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■ Abbreviation / Long Form : SPP / signal peptide peptidase

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Total Number of Papers: 91
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Abbreviation:   SPP  (>> Co-occurring Abbreviation)
Long Form:   signal peptide peptidase
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No. Year Title Co-occurring Abbreviation
2018 MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins. HO-1
2018 Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes. ER, PPI, TAP
2018 Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation. ER, SILAC
2017 Characterization of SPP inhibitors suppressing propagation of HCV and protozoa. HCV
2017 Expression, Purification, and Enzymatic Characterization of Intramembrane Proteases. cryo-EM, PSH, S2P
2017 Insights into the mechanism of isoenzyme-specific signal peptide peptidase-mediated translocation of heme oxygenase. HO-1
2017 Latest emerging functions of SPP/SPPL intramembrane proteases. I-Clip, RIP, SPPL
2017 Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease. AD, ER, IMP1
2017 Role of cleavage at the core-E1 junction of hepatitis C virus polyprotein in viral morphogenesis. ER, HCV, SP
10  2017 Signal peptide peptidase and SPP-like proteases - Possible therapeutic targets? I-CLiPs
11  2017 Signal Peptide Peptidase, Encoded by HM13, Contributes to Tumor Progression by Affecting EGFRvIII Secretion Profiles in Glioblastoma. ---
12  2017 The potential of signal peptide peptidase as a therapeutic target for hepatitis C. DAAs, HCV
13  2016 Inhibitory effect of presenilin inhibitor LY411575 on maturation of hepatitis C virus core protein, production of the viral particle and expression of host proteins involved in pathogenicity. HCV
14  2016 The signal peptide peptidase SppA is involved in sterol regulatory element-binding protein cleavage and hypoxia adaptation in Aspergillus nidulans. RIP, SREBP
15  2016 TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis. ER, HCV
16  2015 A protease-independent function for SPPL3 in NFAT activation. CAD, ER, SPPL3, STIM1
17  2015 Alternative Antigen Processing for MHC Class I: Multiple Roads Lead to Rome. ER
18  2015 gamma-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of gamma-Secretase and Signal Peptide Peptidase. GSIs
19  2015 Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activity. HO-1, t-HO-1, TMs
20  2014 3D structure determination of protein using TEM single particle analysis. I-CLiPs, SPA
21  2014 Binding of HSV-1 glycoprotein K (gK) to signal peptide peptidase (SPP) is required for virus infectivity. gK, HSV-1
22  2014 Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins. ER, HO-1
23  2014 Development of CBAP-BPyne, a probe for gamma-secretase and presenilinase. PS, PSase
24  2014 Hallmarks of hepatitis C virus in equine hepacivirus. EHcV, HCV, UTR
25  2014 Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo. gK
26  2014 Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u. ER, ERAD, UPR
27  2014 The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance. ER, ERAD, ERAD-R, Ypf1
28  2013 Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana. DDM, RIP
29  2013 Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases. SPPL
30  2013 New role of signal peptide peptidase to liberate C-terminal peptides for MHC class I presentation. MHC-I
31  2013 Structure of a presenilin family intramembrane aspartate protease. PSH, TMs
32  2013 TAP expression level in tumor cells defines the nature and processing of MHC class I peptides for recognition by tumor-specific cytotoxic T lymphocytes. CALCA, IFN, ppCT, SP, TAP
33  2012 Development of clickable active site-directed photoaffinity probes for gamma-secretase. GSI, PS1-NTF
34  2012 Expression and characterization of Drosophila signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease. SPPL, SPPL, UPR
35  2012 Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3). FVenv, SPPL3
36  2012 Malaria parasite signal peptide peptidase is an ER-resident protease required for growth but not for invasion. ER
37  2012 Structural analysis of hepatitis C virus core-E1 signal peptide and requirements for cleavage of the genotype 3a signal sequence by signal peptide peptidase. GT1a, HCV, His, NMR, SP
38  2012 Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design. ER, ERAD
39  2012 The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). ADAM10, Bri2, SPPL, SPPL2b, TMD
40  2012 Vigilin interacts with signal peptide peptidase. BN, ER
41  2011 Three-dimensional structure of the signal peptide peptidase. ---
42  2010 Molecular insights into mechanisms of intramembrane proteolysis through signal peptide peptidase (SPP). RIP
43  2010 Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation. ER, PDI
44  2010 Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes. ER
45  2010 Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteases. ---
46  2010 The Drosophila Crumbs signal peptide is unusually long and is a substrate for signal peptide peptidase. ---
47  2009 Characterization of hepatitis C virus core protein multimerization and membrane envelopment: revelation of a cascade of core-membrane interactions. ER, HCV
48  2009 Sequential processing of hepatitis C virus core protein by host cell signal peptidase and signal peptide peptidase: a reassessment. HCV, SP
49  2009 Signal peptide peptidases are expressed in the shoot apex of rice, localized to the endoplasmic reticulum. ---
50  2009 Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis. Itm2b, SPPL
51  2009 The signal peptide peptidase is required for pollen function in Arabidopsis. ---
52  2008 A Presenilin-like protease associated with Plasmodium falciparum micronemes is involved in erythrocyte invasion. PfSPP
53  2008 An internal signal sequence directs intramembrane proteolysis of a cellular immunoglobulin domain protein. SP
54  2008 Distinct pharmacological effects of inhibitors of signal peptide peptidase and gamma-secretase. ---
55  2008 Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation. DRM, HCV
56  2008 Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. betaAPP, FAD, SPPL2b, SPPLs
57  2008 Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. Itm2b, SPPL
58  2008 Signal peptide peptidase and its homologs in Arabidopsis thaliana--plant tissue-specific expression and distinct subcellular localization. ER, GFP
59  2007 A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis. ---
60  2007 Characterization of the cleavage of signal peptide at the C-terminus of hepatitis C virus core protein by signal peptide peptidase. HCV
61  2007 Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology. ---
62  2007 Signal peptide peptidases and gamma-secretase: cousins of the same protease family? ER
63  2007 Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease. APP, I-CLiPs
64  2006 A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. SPPLs, TNF-alpha
65  2006 C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation. PEN-2, PS
66  2006 Cell-surface expression of a new splice variant of the mouse signal peptide peptidase. ---
67  2006 Cellular functions of gamma-secretase-related proteins. NOMO, SPPLs
68  2006 Core protein cleavage by signal peptide peptidase is required for hepatitis C virus-like particle assembly. ER, HCV, HCV-LP
69  2006 Core protein of pestiviruses is processed at the C terminus by signal peptide peptidase. CSFV
70  2006 Efficient cleavage by signal peptide peptidase requires residues within the signal peptide between the core and E1 proteins of hepatitis C virus strain J1. HCV, SP
71  2006 Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase. I-CLiP, mSPP, SPPL2b, SPPL3
72  2006 Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells. CFP, FLIM, FRET, PSs, YFP
73  2006 Signal peptide peptidase cleavage of GB virus B core protein is required for productive infection in vivo. GBV-B, HCV
74  2006 Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals. HCV, I-CLiPs, S2P
75  2006 Signal peptide peptidase is required for dislocation from the endoplasmic reticulum. HCMV, MHC
76  2006 Signal peptide peptidase-catalyzed cleavage of hepatitis C virus core protein is dispensable for virus budding but destabilizes the viral capsid. HCV
77  2006 Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs. PRL
78  2005 Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. ER
79  2005 Drosophila signal peptide peptidase is an essential protease for larval development. ---
80  2005 Signal peptide peptidase promotes the formation of hepatitis C virus non-enveloped particles and is captured on the viral membrane during assembly. HCV, hspp, NLPs, SP
81  2004 A misassembled transmembrane domain of a polytopic protein associates with signal peptide peptidase. ER
82  2004 A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin. ---
83  2004 Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. SPPLs
84  2004 Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein. AD, IMP1
85  2004 Intramembrane proteolysis and endoplasmic reticulum retention of hepatitis C virus core protein. ER, HCV
86  2004 Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor. PS
87  2003 Expression of the presenilin-like signal peptide peptidase (SPP) in mouse adult brain and during development. ---
88  2003 Intramembrane proteolysis by presenilin and presenilin-like proteases. PS
89  2003 Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs. AD, PSs
90  2002 Identification of signal peptide peptidase, a presenilin-type aspartic protease. ---
91  2002 Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis. ---