP1B, SHP-2
2018 Solution structure of SHIP2 SH2 domain and its interaction with a phosphotyrosine peptide from c-MET. HGF, pY
2017 Circulating SHIP2 mRNA as a novel biomarker in the diagnosis and prognosis of gastric cancer. ROC
10  2017 Decreased Sp1 Expression Mediates Downregulation of SHIP2 in Gastric Cancer Cells. BGS, Sp1
11  2017 Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance. EC, PI3K
12  2017 Fibroblasts derived from patients with opsismodysplasia display SHIP2-specific cell migration and adhesion defects. OPS
13  2016 Angiotensin II down-regulates nephrin-Akt signaling and induces podocyte injury: roleof c-Abl. Ang II, siRNA
14  2016 Expression, Purification, Crystallisation and X-ray Crystallographic Analysis of a Truncated Form of Human Src Homology 2 Containing Inositol 5-Phosphatase 2. ---
15  2016 Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation. CRC, PTEN
16  2016 SHIP2 Regulates Lumen Generation, Cell Division, and Ciliogenesis through the Control of Basolateral to Apical Lumen Localization of Aurora A and HEF 1. AMISs
17  2016 Suppression of SHIP2 contributes to tumorigenesis and proliferation of gastric cancer cells via activation of Akt. IHC, qRT-PCR
18  2015 Inhibition of SH2-domain-containing inositol 5-phosphatase (SHIP2) ameliorates palmitate induced-apoptosis through regulating Akt/FOXO1 pathway and ROS production in HepG2 cells. ROS
19  2015 SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells. VLDL
20  2015 SH2 domain-containing inositol 5-phosphatase (SHIP2) regulates de-novo lipogenesis and secretion of apoB100 containing lipoproteins in HepG2 cells. ---
21  2015 Single nucleotide polymorphisms on SHIP2 is associated with Type 2 diabetes mellitus in Chinese Han population. SNPs, T2DM
22  2014 A novel oncogenic role of inositol phosphatase SHIP2 in ER-negative breast cancer stem cells: involvement of JNK/vimentin activation. BCSCs, ER, JNK1, VIM
23  2014 Evidence for SH2 domain-containing 5'-inositol phosphatase-2 (SHIP2) contributing to a lymphatic dysfunction. LEC, NGS, NIRFLI
24  2014 High SHIP2 expression indicates poor survival in colorectal cancer. CRC, IHC, qPCR, TMA
25  2014 Induction of human chronic myeloid leukemia K562 cell apoptosis by virosecurinine and its molecular mechanism. Abl, bcr, CCK, mTOR, PTEN
26  2014 Palmitate induces SHIP2 expression via the ceramide-mediated activation of NF-kappaB, and JNK in skeletal muscle cells. ---
27  2014 SHIP2: a "new" insulin pathway target for aging research. AD, IGF-I, SNP, T2DM
28  2013 Elevated expression of SHIP2 correlates with poor prognosis in non-small cell lung cancer. NSCLC
29  2013 Global phosphotyrosine proteomics identifies PKCdelta as a marker of responsiveness to Src inhibition in colorectal cancer. CDCP1, CRC, pY, RPTPalpha
30  2013 High expression of inositol polyphosphate phosphatase-like 1 associates with unfavorable survival in hepatocellular carcinoma. HCC, IHC, INPPL1, qPCR, TMA
31  2013 Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl. ERK, IRS, PI3K
32  2013 PREP1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice. ACC, AMPK, FAS, LKB1, MCDD, PKC, PREP1
33  2013 Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2). CPDA, 4a, LBDD
34  2013 SH2-containing inositol 5'-phosphatase 2 selectively impairs hypothalamic insulin signalling and regulation of food intake in mice. ---
35  2012 Molecular characterization, expression pattern, and association analysis with carcass traits of the porcine SHIP2 gene. ---
36  2012 The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration. ---
37  2011 SHIP2 multiple functions: a balance between a negative control of PtdIns(3,4,5)P₃ level, a positive control of PtdIns(3,4)P₂ production, and intrinsic docking properties. IPMK, SAM
38  2010 Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes. ---
39  2010 SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo. FGF, MAPK
40  2010 The inositol phosphatase SHIP2 negatively regulates insulin/IGF-I actions implicated in neuroprotection and memory function in mouse brain. ---
41  2009 Catalytically inactive SHIP2 inhibits proliferation by attenuating PDGF signaling in 3T3-L1 preadipocytes. PDGF, PDGFR
42  2009 Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. ---
43  2009 Impact of lipid phosphatases SHIP2 and PTEN on the time- and Akt-isoform-specific amelioration of TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes. ---
44  2009 SHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor. ---
45  2009 Specific tyrosine phosphorylations mediate signal-dependent stimulation of SHIP2 inositol phosphatase activity, while the SH2 domain confers an inhibitory effect to maintain the basal activity. ---
46  2008 High expression of obesity-linked phosphatase SHIP2 in invasive breast cancer correlates with reduced disease-free survival. DCIS, EGFR
47  2008 Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in mice. PI
48  2008 Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover. EGFR, PTEN
49  2008 SHIP2 associates with intersectin and recruits it to the plasma membrane in response to EGF. ITSN1, ITSN1-S
50  2007 Antisense oligonucleotides against the lipid phosphatase SHIP2 improve muscle insulin sensitivity in a dietary rat model of the metabolic syndrome. Akt, AS, HF, IRS
51  2007 Inhibition of SH2-domain containing inositol phosphatase 2 (SHIP2) in insulin producing INS1E cells improves insulin signal transduction and induces proliferation. ---
52  2007 Normalization of prandial blood glucose and improvement of glucose tolerance by liver-specific inhibition of SH2 domain containing inositol phosphatase 2 (SHIP2) in diabetic KKAy mice: SHIP2 inhibition causes insulin-mimetic effects on glycogen metabolism, gluconeogenesis, and glycolysis. ---
53  2007 Regulation of PDGF-stimulated SHIP2 tyrosine phosphorylation and association with Shc in 3T3-L1 preadipocytes. Bis I, PI, PKC, TPA
54  2007 Transcriptional profiling of C2C12 myotubes in response to SHIP2 depletion and insulin stimulation. ---
55  2006 A high-throughput microfluidic assay for SH2 domain-containing inositol 5-phosphatase 2. ---
56  2006 Association of SH-2 containing inositol 5'-phosphatase 2 gene polymorphisms and hyperglycemia. 5'-UTR, IFG, SNPs
57  2006 Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity. PI 3-kinase, PTEN, SKIP
58  2006 The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity. PtdCho, PtdSer, SKIP
59  2005 Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. ---
60  2005 Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling. SNP
61  2005 Impact of the liver-specific expression of SHIP2 (SH2-containing inositol 5'-phosphatase 2) on insulin signaling and glucose metabolism in mice. G6Pase, GK, WT-SHIP2
62  2005 PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes. GSK-3alpha, PI, siRNA
63  2005 Sp-family of transcription factors regulates human SHIP2 gene expression. ---
64  2004 Impact of Src homology 2-containing inositol 5'-phosphatase 2 on the regulation of insulin signaling leading to protein synthesis in 3T3-L1 adipocytes cultured with excess amino acids. ---
65  2004 SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes. PI, PM
66  2003 Brief calorie restriction increases Akt2 phosphorylation in insulin-stimulated rat skeletal muscle. AL, CR
67  2003 Competitive fluorescence polarization assays for the detection of phosphoinositide kinase and phosphatase activity. FP, PI 3-K
68  2003 Regulation of endogenous SH2 domain-containing inositol 5-phosphatase (SHIP2) in 3T3-L1 and human preadipocytes. ---
69  2003 Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade. IR, IRS1, PI
70  2002 Pi 3-kinase and its up- and down-stream modulators as potential targets for the treatment of type II diabetes. PI3K, PTEN
71  2001 Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity. PI, WT-SHIP2
72  1999 Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling. HIRc, PTB, SHIP